The liver is the most frequent site of metastasis in colorectal cancer with up to a quarter of patients having liver metastases at the time of initial diagnosis and a further third subsequently developing liver lesion...The liver is the most frequent site of metastasis in colorectal cancer with up to a quarter of patients having liver metastases at the time of initial diagnosis and a further third subsequently developing liver lesions.Patients who present with metastatic liver disease after treatment of the primary(termed metachronous disease)receive care focused on this new metastatic disease.In contrast,the management of patients who present with colorectal cancer and concurrent liver展开更多
For general volatility structures for forward rates, the evolution of interest rates may not be Markovian and the entire path may be necessary to capture the dynamics of the term structure. This article identifies con...For general volatility structures for forward rates, the evolution of interest rates may not be Markovian and the entire path may be necessary to capture the dynamics of the term structure. This article identifies conditions on the volatility structure of forward rates that permit the dynamics of the term structure to be represented by a finite-dimensional state variable Markov process. In the deterministic volatility case, we interpret then-factor model as a sum ofn unidimensional models.展开更多
It is a great privilege and honour for me to serve again as President of IFToMM for the term 2026- 2029. I thank the delegates and the Chairs of Member Organizations （MOs） for having voted my candidature and for pro...It is a great privilege and honour for me to serve again as President of IFToMM for the term 2026- 2029. I thank the delegates and the Chairs of Member Organizations （MOs） for having voted my candidature and for promising support of my actions for future development of IFToMM.展开更多
文摘The liver is the most frequent site of metastasis in colorectal cancer with up to a quarter of patients having liver metastases at the time of initial diagnosis and a further third subsequently developing liver lesions.Patients who present with metastatic liver disease after treatment of the primary(termed metachronous disease)receive care focused on this new metastatic disease.In contrast,the management of patients who present with colorectal cancer and concurrent liver
文摘For general volatility structures for forward rates, the evolution of interest rates may not be Markovian and the entire path may be necessary to capture the dynamics of the term structure. This article identifies conditions on the volatility structure of forward rates that permit the dynamics of the term structure to be represented by a finite-dimensional state variable Markov process. In the deterministic volatility case, we interpret then-factor model as a sum ofn unidimensional models.
文摘It is a great privilege and honour for me to serve again as President of IFToMM for the term 2026- 2029. I thank the delegates and the Chairs of Member Organizations （MOs） for having voted my candidature and for promising support of my actions for future development of IFToMM.
