Theory,technology and practice of shale gas three-dimensional development:A case study of Fuling shale gas field in Sichuan Basin,SW China

In the Jiaoshiba block of the Fuling shale gas field,the employed reserves and recovery factor by primary well pattern are low,no obvious barrier is found in the development layer series,and layered development is difficult.Based on the understanding of the main factors controlling shale gas enrichment and high production,the theory and technology of shale gas three-dimensional development,such as fine description and modeling of shale gas reservoir,optimization of three-dimensional development strategy,highly efficient drilling with dense well pattern,precision fracturing and real-time control,are discussed.Three-dimensional development refers to the application of optimal and fast drilling and volume fracturing technologies,depending upon the sedimentary characteristics,reservoir characteristics and sweet spot distribution of shale gas,to form"artificial gas reservoir"in a multidimensional space,so as to maximize the employed reserves,recovery factor and yield rate of shale gas development.In the research on shale gas three-dimensional development,the geological+engineering sweet spot description is fundamental,the collaborative optimization of natural fractures and artificial fractures is critical,and the improvement of speed and efficiency in drilling and fracturing engineering is the guarantee.Through the implementation of three-dimensional development,the overall recovery factor in the Jiaoshiba block has increased from 12.6%to 23.3%,providing an important support for the continuous and stable production of the Fuling shale gas field.

Development of multi-functional anchorage support dynamic-static coupling performance test system and its application

In underground engineering with complex conditions,the bolt(cable)anchorage support system is in an environment where static and dynamic stresses coexist,under the action of geological conditions such as high stresses and strong disturbances and construction conditions such as the application of high prestress.It is essential to study the support components performance under dynamic-static coupling conditions.Based on this,a multi-functional anchorage support dynamic-static coupling performance test system(MAC system)is developed,which can achieve 7 types of testing functions,including single component performance,anchored net performance,anchored rock performance and so on.The bolt and cable mechanical tests are conducted by MAC system under different prestress levels.The results showed that compared to the non-prestress condition,the impact resistance performance of prestressed bolts(cables)is significantly reduced.In the prestress range of 50–160 k N,the maximum reduction rate of impact energy resisted by different types of bolts is 53.9%–61.5%compared to non-prestress condition.In the prestress range of 150–300 k N,the impact energy resisted by high-strength cable is reduced by76.8%–84.6%compared to non-prestress condition.The MAC system achieves dynamic-static coupling performance test,which provide an effective means for the design of anchorage support system.

Efficacy Analysis of an Experience on Development of the Combination Therapy Protocol for Endometriosis Management

Purpose: Endometriosis can be managed effectively by medication, surgery, or a combination of both. Numerous studies have been conducted on surgical and medication treatment options, but their results are still under discussion. Therefore, we performed a study to develop a combinational treatment for various stages of endometriosis. Methods: Over a 3-year period, 218 documented endometriosis patients were classified in 4 stages. After first laparoscopy (with electrocoagulation and adhesion removal for stages I to III), the patients were treated with GnRH analogs (Gonadotropin Releasing Hormone Agonist-375 mg of Decapeptyl) for 3, 6 & 6 months, respectively. The second and third laparoscopy procedures were performed after 3 and 6 months, with add-back therapy. The treatment was evaluated by direct observation based on laparoscopic view and the pain relief was measured by the VAS (Visual Analogue Scale) after the first step of medication for patients of stages I-III. Results: After 3 months, 70/76 patients (91.9%) with stage-I endometriosis showed complete recovery (six cases after 6 months) while 65/72 and 32/43 cases with stage-II and -III (90.3 and 74.4%), respectively, showed complete recovery after 6 months of treatment. The remaining patients had GnRH treatment for another 3 months, and all showed a complete recovery after 9 months. Furthermore, 12 of the patients with stage-IV symptoms were candidates for laparoscopy or laparotomy, and their treatment response rate was 55.6%. The pain relief was significant after the combinational treatment in patients with stages I-III (P = 0.0001). Conclusion: Our study showed efficacy of the developed protocol for the endometriosis management.

The status and development strategy of coalbed methane industry in China

To achieve the goals of carbon peaking and carbon neutrality under the backgrounds of poor resource endowments, weak theoretical basis and other factors, the development of the coalbed methane industry of China faces many bottlenecks and challenges. This paper systematically analyzes the coalbed methane resources, key technologies and progress, exploration effect and production performance in China and abroad. The main problems are summarized as low exploration degree, low technical adaptability, low return on investment and small development scale. This study suggests that the coalbed methane industry in China should follow the “two-step”(short-term and long-term) development strategy. The short-term action before 2030, can be divided into two stages:(1) From the present to 2025, to achieve new breakthroughs in theory and technology, and accomplish the target of annual production of 10 billion cubic meters;(2) From 2025 to 2030, to form the technologies suitable for most geological conditions, further expand the industry scale, and achieve an annual output of 30 billion cubic meters, improving the proportion of coalbed methane in the total natural gas production. The long-term action after 2030 is to gradually realize an annual production of 100 billion cubic meters. The strategic countermeasure to achieve the above goals is to adhere to “technology+management dual wheel drive”, realize the synchronous progress of technology and management, and promote the high-quality development of the coalbed methane industry. Technically, the efforts will focus on fine and effective development of coalbed methane in the medium to shallow layers of mature fields, effective development of coalbed methane in new fields, extensive and beneficial development of deep coalbed methane, three-dimensional comingled development of coalbed methane, applying new technologies such as coalbed methane displacement by carbon dioxide, microwave heating and stimulation technology, ultrasonic stimulation, high-temperature heat injection stimulation, rock breaking by high-energy laser. In terms of management, the efforts will focus on coordinative innovation of resource, technology, talent, policy and investment, with technological innovation as the core, to realize an all-round and integrated management and promote the development of coalbed methane industry at a high level.

Application of Tension Leg Platform Combined with Other Systemsin the Development of China Deepwater Oil Fields

The development of deepwater oil fields has reached a new stage with the dramatic increase in water depth and the recent increasing demands of the economic development in the filed. The use of a Tension Leg Platform （TIP） combined with other systems, such as Floating Production Storage and Offloading （FPSO） system, Floating Production Unit （FPU） system, Tender Assisted Drilling （TAD） system, etc., has drawn the industry attention and increased significantly in the past few years. For the areas lacking of pipeline system, the use of TIP（s） combined with FPSO has been chosen to efficiently develop the deepwater fields. The TIP with a Tender Assisted Drilling system significantly reduces the payload of the platform and reduces the investment in the TIP system substantially. This opens the door for many new deepwater field developments to use the tension leg platform. The advantage of the TIP combined with a TAD system is more significant when several TIPs are used for the continuous development of the field. One of the applications for the TIP with a tender assisted drilling system can be in the development of an offshore marginal field. Owing to the increase of water depth, the conventional fixed platform model for the exploration of those fields becomes uneconomical. It also would be too expensive to use a large TIP structure for those marginal fields due to the large amount of initial investment. The TIP system with tender assisted drilling can be used to develop those fields economically. There are many marginal fields in China offshore, especially in shelf areas. The application of this field developing model, combined with the existing field developing experience in China, will open the door for many marginal field developments. This paper will review the application of the combined TIP system through some examples of completed/ongoing projects, and major technical issues encountered in those practices. The potential application of this technology in China deepwater development will be discussed in the end.

Development of an ultra-high-pressure rotary combined dynamic seal and experimental study on its sealing performance in deep energy mining conditions

With the continuous development of deep oil and gas,minerals,geothermal resources,and other resources,there are increasingly more stringent requirements for equipment.In particular,the ultra-highpressure dynamic seals of deep mining device need to be developed.Therefore,considering the use of dynamic seals in unique deep mining environments,an ultra-high-pressure rotating combined dynamic seal was designed and developed and its sealing performance was experimentally measured and analyzed.The results show that the experimental device can operate stably under a pressure of up to150 MPa and a rotating speed of 76 r/min,and can also operate normally under a rotating speed of up to 140 r/min and a sealing pressure of 120 MPa.During the operation of the ultra-high-pressure rotating combined dynamic seal,the sealing ring does not show obvious damage,which vouches for its sealing performance.No leakage of flow and pressure was detected in the all seal structures within the sealing pressure range of 0-150 MPa.Therefore,the dynamic sealing performance of the device is intact under ultra-high-pressure conditions and can be applied in deep mining environments at a certain depth.The research and development of this device can aid future deep energy exploration and exploitation.

Nursing Effects of Medical Treatment Combination on Patients at High Risk of Developing Pressure Ulcers at Rural Homes

Objective:To explore the nursing effects of medical treatment combination on patients at high risk of developing pressure ulcers at rural homes.Methods:From January 2018 to December 2018,86 patients at high risk of developing pressure ulcers at rural homes who were in Wenjiang Hospital were randomly divided into a control group and an observed group.The control group received the routine publicity and education and visiting,while the observed group adopted the cooperative nursing model of medical treatment combination.Then compare the healing status and nursing satisfaction of the two groups.Results:Of the 43 patients with pressure ulcers in the observed group,18 had been in the second stage of pressure ulcers and 16 had been healed;14 had been in the third stage of pressure ulcers and 8 had been healed;11 had been in the fourth stage of pressure ulcers and 5 had been healed.The nursing satisfaction of the patients in the observed group was 95.35%.Conclusion:Conducting medical treatment combination on patients at high risk of developing pressure ulcers at rural homes can effectively improve the patients’and their families’awareness of pressure ulcer nursing,standardize their nursing behaviour,help recover the patients themselves and promote the patients’satisfaction.

Developing high-efficiency base editors by combining optimized synergistic core components with new types of nuclear localization signal peptide

The clustered regularly interspaced short palindromic repeats(CRISPR)–CRISPR-associated protein(Cas) system has been widely used for genome editing. In this system, the cytosine base editor(CBE) and adenine base editor(ABE) allow generating precise and irreversible base mutations in a programmable manner and have been used in many different types of cells and organisms. However, their applications are limited by low editing efficiency at certain genomic target sites or at specific target cytosine(C) or adenine(A) residues. Using a strategy of combining optimized synergistic core components, we developed a new multiplex super-assembled ABE(sABE) in rice that showed higher base-editing efficiency than previously developed ABEs. We also designed a new type of nuclear localization signal(NLS) comprising a FLAG epitope tag with four copies of a codon-optimized NLS(F4NLS^(r2)) to generate another ABE named F4NLS-sABE. This new NLS increased editing efficiency or edited additional A at several target sites. A new multiplex super-assembled CBE(sCBE) and F4NLS^(r2) involved F4NLS-sCBE were also created using the same strategy. F4NLS-sCBE was proven to be much more efficient than sCBE in rice. These optimized base editors will serve as powerful genome-editing tools for basic research or molecular breeding in rice and will provide a reference for the development of superior editing tools for other plants or animals.

Land use suitability analysis for town development planning in Nanjing hilly areas: A case study of Tangshan new town, China

Land use suitability analysis plays an important role in sustainable land use and solving environmental problems caused by rapid urban development.A land use suitability mapping approach for town development planning in hilly areas was constructed based on two multi-criteria evaluation methods:Weighted Linear Combination(WLC)and Ordered Weighted Averaging(OWA),to comparatively evaluate and map land use suitability of Tangshan new town in Nanjing,China.Fourteen evaluation factors related to topographic,environmental,socio-economics and historical sites data were used as suitability criteria.The analytic hierarchy process(AHP)method and GIS techniques were integrated into the evaluation models to create the land use suitability map for town development planning.The results of WLC approach showed that 11.4%of the total area is highly suitable while the 48.6%is unsuitable.The results of WLC and OWA approach showed the distribution of degree of land use suitability is almost the same.The areas located at the southern and eastern flat regions are highly suitable for land use,whereas the areas close to the mountain forests,steep slopes,waters,and hot springs,have lower suitability for land use.Sensitivity analysis indicated that the suitability results of the two proposed methods are robust.Indirect validation was achieved by mutual comparison of suitability maps derived from the WLC and OWA methods.It demonstrated that the overall agreement is 90.81%and kappa coefficient is 0.81,indicating that both methods provide very similar spatial suitability distributions.By overlaying the resultant map with the previous master plan map of Tangshan new town,the overlay map once again indicated a satisfactory ecological fit between the two maps.At last,several recommendations are proposed aiming at improving the long-term town development plan for Tangshan new town.

Fault-sand combination modes and hydrocarbon accumulation in Binhai fault nose of Qikou Sag, Bohai Bay Basin, East China

Based on seismic and logging data,taking the downthrow fault nose of Binhai fault in Qikou Sag as the object of study,we analyzed fault characteristics,sand body distribution,fault-sand combinations and hydrocarbon accumulation to reveal the hydrocarbon enrichment law in the fault-rich area of fault depression lake basin.The results show that the Binhai Cenozoic fault nose is characterized by east-west zoning,the main part of the western fault segment is simple in structure,whereas the broom-shaped faults in the eastern segment are complex in structure,including several groups of faults.The difference of fault evolution controls the spatial distribution of sand bodies.The sand bodies are in continuous large pieces in the downthrow fault trough belt along the Gangdong Fault in the middle segment of the fault nose,forming consequent fault-sand combination;whereas the fault activity period of the eastern part of the fault nose was later,and the sand bodies controlled by paleogeomorphology are distributed in multi-phase north-south finger-shaped pattern,forming vertical fault-sand combination pattern matching with the fault.The configuration between faults and sand bodies,and oil sources and caprocks determine the vertical conductivity,plane distribution and vertical distribution of oil and gas.Two oil and gas accumulation modes,i.e.single main fault hydrocarbon supply-fault sand consequent matching-oil accumulation in multi-layers stereoscopically and fault system transportation-fault sand vertical matching-oil accumulation in banded overlapping layers occur in the middle and eastern segments of the fault nose respectively,and they control the difference of oil and gas distribution and enrichment degree in the Binhai fault nose.

Current Development of Hand-painted Pastel Animation Short Film

With the rapid development of audio-visual language, production of traditional hand-painted animation has failed to keep pace with the times. This paper discussed the current foreign and domestic researches on animation, and found that the researches still focused on application of technology or theories of animation arts. The study tried to integrate traditional hand painting with computer technology, produce hand-painted pastel animation, enrich the artistic forms of hand-painted pastel animation short fi lm, improve the effi ciency of handpainted pastel production, so as to form a complete artistic realization theory system of hand-painted pastel animation short fi lm, and provide a technological and theoretical support for the development of traditional hand-painted animation.

Protecting future antimalarials from the trap of resistance:Lessons from artemisinin-based combination therapy (ACT) failures

Having faced increased clinical treatment failures with dihydroartemisinin-piperaquine(DHA-PPQ),Cambodia swapped the first line artemisinin-based combination therapy(ACT)from DHA-PPQ to artesunate-mefloquine given that parasites resistant to piperaquine are susceptible to mefloquine.However,triple mutants have now emerged,suggesting that drug rotations may not be adequate to keep resistance at bay.There is,therefore,an urgent need for alternative treatment strategies to tackle resistance and prevent its spread.A proper understanding of all contributors to artemisinin resistance may help us identify novel strategies to keep artemisinins effective until new drugs become available for their replacement.This review highlights the role of the key players in artemisinin resistance,the current strategies to deal with it and suggests ways of protecting future antimalarial drugs from bowing to resistance as their predecessors did.

Combined load bearing capacity of rigid piles embedded in a crossanisotropic clay deposit using 3D finite element lower bound

In this study,an iterative-based three-dimensional finite element lower bound in association with the second-order cone programming method is adopted to evaluate the limit load of a single pile embedded in cross-anisotropic soils under general loading condition.The lower bound solutions of the pile embedded in an anisotropic soil deposit can be found by formulating the element equilibrium,equilibrium of shear and normal stresses along discontinuities,boundary conditions,yield function,and optimizing the objective function through the second-order cone programming method in conjunction with an iterative-based update procedure.A general loading condition is considered to profile the expansion of the safe load in the vertical-horizontal-moment(V-H-M)space.The results of this study are compared and validated against three different cases including an isotropic lateral loading,anisotropic end bearing capacity,and a pile embedded in an isotropic soil deposit under general loading condition.A parametric study is conducted to evaluate the impact of different influencing factors.It was found that the effect of anisotropy on the variation of lateral limit load of a single pile is more pronounced than the corresponding vertical and bending moment limit loads,whereas the interface properties have more significant effects on the vertical and bending moment limit loads in comparison to the lateral limit load.

高含水油田“二三结合”转换时机优化

针对现有转换时机研究方法无法满足高含水期老油田“二三结合”转换时机优化设计需要的问题,在综合分析三次采油转换时机和技术经济评价方法的基础上,考虑工程技术可行性和经济效益可行性,提出综合考虑技术、经济、社会价值的“二三结合”全生命周期开发价值链理念,建立高含水期老油田“二三结合”全生命周期效益稳产开发价值链模型,并实例分析“二三结合”转换时机对油藏最终采收率和生命周期的敏感性。结果表明,稳产、效益、生命周期是“二三结合”全生命周期效益稳产开发的主要考虑因素,转换时机对效益和稳产的影响是相对立的。

新疆油田浅层超稠油SAGD高效低碳开发技术研究与展望

针对“双碳”目标背景下超稠油开发高能耗与油田高质量发展矛盾日益加剧的问题,新疆油田通过SAGD机理研究与现场实践,在维持蒸汽腔高效扩展,突破储层渗流屏障遮挡,提高浅薄层驱泄复合效率,实现水平井长水平段高效均衡产液等方面持续攻关,取得显著效果。采用气体辅助技术,实现蒸汽腔隔热保压增能,油汽比可提高20%;利用立体井网及储层升级扩容技术,改善Ⅲ类超稠油油藏渗流特征,泄油速度可增大20%~40%;采用全密闭生产方式,VHSD产液温度由100℃上升至150℃,采油速度提高50%;深化热采流量控制器(FCD)机理研究,完善油藏-井筒耦合优化设计方法,水平井水平段动用程度可提高20%。“十四五”期间,新疆油田将深化溶剂辅助SAGD、无水SAGD和控温水热裂解等技术研究,逐步完善浅层超稠油低碳高效开发技术系列,该研究可为稠油油藏开发提供借鉴。

推进中华传统法律文化创新性发展研究

把马克思主义基本原理同中国具体实际、同中华优秀传统文化相结合,是中国共产党领导人民取得革命和建设成功的“最大法宝”,是党在探索中国特色社会主义道路中得出的规律性认识。“两个结合”是传统文化创新发展的内在动力,为中华传统法律文化创新性发展提供了契机。“第二个结合”是中国又一次的思想解放。“第二个结合”让马克思主义成为中国的,中华优秀传统文化成为现代的,未来需要以“第二个结合”为科学指南建设中华民族现代文明。“第二个结合”铸就了中国式现代化的文化形态,提升了中华传统法律文化创新性发展的思想方法,增强了中华传统法律文化的国际影响力。因此,推进中华传统法律文化创新性发展,应构建科学完备的中华民族共同体理论体系,建构中国自主的法学知识体系,建构中国自主的知识产权体系,构建中国自主的中华文明对外传播体系。

“两个结合”赋能高校思政课的三维向度

“两个结合”作为习近平新时代中国特色社会主义思想的重要组成部分,是走稳走实中国特色社会主义道路极为重要的指导方略,也是赋能高校思政课的关键抓手。高校要从“两个结合”赋能引领思政课高质量发展、强化立德树人实效、坚定学生理想信念这一价值向度领悟“两个结合”的价值意蕴;从立足点、出发点、切入点这一本体向度探寻“两个结合”赋能思政课的现实逻辑;从以“两个结合”和“六个必须坚持”为指导的实践向度探析“两个结合”为思政课高度赋能的实践路径,从而进一步挖掘“两个结合”的深层力量,加强“两个结合”对思政课的科学引导、实践指导,开创思政课高质量发展新局面。

医养结合嵌入河南省社区居家养老的发展策略

河南省健康养老发展正进入快车道,规划引导医养结合嵌入社区居家养老符合省情和老年群体需要。针对发展嵌入式养老面临的政策模糊、筹资匮缺、医护流失等问题,提出如下建议:政府主导,加强筹资运营监督管理;社会参与,打通资源良性嵌入路径;队伍优化,培养人才和提高待遇并举等。

Effects of the Integrated TCM-WM Treatment of Nephrotic Syndrome on Growth and Sexual Development

Fifty children with nephrotic syndrome were treated by using herbal drugs for nourishing yin to reduce pathogenic fire, strengthening qi and tonifying the kidney, and promoting blood circulation and removing blood stasis in combination with glucocorticoid and immunodepressant. The body height, secondary sex characters, age of the first spermatorrhea for male and of menarche for female children, bone age measured with roentgenograms on the left wrist in 50 cases of the treatment group were compared with those in 31 cases of the control group treated by glucocorticoid and immunodepressant. The results showed that the delay of growth and sexual development as side-effects of glucocorticoid and immunodepressant were markedly reduced by the integrated TCM-WM treatment.

医疗机构基于“三结合”中药新药研发及管理体系的构建

目的:在中药审评审批制度改革的政策背景下,围绕医疗机构,探索中医药理论、人用经验和临床试验相结合(简称“三结合”)的审评证据体系落地举措,为医疗机构中药制剂及中药新药研发提供参考。方法:根据“三结合”审评证据体系下中药新药研发的相关要求,从机构层面加强人用经验研究相关配套建设,从管理层面搭建中药研发、成果转化服务平台,从临床层面规范开展人用经验研究,构建医疗机构中药新药研发及管理体系。结果:医疗机构中药新药研发及管理体系的构建,有助于将临床诊疗数据转变为支持中药新药注册的人用经验证据,通过提高中药研发水平促进中药新药转化。结论:在医疗机构构建基于“三结合”的中药新药研发及管理体系,是“三结合”审评证据体系落地、政策引导研发实践的路径之一。