It has become the hot topic of new normal for environmental protection to ＂ impel ecological civilization and create new way of environ- mental protection＂. In this paper, based on current severe environmental prote...It has become the hot topic of new normal for environmental protection to ＂ impel ecological civilization and create new way of environ- mental protection＂. In this paper, based on current severe environmental protection situation, new idea of ＂government taking the stage, research department writing a play,enterprise acting in an opera and the masses supervising＂ and action plan of ＂government having the right but can not be impulsive, research department having the talent and should discharge their duties, enterprise having the money but should keep law, and the mas- ses having the enthusiasm to strengthen supervision＂ for environmental protection are proposed,which aims to contribute ideas and exert efforts for impelling ecological civilization and environmental protection.展开更多
In order to realize sustainable development of the arid area of Northwest China, rational water resources exploitation and optimization are primary prerequisites. Based on the essential principle of sustainable develo...In order to realize sustainable development of the arid area of Northwest China, rational water resources exploitation and optimization are primary prerequisites. Based on the essential principle of sustainable development, this paper puts forward a general idea on water resources optimization and eco-environmental protection in Qaidam Basin, and identifies the competitive multiple targets of water resources optimization. By some qualitative methods such as Input-output Model & AHP Model and some quantitative methods such as System Dynamics Model & Produce Function Model, some standard plans of water resources optimization come into being. According to the Multiple Targets Decision by the Closest Value Model, the best plan of water resources optimization, eco-environmental protection and sustainable development in Qaidam Basin is finally decided.展开更多
Multifunctional drug delivery systems(DDSs)have shown great prospects in overcoming the heterogeneous barrier of delivery drugs to the complex tumor microenvironment(TME).In this study,multifunctional AS/Ge-pNAB micro...Multifunctional drug delivery systems(DDSs)have shown great prospects in overcoming the heterogeneous barrier of delivery drugs to the complex tumor microenvironment(TME).In this study,multifunctional AS/Ge-pNAB microgels with dual-active targeting,triple environment responsiveness,and fluorescence imaging capability were prepared through a straightforward procedure.This was aimed to improve the antitumor therapeutic application of gambogic acid(GA)based on the biological characteristics of TME.The microgels have a uniform double-layer structure with aptamer in the outer layer which helps in recognizing receptors on the tumor cells.The GA loaded nano-herb exhibited environment-responsive drug release profiles under acidic pH,reductant and high temperature.The nano-herb significantly improved the accumulation of GA in tumor sites through the synergistic combination of the enhanced permeability and retention effect and dual-ligand mediated internalization.Then,it accelerated intracellular drug release and killed tumor cells.Therefore,the nano-herb had specific therapeutic effects on the tumor in vitro and in vivo as they remarkably inhibited tumor growth while depicting optimal biosafety and lower levels of off-target toxicity.Overall,these findings demonstrate the great potential of the multifunctional AS/Ge-pNAB microgels for precisely targeted GA delivery and open a new avenue for the facile preparation of multifunctional DDSs.展开更多
基金Supported by Special Fund for Environmental Protection Research in the Public Interest(PM-zx024-201207-046)Special Fund for Basic Research Business of Scientific Research Institutes at the Central Level in the Public Interest(PM-zx021-201212-014)
文摘It has become the hot topic of new normal for environmental protection to ＂ impel ecological civilization and create new way of environ- mental protection＂. In this paper, based on current severe environmental protection situation, new idea of ＂government taking the stage, research department writing a play,enterprise acting in an opera and the masses supervising＂ and action plan of ＂government having the right but can not be impulsive, research department having the talent and should discharge their duties, enterprise having the money but should keep law, and the mas- ses having the enthusiasm to strengthen supervision＂ for environmental protection are proposed,which aims to contribute ideas and exert efforts for impelling ecological civilization and environmental protection.
基金National Natural Science Foundation of China, No.49871035.
文摘In order to realize sustainable development of the arid area of Northwest China, rational water resources exploitation and optimization are primary prerequisites. Based on the essential principle of sustainable development, this paper puts forward a general idea on water resources optimization and eco-environmental protection in Qaidam Basin, and identifies the competitive multiple targets of water resources optimization. By some qualitative methods such as Input-output Model & AHP Model and some quantitative methods such as System Dynamics Model & Produce Function Model, some standard plans of water resources optimization come into being. According to the Multiple Targets Decision by the Closest Value Model, the best plan of water resources optimization, eco-environmental protection and sustainable development in Qaidam Basin is finally decided.
基金financially supported by the National Natural Science Foundation of China(Nos.21907076 and 31901908)Natural Science Foundation of Tianjin(No.22JCQNJC01570)Scientific Project of Tianjin Municipal Education Commission(No.2022KJ026).
文摘Multifunctional drug delivery systems(DDSs)have shown great prospects in overcoming the heterogeneous barrier of delivery drugs to the complex tumor microenvironment(TME).In this study,multifunctional AS/Ge-pNAB microgels with dual-active targeting,triple environment responsiveness,and fluorescence imaging capability were prepared through a straightforward procedure.This was aimed to improve the antitumor therapeutic application of gambogic acid(GA)based on the biological characteristics of TME.The microgels have a uniform double-layer structure with aptamer in the outer layer which helps in recognizing receptors on the tumor cells.The GA loaded nano-herb exhibited environment-responsive drug release profiles under acidic pH,reductant and high temperature.The nano-herb significantly improved the accumulation of GA in tumor sites through the synergistic combination of the enhanced permeability and retention effect and dual-ligand mediated internalization.Then,it accelerated intracellular drug release and killed tumor cells.Therefore,the nano-herb had specific therapeutic effects on the tumor in vitro and in vivo as they remarkably inhibited tumor growth while depicting optimal biosafety and lower levels of off-target toxicity.Overall,these findings demonstrate the great potential of the multifunctional AS/Ge-pNAB microgels for precisely targeted GA delivery and open a new avenue for the facile preparation of multifunctional DDSs.
