Current trends in nanomaterials-mediated biosensing platforms and signal amplification strategies for antibiotics detection in dairy products

Dairy products have become one of the most prevalent daily foods worldwide,but safety concerns are rising.In dairy farming,unscrupulous traders misuse antibiotics to treat some diseases such as mastitis in cows,leading to antibiotic residues in dairy products.Rapid,sensitive,and simple detection methods for antibiotic residues are particularly important for food safety in dairy products.Traditional detection technology can effectively detect antibiotics,but there are defects such as complicated pre-treatment and high cost.Biosensors are widely used in food safety due to fast detection speed,low detection cost,strong anti-interference ability,and suitability for the field application.Nevertheless,these sensors often fail to trigger the signal conversion output due to low target concentration.To cope with this issue,some high-efficiency signal amplification systems can be introduced to improve the detection sensitivity and linear range of biosensors.In this review,we focused on:(i)Sources and toxicity of major antibiotics in animal-derived foods.(ii)Nanomaterial-mediated biosensors for real-time detection of target antibiotics in animal-derived foods.(iii)Signal amplification techniques to increase the sensitivity of biosensors.Finally,future prospects and challenges in this research field are discussed.

Target-induced Trivalent G-quadruplex/hemin DNAzyme for Colorimetric Detection of Hg^(2+) Based on an Exonuclease III Assisted Catalytic Hairpin Assembly

Mercury ion(Hg^(2+)),a highly noxious of heavy metalion,has detrimental effects on the ecological environment and human health.Herein,we have developed an exonuclease III(Exo III)assisted catalytic hairpin assembly formation of a trivalent G-quadruplex/hemin DNAzyme for colorimetric detection of Hg^(2+).A hairpin DNA(Hr)was designed with thymine-Hg^(2+)-thymine pairs that catalyzed by Exo III is prompted to happen upon binding Hg^(2+).A released DNA fragment triggers the catalytic assembly of other three hairpins(H1,H2,and H3)to form many trivalent G-quadruplex/hemin DNA enzymes for signal output.The developed sensor shows a dynamic range from 2 pM to 2μM,with an impressively low detection limit of 0.32 pM for Hg^(2+)detection.Such a sensor also has good selectivity toward Hg^(2+)detection in the presence of other common metal ions.This strategy shows the great potential for visual detection with portable type.

Weak signal detection method based on novel composite multistable stochastic resonance

The weak signal detection method based on stochastic resonance is usually used to extract and identify the weak characteristic signal submerged in strong noise by using the noise energy transfer mechanism.We propose a novel composite multistable stochastic-resonance(NCMSR)model combining the Gaussian potential model and an improved bistable model.Compared with the traditional multistable stochastic resonance method,all the parameters in the novel model have no symmetry,the output signal-to-noise ratio can be optimized and the output amplitude can be improved by adjusting the system parameters.The model retains the advantages of continuity and constraint of the Gaussian potential model and the advantages of the improved bistable model without output saturation,the NCMSR model has a higher utilization of noise.Taking the output signal-to-noise ratio as the index,weak periodic signal is detected based on the NCMSR model in Gaussian noise andαnoise environment respectively,and the detection effect is good.The application of NCMSR to the actual detection of bearing fault signals can realize the fault detection of bearing inner race and outer race.The outstanding advantages of this method in weak signal detection are verified,which provides a theoretical basis for industrial practical applications.

Personal glucose meters coupled with signal amplification technologies for quantitative detection of non-glucose targets:Recent progress and challenges in food safety hazards analysis

Ensuring food safety is paramount worldwide.Developing effective detection methods to ensure food safety can be challenging owing to trace hazards,long detection time,and resource-poor sites,in addition to the matrix effects of food.Personal glucose meter(PGM),a classic point-of-care testing device,possesses unique application advantages,demonstrating promise in food safety.Currently,many studies have used PGM-based biosensors and signal amplification technologies to achieve sensitive and specific detection of food hazards.Signal amplification technologies have the potential to greatly improve the analytical performance and integration of PGMs with biosensors,which is crucial for solving the challenges associated with the use of PGMs for food safety analysis.This review introduces the basic detection principle of a PGM-based sensing strategy,which consists of three key factors:target recognition,signal transduction,and signal output.Representative studies of existing PGM-based sensing strategies combined with various signal amplification technologies(nanomaterial-loaded multienzyme labeling,nucleic acid reaction,DNAzyme catalysis,responsive nanomaterial encapsulation,and others)in the field of food safety detection are reviewed.Future perspectives and potential opportunities and challenges associated with PGMs in the field of food safety are discussed.Despite the need for complex sample preparation and the lack of standardization in the field,using PGMs in combination with signal amplification technology shows promise as a rapid and cost-effective method for food safety hazard analysis.

Feature Selection with Deep Belief Network for Epileptic Seizure Detection on EEG Signals

The term Epilepsy refers to a most commonly occurring brain disorder after a migraine.Early identification of incoming seizures significantly impacts the lives of people with Epilepsy.Automated detection of epileptic seizures(ES)has dramatically improved the life quality of the patients.Recent Electroencephalogram(EEG)related seizure detection mechanisms encountered several difficulties in real-time.The EEGs are the non-stationary signal,and seizure patternswould changewith patients and recording sessions.Further,EEG data were disposed to wide noise varieties that adversely moved the recognition accuracy of ESs.Artificial intelligence(AI)methods in the domain of ES analysis use traditional deep learning(DL),and machine learning(ML)approaches.This article introduces an Oppositional Aquila Optimizer-based Feature Selection with Deep Belief Network for Epileptic Seizure Detection(OAOFS-DBNECD)technique using EEG signals.The primary aim of the presented OAOFS-DBNECD system is to categorize and classify the presence of ESs.The suggested OAOFS-DBNECD technique transforms the EEG signals into.csv format at the initial stage.Next,the OAOFS technique selects an optimal subset of features using the preprocessed data.For seizure classification,the presented OAOFS-DBNECD technique applies Artificial Ecosystem Optimizer(AEO)with a deep belief network(DBN)model.An extensive range of simulations was performed on the benchmark dataset to ensure the enhanced performance of the presented OAOFS-DBNECD algorithm.The comparison study shows the significant outcomes of the OAOFS-DBNECD approach over other methodologies.In addition,the result of the suggested approach has been evaluated using the CHB-MIT database,and the findings demonstrate accuracy of 97.81%.These findings confirmed the best seizure categorization accuracy on the EEG data considered.

Detection of the anthropogenic signal and urbanization effects in extreme temperature changes in eastern China

作为中国经济最发达的地区,中国东部受到城市热岛效应和温室气体排放等人类活动的明显影响.本文利用最新的观测和全球气候模式资料,对极端温度强度,频率和持续时间等16个极端温度指数进行了检测归因分析,研究了人为强迫和城市化效应对中国东部极端温度变化的影响.结果表明,近年来极端温度持续增暖,极端暖事件增加,极端冷事件减少.新一代全球气候模式能够合理地反映这些变暖特征,但是部分模式可能高估或低估了观测到的变化.基于最优指纹方法的双信号检测表明,人为信号和城市化效应只能在暖夜和冷夜两个频率指标上同时被检测并分离,其变化约三分之二可归因于人类活动,剩余的三分之一可归因于城市化效应.而在极端温度其他指数的变化中,只有人类活动的影响能够被检测到.

Deep Learning Based Signal Detector for OFDM Systems

In this paper,we propose a novel deep learning(DL)-based receiver design for orthogonal frequency division multiplexing(OFDM)systems.The entire process of channel estimation,equalization,and signal detection is replaced by a neural network(NN),and hence,the detector is called a NN detector(N^(2)D).First,an OFDM signal model is established.We analyze both temporal and spectral characteristics of OFDM signals,which are the motivation for DL.Then,the generated data based on the simulation of channel statistics is used for offline training of bi-directional long short-term memory(Bi-LSTM)NN.Especially,a discriminator(F)is added to the input of Bi-LSTM NN to look for subcarrier transmission data with optimal channel gain(OCG),which can greatly improve the performance of the detector.Finally,the trained N^(2)D is used for online recovery of OFDM symbols.The performance of the proposed N^(2)D is analyzed theoretically in terms of bit error rate(BER)by Monte Carlo simulation under different parameter scenarios.The simulation results demonstrate that the BER of N^(2)D is obviously lower than other algorithms,especially at high signal-to-noise ratios(SNRs).Meanwhile,the proposed N^(2)D is robust to the fluctuation of parameter values.

Wigner-Hough transform based on slice's entropy and its application to multi-LFM signal detection

To enhance the capacity of the radar-reconnaissance interception receiver recognizing linear frequency modulated (LFM) at a low signal-noise ratio, this paper presents WignerHough transform (WHT) of the LFM signal and its corresponding characteristics, derives the probability density functions of the LFM signal and Gaussian white noise within WHT based on entropy (WHTE), dimension under different assumptions and puts forward a WHT algorithm based on entropy of slice to improve the capacity of detecting the LFM signal. Entropy of the WHT domain slice is adopted to assess the information size of polar radius or angle slice, which is converted into the weight factor to weight every slice. Double-deck weight is used to weaken the influences of noise and disturbance terms and WHTE treatment and signal detection procedure are also summarized. The rationality of the algorithm is demonstrated through theoretical analysis and formula derivation, the efficiency of the algorithm is verified by simulation comparison between WHT, fractional Fourier transform and periodic WHT, and it is highlighted that the WHTE algorithm has better detection accuracy and range of application against strong noise background.

Application of clan member signal method in structural damage detection

It is well known that in most cases, a reference is necessary for structural health diagnosis, and it is very difficult to obtain such a reference for a given structure. In this paper, a clan member signal method （CMSM） is proposed for use in structures consisting of groups （or clans） that have the same geometry, i.e., the same cross section and length, and identical boundary conditions. It is expected that signals measured on any undamaged member in a clan after an event could be used as a reference for any other members in the clan. To verify the applicability of the proposed method, a steel truss model is tested and the results show that the CMSM is very effective in detecting local damage in structures composed of identical slender members.

Combining Radon-ambiguity transform with second-order difference to improve detection probability of LFM signals in low SNR

The Radon-ambiguity transform （RAT）, although efficient for detecting the linear frequency modulated signals （LFMs）, is troubled by the energy accumulation of noise in low signal-to-noise ratio （SNR）. A secondorder difference （SOD） method is proposed to treat with this problem. In the SOD method, the optimal search step and difference step are derived from the LFM rate resolution formula. The sharpness of the peaks of RAT is measured by curvature, and the sharpness, but not the magnitude of the peaks, is used to detect the LFMs. The SOD method removes the noise energy accumulation and reserves the drastically changing components integrally; thus, it improves the detection probability of LFMs in low SNR. The expected performance of the new method is verified by 100 Monte Carlo simulations.

LPI radar signal detection based on the combination of FFT and segmented autocorrelation plus PAHT

This paper proposes a desirable method to detect different kinds of low probability of intercept (LPI) radar signals, targeted at the main intra-pulse modulation method of LPI radar signals including the signals of linear frequency modulation, phase code, and frequency code. Firstly, it improves the coherent integration of LPI radar signals by adding the periodicity of the ambiguity function. Then, it develops a frequency domain detection method based on fast Fourier transform (FFT) and segmented autocorrelation function to detect signals without features of linear frequency modulation by virtue of the distribution characteristics of noise signals in the frequency domain. Finally, this paper gives a verification of the performance of the method for different signal-to-noise ratios by conducting simulation experiments, and compares the method with existing ones. Additionally, this method is characterized by the straightforward calculation and high real-time performance, which is conducive to better detecting all kinds of LPI radar signals.

Wideband Signal Detection Based on MWC Discrete Compressed Sampling Structure

In order to solve the cross-channel signal problem caused by the uniform channelized wideband digital receiver when processing wideband signal and the problem that the sensitivity of the system greatly decreases when the bandwidth of wideband digital receiver increases,which both decrease the wideband radar signal detection performance,a new wideband digital receiver based on the modulated wideband converter(MWC)discrete compressed sampling structure and an energy detection method based on the new receiver are proposed.Firstly,the proposed receiver utilizes periodic pseudo-random sequences to mix wideband signals with baseband and other sub-bands.Then the mixed signals are low-pass filtered and downsampled to obtain the baseband compressed sampling data,which can increase the sensitivity of the system.Meanwhile,the cross-channel signal will all appear in any subbands,so the cross-channel signal problem can be solved easily by processing the baseband compressed sampling data.Secondly,we establish the signal detection model and formulate the criterion of the energy detection method.And we directly utilize the baseband compressed sampling data to carry out signal detection without signal reconstruction,which decreases the complexity of the algorithm and reduces the computational burden.Finally,simulation experiments demonstrate the effectiveness of the proposed receiver and show that the proposed signal detection method is effective in low signal-to-noise ratio(SNR)compared with the conventional energy detection and the probability of detection increases significantly when SNR increases.

Improving Airgun Signal Detection with Small-Aperture Seismic Array in Yunnan

Repeating airgun sources are eco-friendly sources for monitoring the changes in the physical properties of subsurface mediums,but their signals decay quickly and are buried in the noises soon after traveling short distances.Stacking waveforms from different airgun shots recorded by a single seismic station(shot stacking)is the most popular technique to detect weak signals from noisy backgrounds,and has been widely used to process the data of Fixed Airgun Signal Transmission Stations(FASTS)in China.However,shot stacking sacrifices the time resolution in monitoring to recover a qualified airgun signal by stacking many shots at distance stations,and also suffers from persistent local noises.In this paper,we carried out several small-aperture seismic array experiments around the Binchuan FAST Station(BCFASTS)in Yunnan Province,China,and applied the array technique to improve airgun signal detection.The results show that seismic array processing combining with shot stacking can suppress seismic noises more efficiently,and provide better signal-to-noise ratio(SNR)and coherent airgun signals with less airgun shots.This work suggests that the array technique is a feasible and promising tool in FAST to increase the time resolution and reduce noise interference on routine monitoring.

A tunable adaptive detector for distributed targets when signal mismatch occurs

Aiming at the problem of detecting a distributed target when signal mismatch occurs,this paper proposes a tunable detector parameterized by an adjustable parameter.By adjusting the parameter,the tunable detector can achieve robust or selective detection of mismatched signals.Moreover,the proposed tunable detector,with a proper tunable parameter,can provide higher detection probability compared with existing detectors in the case of no signal mismatch.In addition,the proposed tunable detector possesses the constant false alarm rate property with the unknown noise covariance matrix.

Weak wide-band signal detection method based on small-scale periodic state of Duffing oscillator

The conventional Duffing oscillator weak signal detection method, which is based on a strong reference signal, has inherent deficiencies. To address these issues, the characteristics of the Duffing oscillator＇s phase trajectory in a small- scale periodic state are analyzed by introducing the theory of stopping oscillation system. Based on this approach, a novel Duffing oscillator weak wide-band signal detection method is proposed. In this novel method, the reference signal is discarded, and the to-be-detected signal is directly used as a driving force. By calculating the cosine function of a phase space angle, a single Duffing oscillator can be used for weak wide-band signal detection instead of an array of uncoupled Duffing oscillators. Simulation results indicate that, compared with the conventional Duffing oscillator detection method, this approach performs better in frequency detection intervals, and reduces the signal-to-noise ratio detection threshold, while improving the real-time performance of the system.

Detection of phase randomly distributed weak transient signal using chaos

In practical communication and radar systems, the phase of the received signal is random, the arrival time is unknown, the lasting time is limited and the SNR is often very low. In order to realize the detection of the signal, the method of using a group of nonlinear differential equations is presented. The theory of this chaos-based detection is analyzed. Computer simulation indicates that the shortest lasting time of the transient signal that can be detected out is 12 periods, the detection error of arrival time is less than 7/8 signal＇ s period, the detection characteristics are got using Monte-Carlo simulation.

Signal Detection of Carbon in Iron-Based Alloy by Double-Pulse Laser-Induced Breakdown Spectroscopy

Although single-pulse lasers are often used in traditional laser-induced breakdown spectroscopy （LIBS） measurements, their measurement outcomes are generally undesirable because of the low sensitivity of carbon in iron-based alloys. In this article, a double-pulse laser was applied to improve the signal intensity of carbon. Both the inter-pulse delay and the combination of laser wavelengths in double-pulse laser-induced breakdown spectroscopy （DP-LIBS） were optimized in our experiment. At the optimized inter-pulse delay, the combination of a first laser of 532 nm and a second laser of 1,064 nm achieved the highest signal enhancement. The properties of the target also played a role in determining the mass ablation enhancement in DP-LIBS configuration.

Implication of two-coupled tri-stable stochastic resonance in weak signal detection

Stochastic resonance （SR） has been proved to be an effective approach to extract weak signals overwhelmed in noise. However, the detection effect of current SR models is still unsatisfactory. Here, a coupled tri-stable stochastic resonance （CTSSR） model is proposed to further increase the output signal-to-noise ratio （SNR） and improve the detection effect of SR. The effects of parameters a, b, c, and r in the proposed resonance system on the SNR are studied, by which we determine a set of parameters that is relatively optimal to implement a comparison with other classical SR models. Numerical experiment results indicate that this proposed model performs better in weak signal detection applications than the classical ones with merits of higher output SNR and better anti-noise capability.

Bistable Stochastic Resonance Enhanced 4-ary PAM Signal Detection under Low SNR

To boost the performance of 4-ary pulse amplitude modulated(PAM) at low signal-to-noise ratio(SNR), bistable stochastic resonance(BSR) system is introduced into digital communications system and get a reliable signal detection scheme. In this paper, we first analyse BSR system for different amplitudes of 4-ary PAM signals. The steadystate of the bistable system will be statistically distinct, and the feasibility of the proposed detection scheme is confirmed. On this basis, we present a detailed study on steady-state transitions of the BSR system, and an explicit expression of the bistable system parameters is derived. By setting the bistable system parameters, bistable system, 4-ary PAM signal, and noise reach the resonance state, and the BSR-based detection scheme is implemented. Moreover, we derive an analytical expression to calculate the symbol error rate(SER) of 4-ary PAM signals with the BSR-based detection under additive white Gaussian noise(AWGN). Finally, the simulation results validate that BSR-based detection scheme can improve the detection performance while efficiently reducing the symbol error rate.

A new method for coseismic offset detection from GPS coordinate time series

Currently,the extraction of coseismic offset signals primarily relies on earthquake catalog data to determine the occurrence time of earthquakes.This is followed by the process of differencing the average GPS coordinate time series data,with a time interval of 3 to 5 days before and after the earthquake.In the face of the huge amount of GPS coordinate time series data today,the conventional approach of relying on earthquake catalog data to assist in obtaining coseismic offset signals has become increasingly burdensome.To address this problem,we propose a new method for automatically detecting coseismic offset signals in GPS coordinate time series without an extra earthquake catalog for reference.Firstly,we pre-process the GPS coordinate time series data for filtering out stations with significant observations missing and detecting and removing outliers.Secondly,we eliminate other signals and errors in the GPS coordinate time series,such as trend and seasonal signals,leaving the coseismic offset signals as the primary signal.The resulting coordinate time series is then modeled using the first-order difference and data stacking method.The modeling method enables automatic detection of the coseismic offset signals in the GPS coordinate time series.The aforementioned method is applied to automatically detect coseismic offset signals using simulated data and the Searles Valley GPS data in California,USA.The results demonstrate the efficacy of our proposed method,successfully detecting coseismic offsets from vast amounts of GPS coordinate time series data.