Thin-film hydration preparation method and stability test of DOX-loaded disulfide-linked polyethylene glycol 5000-lysine-di-tocopherol succinate nanomicelles

A novel redox-responsive PEG-sheddable copolymer of disulfide-linked polyethylene glycol 5000-lysine-di-tocopherol succinate(P_(5k)SSLV)was designed and synthesized.Thin-film hydration method was used to prepare DOX-loaded P_(5k)SSLV nanomicelle.To optimize the preparation technology,we investigate the effects of dosage,type of organic solvent,hydration temperature and time,and cryoprotectant on drug-loading content,encapsulation efficiency,particle size,and zeta potential.The mean particle size and zeta potential were determined by Zetasizer.The morphology of the P_(5k)SSLV-DOX nanomicelles was visualized by transmission electron microscopy.The drug-loading content and encapsulation efficiency of P_(5k)SSLV-DOX nanomicelle were investigated by UV.The drug-loading content,encapsulation efficiency,particle size,and zeta potential of the final optimized nanomicelles were 4.58%,97.20%,30.21 nm and -0.84 mV,respectively.In addition,the stability of nanomicelles was investigated,which included dilution stability and storage stability.The results showed that P_(5k)SSLV-DOX nanomicelle had good dilution stability and storage stability at 4℃.The preparation method of P_(5k)SSLV-DOX nanomicelle with thinfilm hydration method was practical and simple,which was valuable to be further studied.

Influences of Marangoni convection and variable magnetic field on hybrid nanofluid thin-film flow past a stretching surface

Investigations on thin-film flow play a vital role in the field of optoelectronics and magnetic devices.Thin films are reasonably hard and thermally stable but quite fragile.The thermal stability of a thin film can be further improved by incorporating the effects of nanoparticles.In the current work,a stretchable surface is considered upon which hybrid nanofluid thin-film flow is taken into account.The idea of augmenting heat transmission by making use of a hybrid nanofluid is a focus of the current work.The flow is affected by variations in the viscous forces,along with viscous dissipation effects and Marangoni convection.A time-constrained magnetic field is applied in the normal direction to the flow system.The equations governing the flow system are shifted to a non-dimensional form by applying similarity variables.The homotopy analysis method is employed to find the solution to the resultant equations.It is noticed in this study that the flow characteristics decline with augmentation of magnetic,viscosity and unsteadiness parameters while they increase with enhanced values of thin-film parameters.Thermal characteristics are supported by increasing values of the Eckert number and the unsteadiness parameter and opposed by the viscosity parameter and Prandtl number.The numerical impact of different emerging parameters upon skin friction and the Nusselt number is calculated in tabular form.A comparison of current work with established results is carried out,with good agreement.

Multi-scale simulation of three-dimensional thin-film lubrication

For three-dimensional(3D)mono-layer molecular thin-film lubrication,the elasticity of the substrate affects the tribological behaviors of a thin fluid film confined by two solid substrates.To account for the elastic effects,this study establishes a multi-scale method that combines an atomistic description of the near region with a coarse-grained description of the far region of the solid substrate to simulate the thin-film lubrication.It is demonstrated that for a given temperature range and film-substrate coupling strength,the multi-scale method is in excellent agreement with the fully atomistic simulation.This study reveals that the elastic response of the substrate can be effectively rendered in the hybrid scheme.In the application of the multi-scale method to investigate the tribological properties of the multi-layer molecular thin-film lubrication,it is determined that the systematic static friction coefficient monotonously decreases as the molecular layer thickness in the fluid film increases.In comparison to the mono-layer molecular thin-film lubrication,the multi-layer molecular thin-film lubrication plays a role in reducing the friction and wear of the system.

All-solid-state thin-film batteries based on lithium phosphorus oxynitrides

Lithium phosphorus oxygen nitrogen(LiPON)as solid electrolyte discovered by Bates et al in the 1990s is an important part of all-solid-state thin-film battery(ASSTFB)due to its wide electrochemical stability window and negligible low electronic conductivity.However,the ionic conductivity of LiPON about 2×10^(−6) S cm^(−1) at room temperature is much lower than that of other types of solid electrolytes,which seriously limits the application of ASSTFBs.This review summarizes the research and progress in ASSTFBs based on LiPON,in the solid-state electrolyte of LiPON-derivatives with adjustable chemical compositions of the amorphous structure for the improvement of the ionic conductivity and electrochemical stability,in the critical interface issues between LiPON and electrodes,and in preparation methods for LiPON.This review is helpful for people to understand the interface characteristics and various preparation methods of LiPON in ASSTFBs.The key issues to be addressed concern how to develop solid-state electrolyte films with high conductivity and high-quality interface engineering as well as large-scale preparation technology,so as to realize the practical application of highly integrated ASSTFBs.

Preparation and stability studies of dimethyl curcumin niosomes

In the present work, we aimed to optimize the preparation technology of dimethyl curcumin niosomes, improve its solubility and assess its stability. The novel anti-androgen dimethyl curcumin niosomes were prepared by thin-film dispersion-ultrasonic method, and the prescription composition and preparation process were optimized by single-factor investigation method. Certainly, the solubility and quality evaluation of dimethyl curcumin niosomes were also investigated. The average particle size of prepared dimethyl curcumin niosomes was （310.3＋0.9） nm. The highest encapsulation rate was 88.1%± 1.7%, and the drug-loading amount was 4.03%±1.05%. Moreover, the leakage rate was below 2% within 45 d. Collectively, all these findings indicated that the niosomes, as a vector, could significantly improve the solubility and stability of dimethyl curcumin, offering a theoretical basis for dimethyl curcumin as an anticancer drug in medicine application.