Thermo-respansive chitosan hydrogel system （TRCHS） was prepared and its mierostructure was investigated by scaning electron microscope （SEM） and mercury intrusion poremaster （MIP）. Based on analyzing the data, a...Thermo-respansive chitosan hydrogel system （TRCHS） was prepared and its mierostructure was investigated by scaning electron microscope （SEM） and mercury intrusion poremaster （MIP）. Based on analyzing the data, a special porosity property was reported at the first time. Its gelling mechanism was studied by a group of contrast experiments. Results may provide experimental and theoretical supports for how to apply it on tissue engineering scaffold and how to influeuee or control its essential properties.展开更多
A thermo-responsive chitosan hydrogel system （TRCHS） was prepared by chitosan （ CS ） and β- glycerophosphate （ β- GP ） to deliver Adriamycin （ ADM ） locally for curing osteosarcoma. Release property was inv...A thermo-responsive chitosan hydrogel system （TRCHS） was prepared by chitosan （ CS ） and β- glycerophosphate （ β- GP ） to deliver Adriamycin （ ADM ） locally for curing osteosarcoma. Release property was investigated by release experiments in vitro and results show that it can be applied to local drug release because it is able to release drug at high concentration for 17 days. The treatment effect was studied by injecting intratumorally to osteosarcoma tumors （ CRL- 1427） implanted sabcutaneously on Specific Pathogen-free （SPF） mice. The statistical analytical results show that TRCHS delivering ADM is more efficacioas than saline intratumoral injection, which loads the same quantity of ADM , but is less poisonous. Based on the analysis above, this novel biodegradable polymer implant is an effective and safe vehicle for sustained local delivery of ADM, and is supposed to be applied in neoadjuvant chemotherapy for osteosarcoma.展开更多
文摘Thermo-respansive chitosan hydrogel system （TRCHS） was prepared and its mierostructure was investigated by scaning electron microscope （SEM） and mercury intrusion poremaster （MIP）. Based on analyzing the data, a special porosity property was reported at the first time. Its gelling mechanism was studied by a group of contrast experiments. Results may provide experimental and theoretical supports for how to apply it on tissue engineering scaffold and how to influeuee or control its essential properties.
文摘A thermo-responsive chitosan hydrogel system （TRCHS） was prepared by chitosan （ CS ） and β- glycerophosphate （ β- GP ） to deliver Adriamycin （ ADM ） locally for curing osteosarcoma. Release property was investigated by release experiments in vitro and results show that it can be applied to local drug release because it is able to release drug at high concentration for 17 days. The treatment effect was studied by injecting intratumorally to osteosarcoma tumors （ CRL- 1427） implanted sabcutaneously on Specific Pathogen-free （SPF） mice. The statistical analytical results show that TRCHS delivering ADM is more efficacioas than saline intratumoral injection, which loads the same quantity of ADM , but is less poisonous. Based on the analysis above, this novel biodegradable polymer implant is an effective and safe vehicle for sustained local delivery of ADM, and is supposed to be applied in neoadjuvant chemotherapy for osteosarcoma.
