This paper presents the design and verification of the dual-mode core driven fan stage(CDFS)and high-load compressor with a large flow regulation range.In view of the characteristics of large flow regulation range of ...This paper presents the design and verification of the dual-mode core driven fan stage(CDFS)and high-load compressor with a large flow regulation range.In view of the characteristics of large flow regulation range of the two modes and high average stage load coefficient,this paper investigates the design technology of the dual-mode high-efficiency compressor with a large flow regulation range and high-load compressor with an average stage load coefficient of 0.504.Building upon this research,the design of the dual-mode CDFS and four-stage compressor is completed,and three-dimensional numerical simulation of the two modes is carried out.Finally,performance experiment is conducted to verify the result of three-dimensional numerical simulation.The experiment results show that the compressor performance is improved for the whole working conditions by using the new design method,which realizes the complete fusion design of the CDFS and high-pressure compressor(HPC).The matching mechanism of stage characteristics of single and double bypass modes and the variation rule of different adjustment angles on performance are studied comprehensively.Furthermore,it effectively reduces the length and weight of compressor,and breaks through the key technologies such as high-load compressor with the average load factor of 0.504.These findings provide valuable data and a methodological foundation for the development of the next generation aeroengine.展开更多
The size of pores or the grille spacing of water–sediment separation structures directly affects their regulation effect on the debris flow performance.A suitable pore size or grille spacing can effectively improve t...The size of pores or the grille spacing of water–sediment separation structures directly affects their regulation effect on the debris flow performance.A suitable pore size or grille spacing can effectively improve the water–sediment separation ability of the structure.The new funnel-type grating water–sediment separation structure(FGWSS)combines vertical and horizontal structures and provides a satisfactory water–sediment separation effect.However,the regulation effect of the grille spacing of the structure on the debris flow performance has not been studied.The regulation effect of the structure grille spacing on the debris flow performance is studied through a flume test,and the optimal structure grille spacing is obtained.An empirical equation of the relationship between the relative grille spacing of the structure and the sediment separation rate is established.Finally,the influence of the water–sediment separation structure on the regulation effect of debris flows is examined from two aspects:external factors(properties of debris flows)and internal factors(structural factors).The experimental results show that the gradation characteristics of solid particles in debris flows constitute a key factor affecting the regulation effect of the structure on the debris flow performance.The optimum grille spacing of the FGWSS matches the particle size corresponding to the material distribution curves d85~d90 of the debris flow.The total separation rate of debris flow particles is related to the grille spacing of the structure and the content of coarse and fine particles in the debris flow.展开更多
Multiple loop heat pipes which have two evaporators and two condensers in one loop are a kind of active heat transfer device. Since they have two evaporators and two condensers, the operating mode also becomes multipl...Multiple loop heat pipes which have two evaporators and two condensers in one loop are a kind of active heat transfer device. Since they have two evaporators and two condensers, the operating mode also becomes multiple. This work discusses the cases that multiple loop heat pipes were operated with one condenser at high temperature and the other at low temperature. To avoid the high temperature returning liquid and keep the multiple loop heat pipes work properly, the flow regulator which was made of polyethylene was designed, fabricated and applied in this test. The effect of flow regulator was confirmed and analyzed. In the test that large temperature difference existed between two sinks, it can be found according to the result that the flow regulator worked effectively and prevented the high temperature vapor to enter the inlet of common liquid line, which can keep the evaporators and returning liquid to operate at low temperature. With the increment of heat loads and the temperature difference between two sinks, the pressure difference between two condensers became larger and larger. When the pressure difference was larger than the flow regulator’s capillary force, the flow regulator could not work properly because the high temperature vapor began to flow through the flow regulator. According to the test data, the flow regulator can work properly within the sinks’ temperature 0°C/60°C and the two evaporators’ heat load 30/30 W.展开更多
Objective:The Atrial Flow Regulator(AFR)is a double disc device made of self-expanding Nitinol wire mesh,structured around a central lumen.Once deployed via the transfemoral route,the device stents the atrial septum l...Objective:The Atrial Flow Regulator(AFR)is a double disc device made of self-expanding Nitinol wire mesh,structured around a central lumen.Once deployed via the transfemoral route,the device stents the atrial septum leaving a preselected fixed diameter atrial communication.We sought to evaluate the mid-term performance of the AFR by implanting the device in 5 healthy porcine hearts to assess safety and patency of the device fenestration over a period of 150 days.Method:Five AFR devices were implanted in 5 female Yucatan adult minipigs.The animals were survived to 150 days with periodic assessments at days+3,+30,+60,+90,+120,and+150.These assessments consisted of transesophageal echocardiography and fluoroscopic evaluation.The animals were sacrificed at day+150.Histological and pathological assessments were carried out to characterize neointimal tissue growth,inflammation,thrombus formation,endothelial coverage,endothelial maturity,and the presence of any luminal thrombus.Result:There were no unscheduled deaths.Patency was maintained in all 5 animals across the 150-day study.There was no statistically significant difference in the lumen diameter over the study duration.Neointimal growth was mild to moderate in all specimens and occurred mostly on the surfaces of the device in direct contact with the atrial septum.There was no evidence of any significant inflammatory response on routine blood work or by imaging or histological assessment.Scanning electron microscope(SEM)examination showed nearly complete surface coverage with endothelial tissue.The animals were in a healthy condition for the duration of the study with no attributable pathology and no adverse effects noted on distant organs in any of the 5 animals.Conclusion:As a continuation of our earlier work,this 150-day midterm animal study provides important safety and feasibility information.Our preliminary results show that the AFR is both safe and effective in maintaining a sustainable atrial level communication for the duration of the study.展开更多
Regulators are important components in pneumatic system, and their flow-rate characteristics are the key parameters for designers. According to the correlatively international standard and national standard of China, ...Regulators are important components in pneumatic system, and their flow-rate characteristics are the key parameters for designers. According to the correlatively international standard and national standard of China, which describe the flow-rate characteristics measurement method of pneumatic regulators, the pressure and the flow are measured point by point, and then the flow-rate characteristics curve is plotted point to point. This method has some disadvantages, such as equipment complexity, much air consumption, and low efficiency. To settle the problems presented above, this paper puts forward a new high efficient and energy saving flow-rate characteristics measurement method of regulators, which is based on the pressure response when charging and discharging to an isothermal tank without any flow meters. The measurement principle, the system and the steps are introduced. And the tracking differentiator is used for the data processing of the pressure difference. Two typical kinds of regulators were experimentally investigated, and their flow-rate characteristics curves were obtained with the new and the conventional method, respectively. Comparatively, it's proved that this new method is feasible because it is not only able to meet the demand of the measurement precision, but also to save energy and improve efficiency. Compared to the conventional method, the new method takes only about 1/10 amount of time and consumes about only 1/30 amount of air. Hopefully it will be able to serve as an international standard of flow-rate characteristics measurement method of regulators.展开更多
Beam dams are a highly effective and commonly used open-type check dam in debris-flow hazard mitigation. In this study, dimensional analysis was used to obtain empirical equations for quantitatively determining the se...Beam dams are a highly effective and commonly used open-type check dam in debris-flow hazard mitigation. In this study, dimensional analysis was used to obtain empirical equations for quantitatively determining the sediment-trapping and flow-regulating characteristics of a beam dam. To determine the coefficients of the empirical equations, flume experiments were conducted to simulate the trapping and regulating processes. The flow pattern, trapping, and regulating characteristics were investigated when debris flows passed through a beam dam. Debris-flow bulk density and peak discharge, and sediment-trapping ratios, were measured directly and indirectly. The results showed that three blocking actions occurred, and that blockage-breaking considerably influenced the trapping and regulating performance of the beam dam. The relative opening size and the sediment concentration were the two main factors affecting the performance of the beam dam. The ratio of trapping sediment decreased with relative opening, and increased with sediment concentration as well as reducing ratio of bulk density and reducing ratio of peak discharge. The sediment concentration and relative opening were the leading factors influencing the trapping and regulating sediment of a beam dam, followed by flume gradient. The results showed that the calculated values obtained using empirical equations were in good agreement with the values derived from the experiments, and that the deviation was acceptable. Finally, taking Zechawa Gully as an example, using the empirical equations we designed the opening size of a beam dam aimed to trap sediment and regulate peak discharge of debris flow in the main gully.展开更多
Barrier walls effectively store water,regulate underground flows,improve exploitable reserves and prevent saltwater intrusion.The effectiveness of the underground barrier wall depends not only on the hydrogeological s...Barrier walls effectively store water,regulate underground flows,improve exploitable reserves and prevent saltwater intrusion.The effectiveness of the underground barrier wall depends not only on the hydrogeological structure,the technical parameters of the wall but also on the layout scheme of the exploitation well system.The results showed that in natural conditions,the ground water level upstream of the barrier wall rose in the presence of a barrier wall.In wells located downstream of high barrier walls,the water level decreased.The amount of underground current flowing into the sea decreased,the annual average value of the whole region decreased was 316 m3/day and night.In presence of a wall,both the water level and the amount of evaporation increased.The average increase in evaporation volume during the calculation period of ten thousand days with walls was 4.114 m3/d.So in presence of a wall,the amount of water that can be exploited increases by the total amount of evaporation plus the decrease in discharge to the sea and is equal to 4,424 m3/d.In the exploitation condition,if the water level in the presence of wall is kept as low as in the absence of wall,the exploitation flow will increase to about 4,400 m3/day and night.From the calculated water level values when there is a wall and without a wall,we can see that if the exploitation flow in presence of a wall and in the absence of wall is the same,the water level drop at the calculated observation wells upstream of the wall will decrease from 0.21 m to 3.97 m.The condition of effective exploitation of the wall depends on the mining scheme.The exploitation scheme is reasonable,the exploitation flow of the wells does not exceed the allowable flow so as not to cause the drying of the aquifer at the location of the well.The upstream area of the wall reflects quite clearly as the Total dissolved solids content in observation wells upstream of the wall at the end of the calculation time is significantly reduced compared to that without the wall,ranging from 69 mg/L to 5,629 mg/L.In the presence of a wall,the water level of observation wells upstream of the wall is higher than that of without a wall from 0.10 m to 0.74 m.展开更多
Investigations on thin-film flow play a vital role in the field of optoelectronics and magnetic devices.Thin films are reasonably hard and thermally stable but quite fragile.The thermal stability of a thin film can be...Investigations on thin-film flow play a vital role in the field of optoelectronics and magnetic devices.Thin films are reasonably hard and thermally stable but quite fragile.The thermal stability of a thin film can be further improved by incorporating the effects of nanoparticles.In the current work,a stretchable surface is considered upon which hybrid nanofluid thin-film flow is taken into account.The idea of augmenting heat transmission by making use of a hybrid nanofluid is a focus of the current work.The flow is affected by variations in the viscous forces,along with viscous dissipation effects and Marangoni convection.A time-constrained magnetic field is applied in the normal direction to the flow system.The equations governing the flow system are shifted to a non-dimensional form by applying similarity variables.The homotopy analysis method is employed to find the solution to the resultant equations.It is noticed in this study that the flow characteristics decline with augmentation of magnetic,viscosity and unsteadiness parameters while they increase with enhanced values of thin-film parameters.Thermal characteristics are supported by increasing values of the Eckert number and the unsteadiness parameter and opposed by the viscosity parameter and Prandtl number.The numerical impact of different emerging parameters upon skin friction and the Nusselt number is calculated in tabular form.A comparison of current work with established results is carried out,with good agreement.展开更多
The benefits or detriments of caffeine on the human cardiovascular system have not been thoroughly studied and are still poorly understood. In a world where caffeinated beverages are evidently the adult drug of choice...The benefits or detriments of caffeine on the human cardiovascular system have not been thoroughly studied and are still poorly understood. In a world where caffeinated beverages are evidently the adult drug of choice (e.g. coffee, energy drinks, soda, tea),?investigating its effects on our bodies is of great importance. In this study,?we examined the effects of caffeine, taken as a tablet, on pressure-flow autoregulation. Young adults between 18 and 21 years of age were the experimental subjects. They were instrumented to monitor systemic arterial blood pressure, peripheral blood flow, calculated peripheral vascular resistance, and the electrocardiogram during an autoregulatory maneuver in the absence and presence of caffeine. Caffeine-mediated vasoconstriction was observed as early as 15 minutes after its consumption. Sixty minutes post-caffeine, vasoconstriction was so prominent that autoregulation was abolished. This was reflected, in part, as a significant reduction in blood flow that accompanied a 3-fold increase in calculated peripheral resistance and a significant increase in systemic arterial pressure. Heart rate was unaffected by caffeine under our experimental conditions. We conclude that caffeine has the ability to inhibit significant cardiovascular properties including pressure-flow autoregulation. Even though more work is needed, the significant caffeine-mediated changes in flow, pressure and resistance during autoregulation could have serious consequences for the cardiovascular system specifically, and for one’s overall health in general.展开更多
Regulation of streamflow by a reservoir creates a flow regime much different from the preimpoundment period flow regime. Hydro-Electric Projects(HEPs) commissioned in the Western Ghat regions of the Kerala State, Indi...Regulation of streamflow by a reservoir creates a flow regime much different from the preimpoundment period flow regime. Hydro-Electric Projects(HEPs) commissioned in the Western Ghat regions of the Kerala State, India during the last four decades caused considerable changes in the flow regimes of the rivers of the Kerala State in southwest India. In this paper, the Indicators of Hydrologic Alteration(IHA) approach proposed by Richter et al.(1996) is used to analyze flow regime changes in the Periyar and Muvattupuzha Rivers, due to the construction of the Idukki(1976), Idamalayar(1987) and Lower Periyar(1997) HEPs in the high ranges of the Western Ghats. Normal rainfall years(annual rainfall values within mean ± 0.75 standard deviation limits) are only considered in the analysis to focus on hydrologic alterations due to human activities. The mean hydrologic alteration in the Periyar River(deviation from the pre-development hydrologic indicator values) after commissioning of three HEPs is 35%. Inter-basin water transfer after power generation from the Idukki HEP resulted in a higher discharge in the adjacent Muvattupuzha River, leading to considerable changes in the hydroenvironment(mean hydrologic alterations varying between 57 to 63%). IHA parameters showing hydrologic alterations above the 67 th Percentile werefurther analyzed. For each of the pre-construction hydrologic parameters ± 1 standard deviation from the mean is set as the upper and lower management target limits. The values of each IHA parameter beyond these targets are considered as nonattainment. Considerable hydrologic alterations are observed, especially for low flows in both basins. Inter-basin transfer induced larger changes in flow parameters compared to intra-basin regulations. The study shows that under a proper water release and diversion scheme, the non-attainment of IHA parameters(values fall beyond the target limits) can be reduced. The findings of the study will be greatly beneficial to regional water management and restoration of an eco-environmental system in the humid tropical region.展开更多
Neural elements of the intrinsic cardiac nervous system transduce sensory inputs from the heart, blood vessels and other organs to ensure adequate cardiac function on a beat-to-beat basis. This inter-organ crosstalk i...Neural elements of the intrinsic cardiac nervous system transduce sensory inputs from the heart, blood vessels and other organs to ensure adequate cardiac function on a beat-to-beat basis. This inter-organ crosstalk is critical for normal function of the heart and other organs; derangements within the nervous system hierarchy contribute to pathogenesis of organ dysfunction. The role of intact cardiac nerves in development of, as well as protection against, ischemic injury is of current interest since it may involve recruitment of intrinsic cardiac ganglia. For instance, ischemic conditioning, a novel protection strategy against organ injury, and in particular remote conditioning, is likely mediated by activation of neural pathways or by endogenous cytoprotective bloodborne substances that stimulate different signalling pathways. This discovery reinforces the concept that inter-organ communication, and maintenance thereof, is key. As such, greater understanding of mechanisms and elucidation of treatment strategies is imperative to improve clinical outcomes particularly in patients with comorbidities. For instance, autonomic imbalance between sympathetic and parasympathetic nervous system regulation can initiate cardiovascular autonomic neuropathy that compromises cardiac stability and function. Neuromodulation therapies that directly target the intrinsic cardiac nervous system or other elements of the nervous system hierarchy are currently being investigated for treatment of different maladies in animal and human studies.展开更多
This paper uses the gravity model to examine the effect of environmental regulations on pork trade flows between different regions within China.We apply a linear programming tool to estimate pork trade flows from 2000...This paper uses the gravity model to examine the effect of environmental regulations on pork trade flows between different regions within China.We apply a linear programming tool to estimate pork trade flows from 2000 to 2008,and discuss the environmental acts on livestock pollution and income level to proxy environmental regulations.We use OLS regression and panel data with dummy variable in the cross-sectional GLS estimation.Our results indicate that the gap of environmental regulations between trade partners has a positive relationship with pork trade flows,and the difference in environmental regulations changes the traditional comparative advantage pattern to some extent.This paper provides convincing evidence for the pollution haven effect on livestock in China.展开更多
The flow field and flow state of thin-film evaporators are complex,and it is significant to effectively divide and quantify the flow field and flow state,as well as to study the internal flow field distribution and ma...The flow field and flow state of thin-film evaporators are complex,and it is significant to effectively divide and quantify the flow field and flow state,as well as to study the internal flow field distribution and material mixing characteristics to improve the efficiency of thin-film evaporators.By using computational fluid dynamics(CFD)numerical simulation,the distribution pattern of the high-viscosity fluid flow field in the thin-film evaporators was obtained.It was found that the staggered interrupted blades could greatly promote material mixing and transportation,and impact the film formation of high-viscosity materials on the evaporator wall.Furthermore,a flow field state recognition method based on radial volume fraction statistics was proposed,and could quantitatively describe the internal flow field of thin-film evaporators.The method divides the high-viscosity materials in the thin-film evaporators into three flow states,the liquid film state,the exchange state and the liquid mass state.The three states of materials could be quantitatively described.The results show that the materials in the exchange state can connect the liquid film and the liquid mass,complete the material mixing and exchange,renew the liquid film,and maintain continuous and efficient liquid film evaporation.展开更多
The BZ19-6 gas field is characterized by high temperature and high pressure (HTHP), high condensate content, little difference between the formation pressure and dew point pressure, and large amount of reverse condens...The BZ19-6 gas field is characterized by high temperature and high pressure (HTHP), high condensate content, little difference between the formation pressure and dew point pressure, and large amount of reverse condensate liquid. During the early stage of depletion development, the production gas-oil ratio (GOR) and production capacity remain relatively stable, which is inconsistent with the conventional reverse condensate seepage law. In view of the static and dynamic conflict in development and production, indoor high-temperature and high-pressure PVT experiment was carried out to reveal the mist-like condensation phenomenon of fluids in the BZ19-6 formation. And the seepage characteristics of condensate gas reservoirs with various degrees of depletion under the condition of HTHP were analyzed based on production performance. The change rule of fluid phase state was analyzed in response to the characterization difficulties of the seepage mechanism. The fluid state was described using the miscible mechanism. And the interphase permeability interpolation coefficient was introduced based on interfacial tension. By doing so, the accurate characterization of the “single-phase flow of condensate gas-near-miscible mist-like quasi single-phase flow-oil-gas two-phase flow” during the development process was achieved. Then the accurate fitting of key indicators for oilfield development was completed, and the distribution law of formation pressure and the law of condensate oil precipitation under different reservoir conditions are obtained. Based on research results, the regulation strategy of variable flow rate production was developed. Currently, the work system has been optimized for 11 wells, achieving a “zero increase” in the GOS of the gas field and an annual oil increase of 22,000 cubic meters.展开更多
能流系统和物流系统深度耦合是未来港口综合能源系统(port integrated energy system,PIES)的关键特征之一,开展考虑能流-物流耦合的PIES规划对港口绿色低碳转型具有重要意义。该文首先从传统港口、绿色港口、近零碳港口3个典型阶段展现...能流系统和物流系统深度耦合是未来港口综合能源系统(port integrated energy system,PIES)的关键特征之一,开展考虑能流-物流耦合的PIES规划对港口绿色低碳转型具有重要意义。该文首先从传统港口、绿色港口、近零碳港口3个典型阶段展现PIES的形态结构演变,阐述其发展现状和趋势;其次,分析港口物流系统的用能时空可调性,探究PIES能流-物流耦合机理;在此基础上,分析并构建考虑能流-物流耦合的PIES规划一般性模型,提炼并对比跨(港)区级、港区级和码头级3个层级的PIES规划模型特点和建模要素,梳理并评述不同层级PIES规划关键技术的研究现状;最后,着眼于当前考虑能流-物流耦合后PIES规划中的突出问题,对其未来可能发展方向及挑战进行展望。展开更多
文摘This paper presents the design and verification of the dual-mode core driven fan stage(CDFS)and high-load compressor with a large flow regulation range.In view of the characteristics of large flow regulation range of the two modes and high average stage load coefficient,this paper investigates the design technology of the dual-mode high-efficiency compressor with a large flow regulation range and high-load compressor with an average stage load coefficient of 0.504.Building upon this research,the design of the dual-mode CDFS and four-stage compressor is completed,and three-dimensional numerical simulation of the two modes is carried out.Finally,performance experiment is conducted to verify the result of three-dimensional numerical simulation.The experiment results show that the compressor performance is improved for the whole working conditions by using the new design method,which realizes the complete fusion design of the CDFS and high-pressure compressor(HPC).The matching mechanism of stage characteristics of single and double bypass modes and the variation rule of different adjustment angles on performance are studied comprehensively.Furthermore,it effectively reduces the length and weight of compressor,and breaks through the key technologies such as high-load compressor with the average load factor of 0.504.These findings provide valuable data and a methodological foundation for the development of the next generation aeroengine.
基金supported by the National Natural Science Foundation of China(Grant Nos.42027806 and 42041006)。
文摘The size of pores or the grille spacing of water–sediment separation structures directly affects their regulation effect on the debris flow performance.A suitable pore size or grille spacing can effectively improve the water–sediment separation ability of the structure.The new funnel-type grating water–sediment separation structure(FGWSS)combines vertical and horizontal structures and provides a satisfactory water–sediment separation effect.However,the regulation effect of the grille spacing of the structure on the debris flow performance has not been studied.The regulation effect of the structure grille spacing on the debris flow performance is studied through a flume test,and the optimal structure grille spacing is obtained.An empirical equation of the relationship between the relative grille spacing of the structure and the sediment separation rate is established.Finally,the influence of the water–sediment separation structure on the regulation effect of debris flows is examined from two aspects:external factors(properties of debris flows)and internal factors(structural factors).The experimental results show that the gradation characteristics of solid particles in debris flows constitute a key factor affecting the regulation effect of the structure on the debris flow performance.The optimum grille spacing of the FGWSS matches the particle size corresponding to the material distribution curves d85~d90 of the debris flow.The total separation rate of debris flow particles is related to the grille spacing of the structure and the content of coarse and fine particles in the debris flow.
文摘Multiple loop heat pipes which have two evaporators and two condensers in one loop are a kind of active heat transfer device. Since they have two evaporators and two condensers, the operating mode also becomes multiple. This work discusses the cases that multiple loop heat pipes were operated with one condenser at high temperature and the other at low temperature. To avoid the high temperature returning liquid and keep the multiple loop heat pipes work properly, the flow regulator which was made of polyethylene was designed, fabricated and applied in this test. The effect of flow regulator was confirmed and analyzed. In the test that large temperature difference existed between two sinks, it can be found according to the result that the flow regulator worked effectively and prevented the high temperature vapor to enter the inlet of common liquid line, which can keep the evaporators and returning liquid to operate at low temperature. With the increment of heat loads and the temperature difference between two sinks, the pressure difference between two condensers became larger and larger. When the pressure difference was larger than the flow regulator’s capillary force, the flow regulator could not work properly because the high temperature vapor began to flow through the flow regulator. According to the test data, the flow regulator can work properly within the sinks’ temperature 0°C/60°C and the two evaporators’ heat load 30/30 W.
文摘Objective:The Atrial Flow Regulator(AFR)is a double disc device made of self-expanding Nitinol wire mesh,structured around a central lumen.Once deployed via the transfemoral route,the device stents the atrial septum leaving a preselected fixed diameter atrial communication.We sought to evaluate the mid-term performance of the AFR by implanting the device in 5 healthy porcine hearts to assess safety and patency of the device fenestration over a period of 150 days.Method:Five AFR devices were implanted in 5 female Yucatan adult minipigs.The animals were survived to 150 days with periodic assessments at days+3,+30,+60,+90,+120,and+150.These assessments consisted of transesophageal echocardiography and fluoroscopic evaluation.The animals were sacrificed at day+150.Histological and pathological assessments were carried out to characterize neointimal tissue growth,inflammation,thrombus formation,endothelial coverage,endothelial maturity,and the presence of any luminal thrombus.Result:There were no unscheduled deaths.Patency was maintained in all 5 animals across the 150-day study.There was no statistically significant difference in the lumen diameter over the study duration.Neointimal growth was mild to moderate in all specimens and occurred mostly on the surfaces of the device in direct contact with the atrial septum.There was no evidence of any significant inflammatory response on routine blood work or by imaging or histological assessment.Scanning electron microscope(SEM)examination showed nearly complete surface coverage with endothelial tissue.The animals were in a healthy condition for the duration of the study with no attributable pathology and no adverse effects noted on distant organs in any of the 5 animals.Conclusion:As a continuation of our earlier work,this 150-day midterm animal study provides important safety and feasibility information.Our preliminary results show that the AFR is both safe and effective in maintaining a sustainable atrial level communication for the duration of the study.
文摘Regulators are important components in pneumatic system, and their flow-rate characteristics are the key parameters for designers. According to the correlatively international standard and national standard of China, which describe the flow-rate characteristics measurement method of pneumatic regulators, the pressure and the flow are measured point by point, and then the flow-rate characteristics curve is plotted point to point. This method has some disadvantages, such as equipment complexity, much air consumption, and low efficiency. To settle the problems presented above, this paper puts forward a new high efficient and energy saving flow-rate characteristics measurement method of regulators, which is based on the pressure response when charging and discharging to an isothermal tank without any flow meters. The measurement principle, the system and the steps are introduced. And the tracking differentiator is used for the data processing of the pressure difference. Two typical kinds of regulators were experimentally investigated, and their flow-rate characteristics curves were obtained with the new and the conventional method, respectively. Comparatively, it's proved that this new method is feasible because it is not only able to meet the demand of the measurement precision, but also to save energy and improve efficiency. Compared to the conventional method, the new method takes only about 1/10 amount of time and consumes about only 1/30 amount of air. Hopefully it will be able to serve as an international standard of flow-rate characteristics measurement method of regulators.
基金supported by the Chinese Academy of Sciences and Organization Department of Sichuan Provincial Party Committee“Light of West China”Program(the key control techniques of glacial debris flow along the Sichuan-Tibet Railway)the National Natural Science Foundation of China(Grant No.41772343)STS Project of the Chinese Academy of Sciences(KFJ-STS-ZDTP015)
文摘Beam dams are a highly effective and commonly used open-type check dam in debris-flow hazard mitigation. In this study, dimensional analysis was used to obtain empirical equations for quantitatively determining the sediment-trapping and flow-regulating characteristics of a beam dam. To determine the coefficients of the empirical equations, flume experiments were conducted to simulate the trapping and regulating processes. The flow pattern, trapping, and regulating characteristics were investigated when debris flows passed through a beam dam. Debris-flow bulk density and peak discharge, and sediment-trapping ratios, were measured directly and indirectly. The results showed that three blocking actions occurred, and that blockage-breaking considerably influenced the trapping and regulating performance of the beam dam. The relative opening size and the sediment concentration were the two main factors affecting the performance of the beam dam. The ratio of trapping sediment decreased with relative opening, and increased with sediment concentration as well as reducing ratio of bulk density and reducing ratio of peak discharge. The sediment concentration and relative opening were the leading factors influencing the trapping and regulating sediment of a beam dam, followed by flume gradient. The results showed that the calculated values obtained using empirical equations were in good agreement with the values derived from the experiments, and that the deviation was acceptable. Finally, taking Zechawa Gully as an example, using the empirical equations we designed the opening size of a beam dam aimed to trap sediment and regulate peak discharge of debris flow in the main gully.
文摘Barrier walls effectively store water,regulate underground flows,improve exploitable reserves and prevent saltwater intrusion.The effectiveness of the underground barrier wall depends not only on the hydrogeological structure,the technical parameters of the wall but also on the layout scheme of the exploitation well system.The results showed that in natural conditions,the ground water level upstream of the barrier wall rose in the presence of a barrier wall.In wells located downstream of high barrier walls,the water level decreased.The amount of underground current flowing into the sea decreased,the annual average value of the whole region decreased was 316 m3/day and night.In presence of a wall,both the water level and the amount of evaporation increased.The average increase in evaporation volume during the calculation period of ten thousand days with walls was 4.114 m3/d.So in presence of a wall,the amount of water that can be exploited increases by the total amount of evaporation plus the decrease in discharge to the sea and is equal to 4,424 m3/d.In the exploitation condition,if the water level in the presence of wall is kept as low as in the absence of wall,the exploitation flow will increase to about 4,400 m3/day and night.From the calculated water level values when there is a wall and without a wall,we can see that if the exploitation flow in presence of a wall and in the absence of wall is the same,the water level drop at the calculated observation wells upstream of the wall will decrease from 0.21 m to 3.97 m.The condition of effective exploitation of the wall depends on the mining scheme.The exploitation scheme is reasonable,the exploitation flow of the wells does not exceed the allowable flow so as not to cause the drying of the aquifer at the location of the well.The upstream area of the wall reflects quite clearly as the Total dissolved solids content in observation wells upstream of the wall at the end of the calculation time is significantly reduced compared to that without the wall,ranging from 69 mg/L to 5,629 mg/L.In the presence of a wall,the water level of observation wells upstream of the wall is higher than that of without a wall from 0.10 m to 0.74 m.
基金funding this work through research groups(Grant No.RGP.1/260/42)。
文摘Investigations on thin-film flow play a vital role in the field of optoelectronics and magnetic devices.Thin films are reasonably hard and thermally stable but quite fragile.The thermal stability of a thin film can be further improved by incorporating the effects of nanoparticles.In the current work,a stretchable surface is considered upon which hybrid nanofluid thin-film flow is taken into account.The idea of augmenting heat transmission by making use of a hybrid nanofluid is a focus of the current work.The flow is affected by variations in the viscous forces,along with viscous dissipation effects and Marangoni convection.A time-constrained magnetic field is applied in the normal direction to the flow system.The equations governing the flow system are shifted to a non-dimensional form by applying similarity variables.The homotopy analysis method is employed to find the solution to the resultant equations.It is noticed in this study that the flow characteristics decline with augmentation of magnetic,viscosity and unsteadiness parameters while they increase with enhanced values of thin-film parameters.Thermal characteristics are supported by increasing values of the Eckert number and the unsteadiness parameter and opposed by the viscosity parameter and Prandtl number.The numerical impact of different emerging parameters upon skin friction and the Nusselt number is calculated in tabular form.A comparison of current work with established results is carried out,with good agreement.
文摘The benefits or detriments of caffeine on the human cardiovascular system have not been thoroughly studied and are still poorly understood. In a world where caffeinated beverages are evidently the adult drug of choice (e.g. coffee, energy drinks, soda, tea),?investigating its effects on our bodies is of great importance. In this study,?we examined the effects of caffeine, taken as a tablet, on pressure-flow autoregulation. Young adults between 18 and 21 years of age were the experimental subjects. They were instrumented to monitor systemic arterial blood pressure, peripheral blood flow, calculated peripheral vascular resistance, and the electrocardiogram during an autoregulatory maneuver in the absence and presence of caffeine. Caffeine-mediated vasoconstriction was observed as early as 15 minutes after its consumption. Sixty minutes post-caffeine, vasoconstriction was so prominent that autoregulation was abolished. This was reflected, in part, as a significant reduction in blood flow that accompanied a 3-fold increase in calculated peripheral resistance and a significant increase in systemic arterial pressure. Heart rate was unaffected by caffeine under our experimental conditions. We conclude that caffeine has the ability to inhibit significant cardiovascular properties including pressure-flow autoregulation. Even though more work is needed, the significant caffeine-mediated changes in flow, pressure and resistance during autoregulation could have serious consequences for the cardiovascular system specifically, and for one’s overall health in general.
基金financial support by Kerala State Council for Science Technology and Environment, Government of Kerala
文摘Regulation of streamflow by a reservoir creates a flow regime much different from the preimpoundment period flow regime. Hydro-Electric Projects(HEPs) commissioned in the Western Ghat regions of the Kerala State, India during the last four decades caused considerable changes in the flow regimes of the rivers of the Kerala State in southwest India. In this paper, the Indicators of Hydrologic Alteration(IHA) approach proposed by Richter et al.(1996) is used to analyze flow regime changes in the Periyar and Muvattupuzha Rivers, due to the construction of the Idukki(1976), Idamalayar(1987) and Lower Periyar(1997) HEPs in the high ranges of the Western Ghats. Normal rainfall years(annual rainfall values within mean ± 0.75 standard deviation limits) are only considered in the analysis to focus on hydrologic alterations due to human activities. The mean hydrologic alteration in the Periyar River(deviation from the pre-development hydrologic indicator values) after commissioning of three HEPs is 35%. Inter-basin water transfer after power generation from the Idukki HEP resulted in a higher discharge in the adjacent Muvattupuzha River, leading to considerable changes in the hydroenvironment(mean hydrologic alterations varying between 57 to 63%). IHA parameters showing hydrologic alterations above the 67 th Percentile werefurther analyzed. For each of the pre-construction hydrologic parameters ± 1 standard deviation from the mean is set as the upper and lower management target limits. The values of each IHA parameter beyond these targets are considered as nonattainment. Considerable hydrologic alterations are observed, especially for low flows in both basins. Inter-basin transfer induced larger changes in flow parameters compared to intra-basin regulations. The study shows that under a proper water release and diversion scheme, the non-attainment of IHA parameters(values fall beyond the target limits) can be reduced. The findings of the study will be greatly beneficial to regional water management and restoration of an eco-environmental system in the humid tropical region.
文摘Neural elements of the intrinsic cardiac nervous system transduce sensory inputs from the heart, blood vessels and other organs to ensure adequate cardiac function on a beat-to-beat basis. This inter-organ crosstalk is critical for normal function of the heart and other organs; derangements within the nervous system hierarchy contribute to pathogenesis of organ dysfunction. The role of intact cardiac nerves in development of, as well as protection against, ischemic injury is of current interest since it may involve recruitment of intrinsic cardiac ganglia. For instance, ischemic conditioning, a novel protection strategy against organ injury, and in particular remote conditioning, is likely mediated by activation of neural pathways or by endogenous cytoprotective bloodborne substances that stimulate different signalling pathways. This discovery reinforces the concept that inter-organ communication, and maintenance thereof, is key. As such, greater understanding of mechanisms and elucidation of treatment strategies is imperative to improve clinical outcomes particularly in patients with comorbidities. For instance, autonomic imbalance between sympathetic and parasympathetic nervous system regulation can initiate cardiovascular autonomic neuropathy that compromises cardiac stability and function. Neuromodulation therapies that directly target the intrinsic cardiac nervous system or other elements of the nervous system hierarchy are currently being investigated for treatment of different maladies in animal and human studies.
基金supported by Humanity and Social Science Youth Foundation of Ministry of Education[12YJCZH275]
文摘This paper uses the gravity model to examine the effect of environmental regulations on pork trade flows between different regions within China.We apply a linear programming tool to estimate pork trade flows from 2000 to 2008,and discuss the environmental acts on livestock pollution and income level to proxy environmental regulations.We use OLS regression and panel data with dummy variable in the cross-sectional GLS estimation.Our results indicate that the gap of environmental regulations between trade partners has a positive relationship with pork trade flows,and the difference in environmental regulations changes the traditional comparative advantage pattern to some extent.This paper provides convincing evidence for the pollution haven effect on livestock in China.
基金National Natural Science Foundation of China(Nos.51905089 and 52075093)Special Fund for Basic Research and Operating Costs of Central Colleges and Universities,China(No.22320D-31)Open Fund for National Key Laboratory of Tribology of Tsinghua University,China(No.SKLTKF20B05)。
文摘The flow field and flow state of thin-film evaporators are complex,and it is significant to effectively divide and quantify the flow field and flow state,as well as to study the internal flow field distribution and material mixing characteristics to improve the efficiency of thin-film evaporators.By using computational fluid dynamics(CFD)numerical simulation,the distribution pattern of the high-viscosity fluid flow field in the thin-film evaporators was obtained.It was found that the staggered interrupted blades could greatly promote material mixing and transportation,and impact the film formation of high-viscosity materials on the evaporator wall.Furthermore,a flow field state recognition method based on radial volume fraction statistics was proposed,and could quantitatively describe the internal flow field of thin-film evaporators.The method divides the high-viscosity materials in the thin-film evaporators into three flow states,the liquid film state,the exchange state and the liquid mass state.The three states of materials could be quantitatively described.The results show that the materials in the exchange state can connect the liquid film and the liquid mass,complete the material mixing and exchange,renew the liquid film,and maintain continuous and efficient liquid film evaporation.
文摘The BZ19-6 gas field is characterized by high temperature and high pressure (HTHP), high condensate content, little difference between the formation pressure and dew point pressure, and large amount of reverse condensate liquid. During the early stage of depletion development, the production gas-oil ratio (GOR) and production capacity remain relatively stable, which is inconsistent with the conventional reverse condensate seepage law. In view of the static and dynamic conflict in development and production, indoor high-temperature and high-pressure PVT experiment was carried out to reveal the mist-like condensation phenomenon of fluids in the BZ19-6 formation. And the seepage characteristics of condensate gas reservoirs with various degrees of depletion under the condition of HTHP were analyzed based on production performance. The change rule of fluid phase state was analyzed in response to the characterization difficulties of the seepage mechanism. The fluid state was described using the miscible mechanism. And the interphase permeability interpolation coefficient was introduced based on interfacial tension. By doing so, the accurate characterization of the “single-phase flow of condensate gas-near-miscible mist-like quasi single-phase flow-oil-gas two-phase flow” during the development process was achieved. Then the accurate fitting of key indicators for oilfield development was completed, and the distribution law of formation pressure and the law of condensate oil precipitation under different reservoir conditions are obtained. Based on research results, the regulation strategy of variable flow rate production was developed. Currently, the work system has been optimized for 11 wells, achieving a “zero increase” in the GOS of the gas field and an annual oil increase of 22,000 cubic meters.
文摘能流系统和物流系统深度耦合是未来港口综合能源系统(port integrated energy system,PIES)的关键特征之一,开展考虑能流-物流耦合的PIES规划对港口绿色低碳转型具有重要意义。该文首先从传统港口、绿色港口、近零碳港口3个典型阶段展现PIES的形态结构演变,阐述其发展现状和趋势;其次,分析港口物流系统的用能时空可调性,探究PIES能流-物流耦合机理;在此基础上,分析并构建考虑能流-物流耦合的PIES规划一般性模型,提炼并对比跨(港)区级、港区级和码头级3个层级的PIES规划模型特点和建模要素,梳理并评述不同层级PIES规划关键技术的研究现状;最后,着眼于当前考虑能流-物流耦合后PIES规划中的突出问题,对其未来可能发展方向及挑战进行展望。