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Science and Technology Commissioners Supporting High-Quality Development Project for Hundreds of Counties, Thousands of Towns, and Myriads of Villages in the Context of Rural Revitalization
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作者 Wenwen WEI Cuihong YANG Xiguang ZHU 《Asian Agricultural Research》 2024年第4期1-2,7,共3页
This paper discusses the important role of science and technology commissioners in the high-quality development of hundreds of counties,thousands of towns,and myriads of villages in the context of rural revitalization... This paper discusses the important role of science and technology commissioners in the high-quality development of hundreds of counties,thousands of towns,and myriads of villages in the context of rural revitalization,including building bridges,accelerating the transformation of achievements,promoting the value-added of the whole agricultural industry chain,and promoting the rapid development of rural industrial economy.It also discusses the working achievements of science and technology commissioners,in order to promote further development of rural revitalization in Guangdong Province. 展开更多
关键词 SCIENCE and technology COMMISSIONERS Hundreds of counties thousands of TOWNS and myriads of VILLAGES SCIENCE and technology support
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The Impact of Health Information Technology on Hospital Performance: A Systematic Integrative Literature Review
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作者 Alisa Westerhof Cokky Hilhorst Willem Jan Bos 《Health》 2024年第4期257-279,共23页
Objective: To review, categorise, and synthesise findings from literature on health information technology (HIT) functionalities, HIT use, and the impact of HIT on hospital performance. Materials and Methods: We condu... Objective: To review, categorise, and synthesise findings from literature on health information technology (HIT) functionalities, HIT use, and the impact of HIT on hospital performance. Materials and Methods: We conducted a systematic integrative literature review based on a compre-hensive database search. To organise, categorise and synthesise the ex-isting literature, we adopted the affordance actualization theory. To align the literature with our research framework, we used four categories: 1) the functionalities of HIT and how these functionalities are measured;2) use and immediate outcomes of HIT functionalities;3) different perfor-mance indicators and how HIT functionalities affect them;and 4) what hospital characteristics influence the outcome of hospital performance. Results: Fifty-two studies were included. We identified four types of HIT. Only ten studies (19.2%) define the use of HIT by explicitly meas-uring the use rate of HIT. We identified five dimensions of hospital per-formance indicators. Every dimension showed mixed results;however, in general, HIT has a positive impact on mortality and patient readmis-sions. We found several hospital characteristics that may affect the rela-tionship between HIT and hospital-level outcomes. Discussion: Further efforts should focus on embedded research on HIT functionalities, use and effects of HIT implementations with more performance indicators and adjusted for hospital characteristics. Conclusion: The proposed framework could help hospitals and researchers make decisions regard-ing the functionalities, use and effects of HIT implementation in hospi-tals. Given our research outcomes, we suggest future research opportuni-ties to improve understanding of how HIT affects hospital performance. . 展开更多
关键词 Health Information technology HIT Functionalities Hospital Performance Indicators
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The Value of Modern Information Technology in Nursing Emergencies
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作者 Xushan Zhou Ying Li +2 位作者 Henglong Xu Chenyan Li Hongling Sun 《Health》 2024年第9期849-855,共7页
In first aid, traditional information interchange has numerous shortcomings. For example, delayed information and disorganized departmental communication cause patients to miss out on critical rescue time. Information... In first aid, traditional information interchange has numerous shortcomings. For example, delayed information and disorganized departmental communication cause patients to miss out on critical rescue time. Information technology is becoming more and more mature, and as a result, its use across numerous industries is now standard. China is still in the early stages of developing its integration of emergency medical services with modern information technology;despite our progress, there are still numerous obstacles and constraints to overcome. Our goal is to integrate information technology into every aspect of emergency patient care, offering robust assistance for both patient rescue and the efforts of medical personnel. Information may be communicated in a fast, multiple, and effective manner by utilizing modern information technology. This study aims to examine the current state of this field’s development, current issues, and the field’s future course of development. 展开更多
关键词 Modern Information technology Nursing First Aid Critical Care
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The Application Progress of Skin Imaging Technology in Psoriasis
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作者 Qinyi Wang Jin Gong 《Advances in Bioscience and Biotechnology》 CAS 2024年第7期397-405,共9页
Skin imaging technologies such as dermoscopy, high-frequency ultrasound, reflective confocal microscopy and optical coherence tomography are developing rapidly in clinical application. Skin imaging technology can impr... Skin imaging technologies such as dermoscopy, high-frequency ultrasound, reflective confocal microscopy and optical coherence tomography are developing rapidly in clinical application. Skin imaging technology can improve clinical diagnosis rate, and its non-invasiveness and repeatability make it occupy an irreplaceable position in clinical diagnosis. With the “booming development” of medical technology, skin imaging technology can improve clinical diagnosis rate. Researchers have made significant advances in assisting clinical diagnosis, prediction, and treatment of disease. This article reviews the application and progress of skin imaging in the diagnosis of psoriasis. 展开更多
关键词 PSORIASIS Skin Imaging technology High Frequency Ultrasound Optical Coherence Tomography
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Development review and the prospect of oil shale in-situ catalysis conversion technology
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作者 Li Wang Chen-Hao Gao +2 位作者 Rui-Ying Xiong Xiao-Jun Zhang Ji-Xiang Guo 《Petroleum Science》 SCIE EI CAS CSCD 2024年第2期1385-1395,共11页
As an unconventional resource, oil shale possesses abundant reserves and significant potential for industrial applications. The rational and efficient development of oil shale resources holds immense importance in red... As an unconventional resource, oil shale possesses abundant reserves and significant potential for industrial applications. The rational and efficient development of oil shale resources holds immense importance in reducing national energy demand. In-situ catalytic technology, characterized by its high efficiency, low pollution, and minimal energy consumption, represents a key direction for future oil shale development. This paper provides a comprehensive review of research progress in in-situ oil shale mining technology, oil shale pyrolysis catalysts, the pyrolysis mechanism of kerogen, and the compatibility of different heating processes and catalysts. Furthermore, the paper proposes future research directions and prospects for oil shale in-situ catalytic technology, including reservoir modification, highefficiency catalyst synthesis, injection processes, and high-efficiency heating technology. These insights serve as valuable technical references for the advancement of oil shale in-situ catalytic technology. 展开更多
关键词 Oil shale In-situ catalytic technology Pyrolysis catalyst Kerogen pyrolysis mechanism
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The Impact of Digital Technology on Healthcare Delivery and Patient Outcomes
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作者 Taiwo Raheemah Alawiye 《E-Health Telecommunication Systems and Networks》 2024年第2期13-22,共10页
Digital technology has fundamentally transformed healthcare delivery, exerting profound influence on patient outcomes. This paper delves into the roles played by telemedicine, electronic health records (EHRs), and mob... Digital technology has fundamentally transformed healthcare delivery, exerting profound influence on patient outcomes. This paper delves into the roles played by telemedicine, electronic health records (EHRs), and mobile health applications in augmenting healthcare services. The objective is to scrutinize the ways in which these digital innovations enhance healthcare delivery and patient outcomes, while also identifying the attendant challenges in their adoption. To achieve this, a rigorous literature review encompassing peer-reviewed articles, reports, and case studies that examine the impact of digital technology in healthcare settings was conducted. The findings underscore that digital technology significantly bolsters patient care by enhancing access, operational efficiency, and diagnostic accuracy. Nonetheless, persistent challenges such as safeguarding data privacy, ensuring interoperability across systems, and managing implementation costs continue to pose significant hurdles. 展开更多
关键词 Digital technology Healthcare Delivery Patient Outcomes
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Pay attention to the application of indocyanine green fluorescence imaging technology in laparoscopic liver cancer resection
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作者 Li-Min Kang Fu-Wei Zhang +1 位作者 Fa-Kun Yu Lei Xu 《World Journal of Clinical Cases》 SCIE 2024年第23期5288-5293,共6页
Traditional laparoscopic liver cancer resection faces challenges,such as difficultiesin tumor localization and accurate marking of liver segments,as well as theinability to provide real-time intraoperative navigation.... Traditional laparoscopic liver cancer resection faces challenges,such as difficultiesin tumor localization and accurate marking of liver segments,as well as theinability to provide real-time intraoperative navigation.This approach falls shortof meeting the demands for precise and anatomical liver resection.The introductionof fluorescence imaging technology,particularly indocyanine green,hasdemonstrated significant advantages in visualizing bile ducts,tumor localization,segment staining,microscopic lesion display,margin examination,and lymphnode visualization.This technology addresses the inherent limitations oftraditional laparoscopy,which lacks direct tactile feedback,and is increasinglybecoming the standard in laparoscopic procedures.Guided by fluorescenceimaging technology,laparoscopic liver cancer resection is poised to become thepredominant technique for liver tumor removal,enhancing the accuracy,safetyand efficiency of the procedure. 展开更多
关键词 Indocyanine green Fluorescence imaging technology LAPAROSCOPY HEPATECTOMY Liver tumor
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Unveiling the impact and mechanism of digital technology on agricultural economic resilience
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作者 Tianshu Quan Hui Zhang +1 位作者 Tianli Quan Yi Yu 《Chinese Journal of Population,Resources and Environment》 2024年第2期136-145,共10页
Enhancing the economic resilience of agriculture is essential for promoting sustainable and high-quality agricultural development.The emergence of digital technology has created new opportunities in this field.However... Enhancing the economic resilience of agriculture is essential for promoting sustainable and high-quality agricultural development.The emergence of digital technology has created new opportunities in this field.However,existing research predominantly focuses on traditional agricultural factors and technologies.Therefore,the impact of digital technology on agricultural economic resilience within the broader context of the“production-operation-industry”system in agriculture has not been comprehensively explored.To bridge this gap,this study analyzes panel data from 30 Chinese provinces from 2011 to 2020.It employs the static Van Dorn’s law and a dynamic spatial panel model to examine how digital technology empowers agricultural resilience.The findings indicate a continuous strengthening of digital technology development in China,albeit with significant polarization and spatial imbalances.Moreover,the resilience of the agricultural economy undergoes notable fluctuations,initially narrowing and subsequently displaying an upward trend.Digital technology clearly plays a pivotal role in empowering resilience through agricultural scale operation,industrial transformation,and technological progress.Its impact,particularly on the promotion of resilience in the eastern region and non-grain-producing areas and on high-level agricultural economies,also shows regional and technological variations. 展开更多
关键词 Digital technology Agricultural economic resilience Counterfactual method Dynamic spatial panel model Agricultural scale
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Applying the Technology Acceptance Model (TAM) in Information Technology System to Evaluate the Adoption of Decision Support System
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作者 Md Azhad Hossain Anamika Tiwari +3 位作者 Sanchita Saha Ashok Ghimire Md Ahsan Ullah Imran Rabeya Khatoon 《Journal of Computer and Communications》 2024年第8期242-256,共15页
With the beginning of the information systems’ spreading, people started thinking about using them for making business decisions. Computer technology solutions, such as the Decision Support System, make the decision-... With the beginning of the information systems’ spreading, people started thinking about using them for making business decisions. Computer technology solutions, such as the Decision Support System, make the decision-making process less complex and simpler for problem-solving. In order to make a high-quality business decision, managers need to have a great deal of appropriate information. Nonetheless, this complicates the process of making appropriate decisions. In a situation like that, the possibility of using DSS is quite logical. The aim of this paper is to find out the intended use of DSS for medium and large business organizations in USA by applying the Technology Acceptance Model (TAM). Different models were developed in order to understand and predict the use of information systems, but the information systems community mostly used TAM to ensure this issue. The purpose of the research model is to determine the elements of analysis that contribute to these results. The sample for the research consisted of the target group that was supposed to have completed an online questionnaire about the manager’s use of DSS in medium and large American companies. The information obtained from the questionnaires was analyzed through the SPSS statistical software. The research has indicated that, this is primarily used due to a significant level of Perceived usefulness and For the Perceived ease of use. 展开更多
关键词 Information technology Decision Support System Business Organization in USA technology Acceptance Model
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How R&D investment promotes green technology innovation in the context of digitalization?-An empirical analysis based on provincial panel data
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作者 LIU Jie LI Zhi-hui WEI Fang-xin 《Ecological Economy》 2024年第1期39-52,共14页
Green technology innovation is an important driving force and source to promote my country’s high-quality development,and it is the core path to achieve sustainable development.This paper uses my country’s provincia... Green technology innovation is an important driving force and source to promote my country’s high-quality development,and it is the core path to achieve sustainable development.This paper uses my country’s provincial panel data from 2016 to 2019 to study the impact mechanism of R&D investment on green technology innovation,and introduces the level of digitization,using the panel threshold model to discuss its role in the impact mechanism of R&D investment on green technology innovation.The study found that when the level of digitalization in a region is low,increasing R&D investment does not necessarily improve the ability of green technology innovation;when the level of digitalization is relatively high,R&D investment has a positive role in promoting green technology innovation.Therefore,it is necessary to improve policies to encourage enterprises to increase investment in research and development;at the same time,it is necessary to promote the coordinated development of digital foundation,digital investment,digital literacy,digital economy and digital application,and promote the deep integration of digitalization and green technology innovation. 展开更多
关键词 green technology innovation R&D investment digital level panel model
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Analysis on the Impact of Cattle Fattening Technology on Farmer Households in Atabae Timor-Leste
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作者 Marcolino Estevão Fernandes E. Brito Vicente de Paulo Correia +1 位作者 Carlos da Conceicão de Deus Mateus de Jesus Gomes 《Agricultural Sciences》 2024年第4期399-407,共9页
Agriculture is one of the priority sectors in Timor-Leste. Introducing new agriculture technology is crucial to enhance agricultural production. Practicing cattle fattening can increase beef cattle body weight and gen... Agriculture is one of the priority sectors in Timor-Leste. Introducing new agriculture technology is crucial to enhance agricultural production. Practicing cattle fattening can increase beef cattle body weight and generate income to the beef cattle farmers. As farmers face problems including agricultural production decline, lack of forages and information and weather unfavourable. The study’s purpose was to examine the impact of adoption of cattle fattening technology on farmer households in Atabae administrative post, Bobonaro municipality in Timor-Leste. There were 200 beef cattle farmers households where randomly selected in four villages in Atabae. It consisted of 65 farmers practicing cattle fattening and 135 farmers non-practicing cattle fattening. Face to face interviews used structured questionnaire. Statistical analysis such as t-test and descriptive analysis were used to examine impact adoption of cattle fattening technology by farmers and factor constraints of cattle production and the solutions of it. The results indicated the average value of cattle and profit were significant different from zero and it is associated with practicing of cattle fattening. The average of labour used on cattle activities, the average of cattle sold, and total cost spent on cattle were not significant different from zero. The percentage of farmers said that factors constraints cattle production were shortage of water and forage (53%) and spend time on culture ceremony and lack of capital (33%). The number of farmers said that they collected water from river, feed cattle with sago and forage (55.3%) and cultivated forage (23.4%). This finding contributes information to the farmers, traders, and Timorese government to continue implementing cattle fattening activities as it enhances farmers’ income and developing cattle production. 展开更多
关键词 Cattle Production Adoption of Cattle Fattening technology and Cattle Farmer Households
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The Influence of Information Technology(IT)on Accrual Accounting Adoption:The Case of the Jordanian Public Sector
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作者 Moawiah Awad Alghizzawi Rosnia Masruki 《Journal of Modern Accounting and Auditing》 2024年第2期40-48,共9页
Jordan is one of many countries that intends to reform its public sector by adopting accrual accounting,which is primarily carried out through the International Public Sector Accounting Standards(IPSAS)implementation ... Jordan is one of many countries that intends to reform its public sector by adopting accrual accounting,which is primarily carried out through the International Public Sector Accounting Standards(IPSAS)implementation plan,scheduled to be completed by 2021.Considering the difficulties of adoption,this process cannot be completed without an appropriate Information Technology(IT)system capable of providing the accounting information required for this reform.Therefore,this study aims to examine the influence of IT on accrual accounting adoption in the Jordanian public sector.The study employed the quantitative survey approach.Based on 331 usable questionnaires,the descriptive findings showed that the use of IT in the Jordanian public sector is relevant to daily accounting transactions in general and to accrual accounting in particular.The regression analysis showed a positive,significant relationship between IT use and accrual accounting practice.The IT specialist should be able to understand the needs of public sector in adopting accrual-based accounting.In line with today’s digitalization age,which integrates advanced technologies and numerous techniques,this study suggests that a combination of accounting and IT experts is a value added to sharpen the competitiveness of public sector reform.This study contributes to the extant literature in public sector,concerning the relationship between IT and accrual accounting adoption in the context of Jordan. 展开更多
关键词 public sector accrual accounting adoption information technology JORDAN
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Practice and Thinking of Agricultural Science and Technology Experts Serving the Grassroots to Promote Rural Revitalization
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作者 Lixian CUI Jinli LIU 《Asian Agricultural Research》 2024年第1期44-46,共3页
Provincial agricultural research institutes are local agricultural research institutions.They are familiar with local agricultural and ru-ral conditions,and have advantages in scientific and technological achievements... Provincial agricultural research institutes are local agricultural research institutions.They are familiar with local agricultural and ru-ral conditions,and have advantages in scientific and technological achievements,technical reserves and the construction of scientific and tech-nological talent support systems.In the process of promoting the implementation of the rural revitalization strategy,all the responsibilities and obligations of the agricultural research institute are to identify the focus of scientific and technological support and talent support in rural revital-ization,and break the bottleneck and constraints of rural revitalization.By sorting out the current situation of agricultural science and technolo-gy experts serving the grassroots in the problem of talent support for rural revitalization,this paper analyzed the existing problems and put for-ward countermeasures and recommendations. 展开更多
关键词 Agricultural science and technology experts Serving the grassroots Rural revitalization
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Progress and prospect of mid-deep geothermal reinjection technology
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作者 Jing Hu Yan-guang Liu +2 位作者 Xin Wang Ying-nan Zhang Mei-hua Wei 《Journal of Groundwater Science and Engineering》 2024年第3期321-338,共18页
Mid-deep geothermal reinjection technology is crucial for the sustainable development of geothermal resources,which has garnered significant attention and rapid growth in recent years.Currently,various geothermal rein... Mid-deep geothermal reinjection technology is crucial for the sustainable development of geothermal resources,which has garnered significant attention and rapid growth in recent years.Currently,various geothermal reinjection technologies lag behind,lacking effective integration to address issues like low reinjection rates and thermal breakthrough.This paper reviews the basic principles and development history of mid-deep geothermal reinjection technology,focusing on various technical methods used in the process and analyzing their applicability,advantages,and disadvantages under different geological conditions.It highlights the unique challenges posed by deep geothermal resources,including high temperature,high pressure,high stress,chemical corrosion,and complex geological structures.Additionally,it addresses challenges in equipment selection and durability,system stability and operation safety,environmental impact,and sustainable development.Finally,the paper explores future directions for mid-deep geothermal reinjection technology,highlighting key areas for further research and potential pathways for technological innovation.This comprehensive analysis aims to accelerate the advancement of geothermal reinjection technology,offering essential guidance for the efficient reinjection and sustainable development of geothermal resources. 展开更多
关键词 Middle and deep geothermal Geothermal reinjection Sustainable development Technological progress Research path
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Persuasive Technology for the Future of Smoking Cessation*
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作者 Fatimah Dera M. Alshahrani 《Advances in Internet of Things》 2024年第2期36-52,共17页
This paper explores the integration of persuasive technology into smoking cessation efforts through the development and evaluation of a mobile app, “No-Smoke.” Leveraging compelling features like social support, tra... This paper explores the integration of persuasive technology into smoking cessation efforts through the development and evaluation of a mobile app, “No-Smoke.” Leveraging compelling features like social support, tracking, planning, and motivation, the app aims to augment user engagement and support the process of quitting smoking. The efficacy of these features has been substantiated through both automated testing and user feedback, highlighting their potential to enhance awareness, motivation, and behavior modification. Despite notable successes, limitations, including a limited user base and uncertainties regarding long-term efficacy, have been acknowledged, stemming from the inherent complexities of smoking cessation. Nevertheless, based on user experiences and feedback, “No-Smoke” represents a promising advancement in the use of technology for public health interventions, particularly in the realm of smoking cessation. To address existing challenges, future research is recommended to encompass a comprehensive, long-term study involving a larger and more diverse user base. Additionally, further investigation should focus on personalization enhancements and the integration of machine learning algorithms to better understand and respond to user behavior. 展开更多
关键词 Persuasive technology Smoking Cessation Mobile App
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Theory,technology and application of grouted bolting in soft rock roadways of deep coal mines
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作者 Hongpu Kang Jianwei Yang +4 位作者 Pengfei Jiang Fuqiang Gao Wenzhou Li Jiafeng Li Huiyuan Chen 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2024年第7期1463-1479,共17页
The grouted bolt,combining rock bolting with grouting techniques,provides an effective solution for controlling the surrounding rock in deep soft rock and fractured roadways.It has been extensively applied in numerous... The grouted bolt,combining rock bolting with grouting techniques,provides an effective solution for controlling the surrounding rock in deep soft rock and fractured roadways.It has been extensively applied in numerous deep mining areas characterized by soft rock roadways,where it has demonstrated remarkable control results.This article systematically explores the evolution of grouted bolting,covering its theoretical foundations,design methods,materials,construction processes,monitoring measures,and methods for assessing its effectiveness.The overview encompassed several key elements,delving into anchoring theory and grouting reinforcement theory.The new principle of high pretensioned high-pressure splitting grouted bolting collaborative active control is introduced.A fresh method for dynamic information design is also highlighted.The discussion touches on both conventional grouting rock bolts and cable bolts,as well as innovative grouted rock bolts and cables characterized by their high pretension,strength,and sealing hole pressure.An examination of the merits and demerits of standard inorganic and organic grouting materials versus the new inorganic–organic composite materials,including their specific application conditions,was conducted.Additionally,the article presents various methods and instruments to assess the support effect of grouting rock bolts,cable bolts,and grouting reinforcement.Furthermore,it provides a foundation for understanding the factors influencing decisions on grouted bolting timing,the sequence of grouting,the pressure applied,the volume of grout used,and the strategic arrangement of grouted rock bolts and cable bolts.The application of the high pretensioned high-pressure splitting grouted bolting collaborative control technology in a typical kilometer-deep soft rock mine in China—the soft coal seam and soft rock roadway in the Kouzidong coal mine,Huainan coal mining area,was introduced.Finally,the existing problems in grouted bolting control technology for deep soft rock roadways are analyzed,and the future development trend of grouted bolting control technology is anticipated. 展开更多
关键词 deep coal mine soft rock roadway grouted bolting rock bolt and cable grouting material high-pressure splitting grouting collaborative control technology
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Analysis of Detection and Monitoring Technology in the Construction and Maintenance of Large Bridges
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作者 Shengzhong Xiang Qin Su Shili Zhang 《Journal of Architectural Research and Development》 2024年第3期134-139,共6页
Currently,there is significant attention placed on the construction,management,and maintenance of large service bridges.Within the realm of bridge maintenance management,the utilization of detection and monitoring tec... Currently,there is significant attention placed on the construction,management,and maintenance of large service bridges.Within the realm of bridge maintenance management,the utilization of detection and monitoring technology is indispensable.By employing these technologies,we can effectively identify any structural defects within the bridge,promptly uncover unknown risks,proactively establish maintenance strategies,and prevent the rapid deterioration of bridge conditions.This article aims to explore the advantages of applying bridge monitoring and testing technology and to discuss various methods for implementing detection and monitoring technology throughout the construction,management,and maintenance phases of large bridges.Ultimately,this will contribute to ensuring the safe operation of large bridges. 展开更多
关键词 Large bridges CONSTRUCTION Maintenance Monitoring technology Detection technology
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English-Chinese Translation of Science and Technology Texts Based on the Differences Between Chinese and Western Modes of Thinking
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作者 HUANG Qing ZHANG Le 《Sino-US English Teaching》 2024年第1期49-54,共6页
As a tool for human communication,the use of language is affected by the way of thinking in cross-cultural communication.Due to the differences between Chinese and Western cultures,the way of thinking varies under the... As a tool for human communication,the use of language is affected by the way of thinking in cross-cultural communication.Due to the differences between Chinese and Western cultures,the way of thinking varies under the influence of such cultural differences.In the process of translation,the influence of the different thinking mode on translation activities cannot be ignored.At present,a lot of studies and researches have focused on the influence of Chinese and Western thinking mode on translation.However,it is still worthwhile to study what specific influence the difference between Chinese and Western thinking mode will exert on the translation process of science texts and what kind of measure should be taken to solve the negative influence brought by the differences when we are translating.This paper aims to discuss the influence of thinking differences between Chinese and Western countries on the process of English-Chinese translation of science and technology from the perspectives of long sentences,passive voice and nominalization,and how the translators should appropriately adjust their thinking pattern and use reasonable skills to eliminate the potential negative interference caused by the difference and achieve a better transformation between English and Chinese. 展开更多
关键词 thinking mode English-Chinese translation English of science and technology
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Degradation of FAK-targeting by proteolytic targeting chimera technology to inhibit the metastasis of hepatocellular carcinoma
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作者 XINFENG ZHANG SHUANG LI +8 位作者 MEIRU SONG YUE CHEN LIANGZHENG CHANG ZHERUI LIU HONGYUAN DAI YUTAO WANG GANGQI YANG YUN JIANG YINYING LU 《Oncology Research》 SCIE 2024年第4期679-690,共12页
Liver cancer is a prevalent malignant cancer,ranking third in terms of mortality rate.Metastasis and recurrence primarily contribute to the high mortality rate of liver cancer.Hepatocellular carcinoma(HCC)has low expr... Liver cancer is a prevalent malignant cancer,ranking third in terms of mortality rate.Metastasis and recurrence primarily contribute to the high mortality rate of liver cancer.Hepatocellular carcinoma(HCC)has low expression of focal adhesion kinase(FAK),which increases the risk of metastasis and recurrence.Nevertheless,the efficacy of FAK phosphorylation inhibitors is currently limited.Thus,investigating the mechanisms by which FAK affects HCC metastasis to develop targeted therapies for FAK may present a novel strategy to inhibit HCC metastasis.This study examined the correlation between FAK expression and the prognosis of HCC.Additionally,we explored the impact of FAK degradation on HCC metastasis through wound healing experiments,transwell invasion experiments,and a xenograft tumor model.The expression of proteins related to epithelial-mesenchymal transition(EMT)was measured to elucidate the underlying mechanisms.The results showed that FAK PROTAC can degrade FAK,inhibit the migration and invasion of HCC cells in vitro,and notably decrease the lung metastasis of HCC in vivo.Increased expression of E-cadherin and decreased expression of vimentin indicated that EMT was inhibited.Consequently,degradation of FAK through FAK PROTAC effectively suppressed liver cancer metastasis,holding significant clinical implications for treating liver cancer and developing innovative anti-neoplastic drugs. 展开更多
关键词 Hepatocellular carcinoma(HCC) Focal adhesion kinase(FAK) Proteolytic targeting chimera technology(PROTAC) Epithelial-mesenchymal transformation(EMT) METASTASIS
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How do advancements in technology affect the development and use of textile binders?
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《China Textile》 2024年第4期24-25,共2页
The textile industry is constantly evolving,and advancements in technology are playing a pivotal role in shaping the development and use of textile binders.According to Reports and Insights,the global textile binder m... The textile industry is constantly evolving,and advancements in technology are playing a pivotal role in shaping the development and use of textile binders.According to Reports and Insights,the global textile binder market is expected to reach a value of USD 5.33 billion by 2032,exhibiting a healthy CAGR of 4.4%.This growth is fueled by a confluence of factors,with technological innovation at the forefront.Let's delve into how these advancements are impacting the landscape of textile binders。 展开更多
关键词 advancement LANDSCAPE technology
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