BACKGROUND Laparoscopic gastrectomy for esophagogastric junction(EGJ)carcinoma enables the removal of the carcinoma at the junction between the stomach and esophagus while preserving the gastric function,thereby provi...BACKGROUND Laparoscopic gastrectomy for esophagogastric junction(EGJ)carcinoma enables the removal of the carcinoma at the junction between the stomach and esophagus while preserving the gastric function,thereby providing patients with better treatment outcomes and quality of life.Nonetheless,this surgical technique also presents some challenges and limitations.Therefore,three-dimensional reconstruction visualization technology(3D RVT)has been introduced into the procedure,providing doctors with more comprehensive and intuitive anatomical information that helps with surgical planning,navigation,and outcome evaluation.AIM To discuss the application and advantages of 3D RVT in precise laparoscopic resection of EGJ carcinomas.METHODS Data were obtained from the electronic or paper-based medical records at The First Affiliated Hospital of Hebei North University from January 2020 to June 2022.A total of 120 patients diagnosed with EGJ carcinoma were included in the study.Of these,68 underwent laparoscopic resection after computed tomography(CT)-enhanced scanning and were categorized into the 2D group,whereas 52 underwent laparoscopic resection after CT-enhanced scanning and 3D RVT and were categorized into the 3D group.This study had two outcome measures:the deviation between tumor-related factors(such as maximum tumor diameter and infiltration length)in 3D RVT and clinical reality,and surgical outcome indicators(such as operative time,intraoperative blood loss,number of lymph node dissections,R0 resection rate,postoperative hospital stay,postoperative gas discharge time,drainage tube removal time,and related complications)between the 2D and 3D groups.RESULTS Among patients included in the 3D group,27 had a maximum tumor diameter of less than 3 cm,whereas 25 had a diameter of 3 cm or more.In actual surgical observations,24 had a diameter of less than 3 cm,whereas 28 had a diameter of 3 cm or more.The findings were consistent between the two methods(χ^(2)=0.346,P=0.556),with a kappa consistency coefficient of 0.808.With respect to infiltration length,in the 3D group,23 patients had a length of less than 5 cm,whereas 29 had a length of 5 cm or more.In actual surgical observations,20 cases had a length of less than 5 cm,whereas 32 had a length of 5 cm or more.The findings were consistent between the two methods(χ^(2)=0.357,P=0.550),with a kappa consistency coefficient of 0.486.Pearson correlation analysis showed that the maximum tumor diameter and infiltration length measured using 3D RVT were positively correlated with clinical observations during surgery(r=0.814 and 0.490,both P<0.05).The 3D group had a shorter operative time(157.02±8.38 vs 183.16±23.87),less intraoperative blood loss(83.65±14.22 vs 110.94±22.05),and higher number of lymph node dissections(28.98±2.82 vs 23.56±2.77)and R0 resection rate(80.77%vs 61.64%)than the 2D group.Furthermore,the 3D group had shorter hospital stay[8(8,9)vs 13(14,16)],time to gas passage[3(3,4)vs 4(5,5)],and drainage tube removal time[4(4,5)vs 6(6,7)]than the 2D group.The complication rate was lower in the 3D group(11.54%)than in the 2D group(26.47%)(χ^(2)=4.106,P<0.05).CONCLUSION Using 3D RVT,doctors can gain a more comprehensive and intuitive understanding of the anatomy and related lesions of EGJ carcinomas,thus enabling more accurate surgical planning.展开更多
Objective:To investigate the value of two-dimensional ultrasound speckle tracking(2D-STI)and three-dimensional ultrasound speckle tracking(3D-STI)in evaluating myocardial function in children with Kawasaki disease.Met...Objective:To investigate the value of two-dimensional ultrasound speckle tracking(2D-STI)and three-dimensional ultrasound speckle tracking(3D-STI)in evaluating myocardial function in children with Kawasaki disease.Methods 92 children with Kawasaki disease admitted to our hospital from February 2017 to February 2019 were retrospectively analyzed.50 children who underwent 3D-STI examination were taken as observation group and 42 children who underwent 2D-STI examination were taken as control group.The left ventricular systolic function index,storage time and analysis time of the image,the diameter of coronary artery,the strain difference of left ventricular basal segment,middle segment,apical segment and whole segment were observed.Results The levels of left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV),left ventricular myocardial mass(LVMI)in the observation group were higher than those in the control group(P<0.05),but there was no statistical difference in left ventricular ejection fraction(LVEF)between the two groups(P>0.05).The storage time and analysis time of the image in the observation group were significantly lower than those in the control group(P<0.05).The left coronary artery(LCA)and right coronary artery(RCA)in the observation group were higher than those in the control group(P<0.05).There was no statistical difference between left anterior descending(LAD)in the two groups(P>0.05).The longitudinal peak systolic strain(LS),circumferential peak systolic strain(CS)and radial peak systolic strain(RS)in the observation group were higher than those in the control group(P<0.05).The global longitudinal peak strain(GLS),global circumferential peak strain(GCS)and global radial peak strain(GRS)in the observation group were higher than those in the control group(P<0.05).LS and CS in the middle segment of the observation group were higher than those in the control group(P<0.05).Conclusions Compared with 2D-STI,3D-STI can objectively and accurately reflect the myocardial function of children with Kawasaki disease.展开更多
Objective To investigate the feasibility and clinical efficacy of total three-dimensional laparoscopic pancreatoduodenectomy. Methods The clinical data of 28 patients who underwent total three-dimensional laparoscopic...Objective To investigate the feasibility and clinical efficacy of total three-dimensional laparoscopic pancreatoduodenectomy. Methods The clinical data of 28 patients who underwent total three-dimensional laparoscopic pancreatoduodenectomy at the Second Hospital of Hebei Medical University from August 2015 to May 2016 were retrospectively analyzed. The surgical indications and method of performing total threedimensional laparoscopic pancreatoduodenectomy were similar to those of the patients who underwent two-dimensional laparoscopic pancreatoduodenectomy. All of the patients were followed up via outpatient reviews and telephone interviews through September 2016. Results In all 28 cases, total three-dimensional laparoscopic pancreatoduodenectomy was successfully performed with no conversion to laparotomy, intraoperative complications, or perioperative death. The mean operative time was 406 min(200–520 min) with a mean blood loss of 528 m L(200–1500 m L), a mean number of dissected lymph nodes of 11(6–16), a mean postoperative anus exhaust time of 4.4 d(2–8 d), and a mean length of stay of 16.9 d(9–23 d). There was a postoperative pancreatic fistula in 4 out of the 28 cases, with 3 cases of grade A and 1 case of grade B. Postoperatively, one patient with early-stage intra-abdominal hemorrhage improved after conservative symptomatic treatment, and two patients with gastroplegia were cured with conservative treatment. No complications occurred in the other patients. All of the cases underwent R0 resection with a negative surgical margin. All of the 28 patients were followed up for 6 to 12 months, with a median follow-up period of 9.2 months. During the follow-up period, there were no postoperative complications related to the procedures and no deaths; tumor recurrence was identified 9 months after the procedure using positron emission computed tomography(PECT) in one patient with pancreatic ductal adenocarcinoma.Conclusion Total three-dimensional laparoscopic pancreatoduodenectomy is safe and feasible for the treatment of periampullary carcinoma, with the advantage of favorable short-term outcomes.展开更多
The optimal velocity encoding of phase-contrast magnetic resonance angiography (PC MRA) in measuring cerebral blood flow volume (BFV) ranges from 60 to 80 cm/s. To verify the accuracy of two-dimensional (2D) PC ...The optimal velocity encoding of phase-contrast magnetic resonance angiography (PC MRA) in measuring cerebral blood flow volume (BFV) ranges from 60 to 80 cm/s. To verify the accuracy of two-dimensional (2D) PC MRA, the present study localized the region of interest at blood vessels of the neck using PC MRA based on three-dimensional time-of-flight sequences, and the velocity encoding was set to 80 cm/s. Results of the measurements showed that the error rate was 7.0±6.0% in the estimation of BFV in the internal carotid artery, the external carotid artery and the ipsilateral common carotid artery. There was no significant difference, and a significant correlation in BFV between internal carotid artery + external carotid artery and ipsilateral common carotid artery. In addition, the BFV of the common carotid artery was correlated with that of the ipsilateral internal carotid artery. The main error was attributed to the external carotid artery and its branches. Therefore, after selecting the appropriate scanning parameters and protocols, 2D PC MRA is more accurate in the determination of BFV in the carotid arteries.展开更多
BACKGROUND The benefits of laparoscopic approach for right colectomy have been well established.However,the technical difficulty to construct the intra-corporeal anastomosis is still cumbersome.AIM To analyze the resu...BACKGROUND The benefits of laparoscopic approach for right colectomy have been well established.However,the technical difficulty to construct the intra-corporeal anastomosis is still cumbersome.AIM To analyze the results of 3D and 2D laparoscopic right colectomy and to compare it to the published series through a systematic review and meta-analysis.METHODS A retrospective study with propensity score matching analysis of patients undergoing laparoscopic right colectomy at Umbria2 Hospitals from January 2014 to March 2020 was performed.A systematic review was accomplished comparing 2D and 3D right colectomy.RESULTS In the personal series 47 patients of the 2D group were matched to 47 patients of the 3D group.The 3D group showed a favorable trend in terms of mean operative time(170.7±32.9 min vs 183.8±35.4 min;P=0.053)and a significant lower anastomotic time(16.9±2.3 min vs 19.6±2.9 min,P<0.001).The complete mesocolic excision(CME)subgroups analysis showed a shorter anastomotic time(16.5±1.8 min vs 19.9±3.0 min;P<0.001)and operative time(175.0±38.5 min vs 193.7±37.1 min;P=0.063)in the 3D group.Six studies and our series were included in the meta-analysis with 551 patients(2D group:291;3D group:260).The pooled analysis demonstrated a significant difference in favour of the 3D group regarding the operative time(P<0.001)and the anastomotic time(P<0.001)while no differences were identified between groups in terms of blood loss(P=0.827),LNH yield(P=0.243),time to first flatus(P=0.333),postoperative complications(P=0.718)and length of stay(P=0.835).CONCLUSION The meta-analysis results showed that 3D laparoscopic right colectomy shortens operative and anastomotic time without affecting the standard lymphadenectomy.In our series,the advantage of the 3D system becomes evident when CME and/or more complex associated procedure are requested significantly reducing both the total operative and the anastomotic time.展开更多
Previous studies demonstrated that three-dimensional(3D) multicellular tumor spheroids(MCTS) could more closely mimic solid tumors than two-dimensional(2D) cancer cells in terms of the spatial structure, extracellular...Previous studies demonstrated that three-dimensional(3D) multicellular tumor spheroids(MCTS) could more closely mimic solid tumors than two-dimensional(2D) cancer cells in terms of the spatial structure, extracellular matrix-cell interaction, and gene expression pattern. However, no study has been reported on the differences in lipid metabolism and distribution among 2D cancer cells, MCTS, and solid tumors. Here, we used Hep G2 liver cancer cell lines to establish these three cancer models. The variations of lipid profiles and spatial distribution among them were explored by using mass spectrometry-based lipidomics and matrix-assisted laser desorption/ionization mass spectrometry imaging(MSI). The results revealed that MCTS, relative to 2D cells, had more shared lipid species with solid tumors. Furthermore,MCTS contained more comparable characteristics than 2D cells to solid tumors with respect to the relative abundance of most lipid classes and mass spectra patterns. MSI data showed that 46 of 71 lipids had similar spatial distribution between solid tumors and MCTS, while lipids in 2D cells had no specific spatial distribution. Interestingly, most of detected lipid species in sphingolipids and glycerolipids preferred locating in the necrotic region to the proliferative region of solid tumors and MCTS. Taken together, our study provides the evidence of lipid metabolism and distribution demonstrating that MCTS are a more suitable in vitro model to mimic solid tumors, which may offer insights into tumor metabolism and microenvironment.展开更多
Background: This study was designed to evaluate the clinical and radiographic outcomes of patients with nutcracker syndrome (NCS) who were treated with three-dimensional printing (3DP) extravascular titanium stents (E...Background: This study was designed to evaluate the clinical and radiographic outcomes of patients with nutcracker syndrome (NCS) who were treated with three-dimensional printing (3DP) extravascular titanium stents (EVTSs). The 3DP EVTS was expected to release the hypertension of the left renal vein (LRV) produced by its compression between the superior mesenteric artery (SMA) and the aorta without causing any complications. Method: The pre-operative kidney model of each patient was printed out to enable surgical planning. After that, the EVTS was designed based on the LRV’s primitive physiologic structure using computer-aided design software, and each stent was printed out with a precision setting of 20 μm. Seventeen patients who had been suffering from NCS underwent laparoscopic 3DP EVTS placement. The surgical procedure was designed for the placement of EVTS, taking great care in positioning and fixing the stent. Surgical data, which included patient demographic characteristics as well as pre- and post-operative test results, were collected and analyzed. Results: The mean duration of surgery was 75 ± 9 min, and the mean blood loss was 20 ± 5 mL. Computed tomography examinations revealed that the pre- and post-operative angle between the SMA and the aorta ranged from 18.7°± 4.3° to 48.0°± 8.8°(P < 0.05);in patients with left varicocele, the mean diameter of the left spermatic vein ranged from 3.7 ± 0.5 to 1.3 ± 0.2 mm (P < 0.05). Moreover, Doppler ultrasound examinations showed that the peak velocity of blood flow at the hilar area ranged from 12.4 ± 3.3 to 18.5 ± 3.4 cm/s (P < 0.05). No side effects were observed in the 24 to 42 months following surgery. Conclusion: The findings after 2 years of follow-up suggest that the 3DP EVTS is a safe and effective minimally invasive alternative for the treatment of NCS.展开更多
Background Assessment of the left ventricular (LV) and the right ventricular (RV) volumes and their functions is important for prognostic prediction and clinical decision making. We compared the accuracy for quantify...Background Assessment of the left ventricular (LV) and the right ventricular (RV) volumes and their functions is important for prognostic prediction and clinical decision making. We compared the accuracy for quantifying the LV and the RV volumes in vitro between conventional two-dimensional echocardiography (2DE) and real-time three-dimensional echocardiography (RT3DE) Methods The volumes of 37 rubber-models (10 regularly shaped to simulate normal LV, 7 shaped to simulate LV with symmetric aneurysm, 8 shaped to simulate LV with asymmetric aneurysm, and 12 irregularly shaped to simulate normal RV) and 10 excised canine hearts were measured by RT3DE and 2DE On RT3DE 'full volume' imaging, the inner-surfaces of the rubber-models and canine LV and RV were outlined and the volumes were measured using 2-, 4-, 8- and 16-plane methods with the RT3DE analysis software On 2DE imaging, the volumes were measured by the Simpson method The LV and RV volumes measured by drained water were served as reference values, with which we compared RT3DE and 2DE data Results In rubber models mimicking normal LV and LV with symmetric aneurysms, RT3DE results were strongly correlated with reference values ( r =0 795-0 998) and there was a good correlation between 2DE estimates and reference values ( r =0 715-0 729) There were no significant differences between RT3DE estimates, 2DE results and reference values ( P >0 05) In rubber models mimicking the RV and LV with asymmetric aneurysm, RT3DE strongly correlated with reference values ( r =0 765-0 988), but 2DE weakly correlated with reference values ( r =0 518-0 592) There were no differences between RT3DE and reference values ( P >0 05), but a significant difference between 2DE and reference values occurred ( P <0 05) For excised canine hearts, there was a strong correlation between RT3DE and reference values ( r =0 728-0 914), while 2DE showed a less obvious correlation ( r =0 502-0 615) Again, there were no significant differences between RT3DE and reference values ( P >0 05), but there was a significant difference between 2DE and reference values ( P <0 05) Conclusions RT3DE can accurately quantify LV and RV volumes and provides a new tool to evaluate LV and RV function For LV and RV measurements by RT3DE, 8-plane strategy is the optimum choice for accuracy and convenience展开更多
In the past decade, researchers in the fields of energy production have concentrated on the improvement of new energy storage devices. Lithium-ion batteries(LIBs) and faradaic supercapacitors(FSs) have attracted speci...In the past decade, researchers in the fields of energy production have concentrated on the improvement of new energy storage devices. Lithium-ion batteries(LIBs) and faradaic supercapacitors(FSs) have attracted special attention as a result of the rapid development of new electrode nanomaterials, especially hybrid nanomaterials, which can meet the increasingly higher requirements for future energy, such as the capability to deliver high-power performance and an extremely long life cycle. In these hybrid nanostructures, a series of synergistic effects and unique properties arising from the combination of individual components are a major factor leading to improved charge/discharge capability, energy density, and system lifetime. This paper describes the most recent progress in the growth of hybrid electrode materials for LIBs and FSs systems, focusing on the combination of zero-dimensional(0 D), one-dimensional(1 D), two-dimensional(2 D), and three-dimensional(3 D) nanomaterials, respectively.展开更多
Objective: To explore the clinical diagnostic value of transperineal volume ultrasound combined with two-dimensional high-frequency ultrasound for anal fistula. Methods: A total of 52 patients with anal fistula admitt...Objective: To explore the clinical diagnostic value of transperineal volume ultrasound combined with two-dimensional high-frequency ultrasound for anal fistula. Methods: A total of 52 patients with anal fistula admitted to the Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine from December 2017 to July 2018 were selected. They were all undergoing transperineal 3D volume ultrasound combined with 2D high-frequency ultrasound examination, and the diagnosis results were analyzed. The results of ultrasonography and surgical pathology were compared. Results: Among 52 patients, 3D volume ultrasound combined with 2D high-frequency ultrasound were used to diagnose 32 cases of anal fistula intersphincteric type, 14 cases of transsphincter type, 5 cases of supra-sphincter type, and 1 case of extra-sphincter type. T supervisor classification accuracy rate is 90%. The detection rate of branch pipes was 92%, and the compliance rate of internal fistula was 95%. Two-dimensional high-frequency ultrasound was used to diagnose 34 cases of anal fistula intersphincteric type, 14 cases of transsphincter type, 4 cases of supra-sphincter type, and 0 cases of extra-sphincter type. The detection rate of branch canals was 42%, and the accuracy of type classification was 90%. The coincidence rate was 95%. There was a statistically significant difference in the detection rate of the anal fistula branch and the coincidence rate of the internal fistula between the two methods (both P Conclusion: 1) The overall coincidence rate of three-dimensional volumetric ultrasound combined with two-dimensional high-frequency ultrasound in the diagnosis of anal fistula is high;2) Three-dimensional volumetric ultrasound technology has great application prospects in infants and anal fistulas.展开更多
We proposed a three-dimensional (3D) image authentication method using binarized phase images in double random phase integral imaging (Ini). Two-dimensional (2D) element images obtained from Ini are encoded using a do...We proposed a three-dimensional (3D) image authentication method using binarized phase images in double random phase integral imaging (Ini). Two-dimensional (2D) element images obtained from Ini are encoded using a double random phase encryption (DRPE) algorithm. Only part of the phase information is used in the proposed method rather than using all of the amplitude and phase information, which can make the final data sparse and beneficial to data compression, storage, and transmission. Experimental results verified the method and successfully proved the developed 3D authentication process using a nonlinear cross correlation method.展开更多
Based on two- and three-dimensional potential flow theories, the width effects on the hydrodynamics of a bottom-hinged trapezoidal pendulum wave energy converter are discussed. The two-dimensional eigenfunction expans...Based on two- and three-dimensional potential flow theories, the width effects on the hydrodynamics of a bottom-hinged trapezoidal pendulum wave energy converter are discussed. The two-dimensional eigenfunction expansion method is used to obtain the diffraction and radiation solutions when the converter width tends to be infinity. The trapezoidal section of the converter is approximated by a rectangular section for simplification. The nonlinear viscous damping effects are accounted for by including a drag term in the two- and three-dimensional methods. It is found that the three- dimensional results are in good agreement with the two-dimensional results when the converter width becomes larger, especially when the converter width is infinity, which shows that both of the methods are reasonable. Meantime, it is also found that the peak value of the conversion efficiency decreases as the converter width increases in short wave periods while increases when the converter width increases in long wave periods.展开更多
An orthogonal 2D training image is constructed from the geological analysis results of well logs and sedimentary facies;the 2 D probabilities in three directions are obtained through linear pooling method and then agg...An orthogonal 2D training image is constructed from the geological analysis results of well logs and sedimentary facies;the 2 D probabilities in three directions are obtained through linear pooling method and then aggregated by the logarithmic linear pooling to determine the 3 D multi-point pattern probabilities at the unknown points,to realize the reconstruction of a 3 D model from 2D cross-section.To solve the problems of reducing pattern variability in the 2 D training image and increasing sampling uncertainty,an adaptive spatial sampling method is introduced,and an iterative simulation strategy is adopted,in which sample points from the region with higher reliability of the previous simulation results are extracted to be additional condition points in the following simulation to improve the pattern probability sampling stability.The comparison of lateral accretion layer conceptual models shows that the reconstructing algorithm using self-adaptive spatial sampling can improve the accuracy of pattern sampling and rationality of spatial structure characteristics,and accurately reflect the morphology and distribution pattern of the lateral accretion layer.Application of the method in reconstructing the meandering river reservoir of the Cretaceous McMurray Formation in Canada shows that the new method can accurately reproduce the shape,spatial distribution pattern and development features of complex lateral accretion layers in the meandering river reservoir under tide effect.The test by sparse wells shows that the simulation accuracy is above 85%,and the coincidence rate of interpretation and prediction results of newly drilled horizontal wells is up to 80%.展开更多
Vertical three-dimensional(3D)integration is a highly attractive strategy to integrate a large number of transistor devices per unit area.This approach has emerged to accommodate the higher demand of data processing c...Vertical three-dimensional(3D)integration is a highly attractive strategy to integrate a large number of transistor devices per unit area.This approach has emerged to accommodate the higher demand of data processing capability and to circumvent the scaling limitation.A huge number of research efforts have been attempted to demonstrate vertically stacked electronics in the last two decades.In this review,we revisit materials and devices for the vertically integrated electronics with an emphasis on the emerging semiconductor materials that can be processable by bottom-up fabrication methods,which are suitable for future flexible and wearable electronics.The vertically stacked integrated circuits are reviewed based on the semiconductor materials:organic semiconductors,carbon nanotubes,metal oxide semiconductors,and atomically thin two-dimensional materials including transi-tion metal dichalcogenides.The features,device performance,and fabrication methods for 3D integration of the transistor based on each semiconductor are discussed.Moreover,we highlight recent advances that can be important milestones in the vertically integrated elec-tronics including advanced integrated circuits,sensors,and display systems.There are remaining challenges to overcome;however,we believe that the vertical 3D integration based on emerging semiconductor materials and devices can be a promising strategy for future electronics.展开更多
The manufacturing of three-dimensional textile preforms used for composites started to re-ceive much attention in the last decade.The major barriers to accelerating the transition from thelamination of two-dimensional...The manufacturing of three-dimensional textile preforms used for composites started to re-ceive much attention in the last decade.The major barriers to accelerating the transition from thelamination of two-dimensional fabrics to manufacturing integral three-dimensional near-netshaped textile preforms are high cost and database deficiency.To reduce the cost of weaving three-dimensional preforms,and make full use of the potential of conventional looms,a rig was designedwhich can convert two-dimensional woven fabric to particular three-dimensional preforms wherethe yarn is orientated in the directions of maximum stress.展开更多
In this review we will focus on recent progress in the field of two-dimensional(2D) and three-dimensional(3D)display technologies.We present the current display materials and their applications,including organic l...In this review we will focus on recent progress in the field of two-dimensional(2D) and three-dimensional(3D)display technologies.We present the current display materials and their applications,including organic light-emitting diodes(OLEDs),flexible OLEDs quantum dot light emitting diodes(QLEDs),active-matrix organic light emitting diodes(AMOLEDs),electronic paper(E-paper),curved displays,stereoscopic 3D displays,volumetric 3D displays,light field3 D displays,and holographic 3D displays.Conventional 2D display devices,such as liquid crystal devices(LCDs) often result in ambiguity in high-dimensional data images because of lacking true depth information.This review thus provides a detailed description of 3D display technologies.展开更多
Background Tuberous sclerosis complex(TSC)is an autosomal dominant genetic disorder with a birth incidence of I:6000 in the United States that is characterized by the growth of non-cancerous tumors in multiple organ s...Background Tuberous sclerosis complex(TSC)is an autosomal dominant genetic disorder with a birth incidence of I:6000 in the United States that is characterized by the growth of non-cancerous tumors in multiple organ systems including the brain,kidneys,lungs,and skin.Importantly,TSCis also associated with signicant neurological manifestations including epilepsy TSC-associated neuropsychiatric disorders,intellectual disabilities,and autism spectrum disorder.Mutations in the TSCI or TSC2 genes are well-established causes of TSC,which lead to TSC1/TSC2 deficiency in organs and hyper-activation of the mammalian target of rapamycin signaling pathway.Animal models have been widely used to study the effect of TSCl/2 genes on the development and function of the brain.Despite considerable progress in understanding the molecular mechanisms underlying TSC in animal models,a human-specific model is urgently needed to investigate the effects of TSCl/2 mutations that are unique to human neurodevelopment.Data sources Literature reviews and research articles were published in PubMed-indexed journals.Results Human-induced pluripotent stem cells(iPSCs),which capture risk alleles that are identical to their donors and have the capacity to differentiate into virtually any cell type in the human body,pave the way for the empirical study of previously inaccessible biological systems such as the developing human brain.Conclusions In this review,we present an overview of the recent progress in modeling TSC with human iPSC models,the existing limitations,and potential directions for future research.展开更多
In the last decade,two-dimensional layered materials(2DLMs)have been drawing extensive attentions due to their unique properties,such as absence of surface dangling bonds,thickness-dependent bandgap,high absorption co...In the last decade,two-dimensional layered materials(2DLMs)have been drawing extensive attentions due to their unique properties,such as absence of surface dangling bonds,thickness-dependent bandgap,high absorption coeffi-cient,large specific surface area,and so on.But the high-quality growth and transfer of wafer-scale 2DLMs films is still a great challenge for the commerciali-zation of pure 2DLMs-based photodetectors.Conversely,the material growth and device fabrication technologies of three-dimensional(3D)semiconductors photodetectors tend to be gradually matured.However,the further improvement of the photodetection performance is limited by the difficult heterogeneous inte-gration or the inferior crystal quality via heteroepitaxy.Fortunately,2D/3D van der Waals heterostructures(vdWH)combine the advantages of the two types of materials simultaneously,which may provide a new platform for developing high-performance optoelectronic devices.Here,we first discuss the unique advantages of 2D/3D vdWH for the future development of photodetection field and simply introduce the structure categories,working mechanisms,and the typical fabrication methods of 2D/3D vdWH photodetector.Then,we outline the recent progress on 2D/3D vdWH-based photodetection devices integrating 2DLMs with the traditional 3D semiconductor materials,including Si,Ge,GaAs,AlGaN,SiC,and so on.Finally,we highlight the current challenges and pros-pects of heterointegrating 2DLMs with traditional 3D semiconductors toward photodetection applications.展开更多
Tin-lead(Sn-Pb)alloyed perovskites with tunable bandgaps hold great potential for constructing highly efficient single-junction and tandem photovoltaic devices.However,the efficiency and stability of Sn-Pb perovskite ...Tin-lead(Sn-Pb)alloyed perovskites with tunable bandgaps hold great potential for constructing highly efficient single-junction and tandem photovoltaic devices.However,the efficiency and stability of Sn-Pb perovskite solar cells(PSCs)are greatly hampered by severe nonradiative recombination due to the easy oxidation of Sn(II).In this work,we report the construction of mixed dimensional two-dimensional(2D)Dion–Jacobson(DJ)and three-dimensional(3D)perovskites to improve the efficiency and stability of Sn-Pb alloyed PSCs.Introducing a small amount of 1,4-butanediammonium diiodide as spacer cations of DJ perovskites into precursor,the prepared mixed dimensional Sn-Pb alloyed perovskites exhibit reduced trap-state density due to the passivation of 2D DJ perovskites.As a result,nonradiative charge recombination is greatly suppressed.The prepared Sn-Pb alloyed PSCs based on 2D-DJ/3D heterojunction deliver a power conversion efficiency of 19.02%with an impressive fill factor of 80%.As well,improved device stability is realized due to the presence of DJ perovskites which serves as a protection barrier against oxidation and water invasion.展开更多
Assembling two-dimensional(2D)sheets into macroscopic three-dimensional(3D)forms has created a promising material family with rich functionalities.Multiscale wrinkles are intrinsic features of 2D sheets in their 3D as...Assembling two-dimensional(2D)sheets into macroscopic three-dimensional(3D)forms has created a promising material family with rich functionalities.Multiscale wrinkles are intrinsic features of 2D sheets in their 3D assembles.Therefore,the precise wrinkling modulation optimizes the transition of outstanding properties of 2D sheets to expected performances of assembled materials and dominates their fabrication process.The wrinkling evolution of 2D sheets assembling onto flat surfaces has been extensively understood,however,the wrinkling behaviors on the more generally curved surface still remain unclear.Here,we investigate the wrinkling behaviors of graphene oxide sheets assembled onto curved surfaces and reveal the selection rule of wrinkling modes that determined by the curvature mismatch between 2D sheets and target surfaces.We uncover that three wrinkling modes including isotropic cracked land,labyrinth,and anisotropic curtain phases,respectively emerge on flat,spherical,and cylindrical surfaces.A favorable description paradigm is offered to quantitatively measure the complex wrinkling patterns and assess the curvature mismatch constraint underlying the wrinkling mode selection.This research provides a general and quantitative description framework of wrinkling modulation of 2D materials such as high performance graphene fibers,and guides the precise fabrication of particles and functional coatings.展开更多
文摘BACKGROUND Laparoscopic gastrectomy for esophagogastric junction(EGJ)carcinoma enables the removal of the carcinoma at the junction between the stomach and esophagus while preserving the gastric function,thereby providing patients with better treatment outcomes and quality of life.Nonetheless,this surgical technique also presents some challenges and limitations.Therefore,three-dimensional reconstruction visualization technology(3D RVT)has been introduced into the procedure,providing doctors with more comprehensive and intuitive anatomical information that helps with surgical planning,navigation,and outcome evaluation.AIM To discuss the application and advantages of 3D RVT in precise laparoscopic resection of EGJ carcinomas.METHODS Data were obtained from the electronic or paper-based medical records at The First Affiliated Hospital of Hebei North University from January 2020 to June 2022.A total of 120 patients diagnosed with EGJ carcinoma were included in the study.Of these,68 underwent laparoscopic resection after computed tomography(CT)-enhanced scanning and were categorized into the 2D group,whereas 52 underwent laparoscopic resection after CT-enhanced scanning and 3D RVT and were categorized into the 3D group.This study had two outcome measures:the deviation between tumor-related factors(such as maximum tumor diameter and infiltration length)in 3D RVT and clinical reality,and surgical outcome indicators(such as operative time,intraoperative blood loss,number of lymph node dissections,R0 resection rate,postoperative hospital stay,postoperative gas discharge time,drainage tube removal time,and related complications)between the 2D and 3D groups.RESULTS Among patients included in the 3D group,27 had a maximum tumor diameter of less than 3 cm,whereas 25 had a diameter of 3 cm or more.In actual surgical observations,24 had a diameter of less than 3 cm,whereas 28 had a diameter of 3 cm or more.The findings were consistent between the two methods(χ^(2)=0.346,P=0.556),with a kappa consistency coefficient of 0.808.With respect to infiltration length,in the 3D group,23 patients had a length of less than 5 cm,whereas 29 had a length of 5 cm or more.In actual surgical observations,20 cases had a length of less than 5 cm,whereas 32 had a length of 5 cm or more.The findings were consistent between the two methods(χ^(2)=0.357,P=0.550),with a kappa consistency coefficient of 0.486.Pearson correlation analysis showed that the maximum tumor diameter and infiltration length measured using 3D RVT were positively correlated with clinical observations during surgery(r=0.814 and 0.490,both P<0.05).The 3D group had a shorter operative time(157.02±8.38 vs 183.16±23.87),less intraoperative blood loss(83.65±14.22 vs 110.94±22.05),and higher number of lymph node dissections(28.98±2.82 vs 23.56±2.77)and R0 resection rate(80.77%vs 61.64%)than the 2D group.Furthermore,the 3D group had shorter hospital stay[8(8,9)vs 13(14,16)],time to gas passage[3(3,4)vs 4(5,5)],and drainage tube removal time[4(4,5)vs 6(6,7)]than the 2D group.The complication rate was lower in the 3D group(11.54%)than in the 2D group(26.47%)(χ^(2)=4.106,P<0.05).CONCLUSION Using 3D RVT,doctors can gain a more comprehensive and intuitive understanding of the anatomy and related lesions of EGJ carcinomas,thus enabling more accurate surgical planning.
基金Shaanxi key research and development plan(No.2019SF-211).
文摘Objective:To investigate the value of two-dimensional ultrasound speckle tracking(2D-STI)and three-dimensional ultrasound speckle tracking(3D-STI)in evaluating myocardial function in children with Kawasaki disease.Methods 92 children with Kawasaki disease admitted to our hospital from February 2017 to February 2019 were retrospectively analyzed.50 children who underwent 3D-STI examination were taken as observation group and 42 children who underwent 2D-STI examination were taken as control group.The left ventricular systolic function index,storage time and analysis time of the image,the diameter of coronary artery,the strain difference of left ventricular basal segment,middle segment,apical segment and whole segment were observed.Results The levels of left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV),left ventricular myocardial mass(LVMI)in the observation group were higher than those in the control group(P<0.05),but there was no statistical difference in left ventricular ejection fraction(LVEF)between the two groups(P>0.05).The storage time and analysis time of the image in the observation group were significantly lower than those in the control group(P<0.05).The left coronary artery(LCA)and right coronary artery(RCA)in the observation group were higher than those in the control group(P<0.05).There was no statistical difference between left anterior descending(LAD)in the two groups(P>0.05).The longitudinal peak systolic strain(LS),circumferential peak systolic strain(CS)and radial peak systolic strain(RS)in the observation group were higher than those in the control group(P<0.05).The global longitudinal peak strain(GLS),global circumferential peak strain(GCS)and global radial peak strain(GRS)in the observation group were higher than those in the control group(P<0.05).LS and CS in the middle segment of the observation group were higher than those in the control group(P<0.05).Conclusions Compared with 2D-STI,3D-STI can objectively and accurately reflect the myocardial function of children with Kawasaki disease.
文摘Objective To investigate the feasibility and clinical efficacy of total three-dimensional laparoscopic pancreatoduodenectomy. Methods The clinical data of 28 patients who underwent total three-dimensional laparoscopic pancreatoduodenectomy at the Second Hospital of Hebei Medical University from August 2015 to May 2016 were retrospectively analyzed. The surgical indications and method of performing total threedimensional laparoscopic pancreatoduodenectomy were similar to those of the patients who underwent two-dimensional laparoscopic pancreatoduodenectomy. All of the patients were followed up via outpatient reviews and telephone interviews through September 2016. Results In all 28 cases, total three-dimensional laparoscopic pancreatoduodenectomy was successfully performed with no conversion to laparotomy, intraoperative complications, or perioperative death. The mean operative time was 406 min(200–520 min) with a mean blood loss of 528 m L(200–1500 m L), a mean number of dissected lymph nodes of 11(6–16), a mean postoperative anus exhaust time of 4.4 d(2–8 d), and a mean length of stay of 16.9 d(9–23 d). There was a postoperative pancreatic fistula in 4 out of the 28 cases, with 3 cases of grade A and 1 case of grade B. Postoperatively, one patient with early-stage intra-abdominal hemorrhage improved after conservative symptomatic treatment, and two patients with gastroplegia were cured with conservative treatment. No complications occurred in the other patients. All of the cases underwent R0 resection with a negative surgical margin. All of the 28 patients were followed up for 6 to 12 months, with a median follow-up period of 9.2 months. During the follow-up period, there were no postoperative complications related to the procedures and no deaths; tumor recurrence was identified 9 months after the procedure using positron emission computed tomography(PECT) in one patient with pancreatic ductal adenocarcinoma.Conclusion Total three-dimensional laparoscopic pancreatoduodenectomy is safe and feasible for the treatment of periampullary carcinoma, with the advantage of favorable short-term outcomes.
基金the Medical Program of Scientific & Technical Foundation in Xiamen in 2008, No. 3502Z20084028
文摘The optimal velocity encoding of phase-contrast magnetic resonance angiography (PC MRA) in measuring cerebral blood flow volume (BFV) ranges from 60 to 80 cm/s. To verify the accuracy of two-dimensional (2D) PC MRA, the present study localized the region of interest at blood vessels of the neck using PC MRA based on three-dimensional time-of-flight sequences, and the velocity encoding was set to 80 cm/s. Results of the measurements showed that the error rate was 7.0±6.0% in the estimation of BFV in the internal carotid artery, the external carotid artery and the ipsilateral common carotid artery. There was no significant difference, and a significant correlation in BFV between internal carotid artery + external carotid artery and ipsilateral common carotid artery. In addition, the BFV of the common carotid artery was correlated with that of the ipsilateral internal carotid artery. The main error was attributed to the external carotid artery and its branches. Therefore, after selecting the appropriate scanning parameters and protocols, 2D PC MRA is more accurate in the determination of BFV in the carotid arteries.
文摘BACKGROUND The benefits of laparoscopic approach for right colectomy have been well established.However,the technical difficulty to construct the intra-corporeal anastomosis is still cumbersome.AIM To analyze the results of 3D and 2D laparoscopic right colectomy and to compare it to the published series through a systematic review and meta-analysis.METHODS A retrospective study with propensity score matching analysis of patients undergoing laparoscopic right colectomy at Umbria2 Hospitals from January 2014 to March 2020 was performed.A systematic review was accomplished comparing 2D and 3D right colectomy.RESULTS In the personal series 47 patients of the 2D group were matched to 47 patients of the 3D group.The 3D group showed a favorable trend in terms of mean operative time(170.7±32.9 min vs 183.8±35.4 min;P=0.053)and a significant lower anastomotic time(16.9±2.3 min vs 19.6±2.9 min,P<0.001).The complete mesocolic excision(CME)subgroups analysis showed a shorter anastomotic time(16.5±1.8 min vs 19.9±3.0 min;P<0.001)and operative time(175.0±38.5 min vs 193.7±37.1 min;P=0.063)in the 3D group.Six studies and our series were included in the meta-analysis with 551 patients(2D group:291;3D group:260).The pooled analysis demonstrated a significant difference in favour of the 3D group regarding the operative time(P<0.001)and the anastomotic time(P<0.001)while no differences were identified between groups in terms of blood loss(P=0.827),LNH yield(P=0.243),time to first flatus(P=0.333),postoperative complications(P=0.718)and length of stay(P=0.835).CONCLUSION The meta-analysis results showed that 3D laparoscopic right colectomy shortens operative and anastomotic time without affecting the standard lymphadenectomy.In our series,the advantage of the 3D system becomes evident when CME and/or more complex associated procedure are requested significantly reducing both the total operative and the anastomotic time.
基金supported by National Natural Science Foundation of China (Nos. 22036001, 22106130 and 91843301)Research Grant Council (Nos. 463612 and 14104314) of Hong Kong。
文摘Previous studies demonstrated that three-dimensional(3D) multicellular tumor spheroids(MCTS) could more closely mimic solid tumors than two-dimensional(2D) cancer cells in terms of the spatial structure, extracellular matrix-cell interaction, and gene expression pattern. However, no study has been reported on the differences in lipid metabolism and distribution among 2D cancer cells, MCTS, and solid tumors. Here, we used Hep G2 liver cancer cell lines to establish these three cancer models. The variations of lipid profiles and spatial distribution among them were explored by using mass spectrometry-based lipidomics and matrix-assisted laser desorption/ionization mass spectrometry imaging(MSI). The results revealed that MCTS, relative to 2D cells, had more shared lipid species with solid tumors. Furthermore,MCTS contained more comparable characteristics than 2D cells to solid tumors with respect to the relative abundance of most lipid classes and mass spectra patterns. MSI data showed that 46 of 71 lipids had similar spatial distribution between solid tumors and MCTS, while lipids in 2D cells had no specific spatial distribution. Interestingly, most of detected lipid species in sphingolipids and glycerolipids preferred locating in the necrotic region to the proliferative region of solid tumors and MCTS. Taken together, our study provides the evidence of lipid metabolism and distribution demonstrating that MCTS are a more suitable in vitro model to mimic solid tumors, which may offer insights into tumor metabolism and microenvironment.
文摘Background: This study was designed to evaluate the clinical and radiographic outcomes of patients with nutcracker syndrome (NCS) who were treated with three-dimensional printing (3DP) extravascular titanium stents (EVTSs). The 3DP EVTS was expected to release the hypertension of the left renal vein (LRV) produced by its compression between the superior mesenteric artery (SMA) and the aorta without causing any complications. Method: The pre-operative kidney model of each patient was printed out to enable surgical planning. After that, the EVTS was designed based on the LRV’s primitive physiologic structure using computer-aided design software, and each stent was printed out with a precision setting of 20 μm. Seventeen patients who had been suffering from NCS underwent laparoscopic 3DP EVTS placement. The surgical procedure was designed for the placement of EVTS, taking great care in positioning and fixing the stent. Surgical data, which included patient demographic characteristics as well as pre- and post-operative test results, were collected and analyzed. Results: The mean duration of surgery was 75 ± 9 min, and the mean blood loss was 20 ± 5 mL. Computed tomography examinations revealed that the pre- and post-operative angle between the SMA and the aorta ranged from 18.7°± 4.3° to 48.0°± 8.8°(P < 0.05);in patients with left varicocele, the mean diameter of the left spermatic vein ranged from 3.7 ± 0.5 to 1.3 ± 0.2 mm (P < 0.05). Moreover, Doppler ultrasound examinations showed that the peak velocity of blood flow at the hilar area ranged from 12.4 ± 3.3 to 18.5 ± 3.4 cm/s (P < 0.05). No side effects were observed in the 24 to 42 months following surgery. Conclusion: The findings after 2 years of follow-up suggest that the 3DP EVTS is a safe and effective minimally invasive alternative for the treatment of NCS.
文摘Background Assessment of the left ventricular (LV) and the right ventricular (RV) volumes and their functions is important for prognostic prediction and clinical decision making. We compared the accuracy for quantifying the LV and the RV volumes in vitro between conventional two-dimensional echocardiography (2DE) and real-time three-dimensional echocardiography (RT3DE) Methods The volumes of 37 rubber-models (10 regularly shaped to simulate normal LV, 7 shaped to simulate LV with symmetric aneurysm, 8 shaped to simulate LV with asymmetric aneurysm, and 12 irregularly shaped to simulate normal RV) and 10 excised canine hearts were measured by RT3DE and 2DE On RT3DE 'full volume' imaging, the inner-surfaces of the rubber-models and canine LV and RV were outlined and the volumes were measured using 2-, 4-, 8- and 16-plane methods with the RT3DE analysis software On 2DE imaging, the volumes were measured by the Simpson method The LV and RV volumes measured by drained water were served as reference values, with which we compared RT3DE and 2DE data Results In rubber models mimicking normal LV and LV with symmetric aneurysms, RT3DE results were strongly correlated with reference values ( r =0 795-0 998) and there was a good correlation between 2DE estimates and reference values ( r =0 715-0 729) There were no significant differences between RT3DE estimates, 2DE results and reference values ( P >0 05) In rubber models mimicking the RV and LV with asymmetric aneurysm, RT3DE strongly correlated with reference values ( r =0 765-0 988), but 2DE weakly correlated with reference values ( r =0 518-0 592) There were no differences between RT3DE and reference values ( P >0 05), but a significant difference between 2DE and reference values occurred ( P <0 05) For excised canine hearts, there was a strong correlation between RT3DE and reference values ( r =0 728-0 914), while 2DE showed a less obvious correlation ( r =0 502-0 615) Again, there were no significant differences between RT3DE and reference values ( P >0 05), but there was a significant difference between 2DE and reference values ( P <0 05) Conclusions RT3DE can accurately quantify LV and RV volumes and provides a new tool to evaluate LV and RV function For LV and RV measurements by RT3DE, 8-plane strategy is the optimum choice for accuracy and convenience
基金supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education(NRF-2017R1D1A1A09000642)by a grant from the R&D Program of the Korea Railroad Research Institute (KRRI), Republic of Korea
文摘In the past decade, researchers in the fields of energy production have concentrated on the improvement of new energy storage devices. Lithium-ion batteries(LIBs) and faradaic supercapacitors(FSs) have attracted special attention as a result of the rapid development of new electrode nanomaterials, especially hybrid nanomaterials, which can meet the increasingly higher requirements for future energy, such as the capability to deliver high-power performance and an extremely long life cycle. In these hybrid nanostructures, a series of synergistic effects and unique properties arising from the combination of individual components are a major factor leading to improved charge/discharge capability, energy density, and system lifetime. This paper describes the most recent progress in the growth of hybrid electrode materials for LIBs and FSs systems, focusing on the combination of zero-dimensional(0 D), one-dimensional(1 D), two-dimensional(2 D), and three-dimensional(3 D) nanomaterials, respectively.
文摘Objective: To explore the clinical diagnostic value of transperineal volume ultrasound combined with two-dimensional high-frequency ultrasound for anal fistula. Methods: A total of 52 patients with anal fistula admitted to the Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine from December 2017 to July 2018 were selected. They were all undergoing transperineal 3D volume ultrasound combined with 2D high-frequency ultrasound examination, and the diagnosis results were analyzed. The results of ultrasonography and surgical pathology were compared. Results: Among 52 patients, 3D volume ultrasound combined with 2D high-frequency ultrasound were used to diagnose 32 cases of anal fistula intersphincteric type, 14 cases of transsphincter type, 5 cases of supra-sphincter type, and 1 case of extra-sphincter type. T supervisor classification accuracy rate is 90%. The detection rate of branch pipes was 92%, and the compliance rate of internal fistula was 95%. Two-dimensional high-frequency ultrasound was used to diagnose 34 cases of anal fistula intersphincteric type, 14 cases of transsphincter type, 4 cases of supra-sphincter type, and 0 cases of extra-sphincter type. The detection rate of branch canals was 42%, and the accuracy of type classification was 90%. The coincidence rate was 95%. There was a statistically significant difference in the detection rate of the anal fistula branch and the coincidence rate of the internal fistula between the two methods (both P Conclusion: 1) The overall coincidence rate of three-dimensional volumetric ultrasound combined with two-dimensional high-frequency ultrasound in the diagnosis of anal fistula is high;2) Three-dimensional volumetric ultrasound technology has great application prospects in infants and anal fistulas.
基金supported by the National Key Research and Development Program of China(No.2018YFB1005002)the National Natural Science Foundation of China(No.61727808)the National Research Foundation of Singapore(No.NRF-CRP11-2012-01)
文摘We proposed a three-dimensional (3D) image authentication method using binarized phase images in double random phase integral imaging (Ini). Two-dimensional (2D) element images obtained from Ini are encoded using a double random phase encryption (DRPE) algorithm. Only part of the phase information is used in the proposed method rather than using all of the amplitude and phase information, which can make the final data sparse and beneficial to data compression, storage, and transmission. Experimental results verified the method and successfully proved the developed 3D authentication process using a nonlinear cross correlation method.
基金supported by the Special Fund for Marine Renewable Energy of the Ministry of Finance of China(No.GD2010ZC02)
文摘Based on two- and three-dimensional potential flow theories, the width effects on the hydrodynamics of a bottom-hinged trapezoidal pendulum wave energy converter are discussed. The two-dimensional eigenfunction expansion method is used to obtain the diffraction and radiation solutions when the converter width tends to be infinity. The trapezoidal section of the converter is approximated by a rectangular section for simplification. The nonlinear viscous damping effects are accounted for by including a drag term in the two- and three-dimensional methods. It is found that the three- dimensional results are in good agreement with the two-dimensional results when the converter width becomes larger, especially when the converter width is infinity, which shows that both of the methods are reasonable. Meantime, it is also found that the peak value of the conversion efficiency decreases as the converter width increases in short wave periods while increases when the converter width increases in long wave periods.
基金Supported by the China National Science and Technology Major Project(2017ZX05005-004-002,2016ZX05031-002-001)National Natural Science Foundation of China(41872138)Open Foundation of Top Disciplines in Yangtze University(2019KFJJ0818029)。
文摘An orthogonal 2D training image is constructed from the geological analysis results of well logs and sedimentary facies;the 2 D probabilities in three directions are obtained through linear pooling method and then aggregated by the logarithmic linear pooling to determine the 3 D multi-point pattern probabilities at the unknown points,to realize the reconstruction of a 3 D model from 2D cross-section.To solve the problems of reducing pattern variability in the 2 D training image and increasing sampling uncertainty,an adaptive spatial sampling method is introduced,and an iterative simulation strategy is adopted,in which sample points from the region with higher reliability of the previous simulation results are extracted to be additional condition points in the following simulation to improve the pattern probability sampling stability.The comparison of lateral accretion layer conceptual models shows that the reconstructing algorithm using self-adaptive spatial sampling can improve the accuracy of pattern sampling and rationality of spatial structure characteristics,and accurately reflect the morphology and distribution pattern of the lateral accretion layer.Application of the method in reconstructing the meandering river reservoir of the Cretaceous McMurray Formation in Canada shows that the new method can accurately reproduce the shape,spatial distribution pattern and development features of complex lateral accretion layers in the meandering river reservoir under tide effect.The test by sparse wells shows that the simulation accuracy is above 85%,and the coincidence rate of interpretation and prediction results of newly drilled horizontal wells is up to 80%.
基金This work was supported by the National Research Foundation of Korea(NRF)grants by the Korean Government(MSIT)(NRF-2021R1A6A3A14038580,NRF-2020R1A2C1101647)This work was supported by the Technology Innovation Program(00144300,Interface Technology of 3D Stacked Heterogeneous System for SCM-based Process-in-Memory)funded by the Ministry of Trade,Industry&Energy(MOTIE,Korea).
文摘Vertical three-dimensional(3D)integration is a highly attractive strategy to integrate a large number of transistor devices per unit area.This approach has emerged to accommodate the higher demand of data processing capability and to circumvent the scaling limitation.A huge number of research efforts have been attempted to demonstrate vertically stacked electronics in the last two decades.In this review,we revisit materials and devices for the vertically integrated electronics with an emphasis on the emerging semiconductor materials that can be processable by bottom-up fabrication methods,which are suitable for future flexible and wearable electronics.The vertically stacked integrated circuits are reviewed based on the semiconductor materials:organic semiconductors,carbon nanotubes,metal oxide semiconductors,and atomically thin two-dimensional materials including transi-tion metal dichalcogenides.The features,device performance,and fabrication methods for 3D integration of the transistor based on each semiconductor are discussed.Moreover,we highlight recent advances that can be important milestones in the vertically integrated elec-tronics including advanced integrated circuits,sensors,and display systems.There are remaining challenges to overcome;however,we believe that the vertical 3D integration based on emerging semiconductor materials and devices can be a promising strategy for future electronics.
文摘The manufacturing of three-dimensional textile preforms used for composites started to re-ceive much attention in the last decade.The major barriers to accelerating the transition from thelamination of two-dimensional fabrics to manufacturing integral three-dimensional near-netshaped textile preforms are high cost and database deficiency.To reduce the cost of weaving three-dimensional preforms,and make full use of the potential of conventional looms,a rig was designedwhich can convert two-dimensional woven fabric to particular three-dimensional preforms wherethe yarn is orientated in the directions of maximum stress.
文摘In this review we will focus on recent progress in the field of two-dimensional(2D) and three-dimensional(3D)display technologies.We present the current display materials and their applications,including organic light-emitting diodes(OLEDs),flexible OLEDs quantum dot light emitting diodes(QLEDs),active-matrix organic light emitting diodes(AMOLEDs),electronic paper(E-paper),curved displays,stereoscopic 3D displays,volumetric 3D displays,light field3 D displays,and holographic 3D displays.Conventional 2D display devices,such as liquid crystal devices(LCDs) often result in ambiguity in high-dimensional data images because of lacking true depth information.This review thus provides a detailed description of 3D display technologies.
基金supported by the following funding sources:NIH grants(Nos.R01AG065611,R01MH121102,R21MH123711)Department of Defense grant(No.W81XWH1910353 to ZW).
文摘Background Tuberous sclerosis complex(TSC)is an autosomal dominant genetic disorder with a birth incidence of I:6000 in the United States that is characterized by the growth of non-cancerous tumors in multiple organ systems including the brain,kidneys,lungs,and skin.Importantly,TSCis also associated with signicant neurological manifestations including epilepsy TSC-associated neuropsychiatric disorders,intellectual disabilities,and autism spectrum disorder.Mutations in the TSCI or TSC2 genes are well-established causes of TSC,which lead to TSC1/TSC2 deficiency in organs and hyper-activation of the mammalian target of rapamycin signaling pathway.Animal models have been widely used to study the effect of TSCl/2 genes on the development and function of the brain.Despite considerable progress in understanding the molecular mechanisms underlying TSC in animal models,a human-specific model is urgently needed to investigate the effects of TSCl/2 mutations that are unique to human neurodevelopment.Data sources Literature reviews and research articles were published in PubMed-indexed journals.Results Human-induced pluripotent stem cells(iPSCs),which capture risk alleles that are identical to their donors and have the capacity to differentiate into virtually any cell type in the human body,pave the way for the empirical study of previously inaccessible biological systems such as the developing human brain.Conclusions In this review,we present an overview of the recent progress in modeling TSC with human iPSC models,the existing limitations,and potential directions for future research.
基金Funding information National Natural Science Foundation of China,Grant/Award Numbers:61974174,61904184,62174061,62174063National Key Research and Development Program of China,Grant/Award Number:2022YFB3605104+3 种基金Key Research and Development Program of Hubei Province,Grant/Award Number:2021BAA071Key Laboratory of Infrared Imaging Materials and Detectors,the Shanghai Institute of Technical Physics,the Chinese Academy of Sciences,Grant/Award Number:IIMDKFJJ-21-07Fundamental Research Funds for the Central Universities,Grant/Award Number.2020kfyXJJS124Director Fund of WNLO。
文摘In the last decade,two-dimensional layered materials(2DLMs)have been drawing extensive attentions due to their unique properties,such as absence of surface dangling bonds,thickness-dependent bandgap,high absorption coeffi-cient,large specific surface area,and so on.But the high-quality growth and transfer of wafer-scale 2DLMs films is still a great challenge for the commerciali-zation of pure 2DLMs-based photodetectors.Conversely,the material growth and device fabrication technologies of three-dimensional(3D)semiconductors photodetectors tend to be gradually matured.However,the further improvement of the photodetection performance is limited by the difficult heterogeneous inte-gration or the inferior crystal quality via heteroepitaxy.Fortunately,2D/3D van der Waals heterostructures(vdWH)combine the advantages of the two types of materials simultaneously,which may provide a new platform for developing high-performance optoelectronic devices.Here,we first discuss the unique advantages of 2D/3D vdWH for the future development of photodetection field and simply introduce the structure categories,working mechanisms,and the typical fabrication methods of 2D/3D vdWH photodetector.Then,we outline the recent progress on 2D/3D vdWH-based photodetection devices integrating 2DLMs with the traditional 3D semiconductor materials,including Si,Ge,GaAs,AlGaN,SiC,and so on.Finally,we highlight the current challenges and pros-pects of heterointegrating 2DLMs with traditional 3D semiconductors toward photodetection applications.
基金supported by the National Natural Science Foundation of China(No.62174069)Natural Science Foundation of Guangdong Province(No.2020A1515010853).
文摘Tin-lead(Sn-Pb)alloyed perovskites with tunable bandgaps hold great potential for constructing highly efficient single-junction and tandem photovoltaic devices.However,the efficiency and stability of Sn-Pb perovskite solar cells(PSCs)are greatly hampered by severe nonradiative recombination due to the easy oxidation of Sn(II).In this work,we report the construction of mixed dimensional two-dimensional(2D)Dion–Jacobson(DJ)and three-dimensional(3D)perovskites to improve the efficiency and stability of Sn-Pb alloyed PSCs.Introducing a small amount of 1,4-butanediammonium diiodide as spacer cations of DJ perovskites into precursor,the prepared mixed dimensional Sn-Pb alloyed perovskites exhibit reduced trap-state density due to the passivation of 2D DJ perovskites.As a result,nonradiative charge recombination is greatly suppressed.The prepared Sn-Pb alloyed PSCs based on 2D-DJ/3D heterojunction deliver a power conversion efficiency of 19.02%with an impressive fill factor of 80%.As well,improved device stability is realized due to the presence of DJ perovskites which serves as a protection barrier against oxidation and water invasion.
基金supported by the National Natural Science Foundation of China(Nos.52122301,51973191,52090030,and 51533008)Hundred Talents Program of Zhejiang University(No.188020*194231701/113)+2 种基金Key Research and Development Plan of Zhejiang Province(No.2018C01049)Shanxi-Zheda Institute of New Materials and Chemical Engineering(No.2012SZ-FR004)the Fundamental Research Funds for the Central Universities(Nos.K20200060,2017QNA4036,and 2017XZZX001-04).
文摘Assembling two-dimensional(2D)sheets into macroscopic three-dimensional(3D)forms has created a promising material family with rich functionalities.Multiscale wrinkles are intrinsic features of 2D sheets in their 3D assembles.Therefore,the precise wrinkling modulation optimizes the transition of outstanding properties of 2D sheets to expected performances of assembled materials and dominates their fabrication process.The wrinkling evolution of 2D sheets assembling onto flat surfaces has been extensively understood,however,the wrinkling behaviors on the more generally curved surface still remain unclear.Here,we investigate the wrinkling behaviors of graphene oxide sheets assembled onto curved surfaces and reveal the selection rule of wrinkling modes that determined by the curvature mismatch between 2D sheets and target surfaces.We uncover that three wrinkling modes including isotropic cracked land,labyrinth,and anisotropic curtain phases,respectively emerge on flat,spherical,and cylindrical surfaces.A favorable description paradigm is offered to quantitatively measure the complex wrinkling patterns and assess the curvature mismatch constraint underlying the wrinkling mode selection.This research provides a general and quantitative description framework of wrinkling modulation of 2D materials such as high performance graphene fibers,and guides the precise fabrication of particles and functional coatings.