Potential therapeutic benefits stemming from the thermal nature of irreversible electropora tion of solid cancers

To the Editor：Irreversible electroporation （IRE） is a CE- and FDA- approved treatment modality for pancreatic and liver tumors that is based on the site-confined destruction of tumor tissue by multiple short, high-intensity electrical pulses.

Therapeutic importance of chemical compounds in extra virgin olive oil and their relationship to biological indicators: A narrative review and literature update

Extra Virgin Olive Oil(EVOO)symbolises the prominently cherished Mediterranean food.It is typically a lipidic source within the cookery of the Mediterranean nations,and its intake has been correlated to decreased illness and reduced disease progressions.This review attempts to summarise the empirical evidence concerning the state-of-the-art and illuminate the most crucial point of view concerning future research needs on the prospective therapeutic benefits of EVOO potential health benefits and bioavailability.Therefore,Web of Science,Scopus,and other Databases were queried using some predefined criteria.The literature search was limited to studies published from 2007 to 2022.Subsequently,fifty-three(53)studies were chosen and analysed.These studies present EVOOs analyses and their potential health benefits and bioavailability.Results revealed that fifteen(15)studies(28.3%)have some evaluation concerning the benefits of phenolic compounds.Anti-inflammatory potentials of EVOO were reported by 9.4%of the reviewed articles.Antioxidant-related analysis,Secoiridoids,and Fatty acids constituted 5.7%,respectively.These were followed by antimicrobial activity/antibacterial,polyphenols,healing of human intestinal infection,functional ingredients extraction to develop an essential food blend,and analysis of dynamics and membrane composition,which constituted 3.8%,respectively.The remaining descriptive faces constituted 2%of the reviewed literature.Results further revealed that despite the vast established literature concerning the therapeutic importance of chemical compounds found in extra virgin olive oil and their relationship to biological indicators,there is still a need for further evaluations of the less-reported aspects of EVOO’s health benefits.Therefore,the current and future reviews have to be analysed within the context of existing state-of-the-art knowledge concerning EVOO’s therapeutic benefits to human health and regular standard application of accepted field,laboratory,milling and storage standards in the literature.

Ketogenic diet alleviates cognitive dysfunction and neuroinflammation in APP/PS1 mice via the Nrf2/HO-1 and NF-κB signaling pathways

Alzheimer's disease is a progressive neurological disorder characterized by cognitive decline and chronic inflammation within the brain.The ketogenic diet,a widely recognized therapeutic intervention for refractory epilepsy,has recently been proposed as a potential treatment for a variety of neurological diseases,including Alzheimer's disease.However,the efficacy of ketogenic diet in treating Alzheimer's disease and the underlying mechanism remains unclear.The current investigation aimed to explore the effect of ketogenic diet on cognitive function and the underlying biological mechanisms in a mouse model of Alzheimer's disease.Male amyloid precursor protein/presenilin 1(APP/PS1)mice were randomly assigned to either a ketogenic diet or control diet group,and received their respective diets for a duration of 3 months.The findings show that ketogenic diet administration enhanced cognitive function,attenuated amyloid plaque formation and proinflammatory cytokine levels in APP/PS1 mice,and augmented the nuclear factor-erythroid 2-p45 derived factor 2/heme oxygenase-1 signaling pathway while suppressing the nuclear factor-kappa B pathway.Collectively,these data suggest that ketogenic diet may have a therapeutic potential in treating Alzheimer's disease by ameliorating the neurotoxicity associated with Aβ-induced inflammation.This study highlights the urgent need for further research into the use of ketogenic diet as a potential therapy for Alzheimer's disease.