Evaluation of the famous classic formula Sanhua decoction based on network pharmacology and multi-component quantitative analysis

Background:Sanhua decoction has significant effects in the treatment of stroke.The study of the Sanhua decoction material benchmark was carried out to analyze the value transfer relationship between the Chinese herbal pieces and the substance benchmark.Methods:Network pharmacology was employed to investigate the potential active components and molecular mechanisms of Sanhua decoction in the treatment of stroke.15 batches of Sanhua decoction lyophilized powder were prepared using traditional formulas and subjected to high-performance liquid chromatography analysis to generate fingerprints of the Sanhua decoction substance benchmarks.Then,a multi-component quantitative analysis method was established,allowing for the simultaneous determination of ten components,to study the transfer of quantity values between pieces and substance benchmarks.Results:60 active ingredients were screened from Sanhua decoction by network pharmacology,of which gallic acid,magnolol honokiol,physcion,and aloe-emodin may have a greater effect than other active components.63 key targets and 134 pathways were predicted as the potential mechanism of Sanhua decoction in treating stroke.The fingerprint similarity of the Sanhua decoction substance benchmarks was found to be good among the 15 batches,confirming the 19 common peaks.The content of the 10 components was basically consistent.The components’transfer rates were within 30%of their respective means.Conclusions:This study provided a comprehensive and reliable strategy for the quality evaluation of Sanhua decoction substance benchmarks and held significant importance in improving its application value.

Paraffin–CaCl_(2)·6H_(2)O dosage effects on the strength and heat transfer characteristics of cemented tailings backfill

The challenge of high temperatures in deep mining remains harmful to the health of workers and their production efficiency The addition of phase change materials (PCMs) to filling slurry and the use of the cold storage function of these materials to reduce downhole temperatures is an effective approach to alleviate the aforementioned problem.Paraffin–CaCl_(2)·6H_(2)O composite PCM was prepared in the laboratory.The composition,phase change latent heat,thermal conductivity,and cemented tailing backfill (CTB) compressive strength of the new material were studied.The heat transfer characteristics and endothermic effect of the PCM were simulated using Fluent software.The results showed the following:(1) The new paraffin–CaCl_(2)·6H_(2)O composite PCM improved the thermal conductivity of native paraffin while avoiding the water solubility of CaCl_(2)·6H_(2)O.(2) The calculation formula of the thermal conductivity of CaCl_(2)·6H_(2)O combined with paraffin was deduced,and the reasons were explained in principle.(3) The“enthalpy–mass scale model”was applied to calculate the phase change latent heat of nonreactive composite PCMs.(4)The addition of the paraffin–CaCl_(2)·6H_(2)O composite PCM reduced the CTB strength but increased its heat absorption capacity.This research can give a theoretical foundation for the use of heat storage backfill in green mines.

An Efficient Acceleration of Solving Heat and Mass Transfer Equations with the Second Kind Boundary Conditions in Capillary Porous Composite Cylinder Using Programmable Graphics Hardware

With the recent developments in computing technology, increased efforts have gone into simulation of various scientific methods and phenomenon in engineering fields. One such case is the simulation of heat and mass transfer in capillary porous media, which is becoming more and more important in analysing various scenarios in engineering applications. Analysing such heat and mass transfer phenomenon in a given environment requires us to simulate it. This entails simulation of coupled heat mass transfer equations. However, this process of numerical solution of heat and mass transfer equations is very much time consuming. Therefore, this paper aims at utilizing one of the acceleration techniques developed in the graphics community that exploits a graphics processing unit (GPU) which is applied to the numerical solutions of heat and mass transfer equations. The nVidia Compute Unified Device Architecture (CUDA) programming model caters a good method of applying parallel computing to program the graphical processing unit. This paper shows a good improvement in the performance while solving the heat and mass transfer equations for capillary porous composite cylinder with the second kind of boundary conditions numerically running on GPU. This heat and mass transfer simulation is implemented using CUDA platform on nVidia Quadro FX 4800 graphics card. Our experimental results depict the drastic performance improvement when GPU is used to perform heat and mass transfer simulation. GPU can significantly accelerate the performance with a maximum observed speedup of more than 7-fold times. Therefore, the GPU is a good approach to accelerate the heat and mass transfer simulation.

An Efficient Acceleration of Solving Heat and Mass Transfer Equations with the First Kind Boundary Conditions in Capillary Porous Radially Composite Cylinder Using Programmable Graphics Hardware

With the latest advances in computing technology, a huge amount of efforts have gone into simulation of a range of scientific phenomena in engineering fields. One such case is the simulation of heat and mass transfer in capillary porous media, which is becoming more and more necessary in analyzing a number of eventualities in science and engineering applications. However, this procedure of numerical solution of heat and mass transfer equations for capillary porous media is very time consuming. Therefore, this paper pursuit is at making use of one of the acceleration methods developed in the graphics community that exploits a graphical processing unit (GPU), which is applied to the numerical solutions of such heat and mass transfer equations. The nVidia Compute Unified Device Architecture (CUDA) programming model offers a correct approach of applying parallel computing to applications with graphical processing unit. This paper suggests a true improvement in the performance while solving the heat and mass transfer equations for capillary porous radially composite cylinder with the first type of boundary conditions. This heat and mass transfer simulation is carried out through the usage of CUDA platform on nVidia Quadro FX 4800 graphics card. Our experimental outcomes exhibit the drastic overall performance enhancement when GPU is used to illustrate heat and mass transfer simulation. GPU can considerably accelerate the performance with a maximum found speedup of more than 5-fold times. Therefore, the GPU is a good strategy to accelerate the heat and mass transfer simulation in porous media.

健脾安胎方可改善不孕患者体外受精-胚胎移植的妊娠结局

目的:评价健脾安胎方在接受体外受精-胚胎移植(IVF-ET)患者中的有效性和安全性。方法:研究共纳入浙江大学医学院附属邵逸夫医院生殖医学中心行两枚冷冻优胚移植后的患者300例,按照随机数字表法分为观察组和对照组,观察组给予移植期常规用药+健脾安胎方,对照组仅予移植期常规用药。评估两组一般情况、胚胎种植率、临床妊娠率、活产率及血常规、肝肾功能等安全性指标。结果:277例病例(观察组134例,对照组143例)完成研究并纳入统计。与对照组比较,观察组的胚胎种植率(分别为55.9%和68.7%)、临床妊娠率(分别为44.8%和56.7%)和活产率(分别为37.8%和50.7%)均升高(均P<0.05)。亚组分析发现,高龄患者(≥35岁)中,观察组的胚胎种植率、临床妊娠率和活产率均高于对照组(均P<0.05);卵巢储备功能减退患者(抗米勒管激素<1.68 ng/mL)中,观察组的胚胎种植率、临床妊娠率和活产率均高于对照组(均P<0.05)。随访期间,两组基本生命体征均无异常;均无皮疹、腹泻等不良事件。结论:健脾安胎方能提高接受IVF-ET移植患者的胚胎着床率,降低移植胚胎流产率,改善妊娠结局,且安全性高。

南水北调中线渠首前馈控制方案快速计算分析

明渠调水工程中为适时适量的满足下游用水需求,需要提前制定控制方案。前馈控制方案的设计往往较为复杂,且影响因素众多,调度人员难以快速做出决策。基于蓄量补偿法对南水北调中线工程刁河节制闸至十二里河节制闸段作前馈控制,基于蓄量补偿计算结果,分析了初始流量、分水流量与前馈控制时间的关系,构建了单、双变量的前馈控制时间快速计算公式。探究了不同因素对蓄量补偿控制下游水位偏差的影响,得到初始流量、分水流量与下游水位最大偏差之间的函数关系式。针对工程运行中的极端工况,原蓄量补偿控制的下游水位偏差过大的问题,采用二次蓄量补偿规则对渠池进行前馈控制,有效减小了下游水位偏差。

CCM法膜电极设备用热转移橡胶压辊的研制

以内-外套筒特殊双重结构为辊芯,硅橡胶为基胶,采用辊芯、界面粘合层、过渡底胶层和功能面胶层结构,通过金属辊体表面处理、混炼、成型、硫化和车磨等工艺,制备了CCM法膜电极设备用热转移橡胶压辊。结果表明,该橡胶压辊能满足CCM膜电极制造热转移工艺要求。

补肾健脾方在体外受精-胚胎移植助孕的脾肾两虚型卵巢储备功能减退患者中的应用效果

目的探讨补肾健脾方在体外受精-胚胎移植(IVF-ET)助孕的脾肾两虚型卵巢储备功能减退(DOR)患者中的应用效果。方法选取2021年6月至2023年1月在焦作市妇幼保健院接受IVF-ET助孕的100例脾肾两虚型DOR患者,按随机数字表法分为观察组(50例)与对照组(50例)。IVF-ET前给予对照组口服维生素E 3个月经周期后进入促排卵周期,观察组患者在对照组基础上给予3个月经周期的补肾健脾方进行调节并服用至扳机日。比较两组治疗前后中医症候评分,并对比两组患者用药及治疗情况[促性腺激素(Gn)用药时间、Gn用药总量、扳机日雌激素水平、周期取消率]、取卵及胚胎情况(获卵数、2PN受精数、可利用胚胎数、优质胚胎数)及妊娠结局(首次胚胎解冻移植周期着床率、临床妊娠率、早期流产率)。结果治疗后,两组脾肾两虚症候评分对比,观察组低于对照组(P<0.05);两组Gn用药时间、扳机日雌激素水平、周期取消率差异无统计学意义(P>0.05);两组Gn用药总量对比,观察组低于对照组(P<0.05);两组获卵数、2PN受精数、可利用胚胎数、优质胚胎数对比,观察组均多于对照组(P<0.05);观察组首次胚胎解冻移植周期着床率、妊娠率均高于对照组(P<0.05);两组流产率差异无统计学意义(P>0.05)。结论应用补肾健脾方可增加接受IVF-ET助孕的脾肾两虚型DOR患者获卵数、2PN受精数、可利用胚胎数及优质胚胎数,并能够减少Gn用药总量,改善胚胎着床率及临床妊娠率。

Capacity of Sun-driven lunar swingby sequences and their application in asteroid retrieval

For deep-space mission design,the gravity of the Sun and the Moon can be first considered and utilized.Their gravity can provide the energy change for launching spacecraft and retrieving spacecraft as well as asteroids.Regarding an asteroid retrieval mission,it can lead to the mitigation of asteroid hazards and an easy exploration and exploitation of the asteroid.This paper discusses the application of the Sun-driven lunar swingby sequence for asteroid missions.Characterizing the capacity of this technique is not only interesting in terms of the dynamic insights but also non-trivial for trajectory design.The capacity of a Sun-driven lunar swingby sequence is elucidated in this paper with the help of the“Swingby-Jacobi”graph.The capacity can be represented by a range of the Jacobi integral that encloses around 660 asteroids currently cataloged.To facilitate trajectory design,a database of Sun-perturbed Moon-to-Moon transfers,including multi-revolution cases,is generated and employed.Massive trajectory options for spacecraft launch and asteroid capture can then be explored and optimized.Finally,a number of asteroid flyby,rendezvous,sample-return,and retrieval mission options enabled by the proposed technique are obtained.

全值域有定义的对数紊流流速分布公式研究

目前,声学多普勒流速剖面仪垂线流速盲区插补只能采用指数流速分布、常数流速分布两种模式,而对数紊流流速分布公式是基于动量传递理论推导出的垂线流速分布公式,该公式因在边界处(y=0)没有定义而应用不便。基于此,从天然河道的河床是由泥沙组成的非固定边界的实际出发,提出在边界面上液体质点仍然存在混掺运动的假设,借助动量传递理论推导出全值域有定义的对数紊流流速分布公式。并且采用宜昌水文站4条实测垂线流速对公式进行拟合验证。结果表明:该公式拟合得到的误差有正有负,最大误差为-3.66%,精度符合水文资料整编规范要求。推导出的公式在垂线水深的所有值域内有定义,该公式可为声学多普勒流速剖面仪垂线流速盲区插补提供一种思路。

Theoretical Investigation on Triplet Excitation Energy Transfer in Fluorene Dimer

Triplet-triplet energy transfer in fluorene dimer with electronic structure calculations. The two is investigated by combining rate theories key parameters for the control of energy transfer, electronic coupling and reorganization energy, are calculated based on the diabatic states constructed by the constrained density functional theory. The fluctuation of the electronic coupling is further revealed by molecular dynamics simulation. Succeedingly, the diagonal and off-diagonal fluctuations of the Hamiltonian are mapped from the correlation functions of those parameters, and the rate is then estimated both from the perturbation theory and wavepacket diffusion method. The results manifest that both the static and dynamic fluctuations enhance the rate significantly, but the rate from the dynamic fluctuation is smaller than that from the static fluctuation.

Marcus'Electron Transfer Rate Revisited via a Rice-Ramsperger-Kassel-Marcus Analogue:A Uni ed Formalism for Linear and Nonlinear Solvation Scenarios

In the pioneering work by R.A.Marcus,the solvation effect on electron transfer(ET)processes was investigated,giving rise to the celebrated nonadiabatic ET rate formula.In this work,on the basis of the thermodynamic solvation potentials analysis,we reexamine Marcus’formula with respect to the Rice-Ramsperger-Kassel-Marcus(RRKM)theory.Interestingly,the obtained RRKM analogue,which recovers the original Marcus’rate that is in a linear solvation scenario,is also applicable to the nonlinear solvation scenarios,where the multiple curve-crossing of solvation potentials exists.Parallelly,we revisit the corresponding Fermi’s golden rule results,with some critical comments against the RRKM analogue proposed in this work.For illustration,we consider the quadratic solvation scenarios,on the basis of physically well-supported descriptors.

Full Graph Methods of Switched Current Circuit Solution

Circuits with switched current are described by an admittance matrix and seeking current transfers then means calculating the ratio of algebraic supplements of this matrix. As there are also graph methods of circuit analysis in addition to algebraic methods, it is clearly possible in theory to carry out an analysis of the whole switched circuit in two-phase switching exclusively by the graph method as well. For this purpose it is possible to plot a Mason graph of a circuit, use transformation graphs to reduce Mason graphs for all the four phases of switching, and then plot a summary graph from the transformed graphs obtained this way. First the author draws nodes and possible branches, obtained by transformation graphs for transfers of EE （even-even） and OO （odd-odd） phases. In the next step, branches obtained by transformation graphs for EO and OE phase are drawn between these nodes, while their resulting transfer is 1 multiplied by z^1/2. This summary graph is extended by two branches from input node and to output node, the extended graph can then be interpreted by the Mason＇s relation to provide transparent current transfers. Therefore it is not necessary to compose a sum admittance matrix and to express this consequently in numbers, and so it is possible to reach the final result in a graphical way.

南水北调东线梁济运河段输水流量损失的经验估算方法

传统Kostiakov经验公式计算结果为一定值,在未衬砌的沿程地质变化较大的河段应用时不能充分体现输水损失沿程变化的动态特点。为克服原公式局限性,采用积分学方法及广义简约梯度法对Kostiakov经验公式进行改进,形成改进Kostiakov经验公式法,并以南水北调东线梁济运河段为例,利用2013—2019年实测数据,对改进Kostiakov经验公式中的参数进行率定。考虑梁济运河段运行期间易受春灌影响,分别利用受春灌影响显著的2019—2020年和影响一般的2020—2021年实测数据对改进Kostiakov经验公式进行验证。结果表明:改进Kostiakov经验公式法可克服原公式应用时的局限性,有效提升输水损失计算精度,扩大原公式的应用范围;改进后计算结果与两个时段实测数据的平均相对误差分别由原来的27.26%和11.72%降低为7.9%和6.84%,对调水工程运行调度具有重要意义。

电网厂站接线图人工智能识别关键方法

矢量化的电网厂站接线图需要调度运维人员参考设计图纸进行人工绘制及导入,工作量巨大且极易出错。针对电网厂站接线图中图元、文字以及接线关系3个核心的识别问题,提出一套基于人工智能的完整电网厂站接线图识别方法,显著提升识别的效率和准确性。通过结合分级预处理的重叠滑窗机制与YOLOv4算法,解决电网厂站接线图的“大图像小图元检测”问题;通过迁移学习与卷积循环神经网络结合,提升包含中文电气文本的识别率;通过嵌入电气领域知识与规则,提升接线识别的准确率。最后,根据获取的电气元件信息、文本信息、连接线信息,完成其他下游任务。采用实际调度系统导出的电网接线图数据集,设计了图元、文字、接线识别三方面的对比实验,验证了所提方法的有效性。

R410A在不同直径水平单管管内换热性能研究

本文对管外径分别为25.4 mm和19.05 mm同类型强化管管内换热性能进行了实验研究。结果表明:25.4 mm和19.05 mm强化管相对于光管换热的强化倍率分别为2.147和4.876;在入口水温恒定时,总传热系数与水侧传热系数均随水流量在0.6~1.4 m3/h范围内升高而增大,而制冷剂侧传热系数变化趋势与管径相关;在高流量,总传热系数与制冷剂侧传热系数随入口水温在11~16℃范围内升高逐渐降低,水侧传热系数随入口水温的升高变化不明显。

核电厂蒸汽发生器传热管束流弹失稳评价关键参数分析及实验研究

针对某压水型核电厂新研发蒸汽发生器的传热管,采用ASME BPVC-Ⅲ推荐的半经验公式及相应参数取值,计算得到了悬臂传热管在空泡份额为0%(单相水)、10%、20%、50%、80%、90%下的流弹失稳临界流速。同时,设计开展了悬臂传热管阵在各空泡份额下的流致振动实验,测得了传热管流弹失稳临界流速、动水中的振动阻尼比及固有频率等关键参数。实验中测得的振动阻尼比主要包含了两相阻尼与粘滞阻尼,随空泡份额的变化而变化,范围为1.51%~3.98%,考虑测量不确定度后,该值可用于本文所述蒸汽发生器设计,且具有一定的保守性。分析结果表明,规范推荐的公式及参数计算所得传热管流弹失稳临界流速和实验结果趋势相同、规律一致,前者较后者有较大的保守性,安全系数在1.5以上;采用实验测得的阻尼比及固有频率重新计算得到的临界流速安全系数有所下降,但仍高于1.1。通过实验和分析,讨论了文中所述新研发核电厂蒸汽发生器传热管束流弹失稳评价关键参数取值及分析方法的合理性与保守性,可用于工程产品的设计及分析。

以标准汤剂为基准的小红参配方颗粒量值传递研究

目的以标准汤剂中出膏率、小红参萘酚苷A含量和特征图谱为基准,研究配方颗粒的量值传递规律。方法制备小红参标准汤剂样品,建立小红参萘酚苷A含量及特征图谱测定方法,以其为基准进行药材-饮片-标准汤剂-配方颗粒量值传递研究。结果15批标准汤剂结果表明,出膏率范围为15.3%~28.4%;小红参萘酚苷A的含量范围为15.83~29.39 mg·g^(-1),转移率范围为21.79%~40.47%;共标定6个特征峰,指认峰1小红参萘酚苷A、峰4小红参醌苷乙2个特征峰。收集不同来源15批次小红参药材、饮片及3批中试配方颗粒,并测定小红参萘酚苷A含量及特征图谱,小红参药材中小红参萘酚苷A含量范围为14.32~19.79 mg·g^(-1);小红参饮片中小红参萘酚苷A含量范围为12.71~18.81 mg·g^(-1);小红参配方颗粒中小红参萘酚苷A含量范围为18.71~19.80 mg·g^(-1);其饮片-药材转移率范围为64.41%~119.62%;标准汤剂-饮片转移率范围为21.79%~40.47%;饮片-配方颗粒转移率为26.10%~28.73%。特征图谱结果中小红参药材、饮片、配方颗粒均检测出6个特征峰,且相对保留时间均在规定范围内。结论以小红参标准汤剂为基准,其药材-饮片-标准汤剂-配方颗粒中小红参萘酚苷A,6个特征峰的传递规律稳定,均在标准汤剂范围内,说明小红参配方颗粒制备工艺及质量稳定,与标准汤剂等效。

基于UPLC指纹图谱的西洋参饮片、标准汤剂、配方颗粒的质量相关性研究

为了实现西洋参配方颗粒全生产过程的质量控制,采用超高效液相色谱法(UPLC)对其饮片、标准汤剂和配方颗粒的指纹图谱和量质传递进行了相关性研究。采用UPLC法测定18批西洋参饮片、标准汤剂、3批配方颗粒的指纹图谱、人参皂苷Rg_(1),Re,Rb_(1)总量,以K值和各已知成分的转移率作为量值传递的评价指标,结合相似度评价法研究三者的相关性。结果表明:西洋参饮片、标准汤剂、配方颗粒指纹图谱均呈现8个共有特征峰,并指认出5个成分,三者的指纹图谱与相应对照指纹图谱及三者对照指纹图谱的相似度均大于0.95,人参皂苷Rg_(1),Re,Rb_(1)的转移率及K值趋势一致,量值传递稳定。西洋参饮片、标准汤剂、配方颗粒的化学成分基本一致,三者具有良好的相关性。研究所得可对西洋参配方颗粒的质量标准研究提供实验及理论支持,并为后续以标准汤剂为基准的配方颗粒或经典方制剂质量控制提供了参考依据。

基于城市地域特征的导视图形设计研究——以成都天府广场站为例

从地铁导视图形研究视角出发,以成都天府广场站导视系统图形为设计个案研究,提出城市中心多出口地铁站导视系统图形的设计方法。通过实地调研天府广场站,引入站点地域特征元素,将站内导视与地域图形结合,融入认知地图理论,设置空间叙事布局,满足乘客精准寻路需求。通过上述方法设计具有城市地域特征的天府广场站导视图形。通过乘客在地铁站空间的行为、感官和情感的需求,以图形符号为设计触点,融合地域文化元素,提供具有功能性、文化性和装饰性的站内导视图形设计,变成乘客判断方向的参照物,提升用户空间体验,解决多出口换乘站的寻路难题。