An Exploration of the Three Dimensions and Epochal Strengths of Building a Human Community With a Shared Future

The idea of a human community with a shared future was proposed by the Communist Party of China(CPC)Central Committee with Comrade Xi Jinping at its core for the future development of human beings to face up to the most important question in today's world:“What is happening to the world and what should we do?”It profoundly answers the question of the world,history,and the times.The theory of a human community with a shared future is an innovative theory with a multidimensional formation logic that guides humanity toward continually seeking common interests and values.This paper dives into the profound motivations behind building a human community with a shared future from historical,cultural,and practical dimensions and analyzes its epochal value from both domestic and international perspectives.This not only helps exert China's role in the international community,contributing Chinese strength to the construction of a peaceful,stable,and prosperous human society,but also enhances the influence of the idea of a human community with a shared future in the international community,accelerating the building of a human community with a shared future that considers the legitimate concerns of all countries,and aiding in solving the crises facing the world.

Rectangular tunnel heading stability in three dimensions and its predictive machine learning models

Tunnel heading stability in two dimensions(2D)has been extensively investigated by numerous scholars in the past decade.One significant limitation of 2D analysis is the absence of actual tunnel geometry modeling with a considerable degree of idealization.Nevertheless,it is possible to study the stability of tunnels in three dimensions(3D)with a rectangular shape using finite element limit analysis(FELA)and a nonlinear programming technique.This paper employs 3D FELA to generate rigorous solutions for stability numbers,failure mechanisms,and safety factors for rectangular-shaped tunnels.To further explore the usefulness of the produced results,multivariate adaptive regression spline(MARS)is used for machine learning of big dataset and development of design equations for practical design applications.The study should be of great benefit to tunnel design practices using the developed equations provided in the paper.

Astrocytes integrate time and space

Astrocytes read and react to synaptic transmission through tripartite synapses,where the binding of neurotransmitters onto astrocytic receptors triggers an increase in intracellular calcium.Recent investigations have revealed that astrocytes exhibit two distinct states of intracellular calcium activity:(1)graded subcellular localized clusters with independently active microdomains,likely influenced by nearby synaptic events,and(2)whole-cell astrocyte calcium surges,believed to result from the coordinated activation of multiple synapses.Notably,astrocyte calcium responses are not solely graded;instead,a spatial threshold of intracellular calcium activity can be overcome to elicit an astrocyte calcium surge.Together these calcium responses,in turn,initiate downstream signaling pathways capable of modifying synaptic communication and overall network activity.In summary,astrocytes can function as integrators of local synaptic events,actively contributing to information processing within the brain.

Research status and prospects of the fractal analysis of metal material surfaces and interfaces

As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine properties.Fractal analysis has been used to characterize the shapes of metal materials at various scales and dimensions.Conventional methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and interfaces.However,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal materials.From the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear surfaces.The relationship between the fractal dimensions and properties of metal material surfaces and interfaces is summarized.Starting from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be developed.It is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future.

Challenges and improvement strategies in the hospitalization of chronic multimorbid patients

BACKGROUND Addressing the growing challenge of hospitalizing chronic multimorbid patients,this study examines the strain these conditions impose on healthcare systems at a local level,focusing on a pilot program.Chronic diseases and complex patients require comprehensive management strategies to reduce healthcare burdens and improve patient outcomes.If proven effective,this pilot model has the potential to be replicated in other healthcare settings to enhance the management of chronic multimorbid patients.AIM To evaluate the effectiveness of the high complexity unit(HCU)in managing chronic multimorbid patients through a multidisciplinary care model and to compare it with standard hospital care.METHODS The study employed a descriptive longitudinal approach,analyzing data from the Basic Minimum Data Set(BMDS)to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout 2022.The HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity post-discharge.RESULTS The study employed a descriptive longitudinal approach,analyzing data from the BMDS to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout 2022.The HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity post-discharge.CONCLUSION This study demonstrates the effectiveness of the HCU in managing patients with complex chronic diseases through a multidisciplinary approach.The coordinated care provided by the HCU results in improved patient outcomes,reduced unnecessary hospitalizations,and better management of patient complexity.The superiority of the HCU compared to standard care is evident in key outcomes such as fewer readmissions and higher patient satisfaction,reinforcing its value as a model of care to be replicated.

Multisensory mechanisms of gait and balance in Parkinson’s disease:an integrative review

Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging population.Posture and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous mechanisms.To effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory signals.The mechanisms which underpin the integration of these multisensory signals are the principal topic of the present work.Existing multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older adults.Insufficient emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and balance.In the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s disease.We also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older adults.Lastly,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.

Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal cancer.Therefore,we further explored the survival benefits in the population with BRAF V600E mutant mCRC.AIM To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal cancer.METHODS A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December 2022.The patients were divided into two cohorts.RESULTS A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,respectively.Subgroup analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

New insights and investigation:Morphomolecular notes on the infraciliature,taxonomy,and systematics of pleurostomatid ciliates(Protozoa,Ciliophora),with establishment of a new suborder,two new genera,and three new species

Pleurostomatid ciliates,as a highly diverse and widely distributed unicellular eukaryote group,play a crucial role in the cycling of nutrients and energy in microbial food webs.However,research on pleurostomatids remains insufficient,resulting in a paucity of molecular information and substantial gaps in knowledge of their phylogenetic relationships.In recent years,we investigated pleurostomatid diversity in various Chinese habitats,including their systematic relationships and taxonomic circumscriptions,which were comprehensively analyzed using an integrative morphomolecular approach.Results revealed that:(1)pleurostomatids can be categorized into two suborders,Protolitonotina subord.nov.and Amphileptina Jankowski,1967;(2)Protolitonotina subord.nov.represents the ancestral pleurostomatid group and includes two genera,Protolitonotus and Heterolitonotus gen.nov.,characterized by right kineties progressively shortened along rightmost full kineties and absence of a left dorsolateral kinety;(3)Heterolitonotus gen.nov.represents an orphan lineage and is defined by an oral slit extending to its dorsal margin;(4)“Protolitonotus clampi”does not group with congeners but instead represents an orphan lineage,thus Novilitonotus gen.nov.is established to which P.clampi is transferred as Novilitonotus clampi comb.nov.;(5)three new species,Apoamphileptus paraclaparedii sp.nov.,Heterolitonotus rex gen.nov.,sp.nov.,and Loxophyllum apohelus sp.nov.,are described;and(6)helices 21es6a to 21es6d within the V4 region of small subunit ribosomal RNA(SSU rRNA)may serve as a useful tool for discriminating pleurostomatids.The evolutionary relationships among all main lineages of pleurostomatids are discussed and a key to the identification of pleurostomatid genera is provided.

Experimental investigation of methane explosion fracturing in bedding shales:Load characteristics and three-dimensional fracture propagation

Methane in-situ explosion fracturing(MISEF)enhances permeability in shale reservoirs by detonating desorbed methane to generate detonation waves in perforations.Fracture propagation in bedding shale under varying explosion loads remains unclear.In this study,prefabricated perforated shale samples with parallel and vertical bedding are fractured under five distinct explosion loads using a MISEF experimental setup.High-frequency explosion pressure-time curves were monitored within an equivalent perforation,and computed tomography scanning along with three-dimensional reconstruction techniques were used to investigate fracture propagation patterns.Additionally,the formation mechanism and influencing factors of explosion crack-generated fines(CGF)were clarified by analyzing the morphology and statistics of explosion debris particles.The results indicate that methane explosion generated oscillating-pulse loads within perforations.Explosion characteristic parameters increase with increasing initial pressure.Explosion load and bedding orientation significantly influence fracture propagation patterns.As initial pressure increases,the fracture mode transitions from bi-wing to 4–5 radial fractures.In parallel bedding shale,radial fractures noticeably deflect along the bedding surface.Vertical bedding facilitates the development of transverse fractures oriented parallel to the cross-section.Bifurcation-merging of explosioninduced fractures generated CGF.CGF mass and fractal dimension increase,while average particle size decreases with increasing explosion load.This study provides valuable insights into MISEF technology.

A novel box-counting method for quantitative fractal analysis of threedimensional pore characteristics in sandstone

Fractal theory offers a powerful tool for the precise description and quantification of the complex pore structures in reservoir rocks,crucial for understanding the storage and migration characteristics of media within these rocks.Faced with the challenge of calculating the three-dimensional fractal dimensions of rock porosity,this study proposes an innovative computational process that directly calculates the three-dimensional fractal dimensions from a geometric perspective.By employing a composite denoising approach that integrates Fourier transform(FT)and wavelet transform(WT),coupled with multimodal pore extraction techniques such as threshold segmentation,top-hat transformation,and membrane enhancement,we successfully crafted accurate digital rock models.The improved box-counting method was then applied to analyze the voxel data of these digital rocks,accurately calculating the fractal dimensions of the rock pore distribution.Further numerical simulations of permeability experiments were conducted to explore the physical correlations between the rock pore fractal dimensions,porosity,and absolute permeability.The results reveal that rocks with higher fractal dimensions exhibit more complex pore connectivity pathways and a wider,more uneven pore distribution,suggesting that the ideal rock samples should possess lower fractal dimensions and higher effective porosity rates to achieve optimal fluid transmission properties.The methodology and conclusions of this study provide new tools and insights for the quantitative analysis of complex pores in rocks and contribute to the exploration of the fractal transport properties of media within rocks.

On the global L^(1)-boundedness of Fourier integral operators with rough amplitude and phase functions

Let T_(ϕ,a)be a Fourier integral operator with amplitude a and phase functions ϕ.In this paper,we study the boundedness of Fourier integral operator of rough amplitude a∈L^(∞)S_(ρ)^(m)and rough phase functionsϕ∈L^(m)ϕ^(2)with some measure condition.We prove the global L^(1)boundedness for T_(ϕ,a),when 1/<ρ≤1 and m<ρ-n+1/2.Our theorem improves some known results.

CAUCHY TYPE INTEGRALS AND A BOUNDARY VALUE PROBLEM IN A COMPLEX CLIFFORD ANALYSIS

Clifford analysis is an important branch of modern analysis;it has a very important theoretical significance and application value,and its conclusions can be applied to the Maxwell equation,Yang-Mill field theory,quantum mechanics and value problems.In this paper,we first give the definition of a quasi-Cauchy type integral in complex Clifford analysis,and get the Plemelj formula for it.Second,we discuss the H?lder continuity for the Cauchy-type integral operators with values in a complex Clifford algebra.Finally,we prove the existence of solutions for a class of linear boundary value problems and give the integral representation for the solution.

Results Involving Partial Differential Equations and Their Solution by Certain Integral Transform

In this study,we aimto investigate certain triple integral transformand its application to a class of partial differentialequations.We discuss various properties of the new transformincluding inversion, linearity, existence, scaling andshifting, etc. Then,we derive several results enfolding partial derivatives and establish amulti-convolution theorem.Further, we apply the aforementioned transform to some classical functions and many types of partial differentialequations involving heat equations,wave equations, Laplace equations, and Poisson equations aswell.Moreover,wedraw some figures to illustrate 3-D contour plots for exact solutions of some selected examples involving differentvalues in their variables.

The tangential k-Cauchy-Fueter type operator and Penrose type integral formula on the generalized complex Heisenberg group

The tangential k-Cauchy-Fueter operator and k-CF functions are counterparts of the tangential Cauchy–Riemann operator and CR functions on the Heisenberg group in the theory of several complex variables,respectively.In this paper,we introduce a Lie group that the Heisenberg group can be imbedded into and call it generalized complex Heisenberg.We investigate quaternionic analysis on the generalized complex Heisenberg.We also give the Penrose integral formula for k-CF functions and construct the tangential k-Cauchy-Fueter complex.

Development Level and Dynamic Analysis of the Integration of Three Rural Industries in the Context of Rural Revitalization

As a key measure to comprehensively promote the strategy of rural revitalization,especially in the field of industrial prosperity,the integration of rural three industries is of great strategic significance.In this study,entropy method and TOPSIS method were employed to calculate the comprehensive evaluation index of integration of three industries and the ideal development value respectively.The development status of integration of three rural industries was systematically evaluated,and the development trend of different regions was compared and analyzed.The results indicate that the development index of integration of three industries showed a steady growth trend,among which the development level of Jiangsu Province ranked first,followed by Hubei Province,while the development level of Shaanxi Province was relatively low.When analyzing the Level I indicators of integration of three rural industries,the contribution of industrial integration behavior exceeded the performance of industrial integration.Among the behavioral indicators of industrial integration,the weight of agricultural multi-functionality and service integration was relatively large,which plays a significant role in promoting the development of integration of three rural industries.The scores and growth rates of Jiangsu Province in increasing farmers income,increasing agricultural production and rural economic development were higher than those of other regions,while Shaanxi Province still had a certain gap in rural industrial integration indicators compared with Jiangsu Province and Hubei Province.In view of this,we came up with some strategic recommendations for further promoting the development of integration of three rural industries.

Solvability and Construction of a Solution to the Fredholm Integral Equation of the First Kind

The issues of solvability and construction of a solution of the Fredholm integral equation of the first kind are considered. It is done by immersing the original problem into solving an extremal problem in Hilbert space. Necessary and sufficient conditions for the existence of a solution are obtained. A method of constructing a solution of the Fredholm integral equation of the first kind is developed. A constructive theory of solvability and construction of a solution to a boundary value problem of a linear integrodifferential equation with a distributed delay in control, generated by the Fredholm integral equation of the first kind, has been created.

Possibilities and challenges of expanding dimensions of waterway downstream of Three Gorges Dam

The waterway in the middle and lower reaches of the Yangtze River has long been known as the Golden Waterway and has served as an important link in the construction of the Yangtze River Economic Belt.Therefore,expanding its dimensions is a significant goal,particularly given the long-range cumulative erosion occurring downstream of the Three Gorges Dam (TGD),which has been concentrated in the dry river channel.With the regulation of the volume from upstream reservoirs and the TGD,the minimum discharge and water level of the river downstream are increasing,and creating favorable conditions for the increase of the depth of the waterway.The discharge compensation effect during the dry season offsets the decline in the water level of the river channel caused by the down-cutting of part of the riverbed,but the minimum navigable water level of the segment near the dam still shows a declining trend.In recent years,several waterway remediation projects have been implemented in the downstream reaches of the TGD and although the waterway depth and width have been increased,the channel dimensions are still insufficient in the Yichang-Anqing reach (with a total length of 1026 km),as compared to the upstream reservoir area and the deep water channel in the downstream tidal reaches.A comprehensive analysis of the water depth and the number and length of shoals in the waterway indicates that its dimensions can be increased to 4.5 m ×200 m and 6.0 m×200 m in the Yichang-Wuhan and Wuhan-Anqing reaches,respectively.This is also feasible given the remediation technologies currently available,but remediation projects need to be coordinated with those for flood prevention and ecological protection.

Real-time in situ three-dimensional integral videography and surgical navigation using augmented reality: a pilot study

To evaluate the feasibility and accuracy of a three-dimensional augmented reality system incorporating integral videography for imaging oral and maxillofacial regions, based on preoperative computed tomography data. Three-dimensional surface models of the jawbones, based on the computed tomography data, were used to create the integral videography images of a subject＇s maxillofacial area. The three-dimensional augmented reality system （integral videography display, computed tomography, a position tracker and a computer） was used to generate a three-dimensional overlay that was projected on the surgical site via a half-silvered mirror. Thereafter, a feasibility study was performed on a volunteer. The accuracy of this system was verified on a solid model while simulating bone resection. Positional registration was attained by identifying and tracking the patient/surgical instrument＇s position. Thus, integral videography images of jawbones, teeth and the surgical tool were superimposed in the correct position. Stereoscopic images viewed from various angles were accurately displayed. Change in the viewing angle did not negatively affect the surgeon＇s ability to simultaneously observe the three-dimensional images and the patient, without special glasses. The difference in three-dimensional position of each measuring point on the solid model and augmented reality navigation was almost negligible （〈1 mm）; this indicates that the system was highly accurate. This augmented reality system was highly accurate and effective for surgical navigation and for overlaying a three-dimensional computed tomography image on a patient＇s surgical area, enabling the surgeon to understand the positional relationship between the preoperative image and the actual surgical site, with the naked eye.

A Hilbert-Type Inequality with Some Parameters and the Integral in Whole Plane

In this paper, by introducing some parameters and estimating the weight coefficient, we give a new Hilbert’s inequality with the integral in whole plane and with a non-homogeneous and the equivalent form is given as well. The best constant factor is calculated by the way of Complex Analysis.

The Historical Position and Value Dimensions of Human Rights Civilization

Human beings are the mainstay and the ultimate goal of civilization.The history of human civilization is a continuous struggle to realize the respect,liberation,protection,and development of humanity.Human rights are an achievement of humanity and a symbol of progress,and the human rights civilization is an important component of human civilization.Understanding and interpreting human rights from the perspective of human rights civilization means that human rights are not only a concept or an idea but also a grand historical and long-term social practice.Up to now,the development of human rights civilization has roughly experienced four awakening eras:initialization,revolution,popularization,and globalization.In terms of its value dimensions,it has the characteristics of progressiveness,diversity,commonality,inclusiveness,indivisibility,openness,and so on.The historical position of human rights civilization and the development of its value dimensions have shown to the world that human rights are the common wealth of humanity,and human rights belong to all mankind;human rights are historical,concrete,and developmental;the concept of human rights is constantly evolving,and its connotations and categories are constantly expanding;achieving the free and well-rounded development of every person is the highest value realm of human rights civilization.The Chinese modernization endows Chinese civilization with modern strength and opens up new horizons for human rights civilization.The new pattern of human rights civilization to be created by Chinese modernization not only possesses the common characteristics of human rights civilization but also enjoys Chinese characteristics based on its own national conditions,enriching and developing the diversity of human rights civilization for all mankind.