The title compounds are prepared in good yields by iodination of the corresponding flavones, thioflavones and thiochromones respectively using I_2-CAN(ceric ammonium nitrate) system. The compounds thus prepared are po...The title compounds are prepared in good yields by iodination of the corresponding flavones, thioflavones and thiochromones respectively using I_2-CAN(ceric ammonium nitrate) system. The compounds thus prepared are potentially useful precursors for the synthesis of C-3 linked binuclear compounds.展开更多
Difunctionalizing carboxylation of alkynes with CO_(2)is a sustainable and important strategy to generate valuable acrylate derivatives from both readily available starting materials.Such protocols,however,always suff...Difunctionalizing carboxylation of alkynes with CO_(2)is a sustainable and important strategy to generate valuable acrylate derivatives from both readily available starting materials.Such protocols,however,always suffer from the use of excess metallic reagents and transition metal residue.Herein,we report the first thio-carboxylation of alkynes with thiophenols and CO_(2),which is a visible-light-driven and transition metal-free process.In contrast to previous carboxylations of alkynes via two-electron activation of CO_(2),mechanistic and computational investigations suggest that the single-electron activation of CO_(2)is involved in the thio-carboxylation,rendering uniqueβ-carboxylation.The following cyclizing acylation affords important thiochromones efficiently.Moreover,the one-pot method features mild reaction conditions(room temperature,1 atmosphere of CO_(2)),high chemo-and regio-selectivity,easy scalability and facile derivatization of products to bioactive compounds.展开更多
文摘The title compounds are prepared in good yields by iodination of the corresponding flavones, thioflavones and thiochromones respectively using I_2-CAN(ceric ammonium nitrate) system. The compounds thus prepared are potentially useful precursors for the synthesis of C-3 linked binuclear compounds.
基金supported by the National Natural Science Foundation of China(22225106,21822108,21822303)the Sichuan Science and Technology Program(20CXTD0112)+2 种基金the Central Government Funds of Guiding Local Scientific and Technological Development for Sichuan Province(2021ZYD0063)the Fundamental Research Funds from Sichuan University(2020SCUNL102)the Fundamental Research Funds for the Central Universities。
文摘Difunctionalizing carboxylation of alkynes with CO_(2)is a sustainable and important strategy to generate valuable acrylate derivatives from both readily available starting materials.Such protocols,however,always suffer from the use of excess metallic reagents and transition metal residue.Herein,we report the first thio-carboxylation of alkynes with thiophenols and CO_(2),which is a visible-light-driven and transition metal-free process.In contrast to previous carboxylations of alkynes via two-electron activation of CO_(2),mechanistic and computational investigations suggest that the single-electron activation of CO_(2)is involved in the thio-carboxylation,rendering uniqueβ-carboxylation.The following cyclizing acylation affords important thiochromones efficiently.Moreover,the one-pot method features mild reaction conditions(room temperature,1 atmosphere of CO_(2)),high chemo-and regio-selectivity,easy scalability and facile derivatization of products to bioactive compounds.
