Traditional Chinese medicine(TCM)has become very popular in the treatment of complex diseases worldwide in recent decades.Despite the promising performance of TCM,how herbs work synergistically in a formula and their ...Traditional Chinese medicine(TCM)has become very popular in the treatment of complex diseases worldwide in recent decades.Despite the promising performance of TCM,how herbs work synergistically in a formula and their therapeutic targets remain ambiguous.This largely limits the correct use and modernization of TCM formulas clinically.The study of disassembled prescriptions is important for investigating the compatibility theory of Chinese medicines.By dissecting the mechanisms of TCM formulae,the compatibility principles of some well-known formulae,such as Realgar-Indigo naturalis,have been elucidated to a certain extent.In this review,several common methods of disassembled prescription studies are summarized,including those of single herb or mineral,sub-prescription,active ingredients or effective parts,large formulae,and systems pharmacology studies,as well as the methods of grouping based on the properties or efficacy of Chinese medicines,in order to provide evidence for formulae study.Moreover,some challenges to be addressed in disassembled prescriptions studies have been identified in this review.展开更多
Using the Splitting Hopkinson Pressure Bar （SHPB） experimental system, investigations were made into the dynamic mechanical performances of underground soft rocks. The experiments proved that the measured stress-str...Using the Splitting Hopkinson Pressure Bar （SHPB） experimental system, investigations were made into the dynamic mechanical performances of underground soft rocks. The experiments proved that the measured stress-strain curves display the characteristics of plastic deformation. By making use of a revised overstress constitutive formula for the stress model and by taking into account that the strain rate and strain are a function of I - E（t）/Eo, a revised overstress constitutive formula for the stress model was simplified by applying dimensional analysis and consequently, a simplified overstress formula was obtained for the stress model. Then, by taking into consideration the effects of damage under a dynamic load on the dynamic loading strength of the rock, the continuous damage theory and the statistical strength theory were introduced into the development of the simplified overstress constitutive formula for the stress model. Hence, a damage-based constitutive formula for an overstress model, which can be appropriately applied to the analysis of full dynamic stress-strain curves, was developed. By using the simplified damage-based constitutive formula for an overstress model, the actually measured curves are fitted, indicating that the fitting curves and those actually measured are in good agreement.展开更多
基金the project of Young Technical Talents of Tianjin Medical University General Hospital(GG-2021-08209060209507).
文摘Traditional Chinese medicine(TCM)has become very popular in the treatment of complex diseases worldwide in recent decades.Despite the promising performance of TCM,how herbs work synergistically in a formula and their therapeutic targets remain ambiguous.This largely limits the correct use and modernization of TCM formulas clinically.The study of disassembled prescriptions is important for investigating the compatibility theory of Chinese medicines.By dissecting the mechanisms of TCM formulae,the compatibility principles of some well-known formulae,such as Realgar-Indigo naturalis,have been elucidated to a certain extent.In this review,several common methods of disassembled prescription studies are summarized,including those of single herb or mineral,sub-prescription,active ingredients or effective parts,large formulae,and systems pharmacology studies,as well as the methods of grouping based on the properties or efficacy of Chinese medicines,in order to provide evidence for formulae study.Moreover,some challenges to be addressed in disassembled prescriptions studies have been identified in this review.
基金supported by funds from the National Natural Science Foundation of China (Nos. 51374013, 51174005 and 51134012)the Huo Yingdong Funds for Young Teachers to Conduct Researches on Basic Sciences (No. 121050)+1 种基金the academic research activities subsidies for academic and technical leaders and backup candidate in Anhui provincethe funds for the Doctoral Program of Higher Education (No. 20133415110006)
文摘Using the Splitting Hopkinson Pressure Bar （SHPB） experimental system, investigations were made into the dynamic mechanical performances of underground soft rocks. The experiments proved that the measured stress-strain curves display the characteristics of plastic deformation. By making use of a revised overstress constitutive formula for the stress model and by taking into account that the strain rate and strain are a function of I - E（t）/Eo, a revised overstress constitutive formula for the stress model was simplified by applying dimensional analysis and consequently, a simplified overstress formula was obtained for the stress model. Then, by taking into consideration the effects of damage under a dynamic load on the dynamic loading strength of the rock, the continuous damage theory and the statistical strength theory were introduced into the development of the simplified overstress constitutive formula for the stress model. Hence, a damage-based constitutive formula for an overstress model, which can be appropriately applied to the analysis of full dynamic stress-strain curves, was developed. By using the simplified damage-based constitutive formula for an overstress model, the actually measured curves are fitted, indicating that the fitting curves and those actually measured are in good agreement.
