AIMTo examine the occurrence of commonly known clinical signs of keratoconus (KC), i.e. Fleischer ring, prominent corneal nerves and thinning, among unaffected family members of KC patients and healthy control individ...AIMTo examine the occurrence of commonly known clinical signs of keratoconus (KC), i.e. Fleischer ring, prominent corneal nerves and thinning, among unaffected family members of KC patients and healthy control individuals.METHODSData of both eyes of 117 relatives of KC patients having no manifest disease based on videokeratography indices (KC relatives), and 142 controls were used for Pearson correlation and t-test statistics. Correlation of Fleischer ring, prominent corneal nerves and central pachymetry data were tested with each other and with videokeratography indices (KSI, KISA, 3 and 6 mm Fourier asymmetry, and I-S).RESULTSA moderate correlation was found between Fleischer ring and all examined topographical indices. Most important correlation was present with 6 mm Fourier asymmetry, and corneal pachymetry (r=0.272, P<0.001; r=-0.234, P=0.027, respectively). Similar correlations were found with prominent corneal nerves (r=0.234, P<0.001 for 6 mm Fourier asymmetry and r=-0.235, P=0.0265 for pachymetry). KC family members who exhibited Fleischer ring or prominent nerves had thinner and more asymmetric corneas than those without Fleischer ring or prominent corneal nerves (P<0.05 for pachymetry and topographic indices with t-test and Mann-Whitney rank sum test). Though rarely, Fleischer ring and prominent corneal nerves occurred among normal controls, indicating the existence of forme fruste cases in the normal population. Control subjects, who had corneal Fleischer ring or prominent nerves had corneas more similar to KC than other controls (t-test: increased KSI and KISA, P=0.048 and 0.012, respectively).CONCLUSIONIn KC family members and healthy individuals, Fleischer ring and prominent corneal nerves are associated with features of KC and may suggest a possibility of forme fruste KC. Searching for the possible presence of Fleischer ring or prominent nerves on the cornea may help in the decision whether or not to diagnose subclinical KC in a borderline case.展开更多
为研究单层弹性环式挤压油膜阻尼器(elastic ring squeeze film damper,ERSFD)的油膜压力特性,建立薄环-紊动射流小孔模型。通过平面薄环弯曲理论和普朗特边界层理论分别计算弹性环变形和阻尼孔出口净流速;分析弹性环柔度、阻尼孔直径...为研究单层弹性环式挤压油膜阻尼器(elastic ring squeeze film damper,ERSFD)的油膜压力特性,建立薄环-紊动射流小孔模型。通过平面薄环弯曲理论和普朗特边界层理论分别计算弹性环变形和阻尼孔出口净流速;分析弹性环柔度、阻尼孔直径及进动角变化对油膜压力特性的影响,并开展外腔油膜压力多转速测量试验。结果表明:外腔油膜压力随弹性环柔度的减小而下降,但随阻尼孔直径的减小而增加;对于内腔油膜压力,阻尼孔直径的影响与外腔相似,但减小弹性环柔度导致压力增加。试验表明,外腔油膜压力在不同转速下均同步方位角周期变化,而高转速时,压力幅值略有增加。展开更多
基金Supported by Hungarian National Research Fund Grants OTKA F046321 and TAMOP-4.2.1/B-09/1/KONV-2010-0007
文摘AIMTo examine the occurrence of commonly known clinical signs of keratoconus (KC), i.e. Fleischer ring, prominent corneal nerves and thinning, among unaffected family members of KC patients and healthy control individuals.METHODSData of both eyes of 117 relatives of KC patients having no manifest disease based on videokeratography indices (KC relatives), and 142 controls were used for Pearson correlation and t-test statistics. Correlation of Fleischer ring, prominent corneal nerves and central pachymetry data were tested with each other and with videokeratography indices (KSI, KISA, 3 and 6 mm Fourier asymmetry, and I-S).RESULTSA moderate correlation was found between Fleischer ring and all examined topographical indices. Most important correlation was present with 6 mm Fourier asymmetry, and corneal pachymetry (r=0.272, P<0.001; r=-0.234, P=0.027, respectively). Similar correlations were found with prominent corneal nerves (r=0.234, P<0.001 for 6 mm Fourier asymmetry and r=-0.235, P=0.0265 for pachymetry). KC family members who exhibited Fleischer ring or prominent nerves had thinner and more asymmetric corneas than those without Fleischer ring or prominent corneal nerves (P<0.05 for pachymetry and topographic indices with t-test and Mann-Whitney rank sum test). Though rarely, Fleischer ring and prominent corneal nerves occurred among normal controls, indicating the existence of forme fruste cases in the normal population. Control subjects, who had corneal Fleischer ring or prominent nerves had corneas more similar to KC than other controls (t-test: increased KSI and KISA, P=0.048 and 0.012, respectively).CONCLUSIONIn KC family members and healthy individuals, Fleischer ring and prominent corneal nerves are associated with features of KC and may suggest a possibility of forme fruste KC. Searching for the possible presence of Fleischer ring or prominent nerves on the cornea may help in the decision whether or not to diagnose subclinical KC in a borderline case.
文摘为研究单层弹性环式挤压油膜阻尼器(elastic ring squeeze film damper,ERSFD)的油膜压力特性,建立薄环-紊动射流小孔模型。通过平面薄环弯曲理论和普朗特边界层理论分别计算弹性环变形和阻尼孔出口净流速;分析弹性环柔度、阻尼孔直径及进动角变化对油膜压力特性的影响,并开展外腔油膜压力多转速测量试验。结果表明:外腔油膜压力随弹性环柔度的减小而下降,但随阻尼孔直径的减小而增加;对于内腔油膜压力,阻尼孔直径的影响与外腔相似,但减小弹性环柔度导致压力增加。试验表明,外腔油膜压力在不同转速下均同步方位角周期变化,而高转速时,压力幅值略有增加。
