Objective The aim of this study was to evaluate the efficacy, complications and cosmetic results of three-dimensional conformal radiation therapy for early breast cancer after conservative surgery.
Introduction: In medulloblastoma patients craniospinal irradiation is an important element the treatment. Our study aimed to evaluate the effect of absorbed dose to organs at risk using the hybrid intensity-modulated ...Introduction: In medulloblastoma patients craniospinal irradiation is an important element the treatment. Our study aimed to evaluate the effect of absorbed dose to organs at risk using the hybrid intensity-modulated radiation therapy (IMRT) versus three-dimensional conformal radiotherapy (3DCRT) for craniospinal irradiation (CSI) in average risk medulloblastoma patients. Materials and Methods: In this study, thirteen medulloblastoma patients were included. The prescribed total dose to the planning target volume (PTV) was 23, 40 Gy in 13 fractions. Two radiotherapy techniques, three dimensional conformal radiotherapy (3DCRT) and hybrid intensity modulated radiotherapy (IMRT) were used to treat these patients. The coverage of the Target was evaluated using the D mean, D95%, D2%, D98% and V95%. Other parameters were also compared such as Integral dose (ID), Homogeneity index (HI) and doses to the organs at risk (OARs). Results: There was no significant difference in the mean dose received by the PTV-Brain or the dose received by 95% and 98% of PTV volume using the two techniques. For PTV-Spine, the percentage volume receiving 95% of the total dose increased significantly in the hybrid IMRT technique compared to the conformal technique. So, hybrid IMRT plan achieved the best coverage for PTV spine. Lower dose for OAR was delivered by 3DCRT, except the heart and thyroid, hybrid IMRT achieved better sparing. All plans resulted in the same dose homogeneity index (DHI) for PTV-Brain. For PTV-Spine, hybrid IMRT technique achieved better dose homogeneity compared to 3DCRT technique (1.09 vs. 1.12;p > 0.05). Conclusions: hybrid IMRT technique can be realized on conformal technique because it achieved better dose coverage for the (PTV) and organ at risk (OAR). 3DCRT reduced mean dose to most OARS, except the heart and thyroid. Therefore, the hybrid IMRT technique may be a CSI treatment alternative to 3DCRT.展开更多
目的探讨苦参素(0MT)对三维适形放射治疗中晚期肺癌临床疗效及患者血清VEGF、MMP-9水平的影响。方法将136例中晚期肺癌患者临床资料,按照治疗方案分为对照组(62例)和观察组(74例)。对照组患者给予三维适形放射治疗,观察组在对照组基础...目的探讨苦参素(0MT)对三维适形放射治疗中晚期肺癌临床疗效及患者血清VEGF、MMP-9水平的影响。方法将136例中晚期肺癌患者临床资料,按照治疗方案分为对照组(62例)和观察组(74例)。对照组患者给予三维适形放射治疗,观察组在对照组基础上给予0MT治疗。比较两组中晚期肺癌患者近期疗效、毒副反应及血清VEGF、MMP-9水平。结果两组中晚期肺癌患者近期疗效评价结果显示,观察组总有效率高于对照组(75.7%vs 56.4%,P<0.05)。治疗期间,观察组患者骨髓抑制、胃肠道反应、肝功能损害毒副反应发生率均低于对照组(P<0.05)。治疗后,与对照组相比,观察组患者血清VEGF、MMP-9水平降低(347.3±38.2 vs 404.5±42.0ng/L,476.8±47.3 vs 512.2±53.5ng/L),组间比较均有统计学差异(P<0.05)。结论在三维适形放疗基础上给予0MT治疗可以提高中晚期肺癌近期疗效,降低毒副反应发生率,而且能够降低血清VEGF、MMP-9水平,临床上值得进一步研究。展开更多
基金Supported by grants from the "Network Researches of Tumor Precise Radiation Therapy" of Ministry of Health of China (No. WKJ2005-3-006)the "Natural Science Foundation " of Science and Technology Commission of Shanghai (No. 06ZR4075)
文摘Objective The aim of this study was to evaluate the efficacy, complications and cosmetic results of three-dimensional conformal radiation therapy for early breast cancer after conservative surgery.
文摘Introduction: In medulloblastoma patients craniospinal irradiation is an important element the treatment. Our study aimed to evaluate the effect of absorbed dose to organs at risk using the hybrid intensity-modulated radiation therapy (IMRT) versus three-dimensional conformal radiotherapy (3DCRT) for craniospinal irradiation (CSI) in average risk medulloblastoma patients. Materials and Methods: In this study, thirteen medulloblastoma patients were included. The prescribed total dose to the planning target volume (PTV) was 23, 40 Gy in 13 fractions. Two radiotherapy techniques, three dimensional conformal radiotherapy (3DCRT) and hybrid intensity modulated radiotherapy (IMRT) were used to treat these patients. The coverage of the Target was evaluated using the D mean, D95%, D2%, D98% and V95%. Other parameters were also compared such as Integral dose (ID), Homogeneity index (HI) and doses to the organs at risk (OARs). Results: There was no significant difference in the mean dose received by the PTV-Brain or the dose received by 95% and 98% of PTV volume using the two techniques. For PTV-Spine, the percentage volume receiving 95% of the total dose increased significantly in the hybrid IMRT technique compared to the conformal technique. So, hybrid IMRT plan achieved the best coverage for PTV spine. Lower dose for OAR was delivered by 3DCRT, except the heart and thyroid, hybrid IMRT achieved better sparing. All plans resulted in the same dose homogeneity index (DHI) for PTV-Brain. For PTV-Spine, hybrid IMRT technique achieved better dose homogeneity compared to 3DCRT technique (1.09 vs. 1.12;p > 0.05). Conclusions: hybrid IMRT technique can be realized on conformal technique because it achieved better dose coverage for the (PTV) and organ at risk (OAR). 3DCRT reduced mean dose to most OARS, except the heart and thyroid. Therefore, the hybrid IMRT technique may be a CSI treatment alternative to 3DCRT.
文摘目的探讨苦参素(0MT)对三维适形放射治疗中晚期肺癌临床疗效及患者血清VEGF、MMP-9水平的影响。方法将136例中晚期肺癌患者临床资料,按照治疗方案分为对照组(62例)和观察组(74例)。对照组患者给予三维适形放射治疗,观察组在对照组基础上给予0MT治疗。比较两组中晚期肺癌患者近期疗效、毒副反应及血清VEGF、MMP-9水平。结果两组中晚期肺癌患者近期疗效评价结果显示,观察组总有效率高于对照组(75.7%vs 56.4%,P<0.05)。治疗期间,观察组患者骨髓抑制、胃肠道反应、肝功能损害毒副反应发生率均低于对照组(P<0.05)。治疗后,与对照组相比,观察组患者血清VEGF、MMP-9水平降低(347.3±38.2 vs 404.5±42.0ng/L,476.8±47.3 vs 512.2±53.5ng/L),组间比较均有统计学差异(P<0.05)。结论在三维适形放疗基础上给予0MT治疗可以提高中晚期肺癌近期疗效,降低毒副反应发生率,而且能够降低血清VEGF、MMP-9水平,临床上值得进一步研究。
