目的分析血清免疫球蛋白4(immunoglobulin 4,IgG4)、辅助性T细胞17(helper T 17,Th17)/调节性T细胞(regulatory T cells,Treg)评估激素治疗自身免疫性胰腺炎(autoimmune pancreatitis,AIP)患者效果的价值。方法选取铜川市人民医院2021年...目的分析血清免疫球蛋白4(immunoglobulin 4,IgG4)、辅助性T细胞17(helper T 17,Th17)/调节性T细胞(regulatory T cells,Treg)评估激素治疗自身免疫性胰腺炎(autoimmune pancreatitis,AIP)患者效果的价值。方法选取铜川市人民医院2021年4月至2023年9月收治的95例AIP患者,其中男55例,女40例,年龄(54.28±5.51)岁;48例有吸烟史,49例有饮酒史。治疗前,用流式细胞仪检测患者Th17、Treg,计算Th17/Treg,用酶联免疫吸附法检测AMY水平。所有患者均采用激素治疗。根据疗效将患者分为有效组(完全缓解、部分缓解)和无效组(治疗失败)。对比两组患者基础资料和血清学指标。分析血清IgG4、Th17/Treg评估激素治疗AIP患者效果的价值。采用t检验和χ^(2)检验。采用二元logistic逐步回归模型进行影响因素分析,绘制受试者操作特征曲线(ROC)评估预测效能。结果AIP患者激素治疗后,完全缓解43例,部分缓解30例,治疗失败22例,有效率为75.00%(73/95),无效率为23.16%(22/95)。有效组Th17/Treg和D-D、AMY、IgG4水平低于无效组[(1.05±0.14)比(2.21±0.34)、(0.23±0.05)mg/L比(0.52±0.12)mg/L、(296.56±15.74)U/L比(436.26±18.52)U/L、(2.47±0.41)g/L比(4.62±0.78)g/L],差异有统计学意义(t=23.475、16.556、35.005、17.091,均P<0.001)。二元logistic回归分析结果显示,Th17/Treg(OR=4.486,95%CI 1.533~13.125)、D-D水平(OR=3.333,95%CI 1.139~9.753)、AMY水平(OR=3.912,95%CI 1.337~11.445)、IgG4水平(OR=3.077,95%CI 1.052~9.003)是AIP患者激素治疗无效的影响因素(均P<0.05)。ROC分析显示,Th17/Treg、D-D、AMY、IgG4、四者联合预测AIP患者激素治疗无效的灵敏度分别为77.27%、63.64%、68.18%、72.73%、90.91%,特异度分别为76.71%、68.49%、69.86%、73.97%、91.78%。结论Th17/Treg、D-D、AMY、IgG4水平与AIP患者激素治疗无效相关,联合检测预测AIP患者激素治疗效果更为精准且高效。展开更多
The spirit of the May 4th Movement has a profound influence on China’s self-confidence in its path,political system,guiding theories,and culture.This spirit,which conceived the choice of socialist path,has become the...The spirit of the May 4th Movement has a profound influence on China’s self-confidence in its path,political system,guiding theories,and culture.This spirit,which conceived the choice of socialist path,has become the foundation of confidence in the socialist path with Chinese characteristics.The Marxist theory contained in the spirit is the core of the theoretical self-confidence of socialism;the socialist system bred by the spirit has borne the fruit of confidence in the socialist system with Chinese characteristics;the new culture movement produced by the spirit is the thrust of cultural self-confidence of socialism with Chinese characteristics.Inheriting and developing the spirit of the May Fourth Movement in the new era is conducive to strengthen the Four Confidences.展开更多
基金The key project of Humanities and Social Sciences of Chongqing Municipal Commission of Education“Research on the Construction of China’s National Cohesion in the New Era based on Cultural Soft Power”(19SKGH140)and the special theoretical key project of Chongqing Social Sciences Planning:“Research on‘Four Comprehensives’and National Cohesion in the Philosophical Context”(17ZDZT29).
文摘The spirit of the May 4th Movement has a profound influence on China’s self-confidence in its path,political system,guiding theories,and culture.This spirit,which conceived the choice of socialist path,has become the foundation of confidence in the socialist path with Chinese characteristics.The Marxist theory contained in the spirit is the core of the theoretical self-confidence of socialism;the socialist system bred by the spirit has borne the fruit of confidence in the socialist system with Chinese characteristics;the new culture movement produced by the spirit is the thrust of cultural self-confidence of socialism with Chinese characteristics.Inheriting and developing the spirit of the May Fourth Movement in the new era is conducive to strengthen the Four Confidences.
