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Clinical usefulness of the baby vision test in young children and its correlation with the Snellen chart
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作者 Ya-Lan Wang Jia-Jun Wang +2 位作者 Xi-Cong Lou Han Zou Yun-E Zhao 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第2期348-352,共5页
AIM:To investigate the efficacy of a new visual acuity(VA)screening method,the baby vision test for young children.METHODS:A total 105 eyes of 65 children aged 2-8y were included in the study.Acuity testing was conduc... AIM:To investigate the efficacy of a new visual acuity(VA)screening method,the baby vision test for young children.METHODS:A total 105 eyes of 65 children aged 2-8y were included in the study.Acuity testing was conducted using a standardized recognition acuity chart(Snellen visual chart:at 3 m)and the baby vision model assessment.The baby vision device includes a screen,a near infrared camera and a computer.Children were seated at a measured distance of 33-40 cm from a display for testing.VA was estimated according to the highest resolution the children could follow.Decimal VA data were converted to logarithm of the minimum angle of resolution(logMAR)for statistical analysis.The VA results for each child were recorded and analyzed for consistency.RESULTS:The mean VA measured using the Snellen visual chart was 0.62±0.32,and that assessed using the baby vision test was 0.66±0.27.The 95%limit of agreement was-0.609 to 0.695,with 95.2%(100/105)plots within the 95%limits of agreement.VA values of the baby vision test were significantly correlated with those of the Snellen chart(R=0.274,P=0.005).CONCLUSION:The baby vision test can be used as a relatively reliable method for estimating VA in young children.This new acuity assessment might be a valid predictor of optotype-measured acuity later in preverbal children. 展开更多
关键词 baby vision test acuity assessment fix-and-follow system Snellen chart
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Revisiting the theoretical prediction of the explosive performance found by the Trauzl test
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作者 Ivana Dobrilovic Mario Dobrilovic Muhamed Suceska 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第6期163-174,共12页
The Trauzl lead block test allows the determination of the approximate performance of explosives in blasting applications by measuring the volume increase(expansion)that is produced by the detonation of an explosive c... The Trauzl lead block test allows the determination of the approximate performance of explosives in blasting applications by measuring the volume increase(expansion)that is produced by the detonation of an explosive charge in the cavity of a lead block.In this paper,we reconsider the possibility of interpreting the Trauzl test results in terms of detonation parameters or quantities.The detonation parameters used in the analysis are calculated using the thermochemical code EXPLO5,while the hydrocode AUTODYN is used to simulate the effect of explosive charge density and reaction rate on the results of the Trauzl test.The increase in the volume of the lead block cavity was found to correlate best with the product of the detonation heat and the root of the volume of detonation products.Hydrocode simulation showed that the density of explosive charge and the rate of explosive decomposition affect the dynamics of the interaction of the detonation product and the lead block,and consequently the lead block cavity volume increase. 展开更多
关键词 Trauzl lead block test Performance of explosives EXPLO5 AUTODYN Detonation heat
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Fracture network types revealed by well test curves for shale reservoirs in the Sichuan Basin,China
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作者 Yanyan Wang Hua Liu +2 位作者 Xiaohu Hu Cheng Dai Sidong Fang 《Energy Geoscience》 EI 2024年第1期264-274,共11页
Pressure buildup testing can be used to analyze fracture network characteristics and conduct quantitative interpretation of relevant parameters for shale gas wells,thus providing bases for assessing the well productiv... Pressure buildup testing can be used to analyze fracture network characteristics and conduct quantitative interpretation of relevant parameters for shale gas wells,thus providing bases for assessing the well productivity and formulating proper development strategies.This study establishes a new well test interpretation model for fractured horizontal wells based on seepage mechanisms of shale reservoirs and proposes a method for identifying fracturing patterns based on the characteristic slopes of pressure buildup curves and curve combination patterns.The pressure buildup curve patterns are identified to represent three types of shale reservoirs in the Sichuan Basin,namely the moderately deep shale reservoirs with high pressure,deep shale reservoirs with ultra-high pressure,and moderately deep shale reservoirs with normal pressure.Based on this,the relationship between the typical pressure buildup curve patterns and the fracture network types are put forward.Fracturing effects of three types of shale gas reservoir are compared and analyzed.The results show that typical flow patterns of shale reservoirs include bilinear flow in primary and secondary fractures,linear flow in secondary fractures,bilinear flow in secondary fractures and matrix,and linear flow in matrix.The fracture network characteristics can be determined using the characteristic slopes of pressure buildup curves and curve combinations.The linear flow in early secondary fractures is increasingly distinct with an increase in primary fracture conductivity.Moreover,the bilinear flow in secondary fractures and matrix and the subsequent linear flow in the matrix occur as the propping and density of secondary fractures increase.The increase in the burial depth,in-situ stress,and stress difference corresponds to a decrease in the propping of primary fractures that expand along different directions in the shale gas wells in the Sichuan Basin.Four pressure buildup curve patterns exist in the Sichuan Basin and its periphery.The pattern of pressure buildup curves of shale reservoirs in the Yongchuan area can be described as 1/2/→1/4,indicating limited stimulated reservoir volume,poorly propped secondary fractures,and the forming of primary fractures that extend only to certain directions.The pressure buildup curves of shale reservoirs in the main block of the Fuling area show a pattern of 1/4/→1/2 or 1/2,indicating greater stimulated reservoir volume,well propped secondary fractures,and the forming of complex fracture networks.The pattern of pressure buildup curves of shale reservoirs in the Pingqiao area is 1/2/→1/4→/1/2,indicating a fracturing effect somewhere between that of the Fuling and Yongchuan areas.For reservoirs with normal pressure,it is difficult to determine fracture network characteristics from pressure buildup curves due to insufficient formation energy and limited liquid drainage. 展开更多
关键词 Shale gas Fractured horizontal well Well testing interpretation Flow pattern characterization Parameter inversion Fracture network characteristics Sichuan basin
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Changes in reaction time, coefficient of variance of reaction time, and autonomic nerve function in the mental fatigue state caused by long-term computerized Kraepelin test workload in healthy volunteers 被引量:1
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作者 Daisuke Kuratsune Seiki Tajima +10 位作者 Junichi Koizumi Kouzi Yamaguti Tetsuya Sasabe Kei Mizuno Masaaki Tanaka Naoko Okawa Hideki Mito Hirokazu Tsubone Yasuyoshi Watanabe Masayasu Inoue Hirohiko Kuratsune 《World Journal of Neuroscience》 2012年第2期113-118,共6页
Fatigue is a common sense caused by crushing labor, stressful social events and various illnesses. It is usually judged by their subjective symptoms, but it should be evaluated in an objective perspective. Here we sho... Fatigue is a common sense caused by crushing labor, stressful social events and various illnesses. It is usually judged by their subjective symptoms, but it should be evaluated in an objective perspective. Here we show that the decrease of working efficiency and sympathetic hyperactivity are associated with mental fatigue state caused by prolonged mental workload. Recently we made a new mental fatigue model of healthy volunteers caused by long-term computerized Kraepelin test (CKT) workload. CKT is our new software for automatically checking the calculation capability, with which it is easy to determine the reaction time (RT), coefficient of variance of reaction time (CV), and accuracy of the answers (AC) during tasks. We put 24 healthy volunteers into the fatigue state by subjecting them to 120 minutes’ CKT workload, and then studied the changes in fatigue sensation, RT, CV, and AC before and after the CKT workload. The fatigue sensation, RT, and CV were clearly increased by the fatigue-inducing task and recovered during the resting period. We also studied the changes in autonomic nerve activity by using heart rate variability analysis. The low/high frequency component ratio (LF/HF) was signifi-cantly increased by the fatigue-inducing task and decreased by resting, suggesting that mental stress causes a relatively sympathetic nerve activity-dominant state. Therefore, our new fatigue model involving a long-term CKT workload is a good mental fatigue model to provide much information about the fatigue state simultane-ously, and the increase of RT, CV, and proportion of sympathetic activity (LF/HF) are associated with mental fatigue state. These might be useful objective biomarkers or evaluating a mental fatigue state. 展开更多
关键词 Fatigue computerIZED Kraepelin test Reaction Time Accuracy of the ANSWERS AUTONOMIC NERVE Activity
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Unbound^(28)O,the heaviest oxygen isotope observed:a cutting-edge probe for testing nuclear models 被引量:1
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作者 Jian-Guo Li Bai-Shan Hu +1 位作者 Shuang Zhang Fu-Rong Xu 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第2期1-2,共2页
The beyond-dripline oxygen isotopes^(27,28)O were recently observed at RIKEN,and were found to be unbound decaying into^(24)O by emitting neutrons.The unbound feature of the heaviest oxygen isotope,^(28)O,provides an ... The beyond-dripline oxygen isotopes^(27,28)O were recently observed at RIKEN,and were found to be unbound decaying into^(24)O by emitting neutrons.The unbound feature of the heaviest oxygen isotope,^(28)O,provides an excellent test for stateof-the-art nuclear models.The atomic nucleus is a self-organized quantum manybody system comprising specific numbers of protons Z and neutrons N. 展开更多
关键词 testING QUANTUM system
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Determination of Elastoplastic Mechanical Properties of the Weld and Heat Affected Zone Metals in Tailor-Welded Blanks by Nanoindentation Test 被引量:7
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作者 MA Xiangdong GUAN Yingping YANG Liu 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2015年第5期911-918,共8页
The elastoplastic mechanical properties of the weld and heat affected zone metals have comparatively major impact on the forming process of tailor-welded blanks. A few scholars investigated the elastoplastic mechanica... The elastoplastic mechanical properties of the weld and heat affected zone metals have comparatively major impact on the forming process of tailor-welded blanks. A few scholars investigated the elastoplastic mechanical properties of the weld and heat affected zone, but they only simply assumed that it was a uniform distribution elastoplastic material different from the base materials. Four types of tailor-welded blanks which consist of ST12 and 304 stainless steel plates are selected as the research objects, the elastoplastic mechanical properties of the tailor-welded blanks weld and heat affected zone metals are obtained based on the nanoindentation tests, and the Erichsen cupping tests are conducted by combining numerical simulation with physical experiment. The nanoindentation tests results demonstrate that the elastoplastic mechanical properties of the weld and heat affected zone metals are not only different from the base materials, but also varying between the weld metals and the heat affected zone metals. Comparing the Erichsen cupping test resulted from numerical with that from experimental method, it is found that the numerical value of Erichsen cupping test which consider the elastoplastic mechanical properties of the weld and heat affected zone metals have a good agreement with the experimental result, and the relative error is only 4.8%. The proposed research provides good solutions for the inhomogeneous elastoplastic mechanical properties of the tailor-welded blanks weld and heat affected zone metals, and improves the control performance of tailor-welded blanks forming accuracy. 展开更多
关键词 tailor-welded blanks elastoplastic mechanical properties nanoindentation test Erichsen cupping test
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Alleviating effects of melatonin on oxidative changes in the testes and pituitary glands evoked by subacute chlorpyrifos administration in Wistar rats 被引量:6
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作者 Angela J Umosen Suleiman F Ambali +2 位作者 Joseph O Ayo Bisala Mohammed Chidiebere Uchendu 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2012年第8期645-650,共6页
Objective:To evaluate the alleviating effects of melatonin on oxidative changes in the testes and pituitary gland induced by subacute chlopyrifos(CPF) exposure in rats.Methods:Forty adult male Wistar rats divided in... Objective:To evaluate the alleviating effects of melatonin on oxidative changes in the testes and pituitary gland induced by subacute chlopyrifos(CPF) exposure in rats.Methods:Forty adult male Wistar rats divided into 4 groups of 10 animals were used for the study.Croup I received soya oil(2 mL/kg) while group II was administered with melatonin(0.5 mg/kg).Group III was administered CPF only(8.5 mg/kg <sup> </sup>l/10th of the LD<sub>50</sub>) while group Ⅳ was pretreated with melatonin(0.5 mg/kg) and then exposed to CPF(8.5 mg/kg),10 min later.The regimens were administered by gavage once daily for a period of 28 d.At the end of the exposure period, the rats were sacrificed and the testicular tissues and pituitary glands were evaluated for the malonaldehyde(MDA) concentration and activities of superoxide dismutase(SOD) and catalase(CAT).Results:CPF increased MDA concentrations and reduced the activities of SOD and CAT in the testes and pituitary gland.Melatonin pretreatment reduced the testicular and pituitary MDA concentrations and improves the SOD and CAT activities.Conclusions:the study showed that subacute CPF-induced oxidative stress in the testes and pituitary glands were alleviated by melatonin due to its antioxidant property. 展开更多
关键词 CHLORPYRIFOS OXIDATIVE stress testES Pituitary GLANDS Alleviation MELATONIN
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Adult reference values of the computerized diplopia test 被引量:7
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作者 Ling-Yun Zhou Tie-Juan Liu Xue-Mei Li 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2016年第11期1646-1650,共5页
AIM: To estimate the adult reference values for measured deviations by a computerized diplopia test and testify the validity.METHODS: Totally 391 participants were recruited and taken the computerized diplopia test.... AIM: To estimate the adult reference values for measured deviations by a computerized diplopia test and testify the validity.METHODS: Totally 391 participants were recruited and taken the computerized diplopia test. The plots and amplitude of deviations were recorded. The differences in different gender, age and visual acuity groups were analyzed respectively. Of 30 subjects were enrolled to testify the interobserver reliability. Another 46 subjects(including 26 normal subjects and 20 patients) were taken the test and theirs deviations were recorded to testify the validity of the reference value.RESULTS: The max horizontal and vertical deviations were 2.55° and 0.76° with normal corrected visual acuity while 3.88° and 1.46° for subjects with poor corrected vision. The differences between age groups was insignificant(Z =3.615, 4.758; P =0.461, 0.313 for horizontal and vertical respectively). The max horizontal deviation of female was smaller than male(Z =-2.177; P =0.029),but the difference in max vertical deviation was insignificant(Z =-1.296; P =0.195). The mean difference between observers were both-0.1°, with 95% confidence limits(CI) of-1.4° and 1.6° in max horizontal deviations while-2.1° and 1.8° in max vertical deviation. The mean deviation of 26 normal subjects was 1.02° ±0.84° for horizontal and 0.47° ±0.30° for vertical which both within the range of reference values. The mean deviation of 20 patients was 13.51°±11.69° for horizontal and 8.34°±8.58°for vertical which both beyond the reference range.CONCLUSION: The max amplitude of horizontal and vertical deviation is pointed as the numerical parameters of computerized diplopia test. The reference values are different between normal corrected visual acuity and poor corrected vision. These values may useful for evaluating patients with diplopia in veriety conditions during clinical practice. 展开更多
关键词 computerized diplopia test referencevalues amplitude of deviations
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Considerations of rock dilation on modeling failure and deformation of hard rocks-a case study of the mine-by test tunnel in Canada 被引量:9
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作者 Xingguang Zhao Meifeng Cai MCai 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE 2010年第4期338-349,共12页
For the compressive stress-induced failure of tunnels at depth, rock fracturing process is often closely associated with the generation of surface parallel fractures in the initial stage, and shear failure is likely t... For the compressive stress-induced failure of tunnels at depth, rock fracturing process is often closely associated with the generation of surface parallel fractures in the initial stage, and shear failure is likely to occur in the final process during the formation of shear bands, breakouts or V-shaped notches close to the excavation boundaries. However, the perfectly elastoplastic, strain-softening and elasto-brittle-plastic models cannot reasonably describe the brittle failure of hard rock tunnels under high in-situ stress conditions. These approaches often underestimate the depth of failure and overestimate the lateral extent of failure near the excavation. Based on a practical case of the mine-by test tunnel at an underground research laboratory (URL) in Canada, the influence of rock mass dilation on the depth and extent of failure and deformation is investigated using a calibrated cohesion weakening and frictional strengthening (CWFS) model. It can be found that, when modeling brittle failure of rock masses, the calibrated CWFS model with a constant dilation angle can capture the depth and extent of stress-induced brittle failure in hard rocks at a low confinement if the stress path is correctly represented, as demonstrated by the failure shape observed in the tunnel. However, using a constant dilation angle cannot simulate the nonlinear deformation behavior near the excavation boundary accurately because the dependence of rock mass dilation on confinement and plastic shear strain is not considered. It is illustrated from the numerical simulations that the proposed plastic shear strain and confinement-dependent dilation angle model in combination with the calibrated CWFS model implemented in FLAC can reasonably reveal both rock mass failure and displacement distribution in vicinity of the excavation simultaneously. The simulation results are in good agreement with the field observations and displacement measurement data. 展开更多
关键词 hard rocks brittle failure deformation dilation angle model confinement plastic shear strain mine-by test tunnel
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C-CORE:Clustering by Code Representation to Prioritize Test Cases in Compiler Testing
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作者 Wei Zhou Xincong Jiang Chuan Qin 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第5期2069-2093,共25页
Edge devices,due to their limited computational and storage resources,often require the use of compilers for program optimization.Therefore,ensuring the security and reliability of these compilers is of paramount impo... Edge devices,due to their limited computational and storage resources,often require the use of compilers for program optimization.Therefore,ensuring the security and reliability of these compilers is of paramount importance in the emerging field of edge AI.One widely used testing method for this purpose is fuzz testing,which detects bugs by inputting random test cases into the target program.However,this process consumes significant time and resources.To improve the efficiency of compiler fuzz testing,it is common practice to utilize test case prioritization techniques.Some researchers use machine learning to predict the code coverage of test cases,aiming to maximize the test capability for the target compiler by increasing the overall predicted coverage of the test cases.Nevertheless,these methods can only forecast the code coverage of the compiler at a specific optimization level,potentially missing many optimization-related bugs.In this paper,we introduce C-CORE(short for Clustering by Code Representation),the first framework to prioritize test cases according to their code representations,which are derived directly from the source codes.This approach avoids being limited to specific compiler states and extends to a broader range of compiler bugs.Specifically,we first train a scaled pre-trained programming language model to capture as many common features as possible from the test cases generated by a fuzzer.Using this pre-trained model,we then train two downstream models:one for predicting the likelihood of triggering a bug and another for identifying code representations associated with bugs.Subsequently,we cluster the test cases according to their code representations and select the highest-scoring test case from each cluster as the high-quality test case.This reduction in redundant testing cases leads to time savings.Comprehensive evaluation results reveal that code representations are better at distinguishing test capabilities,and C-CORE significantly enhances testing efficiency.Across four datasets,C-CORE increases the average of the percentage of faults detected(APFD)value by 0.16 to 0.31 and reduces test time by over 50% in 46% of cases.When compared to the best results from approaches using predicted code coverage,C-CORE improves the APFD value by 1.1% to 12.3% and achieves an overall time-saving of 159.1%. 展开更多
关键词 Compiler testing test case prioritization code representation
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Real-world utility of serological tests in patients with suspected scrub typhus in the Republic of Korea:A single-center,retrospective,observational study
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作者 Seulki Kim A Reum Kim +2 位作者 Seungjin Lim Su Jin Lee Moonsuk Bae 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2024年第6期273-280,I0004,I0005,共10页
Objective:Serological tests are widely used for scrub typhus diagnosis;however,their limitations are evident.This study aims to assess their practical value in clinical settings.Methods:We analyzed the data of adult p... Objective:Serological tests are widely used for scrub typhus diagnosis;however,their limitations are evident.This study aims to assess their practical value in clinical settings.Methods:We analyzed the data of adult patients with suspected scrub typhus who visited a tertiary care hospital in the Republic of Korea from September to December from 2019 to 2021.The included patients had an acute fever and at least one of the following ten secondary findings:myalgia,skin rash,eschar,headache,thrombocytopenia,increased liver enzyme levels,lymphadenopathy,hepatomegaly,splenomegaly,and pleural effusion.The diagnoses were grouped as scrub typhus or other diseases by two infectious disease physicians.Results:Among 136 patients who met the eligibility criteria,109 had scrub typhus and 27 had different diseases.Single and paired total antibodies using immunofluorescence assay(IFA),and total antibodies using immunochromatography-based rapid diagnostic testing(ICT)were measured in 98%,22%,and 75%of all patients,respectively.Confirmation using paired samples for scrub typhus was established at a median of 11[interquartile range(IQR)10-16]days following the first visit.Among the 82 admitted patients,the median admission time was 9(IQR 7-13)days.According to IFA,58(55%)patients with scrub typhus had total immunoglobulin titers≥1:320,while 23(85%)patients with other disease had titers<1:320.Positive ICT results were observed in 64(74%)patients with scrub typhus and 10(67%)patients with other diseases showed negative ICT results.Conclusions:Serological testing for scrub typhus is currently insufficient for decision-making in clinical practice. 展开更多
关键词 Scrub typhus Serological test Immunofluorescence assay IMMUNOCHROMATOGRAPHY Rapid detecting test
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Application of Iron Nanoparticles Synthesized by Green Tea for the Removal of Hexavalent Chromium in Column Tests 被引量:6
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作者 C. Mystrioti A. Xenidis N. Papassiopi 《Journal of Geoscience and Environment Protection》 2014年第4期28-36,共9页
Nano zero valent iron particles (nZVI) are popular the last few years because of the numerous applications in remediation of a wide range of pollutants in contaminated soils and aquifers. The nZVI particles can be 10 ... Nano zero valent iron particles (nZVI) are popular the last few years because of the numerous applications in remediation of a wide range of pollutants in contaminated soils and aquifers. The nZVI particles can be 10 - 1000 times more reactive than granular or micro-scale ZVI particles due to the small particle size, large specific surface area and high reactivity. An alternative green synthesis procedure was used for the production of nano zero valent iron particles (nZVI) using green tea (GT) extract, which is characterized by its high antioxidant content. Polyphenols in green tea extract possess double role in the synthesis of nZVI, because they not only reduce ferric cations, but also protect nZVI from oxidation and agglomeration as capping agents. The objective of current study was to simulate ata laboratory scale the attachment of GT-nZVI particles on soil material and study the effectiveness of attached nanoparticles for removing hexavalent chromium (Cr(VI)) from contaminated groundwater flowing through the porous soil bed. Column tests were carried out with various flowrates in order to examine the effect of contact time between the attached on porous medium nZVI and the flow-through solution on Cr(VI) reduction. After the completion of column tests the soil material in each column was split in 5 vertical sections, which were further subjected to chemical analyses and leaching tests. According to the results of the study increasing the contact time favors the reduction and removal of Cr(VI) from the aqueous phase. The reductive precipitation of Cr can be described as a reaction that follows a pseudo-first order kinetic law, with rate constant equal to k = 0.0243 ± 0.0011 min-1. Leaching tests indicated that precipitated chromium is not soluble. In the examined soil material, the total amount of precipitated Cr was found to range between 280 and 890 mg/(kg soil), while soluble Cr was less than 1.4 mg/kg and most probably it was due to the presence of residual Cr(VI) solution in the porosity of soil. 展开更多
关键词 NANOSCALE Zero Valent Iron NZVI Hexavalent CHROMIUM REDUCTIVE Capacity COLUMN tests
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Infectious Disease Update in Obstetrics: A Modern Approach to the Patient with a Positive Screening Test for Syphyilis in Pregnancy
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作者 Papa Essilfie 《Open Journal of Obstetrics and Gynecology》 2024年第1期102-109,共8页
Screening for maternal syphilis has been an essential component of routine antenatal screening tests in most countries for many years. This is not only because of the virulence of the spirochete which causes the infec... Screening for maternal syphilis has been an essential component of routine antenatal screening tests in most countries for many years. This is not only because of the virulence of the spirochete which causes the infection but also because of its vertical transmission rate and the potential severe adverse complications/morbidity that can result from its transmission to the fetus. Although the incidence of maternal syphilis and its fetal sequalae in low-income countries has been considerable for several years, the disease has been almost non-existent in high income countries with wide antenatal screening coverage and effective treatment programmes for Syphilis. The recent alarming increase in the incidence of maternal syphilis in high income countries has spawned a renewed public health interest in the infection, with several countries updating and strengthening public health guidance in an attempt to stem this dramatic trend. This is a short clinical update for the practising obstetrician on how to manage the antenatal patient with a positive syphilis screening test. 展开更多
关键词 Treponema Pallidum CHANCRE Condyloma Lata Gummas VDRL test RPR test Revere-Sequence testing Jarisch-Herxheimer Reaction
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Quantitative evaluation of DNA damage caused by atmospheric and room-temperature plasma (ARTP) and other mutagenesis methods using a rapid umu-microplate test protocol for microbial mutation breeding 被引量:6
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作者 Yuting Huang Liyang Wang +4 位作者 Xue Zhang Nan Su Heping Li Yoshimitsu Oda Xinhui Xing 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2021年第11期205-210,共6页
Mutagenesis is an important technique for microbial mutation breeding.As the source of mutations,DNA damage extent is a key indicator for the effectiveness of mutagenesis.Therefore,a rapid and easy DNA damage quantifi... Mutagenesis is an important technique for microbial mutation breeding.As the source of mutations,DNA damage extent is a key indicator for the effectiveness of mutagenesis.Therefore,a rapid and easy DNA damage quantification method is required for the comparison of mutagenesis effects and development of mutagenesis tools.Here,we used the umu-microplate test system to quantitatively compare the DNA damage strength caused by atmospheric and room-temperature plasma(ARTP)and other traditional mutagenesis methods including:ultraviolet radiation(UV),diethyl sulfate(DES)and 4-nitroquinoline-1-oxide(4-NQO).The test strain of Salmonella typhimurium TA1535/pSK1002 was used to monitor the time-course profile of b-galactosidase activity induced by DNA damage caused by different mutagenesis methods using a microplate reader.The umu-microplate test results showed that ARTP caused higher extent of DNA damage than UV and chemical mutagens,which agrees well with the result obtained by SOS-FACS-based quantification method as reported previously.This umu-microplate test is accessible for broad researchers who are lack of the expensive FACS instruments and allows the quick quantitative evaluation of DNA damage among living cells for different mutagenesis methods in the study of the microbial mutation breeding. 展开更多
关键词 ARTP mutagenesis umu-Microplate test Biological engineering Cell engineering BIOTECHNOLOGY
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Forecasting and Evaluating the Efficiency of Test Generation Algorithms by Genetic Algorithm 被引量:1
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作者 Shiyi Xu and Wei Cen School of Computers Shanghai University, Shanghai, China 200072 《湖南大学学报(自然科学版)》 EI CAS CSCD 2000年第S2期86-94,共9页
To generate a test set for a given circuit (including both combinational and sequential circuits), choice of an algorithm within a number of existing test generation algorithms to apply is bound to vary from circuit t... To generate a test set for a given circuit (including both combinational and sequential circuits), choice of an algorithm within a number of existing test generation algorithms to apply is bound to vary from circuit to circuit. In this paper, the genetic algorithms are used to construct the models of existing test generation algorithms in making such choice more easily. Therefore, we may forecast the testability parameters of a circuit before using the real test generation algorithm. The results also can be used to evaluate the efficiency of the existing test generation algorithms. Experimental results are given to convince the readers of the truth and the usefulness of this approach. 展开更多
关键词 testABILITY GENETIC Algorithm Forecasting EVALUATING test Generation.
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Thermal fatigue behaviors of SiC power module by Ag sinter joining under harsh thermal shock test 被引量:4
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作者 Chen Chuantong Zhang Hao +2 位作者 Jiu Jinting Long Xu Suganuma Katsuaki 《China Welding》 CAS 2022年第1期15-21,共7页
The excellent properties of SiC bring new challenges for the device packaging.In this study,the bonding strength,fracture behaviors and microstructural evolution of micron-porous Ag joint were elevated during thermal ... The excellent properties of SiC bring new challenges for the device packaging.In this study,the bonding strength,fracture behaviors and microstructural evolution of micron-porous Ag joint were elevated during thermal cycling(–50 ℃–250 ℃) in SiC/DBC(direct bonding copper) die attachment structure for different time.During harsh thermal shock test,the strength of sintered joint deceased gradually with the increase of cycling number,and the value just was half of the value of as-sintered after 1 000 cycles.Coarsening of Ag grains was observed in micron-porous joint with the structure inhomogeneity and defects increasing,which were the reasons of the strength decease.In addition,it was also found that the fracture behavior of sintered joints was changed from ductile deformation of Ag grain to brittle fracture of crack propagation after 1 000 cycles.This study will add the understanding in the mechanical properties of Ag sinter joining and its applications at high temperature. 展开更多
关键词 power module high-temperature reliability Ag sinter joining low stress structure thermal shock test
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Technical problems produced by the Bravo pH test in nonerosive reflux disease patients 被引量:2
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作者 Andrés de Hoyos Edgar Alain Esparza 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第25期3183-3186,共4页
AIM: To evaluate the technical failures of the Bravo pH test in a population with nonerosive gastroesophageal reflux disease. METHODS: Over the course of a year, we prospectively studied a population of 66 nonerosive ... AIM: To evaluate the technical failures of the Bravo pH test in a population with nonerosive gastroesophageal reflux disease. METHODS: Over the course of a year, we prospectively studied a population of 66 nonerosive reflux disease patients who received a Bravo pH test. The number and frequency of all technical failures were documented, quantified and analyzed. RESULTS: A total of 66 patients, with a mean age of 41.7 years, were studied. Technical failures occurred in 15.15% of the sample. The most frequent failures were due to poor data reception (4.5%), early dislodgement (4.5%) and capsule removal (6.1%). CONCLUSION: The Bravo capsule pH test involves a low but non-negligible rate of technical problems, a fact that must always be considered by physicians. 展开更多
关键词 Bravo test Capsule dislodgement Nonerosive reflux disease Poor data reception Technical problems
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Mechanical properties of silicon nanobeams with an undercut evaluated by combining the dynamic resonance test and finite element analysis 被引量:2
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作者 张加宏 冒晓莉 +4 位作者 刘清惓 顾芳 李敏 刘恒 葛益娴 《Chinese Physics B》 SCIE EI CAS CSCD 2012年第8期330-338,共9页
Mechanical properties of silicon nanobeams are of prime importance in nanoelectromechanical system applications. A numerical experimental method of determining resonant frequencies and Young's modulus of nanobeams by... Mechanical properties of silicon nanobeams are of prime importance in nanoelectromechanical system applications. A numerical experimental method of determining resonant frequencies and Young's modulus of nanobeams by combining finite element analysis and frequency response tests based on an electrostatic excitation and visual detection by using a laser Doppler vibrometer is presented in this paper. Silicon nanobeam test structures are fabricated from silicon-oninsulator wafers by using a standard lithography and anisotropic wet etching release process, which inevitably generates the undercut of the nanobeam clamping. In conjunction with three-dimensional finite element numerical simulations incorporating the geometric undercut, dynamic resonance tests reveal that the undercut significantly reduces resonant frequencies of nanobeams due to the fact that it effectively increases the nanobeam length by a correct value △L, which is a key parameter that is correlated with deviations in the resonant frequencies predicted from the ideal Euler-Bernoulli beam theory and experimentally measured data. By using a least-square fit expression including △L, we finally extract Young's modulus from the measured resonance frequency versus effective length dependency and find that Young's modulus of a silicon nanobeam with 200-nm thickness is close to that of bulk silicon. This result supports that the finite size effect due to the surface effect does not play a role in the mechanical elastic behaviour of silicon nanobeams with thickness larger than 200 nm. 展开更多
关键词 silicon nanobeams with undercut mechanical properties mechanical testing finite element method
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Adjustments for Kurtosis and Continuity on the Prentice Test
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作者 Lily Gebhart John Kolassa 《Advances in Pure Mathematics》 2024年第2期101-117,共17页
The test of Prentice [1] is a non-parametric statistical test for the two-way analysis of variance using ranks. The null distribution of this test typically is approximated using the Chi-square distribution. However, ... The test of Prentice [1] is a non-parametric statistical test for the two-way analysis of variance using ranks. The null distribution of this test typically is approximated using the Chi-square distribution. However, the exact null distribution deviates from the Chi-square approximation in certain cases commonly found in applications of the test, motivating adjustments to the distribution. This manuscript presents adjustments to this null distribution correcting for continuity, multivariate skewness, and multivariate kurtosis. The effects of alternative scoring methods as non-polynomial functions of rank sums are also presented as a broader application of the approximation. 展开更多
关键词 Friedman test Prentice test Edgeworth Approximation
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Contribution of Stress Testing to the Management of Ischemic Heart Disease in Mali
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作者 Youssouf Camara Hamidou Oumar Ba +7 位作者 Ibrahima Sangaré Boubacar Sonfo Coumba Adiaratou Thiam Mahamadou Sékou Diakité Koniba Diarra Karamba Touré Massama Konaté Ichaka Menta 《World Journal of Cardiovascular Diseases》 CAS 2024年第2期77-87,共11页
Introduction: Exercise stress testing (on a treadmill or ergometer bicycle) is an important test in cardiology for diagnosing myocardial ischemia. This test in Mali is still in its beginning compared to other countrie... Introduction: Exercise stress testing (on a treadmill or ergometer bicycle) is an important test in cardiology for diagnosing myocardial ischemia. This test in Mali is still in its beginning compared to other countries in the sub-region. The lack of data in Mali prompted this study, which aimed to evaluate the indications of this activity and its diagnostic contribution to cardiology in Mali. Materials and Methods: This was a retrospective, descriptive study. The study was conducted at the “TOUCAM” medical clinic in Kati based on the analysis of stress test reports between January 2016 and August 2022. Result: During the study period, we documented 73 patients who underwent exercise testing on a bicycle ergometer for suspected coronary heart disease. The mean age of our patients was 47.5 ± 13.8 years (14 and 79 years). Males accounted for the majority (78.1%). The sex ratio is 3.5. More than half of our patients were overweight or obese (77.1%). Hypertension and diabetes affected 52.1% and 25.8% of patients, respectively. 20.8% of patients had coronary artery disease. renin-angiotensin-aldosterone system blockers (56.8%) and beta-blockers (51.3%). The main indications were chest pain (63.0%) and ischemia detection (15.1%). A modified STEEP protocol was used. The majority of our patients (71.2%) achieved at least 85% of their maximum theoretical heart rate. The main reason for the termination of the study was fatigue (57.3%). The average duration was 11.3 ± 4.2 minutes. 24.7% thought the stress tests were positive and 17.8% thought they were controversial. Conclusion: This study demonstrates the importance of stress testing in the diagnosis and treatment of ischemic heart disease, especially in settings where we have very limited access to coronary angiography. 展开更多
关键词 Stress test Ischemic Heart Disease MALI
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