A multichannel thermal bubble-actuated impedance flow cytometer with on-chip TIA based on CMOS-MEMS

Electrochemical impedance spectroscopy(EIS)flow cytometry offers the advantages of speed,affordability,and portability in cell analysis and cytometry applications.However,the integration challenges of microfluidic and EIS read-out circuits hinder the downsizing of cytometry devices.To address this,we developed a thermal-bubble-driven impedance flow cytometric application-specific integrated circuit(ASIC).The thermal-bubble micropump avoids external piping and equipment,enabling high-throughput designs.With a total of 36 cell counting channels,each measuring 884×220μm^(2),the chip significantly enhances the throughput of flow cytometers.Each cell counting channel incorporates a differential trans-impedance amplifier(TIA)to amplify weak biosensing signals.By eliminating the parasitic parameters created at the complementary metal-oxidesemiconductor transistor(CMOS)-micro-electromechanical systems(MEMS)interface,the counting accuracy can be increased.The on-chip TIA can adjust feedback resistance from 5 to 60 kΩto accommodate solutions with different impedances.The chip effectively classifies particles of varying sizes,demonstrated by the average peak voltages of 0.0529 and 0.4510 mV for 7 and 14μm polystyrene beads,respectively.Moreover,the counting accuracies of the chip for polystyrene beads and MSTO-211H cells are both greater than 97.6%.The chip exhibits potential for impedance flow cytometer at low cost,high-throughput,and miniaturization for the application of point-of-care diagnostics.

Mechanism of Thermally Radiative Prandtl Nanofluids and Double-Diffusive Convection in Tapered Channel on Peristaltic Flow with Viscous Dissipation and Induced Magnetic Field

The application of mathematical modeling to biological fluids is of utmost importance, as it has diverse applicationsin medicine. The peristaltic mechanism plays a crucial role in understanding numerous biological flows. In thispaper, we present a theoretical investigation of the double diffusion convection in the peristaltic transport of aPrandtl nanofluid through an asymmetric tapered channel under the combined action of thermal radiation andan induced magnetic field. The equations for the current flow scenario are developed, incorporating relevantassumptions, and considering the effect of viscous dissipation. The impact of thermal radiation and doublediffusion on public health is of particular interest. For instance, infrared radiation techniques have been used totreat various skin-related diseases and can also be employed as a measure of thermotherapy for some bones toenhance blood circulation, with radiation increasing blood flow by approximately 80%. To solve the governingequations, we employ a numerical method with the aid of symbolic software such as Mathematica and MATLAB.The velocity, magnetic force function, pressure rise, temperature, solute (species) concentration, and nanoparticlevolume fraction profiles are analytically derived and graphically displayed. The results outcomes are compared withthe findings of limiting situations for verification.

Analyzing Thermal Stratification and Nanoparticle Shapes Influence on an EMHD Ternary Nanofluid Flow amidst Two Spinning Disks

The present study examines the thermal distribution of ternary nanofluid flow amid two spinning disks influenced by electric and magnetic fields. Keeping in view the shape of the particles, the electrically conducting ternary nanofluid is analyzed with variable thermophysical features. Three types of nanoparticles namely Copper, Aluminum Oxide, and Graphene with spherical, cylindrical, and platelet shapes are taken respectively and are immersed in a (50-50)% ratio of water and ethylene glycol mixture which acts as a base fluid. The anticipated problem is addressed by employing a reliable and user-friendly numerical bvp4c built-in collocation scheme. This solution is then showcased through illustrations and tables. Strengthening the radiation results in an enhanced heat transfer rate. Radial and azimuthal velocities once rotation of disks is enhanced. The key findings provide a strong theoretical background in photovoltaic cells, solar collectors, radiators, solar water heaters, and many other applications.

Effects of fracture evolution and non-Darcy flow on the thermal performance of enhanced geothermal system in 3D complex fractured rock

In fractured geothermal reservoirs,the fracture networks and internal fluid flow behaviors can significantly impact the thermal performance.In this study,we proposed a non-Darcy rough discrete fracture network(NR-DFN)model that can simultaneously consider the fracture evolution and non-Darcy flow dynamics in studying the thermo-hydro-mechanical(THM)coupling processes for heat extraction in geothermal reservoir.We further employed the model on the Habanero enhanced geothermal systems(EGS)project located in Australia.First,our findings illustrate a clear spatial-temporal variation in the thermal stress and pressure perturbations,as well as uneven spatial distribution of shear failure in 3D fracture networks.Activated shear failure is mainly concentrated in the first fracture cluster.Secondly,channeling flow have also been observed in DFNs during heat extraction and are further intensified by the expansion of fractures driven by thermal stresses.Moreover,the combined effect of non-Darcy flow and fracture evolution triggers a rapid decline in the resulting heat rate and temperature.The NR-DFN model framework and the Habanero EGS's results illustrate the importance of both fracture evolution and non-Darcy flow on the efficiency of EGS production and have the potential to promote the development of more sustainable and efficient EGS operations for stakeholders.

Impact of well placement and flow rate on production efficiency and stress field in the fractured geothermal reservoirs

Geothermal energy has gained wide attention as a renewable alternative for mitigating greenhouse gas emissions.The advancements in enhanced geothermal system technology have enabled the exploitation of previously inaccessible geothermal resources.However,the extraction of geothermal energy from deep reservoirs poses many challenges due to high‐temperature and high‐geostress conditions.These factors can significantly impact the surrounding rock and its fracture formation.A comprehensive understanding of the thermal–hydraulic–mechanical(THM)coupling effect is crucial to the safe and efficient exploitation of geothermal resources.This study presented a THM coupling numerical model for the geothermal reservoir of the Yangbajing geothermal system.This proposed model investigated the geothermal exploitation performance and the stress distribution within the reservoir under various combinations of geothermal wells and mass flow rates.The geothermal system performance was evaluated by the criteria of outlet temperature and geothermal productivity.The results indicate that the longer distance between wells can increase the outlet temperature of production wells and improve extraction efficiency in the short term.In contrast,the shorter distance between wells can reduce the heat exchange area and thus mitigate the impact on the reservoir stress.A larger mass flow rate is conducive to the production capacity enhancement of the geothermal system and,in turn causes a wider range of stress disturbance.These findings provide valuable insights into the optimization of geothermal energy extraction while considering reservoir safety and long‐term sustainability.This study deepens the understanding of the THM coupling effects in geothermal systems and provides an efficient and environmentally friendly strategy for a geothermal energy system.

4D-Flow MRI在肥厚型心肌病左室流出道血流评估中的价值探索

目的 探索四维血流(four-dimensional flow,4D-Flow)磁共振成像(magnetic resonance imaging,MRI)技术在左心室腔内应用的可行性。材料与方法 本研究为前瞻性、横断面研究,纳入2022年8月至2023年1月于我院接受心脏MRI检查的21例肥厚型心肌病患者,采用3.0 T MRI扫描仪进行二维血流(tow-dimensional flow,2D-Flow)及4D-Flow成像,收集患者一周内进行的超声心动图检查结果。采用组内相关系数(inter-class correlation coefficient,ICC)、变异系数(coefficients of variation,COV)及Bland-Altman分析比较2D-Flow、4D-Flow评估左室流出道峰值流速的可重复性及一致性,并通过Pearson相关性分析探究二者与超声心动图测量结果的关系。结果 2D-Flow和4D-Flow观察者内/观察者间的ICC分别为0.999/0.999和0.995/0.992,COV分别为0.5%/0.5%和2.4%/2.6%。4D-Flow与超声心动图的测量结果呈中度相关,相关系数r值为0.574(P=0.006),但一致性较差,ICC为0.375(P=0.013)。2D-Flow与4D-Flow和超声心动图间无显著的一致性及相关性。结论 4D-Flow技术能够可视化心腔内血流模式,对左室流出道峰值流速的测量具有高度可重复性,且与超声心动图的测量结果具有显著的一致性。

基于Flow Simulation的某发动机涡轮压气机流场与效率分析

涡轮机内部流场对涡轮增压器的性能和效率有着重要影响,采用SolidWorks Flow Simulation模块对某发动机涡轮压气机侧流场和压气效率分析。在六种不同空气体积流量工况下,体积流量为0.29时,压气机效率最高,达到80%左右。模型的建模和流体分析均在SolidWorks环境下,分析效率高,为涡轮增压器设计和优化提供了支撑。

iFlow彩色血流编码成像技术在下肢动脉硬化闭塞症诊断中的应用价值

目的研究iFlow彩色血流编码成像技术在下肢动脉硬化闭塞症(LEASO)诊断中的应用价值。方法选择2022年3月至2023年10月期间确诊的106例LEASO患者作为本研究的LEASO组,以一般资料与LEASO组匹配且无动脉病变的80例志愿者作为对照组。两组受试者均进行数字减影血管造影(DSA)并采用iFlow彩色血流编码成像技术检测股骨头区域和踝关节区域达峰时间(TTP)、计算踝关节区域与股骨头区域TTP的差值,测量踝肱指数(ABI)。结果两组研究对象年龄、性别、体质量指数、吸烟史、高血压病史、糖尿病史、冠心病史、股骨头区域TTP的比较,差异无统计学意义(P>0.05);LEASO组踝关节区域TTP及TTP差值均高于对照组,差异有统计学意义(P<0.05);LEASO组中不同Rutherford分类患者股骨头区域TTP的比较以及左侧病变患者与右侧病变患者股骨头区域TTP、踝关节区域TTP、TTP差值的比较,差异无统计学意义(P>0.05),Rutherford分类越高,踝关节区域TTP及TTP差值越低(P<0.05);经Pearson检验,LEASO患者的踝关节区域TTP、TTP差值与ABI呈负相关(P<0.05);经受试者工作特征(ROC)曲线分析,踝关节区域TTP、TTP差值对LEASO具有诊断效能;经Delong检验,TTP差值诊断的ROC曲线下面积高于踝关节区域TTP(P<0.05)。结论iFlow彩色血流编码成像技术测定踝关节区TTP及TTP差值是诊断LEASO的量化指标。

The Effects of Thermal Radiation and Viscous Dissipation on the Stagnation Point Flow of a Micropolar Fluid over a Permeable Stretching Sheet in the Presence of Porous Dissipation

In this paper,the effects of thermal radiation and viscous dissipation on the stagnation–point flow of a micropolar fluid over a permeable stretching sheet with suction and injection are analyzed and discussed.A suitable similarity transformation is used to convert the governing nonlinear partial differential equations into a system of nonlinear ordinary differential equations,which are then solved numerically by a fourth–order Runge–Kutta method.It is found that the linear fluid velocity decreases with the enhancement of the porosity,boundary,and suction parameters.Conversely,it increases with the micropolar and injection parameters.The angular velocity grows with the boundary,porosity,and suction parameters,whereas it is reduced if the micropolar and injection parameters become larger.It is concluded that the thermal boundary layer extension increases with the injection parameter and decreases with the suction parameter.

High-precision nonisothermal transient wellbore drift flow model suitable for the full flow pattern domain and full dip range

A reliable multiphase flow simulator is an important tool to improve wellbore integrity and production decision-making.To develop a multiphase flow model with high adaptability and high accuracy,we first build a multiphase flow database with 3561 groups of data and developed a drift closure relationship with stable continuity and high adaptability.Second,a high-order numerical scheme with strong fault capture ability is constructed by effectively combining MUSCL technology,van Albada slope limiter and AUSMV numerical scheme.Finally,the energy equation is coupled into the AUSMV numerical scheme of the drift flow model in the form of finite difference.A transient non-isothermal wellbore multiphase flow model with wide applicability is formed by integrating the three technologies,and the effects of various factors on the calculation accuracy are studied.The accuracy of the simulator is verified by comparing the measurement results with the blowout experiment of a full-scale experimental well.

基于Flow-3D的桩林坝不同布置形式对坝基的冲刷侵蚀

桩林坝是一种以桩为基础的竖向格子坝,既有良好的受力条件,又相对节约材料,同时拥有“拦粗排细”的功效,现有桩林坝的研究,多在冲击荷载、拦截固源和调控泥石流性能等方面构建不同布置形式的桩林坝模型。以杨家沟为例,通过野外现场踏勘和数值仿真计算,基于Flow-3D软件开展数值模拟研究,建立不同布置形式(单排桩、双排桩、桩间距、排间距)的桩林坝模型,探讨不同影响因素下桩林坝坝基冲刷侵蚀规律。结果表明:桩林坝的整体设计中桩林不宜过密,桩间距和排间距以2.5 m为宜;单排桩的稳定性较弱,在泥石流冲击下极易发生剪切破坏,且对上游的“固源”作用远不如多排桩,但单排桩的冲刷深度及侵蚀规模均小于多排桩。研究成果对桩林坝的布置形式及冲刷机制提供数据支撑,并为震后泥石流防治工程设计提供参考。

袋型阻尼密封动力学特性双控制体Bulk Flow模型

为快速准确预测袋型阻尼密封泄漏特性和动力学特性,针对传统单控制体Bulk Flow模型预测精度低、无法预测交叉动力系数的问题,提出了袋型阻尼密封双控制体Bulk Flow模型和动力学特性数值预测方法,并开发了计算程序。首先,依据边界层理论,将袋型密封腔室划分为两个控制体,推导了控制体的连续性、周向动量和能量方程,引入Swamee-Jain和Takahashi方程,计算流体-壁面间和流体-流体间的周向黏性摩擦力;其次,采用牛顿-拉夫森算法和摄动分析法分别求解0阶和1阶控制方程,获得各刚度、阻尼动力特性系数;然后,通过与袋型阻尼密封泄漏量和动力特性系数的实验值、单控制体Bulk Flow模型和非定常计算流体动力学(CFD)数值结果进行比较,验证了模型和方法的准确性和可靠性;最后,研究了转子转速(10 000、15 000、20 000 r/min)和预旋比(0.067、0.724、0.997)对袋型阻尼密封动力学特性的影响。结果表明:所发展的模型和方法具有计算速度快、预测精度高(泄漏量预测误差小于6%,动力特性系数预测误差小于38%)的优点;转子转速和进口预旋的增大均会导致袋型阻尼密封有效阻尼显著减小,穿越频率显著增大,易诱发轴系失稳。

Inherent thermal-responsive strategies for safe lithium batteries

Safe batteries are the basis for next-generation application scenarios such as portable energy storage devices and electric vehicles,which are crucial to achieving carbon neutralization.Electrolytes,separators,and electrodes as main components of lithium batteries strongly affect the occurrence of safety accidents.Responsive materials,which can respond to external stimuli or environmental change,have triggered extensive attentions recently,holding great promise in facilitating safe and smart batteries.This review thoroughly discusses recent advances regarding the construction of high-safety lithium batteries based on internal thermal-responsive strategies,together with the corresponding changes in electrochemical performance under external stimulus.Furthermore,the existing challenges and outlook for the design of safe batteries are presented,creating valuable insights and proposing directions for the practical implementation of safe lithium batteries.

Flow and heat transfer of a nanofluid through a porous medium due to stretching/shrinking sheet with suction,magnetic field and thermal radiation

This study investigates the suction and magnetic field effects on the two-dimensional nanofluid flow through a stretching/shrinking sheet at the stagnation point in the porous medium with thermal radiation.The governing partial differential equations(PDEs)are converted into ordinary differential equations(ODEs)using the similarity transformation.The resulting ODEs are then solved numerically by using the bvp4c solver in MATLAB software.It was found that dual solutions exist for the shrinking parameter values up to a certain range.The numerical results obtained are compared,and the comparison showed a good agreement with the existing results in the literature.The governing parameters’effect on the velocity,temperature and nanoparticle fraction fields as well as the skin friction coefficient,the local Nusselt number and the Sherwood number are represented graphically and analyzed.The variation of the velocity,temperature and concentration increase with the increase in the suction and magnetic field parameters.It seems that the thermal radiation effect has increased the local Sherwood number while the local Nusselt number is reduced with it.

肝硬化患者4D flow MRI血流动力学参数与中医证型的相关性研究

目的探讨肝硬化患者4D flow MRI血流动力学参数与中医证型的相关性。方法将118例肝硬化患者依据中医辨证分为肝气郁结证、湿热蕴结证、肝肾阴虚证、脾肾阳虚证、瘀血阻络证5个证型,所有患者均行门静脉4D flow MRI检查,统计不同证型肝硬化患者分布情况,观察门静脉系统(门静脉主干、脾静脉、肠系膜上静脉)的血流动力学参数,包括血流量、流速、壁剪切力等,比较不同证型患者门静脉血流动力学参数差异。结果肝硬化代偿期以肝气郁结证、湿热蕴结证为主,肝硬化失代偿期以脾肾阳虚、瘀血络阻证为主;A级以肝气郁结证、湿热蕴结证为主,B、C级以瘀血络阻证为主。瘀血络阻证肝硬化患者门静脉主干及脾静脉血流量明显高于肝气郁结证、湿热蕴结证患者(P<0.05);脾肾阳虚证门静脉主干血流量明显高于肝气郁结证肝硬化患者(P<0.05);瘀血络阻证肝硬化患者门静脉主干流速及剪切力较肝气郁结证和湿热蕴结证低。结论肝硬化患者中医辨证分型与门静脉血流动力学参数具有一定相关性,4D flow MRI可为肝硬化的中医辨证提供血流动力学参考。

Quasi-direct numerical simulations of the flow characteristics of a thermal plasma reactor with counterflow jet

Three-dimensional quasi-direct numerical simulations have been performed to investigate a thermal plasma reactor with a counterflow jet. The effects of the momentum flux ratio and distance between the counterflow jet and the thermal plasma jet on the flow characteristics are addressed. The numerical results show that the dimensionless location of the stagnation layer is significantly affected by the momentum flux ratio, but it is not dependent on the distance.Specifically, the stagnation layer is closer to the plasma torch outlet with the increase of the momentum flux ratio. Furthermore, the flow regimes of the stagnation layer and the flow characteristics of the thermal plasma jet are closely related to the momentum flux ratio. The characteristic frequencies associated with the different regimes are identified. The deflecting oscillation flow regimes are found when the momentum flux ratio is low, which provokes axial velocity fluctuations inside the thermal plasma jet. By contrast, for cases with a high momentum flux ratio, flapping flow regimes are distinguished. The thermal plasma jets are very stable and the axial velocity fluctuations mainly exist in the stagnation layer.

An Experimental Observation of the Thermal Effects and NO Emissions during Dissociation and Oxidation of Ammonia in the Presence of a Bundle of Thermocouples in a Vertical Flow Reactor

Ammonia (NH3) dissociation and oxidation in a cylindrical quartz reactor has been experimentally studied for various inlet NH3 concentrations (5%, 10%, and 15%) and reactor temperatures between 700 K and 1000 K. The thermal effects during both NH3 dissociation (endothermic) and oxidation (exothermic) were observed using a bundle of thermocouples positioned along the central axis of the quartz reactor, while the corresponding NH3 conversions and nitrogen oxides emissions were determined by analysing the gas composition of the reactor exit stream. A stronger endothermic effect, as indicated by a greater temperature drop during NH3 dissociation, was observed as the NH3 feed concentration and reactor temperature increased. During NH3 oxidation, a predominantly greater exothermic effect with increasing NH3 feed concentration and reactor temperature was also evident;however, it was apparent that NH3 dissociation occurred near the reactor inlet, preceding the downstream NH3 and H2 oxidation. For both NH3 dissociation and oxidation, NH3 conversion increased with increasing temperature and decreasing initial NH3 concentration. Significant levels of NOX emissions were observed during NH3 oxidation, which increased with increasing temperature. From the experimental results, it is speculated that the stainless-steel in the thermocouple bundle may have catalysed NH3 dissociation and thus changed the reaction chemistry during NH3 oxidation.

Mechanism of internal thermal runaway propagation in blade batteries

Blade batteries are extensively used in electric vehicles,but unavoidable thermal runaway is an inherent threat to their safe use.This study experimentally investigated the mechanism underlying thermal runaway propagation within a blade battery by using a nail to trigger thermal runaway and thermocouples to track its propagation inside a cell.The results showed that the internal thermal runaway could propagate for up to 272 s,which is comparable to that of a traditional battery module.The velocity of the thermal runaway propagation fluctuated between 1 and 8 mm s^(-1),depending on both the electrolyte content and high-temperature gas diffusion.In the early stages of thermal runaway,the electrolyte participated in the reaction,which intensified the thermal runaway and accelerated its propagation.As the battery temperature increased,the electrolyte evaporated,which attenuated the acceleration effect.Gas diffusion affected thermal runaway propagation through both heat transfer and mass transfer.The experimental results indicated that gas diffusion accelerated the velocity of thermal runaway propagation by 36.84%.We used a 1D mathematical model and confirmed that convective heat transfer induced by gas diffusion increased the velocity of thermal runaway propagation by 5.46%-17.06%.Finally,the temperature rate curve was analyzed,and a three-stage mechanism for internal thermal runaway propagation was proposed.In Stage I,convective heat transfer from electrolyte evaporation locally increased the temperature to 100℃.In Stage II,solid heat transfer locally increases the temperature to trigger thermal runaway.In StageⅢ,thermal runaway sharply increases the local temperature.The proposed mechanism sheds light on the internal thermal runaway propagation of blade batteries and offers valuable insights into safety considerations for future design.

基于 Moldflow 的汽车中控台框架翘曲变形分析及优化

以某汽车中控台框架为研究对象,测量试模样品发现其翘曲变形量超过了装配要求。通过Moldflow软件模拟了该塑件实际的注塑过程,翘曲变形量的模拟值与实测平均值的最大误差为5.98%,发现该塑件翘曲变形的主要因素为冷却不均和收缩不均。本文在原物料中添加质量分数为25%的玻璃纤维以及优化工艺参数后,翘曲变形量的模拟值与初始方案相比降低了86.22%。试模验证表明,优化后的翘曲变形量模拟值与实测平均值的最大误差为4.35%,证明了Moldflow软件模拟分析的准确性。试模后各检测点的最大翘曲变形量降到了1.6 mm以下,较优化之前降低了80%以上,为类似大型复杂注塑件的翘曲变形分析及优化提供了思路。

Heat transfer enhanced inorganic phase change material compositing carbon nanotubes for battery thermal management and thermal runaway propagation mitigation

Developing technologies that can be applied simultaneously in battery thermal management(BTM)and thermal runaway(TR)mitigation is significant to improving the safety of lithium-ion battery systems.Inorganic phase change material(PCM)with nonflammability has the potential to achieve this dual function.This study proposed an encapsulated inorganic phase change material(EPCM)with a heat transfer enhancement for battery systems,where Na_(2)HPO_(4)·12H_(2)O was used as the core PCM encapsulated by silica and the additive of carbon nanotube(CNT)was applied to enhance the thermal conductivity.The microstructure and thermal properties of the EPCM/CNT were analyzed by a series of characterization tests.Two different incorporating methods of CNT were compared and the proper CNT adding amount was also studied.After preparation,the battery thermal management performance and TR propagation mitigation effects of EPCM/CNT were further investigated on the battery modules.The experimental results of thermal management tests showed that EPCM/CNT not only slowed down the temperature rising of the module but also improved the temperature uniformity during normal operation.The peak battery temperature decreased from 76℃to 61.2℃at 2 C discharge rate and the temperature difference was controlled below 3℃.Moreover,the results of TR propagation tests demonstrated that nonflammable EPCM/CNT with good heat absorption could work as a TR barrier,which exhibited effective mitigation on TR and TR propagation.The trigger time of three cells was successfully delayed by 129,474 and 551 s,respectively and the propagation intervals were greatly extended as well.