Association of a SLC30A8 Genetic Variant with Monotherapy of Repaglinide and Rosiglitazone Effect in Newly Diagnosed Type 2 Diabetes Patients in China

Objective To investigate a potential relationship between Solute carrier family 30 （zinc transporter） member 8 （SLC3OAS） rs13266634 variant and efficacy of rosiglitazone or repaglinide in treating newly diagnosed Chinese type 2 diabetes patients. Methods A total of 209 diabetic patients without any antihyperglycemic history were recruited and treated with repaglinide or rosiglitazone randomly for 48 weeks （104 and 105 patients, respectively）. Anthropometric measurements and clinical laboratory tests were carried out before and after the treatment. An non-synonymous variant rs13266634 was genotyped by matrix-assisted laser desorption ionization-time of flight mass spectroscopy. Results Ninety-one patients in repaglinide group and ninety-three patients in rosiglitazone group completed the study. 6 value of homeostasis model assessment of beta cell function （HOMA-B） and 6 value of fasting proinsulin levels were statistically significant between three genotype groups （P=0.0149 and 0.0246, respectively） after rosiglitazone treatment. However, no genotype association was observed in the repaglinide or rosiglitazone group with other parameters. Conclusion The SLC3OA8 variant was associated with the efficacy of insulin sensitizer monotherapy on insulin secretion in patients with newly diagnosed type 2 diabetes mellitus in Shanghai, China.

Sedimentary model reconstruction and exploration significance of Permian He 8 Member in Ordos Basin,NW China

Based on the Late Paleozoic geological background and the latest exploration achievements of the Ordos Basin and North China platform, it is concluded that during the sedimentary period of Permian He 8 Member, the area in concern had multiple material sources, multiple river systems, flat terrain, shallow sedimentary water, widely distributed fluvial facies sand body and no continuous lake area, so alluvial river sedimentary system developed in the whole region. Based on stratigraphic correlation and division, and a large number of drilling and outcrop data, a comprehensive analysis of lithofacies and sedimentary facies types and distribution was carried out to reconstruct the ancient geographic pattern of the He 8 Member sedimentary period. The results of paleogeography restoration show that the area of Ordos Basin was the "runoff area" in the sedimentary slope in the western part of the North China platform during the sedimentary period of He 8 Member, the whole region was mainly alluvial plain sedimentation featuring alternate fluvial facies, flood plain facies and flood-plain lake facies. According to the results of flume deposition simulation experiment, a new sedimentary model of "alluvial river & flood-plain lake" is established, which reveals the genesis of large area gravel sand body in He 8 Member of this area and provides geological basis for the exploration of tight gas in the south of the basin.

鄂尔多斯盆地二叠系盒8段河流扇沉积模式及勘探意义

根据野外露头及岩心的分析化验资料,在源-汇系统分析的基础上,对鄂尔多斯盆地二叠系盒8段的古气候环境及沉积相特征进行了详细研究。研究结果表明:(1)鄂尔多斯盆地二叠系盒8段Sr/Cu的值多大于10,V/Cr值多小于2.0,地层厚度差小于30 m,未出现明显的突变,古沉积坡度为0.5°~1.0°,古地貌开阔平缓且无明显坡折带,沉积水体较浅,是在古气候干旱、古地形平缓的背景下,受阶段性洪水作用主导的事件沉积。(2)盒8段沉积期,盆地不存在大面积汇水区,沉积体系中河流并未进入湖泊水体,而是向东南流出盆地或是消失在内陆干旱地区,全盆地以洪泛平原沉积为主,表现为河道与泛滥平原交互分布的沉积格局,形成了河流扇沉积模式。(3)湖水进退往复,洪水期与枯水期间歇发育,洪水期多期次决口河道接力搬运使得粗粒级砂岩向湖盆长距离延伸,枯水期发育厚层泥质沉积可作为区域性盖层,形成了良好的储盖组合,勘探潜力大。

盐池地区延长组长8段致密油储层脆性指数测井评价

致密砂岩油气通常需要通过压裂等技术措施方可获得工业产量,而脆性指数是评价储层可压裂性的重要参数,对致密油储层勘探开发甜点优选至关重要。以鄂尔多斯盆地盐池地区三叠系延长组长8段为例,针对致密砂岩储层脆性指数测井评价方法开展系统研究。首先,利用阵列声波测井、岩石声波特性室内实验测试资料,通过求取杨氏模量、泊松比等岩石弹性力学参数,定量计算长8段脆性指数;随后,将利用阵列声波测井资料计算的脆性指数作为目标值,寻找其与自然伽马、横波时差等常规测井资料之间的对应关系;在此基础上,建立基于岩石脆性指数测井预测模型;最后,通过多元回归,全面提取常规测井信息,建立基于常规测井资料的脆性指数多元函数评价模型。根据研究区内单井实例,测井预测脆性指数与岩石声波特性实验测试结果匹配良好,对于脆性指数定量预测,基于岩性指数模型的拟合优度为0.733,基于物性指数模型的拟合优度为0.719,基于多元回归模型的拟合优度为0.789。通过实例验证,脆性指数预测值与实测值变化趋势一致,相关性明显,相关系数达0.936。

苏里格气田46区盒8段致密砂岩储层特征及主控因素

为查明苏里格气田46区盒8段致密砂岩储层特征及主控因素,文中利用铸体薄片、岩心物性、扫描电镜、压汞、T2核磁等测试分析,对盒8段致密砂岩储层开展了系统研究。结果表明:研究区盒8段致密砂岩储层储集空间类型主要为粒间溶孔、粒内溶孔、杂基孔,平均孔隙度为6.93%,平均渗透率为1.620×10-3μm2,为一套特低孔—超低孔、超低渗储层。孔喉分布不均匀,分选相对较差,以中小孔-细微喉组合为主。低体积分数岩屑、高体积分数石英、大粒径颗粒是优质储层发育的物质基础;沉积作用保留的原生粒间孔隙是次生孔隙、成岩裂缝发育的基础,也是寻找优质储层的关键。

鄂尔多斯盆地中部上古生界盒8段储层特征及敏感性分析

研究区紧邻苏里格气田,但是作为苏里格气田主要产气层段的盒8段在研究区产气较差,为究其原因,针对上古生界盒8段储层应用X衍射、全岩定量分析、薄片鉴定、水驱敏感性流动实验等方法开展储层特征和敏感性研究,明确其影响因素,为下一步增产开发提供思路。实验结果表明,研究区目的层段以石英岩屑砂岩为主,为低-特低孔、特低渗储层。孔隙分选较差,以小孔喉为主;储层具有弱-中等偏弱速敏、强-中等偏强水敏、弱酸敏、中等偏弱盐敏、弱碱敏等特点。研究区伊蒙混层、伊利石和高岭石对储层的水敏、速敏和盐敏具有控制作用,此外储层物性于敏感性也存在一定的相关性,储层物性差时,敏感性增强。

Changes of the cytokine profile in inflammatory bowel diseases

Cytokines are indispensable signals of the mucosaassociated immune system for maintaining normal gut homeostasis.An imbalance of their profile in favour of inflammation initiation may lead to disease states,such as that is observed in inflammatory bowel diseases(IBD).Although Crohn's disease(CD) is often described as a prototype of T-helper 1-type diseases,and ulcerative colitis(UC) is traditionally viewed as a T-helper 2-mediated condition,the classic paradigm,which categorises cytokines into pro-and anti-inflammatory groups,has recently been changed.The inflammation regulatory pathways may not be mutually exclusive as individual cytokines can have diverse and even opposing functions in various clinical and immunological settings.None the less there are many common immunological responses in IBD that are mediated by cytokines.Although they regulate and influence the development,course and recurrence of the inflammatory process,the concrete pathogenic role of these small signaling molecules is sometimes not unambiguous in the subtypes of the disease.Our aim is to review the current information about pro-and anti-inflammatory effects of traditionally studied and recently discovered cytokines in the pathogenesis of UC and CD.The better understanding of their production and functional activity may lead to the development of new therapeutic modalities.

鄂北S井区盒8上亚段砂体叠置类型及其对气藏分布的影响

为明确鄂北S井区盒8上亚段地层砂体叠置类型及其与气藏分布的关系,通过岩心观察、测井解释等方法对研究区盒8上亚段沉积微相类型、砂体的垂向叠置及侧向接触关系进行深入研究,再结合试气资料探讨不同砂体叠置类型的气藏分布特征。结果表明:鄂北S井区盒8上亚段为曲流河三角洲平原亚相,有利砂体对应的沉积微相类型为边滩与河道充填微相;砂体垂向叠置类型可划分为分离式、叠加式、切叠式、替代式,侧向接触关系可划分为间湾接触、堤岸接触、对接式、侧切式、替代式;鄂北S井区盒8上亚段砂体垂向叠置类型主要为侧向切叠式和替代式,增加了砂体在侧向上的连通性;盒8上亚段砂体侧向接触关系主要为侧切式,提升了砂体侧向上的连通程度,气藏储存关系较好;单一、孤立存在的砂体,其连通性较差,整体的含气性也较差。该研究对寻找低渗透背景下产能高、潜力大的砂体分布区具有重要指导意义。

鄂尔多斯盆地北部S井区盒8上亚段砂岩气藏沉积微相研究

鄂尔多斯盆地北部(鄂北)S井区盒8段气藏属于致密砂岩气藏。目前该井区盒8上亚段作为主力层位之一已进入开采中后期,存在剩余气分布特征不清的问题,进一步开采难度较大。为解决此问题,综合利用动静态资料,对该层位开展沉积微相的精细研究。研究区盒8上亚段自下而上分别划分为盒8上1、盒8上2两个小层,通过沉积相标志以及测井相分析,识别盒8上亚段单井沉积微相发育特征,并在横向上对该井区内的沉积微相及其组合关系进行分析,最终确定该研究井区盒8上亚段的沉积微相平面展布特征。结果表明:研究区气藏范围内发育边滩、河道充填、废弃河道、堤岸(天然堤、决口扇)、河道间5种微相;边滩以及河道充填为主要的控砂微相类型;盒8上1小层的西北部分布较大规模边滩,东部零星分散,盒8上2小层的东南部零星分布有边滩,西部分布有较大规模。研究成果可为鄂北地区储层非均质性特征和剩余气藏分布预测提供地质依据。

Basic characteristics of key interfaces in Upper Ordovician Wufeng Formation – Lower Silurian Longmaxi Formation in Sichuan Basin and its periphery,SW China

Based on anatomy of key areas and data points and analysis of typical features of shell layer in Guanyinqiao Member, basic characteristics of key interfaces, mainly bentonite layers, in the Upper Ordovician Wufeng Formation-Lower Silurian Longmaxi Formation in the Sichuan Basin and its surrounding areas and the relationship between these key interfaces with the deposition of organic-rich shale have been examined systematically. The Wufeng Formation-Longmaxi Formation has four types of marker beds with interface attributes, namely, the characteristic graptolite belt, Guanyinqiao Member shell layer, section with dense bentonite layers, and concretion section, which can be taken as key interfaces for stratigraphic division and correlation of the graptolite shale. The shell layer in Guanyinqiao Member is the most standard key interface in Wufeng Formation-Longmaxi Formation, and can also be regarded as an important indicator for judging the depositional scale of organic-rich shale in key areas. There are 8 dense bentonite sections of two types mainly occurring in 7 graptolite belts in these formations. They have similar interface characteristics with the shell layer in Guanyinqiao Member in thickness and natural gamma response, and belong to tectonic interfaces(i.e., event deposits). They have three kinds of distribution scales: whole region, large part of the region, and local part, and can be the third, fourth and fifth order sequence interfaces, and have a differential control effect on organic-rich shale deposits. The horizon the characteristic graptolite belt occurs first is the isochronous interface, which is not directly related to the deposition of organic-rich shale. Concretions only appear in local areas, and show poor stability in vertical and horizontal directions, and have no obvious relationship with the deposition of the organic-rich shale.

冰片通过TRPM8减轻小鼠心肌梗死后炎症反应并抑制心脏重构

目的:研究冰片(borneol)对小鼠心肌梗死(myocardial infarction,MI)后炎症反应和心脏重构的作用及可能机制。方法:8周龄野生型(wild-type,WT)C57BL/6小鼠和瞬时受体电位阳离子通道M亚家族成员8(transient receptor potential cation channel subfamily M member 8,TRPM8)基因敲除(TRPM8 gene knockout,TRPM8−/−)小鼠随机分为假手术组和MI组,再分别用生理盐水(对照组)或冰片(冰片组)灌胃。绘制小鼠MI后生存曲线,28 d后超声心动图检测心脏功能,多导生理记录仪测量血流动力学参数,病理染色观察MI面积、心肌肥大和间质纤维化,并检测梗死交界区心肌中炎症反应情况。结果:在WT小鼠中,梗死交界区心肌组织中TRPM8表达显著增加(P<0.05),冰片对心脏中TRPM8表达无影响(P>0.05),但可提高小鼠生存率,缩小MI面积,抑制MI后心脏重构,改善心脏功能(P<0.05或P<0.01);在TRPM8−/−小鼠中,冰片对小鼠生存率、MI面积、心肌肥大、心肌纤维化和心脏功能未见明显影响(P>0.05)。在WT小鼠中,冰片可减少中性粒细胞和巨噬细胞的浸润(P<0.01),抑制炎症因子肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)、白细胞介素1β(interleukin-1β,IL-1β)、IL-6和单核细胞趋化蛋白1(monocyte chemotactic protein-1,MCP-1)过度表达(P<0.05或P<0.01);而在TRPM8−/−小鼠中,冰片对炎症细胞数量和炎症因子表达未见明显影响(P>0.05)。结论:TRPM8可能是冰片在心脏的作用靶点;冰片可能通过TRPM8减轻MI后炎症反应和抑制心脏重构,改善小鼠MI后的心脏功能。

鄂尔多斯盆地东南部大宁—吉县区块上古生界盒8段流体包裹体特征及成藏意义

鄂尔多斯盆地东南部大宁—吉县区块相较于盆地内部,其构造活动强烈,地层抬升幅度大,有机质成熟度高,导致研究区与盆地内部天然气成藏存在差异。利用单偏光显微镜、激光拉曼光谱仪及冷热台等实验仪器,对研究区盒8段13块流体包裹体样品开展了岩相学显微观察、测温测盐和古压力恢复,并结合地层埋藏史—热史厘定了大宁—吉县区块盒8段天然气成藏期次及成藏过程。结果表明,烃类包裹体类型有CH_(4)+CO_(2)包裹体、CH_(4)包裹体及含碳质沥青包裹体。前两类烃类包裹体对应的共生盐水包裹体均一温度介于90~160℃,具有双峰分布特征,第3类包裹体形成时期温度较高,成岩作用阶段已达到晚期,几乎不发育与其伴生的盐水包裹体,通过计算得出含碳质沥青反射率介于2.79%~3.32%,处于高成熟阶段,为原油裂解形成。综合分析表明研究区天然气存在三期充注成藏过程:第Ⅰ期共生盐水包裹体均一温度分布区间为90~120℃,天然气充注期距今175~155 Ma,古压力系数达到1.43,对应于早侏罗世晚期-晚侏罗世早期;第Ⅱ期共生盐水包裹体均一温度区间为130~160℃,天然气充注期距今145~110 Ma,为主成藏期,充注完成时古压力系数达1.57,对应于早白垩世;第Ш期为裂解期,烃类包裹体为含碳质沥青包裹体,形成时的地层温度高于200℃,其成因为原油在早白垩世末裂解形成,古压力系数增加到2.0,距今110~100 Ma。

Study of Upper Critical Magnetic Field of Superconducting HoMo₆Se₈

This work focuses on the study of mathematical aspects of upper critical magnetic field of superconducting HoMo6Se8. At zero external magnetic field, HoMo6Se8 was found to undergo a transition from the normal state to the superconducting state at 5.6 K and returned to a normal but magnetically ordered state between the temperature range of 0.3 K and 0.53 K. The main objective of this work is to show the temperature dependence of the upper critical magnetic field of superconducting HoMo6Se8 by using the Ginzburg-Landau (GL) phenomenological Equation. We found the direct relationship between the GL coherence length (ξGL) and penetration depth (λGL) with temperature. From the GL Equations and the results obtained for the GL coherence length, the expression for upper critical magnetic field (Hc2) is obtained for the superconducting HoMo6Se8. The result is plotted as a function of temperature. The graph shows the linear dependence of upper critical magnetic field (Hc2) with temperature (T) and our finding is in agreement with experimental observations.

ABCA8通过调控Wnt/β-catenin通路抑制结直肠癌细胞增殖、迁移和侵袭

目的:研究ATP结合盒亚家族A成员8(ABCA8)对结直肠癌(CRC)细胞增殖、迁移与侵袭的影响,并阐明其作用机制。方法:采用生物信息学分析ABCA8在CRC组织中的表达情况;采用实时荧光定量PCR(RT-qPCR)法检测临床CRC癌组织和CRC细胞系中ABCA8 mRNA表达水平。采用ABCA8基因过表达慢病毒感染SW480细胞,再将细胞分为对照(Blank)组、空载(Vector)组、ABCA8过表达(Oe-ABCA8)组、Vector+HLY78组和Oe-ABCA8+HLY78组,其中Wnt/β-catenin信号通路激动剂HLY78干预浓度为10μmol/L。CCK-8法检测各组细胞增殖活性;Transwell实验检测各组细胞迁移与侵袭细胞数量;Western blot法检测各组细胞中ABCA8、β-catenin、c-Myc和金属基质蛋白酶9(MMP-9)蛋白表达水平。结果:ABCA8在CRC癌组织和CRC细胞系SW480、SW620、 HCT116和HT-29中均呈低表达水平。与Blank组比较,Oe-ABCA8组SW480细胞增殖活性显著降低(P<0.05),迁移与侵袭细胞数量显著减少(P<0.05),细胞中ABCA8表达显著升高(P<0.05),β-catenin、c-Myc和MMP-9蛋白表达水平均显著降低(P<0.05),而Vector组各指标无显著性差异(P>0.05)。与Vector组比较,Vector+HLY78组SW480细胞增殖活性显著升高(P<0.05),迁移与侵袭细胞数量显著增多(P<0.05),细胞中β-catenin、c-Myc和MMP-9蛋白表达水平均显著升高(P<0.05)。与Oe-ABCA8组比较,Oe-ABCA8+HLY78组SW480细胞增殖活性显著升高(P<0.05),迁移与侵袭细胞数量显著增多(P<0.05),细胞中β-catenin、c-Myc和MMP-9蛋白表达水平均显著升高(P<0.05)。结论:ABCA8在CRC组织和细胞系中低表达,过表达ABCA8可抑制CRC细胞系SW480的增殖、迁移与侵袭,其作用机制可能与抑制Wnt/β-catenin信号传导有关。

鄂尔多斯盆地富县地区长8段油气成藏主控因素研究

近年来,富县地区延长组长8段油层组发现了工业油流井,但平面分布不均,具有点状含油的特点,勘探开发总体显示出该区具有多层位含油、局部层位富集的特征,但油水分布主控因素与富集规律尚不清楚,制约了该区下组合油气的勘探开发,为此,基于钻井和生产资料,分析了研究区长8段油层组的油藏类型、主控因素和成藏模式,研究表明,区内长8段油藏类型主要为上倾尖灭岩性油藏、透镜状岩性油藏和致密层遮挡岩性油藏;油气成藏受烃源岩、储层物性、砂体厚度、局部构造共同控制;长8段油气成藏模式为典型的三明治型,有利于致密油的形成。

Paleo-sedimentary environmental restoration and its significance of Chang 7 Member of Triassic Yanchang Formation in Ordos Basin,NW China

Paleo-sedimentary environment of Chang 7 Member of Upper Triassic Yanchang Formation in Ordos Basin, including the paleoclimate, paleo-salinity and paleo-redox conditions were restored through geochemical elements analysis of 289 samples collected from the outcrop sections around and wells drilled in the basin and using a series of identification indexes of paleo-climate, paleo-salinity and paleo-redox conditions, such as CaO/MgO?Al2 O3, Sr/Cu, Rb/Sr, Rb/K2 O, Th/U, V/(V+Ni), the content of element B tested from the mudstone. Comprehensive analysis shows that in sedimentary period of the Chang 7, the paleo-climate was warm temperate to subtropical climate with temperature higher than 15 ?C, the water body was continental brackish water to freshwater, and the sediments were deposited under strong reduction conditions. Suitable temperature, extensively deep lake basin and strongly reductive paleo-sedimentary environment led to the blooming, enrichment and preservation of organic matter in the submember Chang 73. As a result, a set of high-quality source rock was formed, laying material foundation for large-scale accumulation of shale oil.

鄂尔多斯盆地平凉北地区上三叠统长8段储层低含油饱和度油藏特征及成因

通过岩心物性分析、恒压压汞和核磁共振测试,结合油源、构造等资料,对鄂尔多斯盆地平凉北地区上三叠统长8段储层低含油饱和度油藏的特征及成因进行了分析。研究结果表明:①平凉北地区上三叠统长8段储层含油饱和度普遍低于20%,而含水饱和度则普遍高于50%,属于典型的低含油饱和度油藏,且单井产量低,油水分异差,油藏呈零星状分布在长8段储层顶部。②供烃量不足是研究区油藏含油饱和度低的根本原因。M53井区为异地成藏,供烃距离较远导致供烃量不足;Y80井区为原地成藏,原地烃源岩排烃量小导致油气充注不足。③M53井区受低幅度构造影响,油气垂向和侧向运移动力不足。全区储层物性非均质性强,微细孔喉较为发育,束缚水占比大,可动水占比小,导致油气驱替可动水后其饱和度较低,从而使研究区油藏分布较分散、含油饱和度较低。④M53井区上新庄地区西南部构造高部位物性较好的储层为下一步增储上产的重要目标。

Origin and diagenetic evolution of dolomites in Paleogene Shahejie Formation lacustrine organic shale of Jiyang Depression,Bohai Bay Basin,East China

The origin of dolomite in Shahejie Formation shale of Jiyang Depression in eastern China were studied by means of petrologic identification, compositional analysis by X-ray diffraction, stable carbon and oxygen isotopic composition, and trace element and rare earth element analyses. The results show that the development of dolomite is limited in the lacustrine organic rich shale of Shahejie Formation in the study area. Three kinds of dolomite minerals can be identified: primary dolomite(D1), penecontemporaneous dolomite(D2), and ankerite(Ak). D1 has the structure of primary spherical dolomite, high magnesium and high calcium, with order degree of 0.3-0.5, and is characterized by the intracrystalline corrosion and coexistence of secondary enlargement along the outer edge. D2 has the characteristics of secondary enlargement, order degree of 0.5-0.7, high magnesium, high calcium and containing a little iron and manganese elements. Ak is characterized by high order degree of 0.7-0.9, rhombic crystal, high magnesium, high calcium and high iron. The micritic calcite belongs to primary origin on the basis of the carbon and oxygen isotopic compositions and the fractionation characteristics of rare earth elements. According to the oxygen isotopic fractionation equation between paragenetic dolomite and calcite, it is calculated that the formation temperature of dolomite in the shale is between 36.76-45.83 ℃, belonging to lacustrine low-temperature dolomite. Based on the maturation and growth mechanism of primary and penecontemporaneous dolomite crystals, a dolomite diagenetic sequence and the dolomitization process are proposed, which is corresponding to the diagenetic environment of Shahejie Formation shale in the study area.

鄂尔多斯盆地延长组7-8段深水沉积特征及演化规律

为明确鄂尔多斯盆地富县-志丹地区延长组7-8段深水细粒层系沉积特征及演化规律,利用研究区测录井、岩心、薄片,结合总有机碳(total organic carbon,TOC)、全岩X射线衍射等资料识别细粒沉积岩的岩相类型,分为粉砂岩和泥页岩2大类,细分为7亚类,分别是风暴粉砂岩、地震滑塌粉砂岩、异重流粉砂岩;中低有机质纹层状长英质页岩、高有机质纹层状长英质页岩、高有机质纹层状黏土岩、低有机质块状长英质页岩。利用标志层、测井响应特征、地球化学等高精度测试资料将研究区长7-8段划分为一个Ⅲ级层序、3个体系域、7个准层序组,并建立剖面精度到准层序组(10~20 m)的精细层序地层格架;讨论精细层序地层格架演变约束下的细粒沉积岩分布规律。对于粉砂岩:低位和高位体系域晚期水深相对较小,受风暴影响大,发育风暴粉砂岩;高位体系域早期,受陆源洪水影响,发育异重流粉砂岩;地震滑塌粉砂岩的分布受幕式构造运动控制,在低位和湖侵体系域均有分布:对于泥页岩:中低有机质泥页岩分布在低位和高位体系域晚期,高有机质泥页岩则分布在湖侵和高位体系域早期。可见湖平面的升降变化控制了不同岩相类型的垂向分布,体现为粉砂岩与泥页岩高频互层,其中地震滑塌粉砂岩主要受控于幕式构造运动。此外,平面岩相分布规律表明,泥页岩和粉砂岩生储配置关系较好,且分布范围较广,整体呈条带状沿物源方向平行岸线分布,是岩性油气藏勘探开发有利区。

鄂尔多斯盆地华池地区长8段致密砂岩储层微观孔隙结构及流体可动性

为了深入研究鄂尔多斯盆地华池地区致密砂岩储层微观孔隙结构特征及储层流体可动性,优选长8段10块典型致密砂岩样品,分别开展铸体薄片、扫描电镜、X衍射、高压压汞和核磁共振等实验,分析不同孔隙结构和孔喉类型条件下的流体可动性及其影响因素。结果表明:华池地区长8段储层主要发育残余粒间孔、溶蚀孔和晶间孔3种孔隙类型;根据毛细管压力曲线形态和排驱压力大小,可将研究区储层孔隙结构划分为Ⅰ类、Ⅱ类和Ⅲ类,对应的储层物性和流体可动性依次变差;不同孔喉类型对应的可动流体赋存特征存在较大差异,中孔喉和小孔喉是研究区储层的主要孔喉类型,同时也是储层可动流体的主要赋存场所;致密砂岩储层微观孔隙结构是影响流体可动性的主要因素,此外,储层流体的可动性还受储层物性和黏土矿物含量的综合影响。研究成果为华池地区致密砂岩储层的质量评价、油气资源评估和高效开发提供了理论依据。