To find analytical solutions of nonlinear systems for locating the acoustic emission/microseismic(AE/MS) source without knowing the wave velocity of structures, the sensor location coordinates were simplified as a c...To find analytical solutions of nonlinear systems for locating the acoustic emission/microseismic(AE/MS) source without knowing the wave velocity of structures, the sensor location coordinates were simplified as a cuboid monitoring network. Different locations of sensors on upper and lower surfaces were considered and used to establish nonlinear equations. Based on the proposed functions of time difference of arrivals, the analytical solutions were obtained using five sensors under three networks. The proposed analytical solutions were validated using authentic data of numerical tests and experiments. The results show that located results are consistent with authentic data, and the outstanding characteristics of the new solution are that the solved process is not influenced by the wave velocity knowledge and iterated algorithms.展开更多
To find the analytical solution of the acoustic emission/microseismic(AE/MS) source location coordinates, the sensor location coordinates were optimized and simplified. A cube monitoring network of sensor location was...To find the analytical solution of the acoustic emission/microseismic(AE/MS) source location coordinates, the sensor location coordinates were optimized and simplified. A cube monitoring network of sensor location was selected, and the AE/MS source localization equations were established. A location method with P-wave velocity by analytical solutions (P-VAS) was obtained with these equations. The virtual location tests show that the relocation results of analytical method are fully consistent with the actual coordinates for events both inside and outside the monitoring network; whereas the location error of traditional time difference method is between 0.01 and 0.03 m for events inside the sensor array, and the location errors are larger, which is up to 1080986 m for events outside the sensor array. The broken pencil location tests were carried out in the cross section of 100 mm×98 mm, 350 mm-length granite rock specimen using five AE sensors. Five AE sources were relocated with the conventional method and the P-VAS method. For the four events outside monitoring network, the positioning accuracy by P-VAS method is higher than that by the traditional method, and the location accuracy of the larger one can be increased by 17.61 mm. The results of both virtual and broken pencil location tests show that the proposed analytical solution is effective to improve the positioning accuracy. It can locate the coordinates of AE/MS source only using simple four arithmetic operations, without determining the fitting initial value and iterative calculation, which can be solved by a conventional calculator or Microsoft Excel.展开更多
Through combined applications of the transfer-matrix method and asymptotic expansion technique,we formulate a theory to predict the three-dimensional response of micropolar plates.No ad hoc assumptions regarding throu...Through combined applications of the transfer-matrix method and asymptotic expansion technique,we formulate a theory to predict the three-dimensional response of micropolar plates.No ad hoc assumptions regarding through-thickness assumptions of the field variables are made,and the governing equations are two-dimensional,with the displacements and microrotations of the mid-plane as the unknowns.Once the deformation of the mid-plane is solved,a three-dimensional micropolar elastic field within the plate is generated,which is exact up to the second order except in the boundary region close to the plate edge.As an illustrative example,the bending of a clamped infinitely long plate caused by a uniformly distributed transverse force is analyzed and discussed in detail.展开更多
Hypoxia is a typical feature of the tumor microenvironment,one of the most critical factors affecting cell behavior and tumor progression.However,the lack of tumor models able to precisely emulate natural brain tumor ...Hypoxia is a typical feature of the tumor microenvironment,one of the most critical factors affecting cell behavior and tumor progression.However,the lack of tumor models able to precisely emulate natural brain tumor tissue has impeded the study of the effects of hypoxia on the progression and growth of tumor cells.This study reports a three-dimensional(3D)brain tumor model obtained by encapsulating U87MG(U87)cells in a hydrogel containing type I collagen.It also documents the effect of various oxygen concentrations(1%,7%,and 21%)in the culture environment on U87 cell morphology,proliferation,viability,cell cycle,apoptosis rate,and migration.Finally,it compares two-dimensional(2D)and 3D cultures.For comparison purposes,cells cultured in flat culture dishes were used as the control(2D model).Cells cultured in the 3D model proliferated more slowly but had a higher apoptosis rate and proportion of cells in the resting phase(G0 phase)/gap I phase(G1 phase)than those cultured in the 2D model.Besides,the two models yielded significantly different cell morphologies.Finally,hypoxia(e.g.,1%O2)affected cell morphology,slowed cell growth,reduced cell viability,and increased the apoptosis rate in the 3D model.These results indicate that the constructed 3D model is effective for investigating the effects of biological and chemical factors on cell morphology and function,and can be more representative of the tumor microenvironment than 2D culture systems.The developed 3D glioblastoma tumor model is equally applicable to other studies in pharmacology and pathology.展开更多
Liver regeneration and the development of effective therapies for liver failure remain formidable challenges in modern medicine.In recent years,the utilization of 3D cell-based strategies has emerged as a promising ap...Liver regeneration and the development of effective therapies for liver failure remain formidable challenges in modern medicine.In recent years,the utilization of 3D cell-based strategies has emerged as a promising approach for addressing these urgent clinical requirements.This review provides a thorough analysis of the application of 3D cell-based approaches to liver regeneration and their potential impact on patients with end-stage liver failure.Here,we discuss various 3D culture models that incorporate hepatocytes and stem cells to restore liver function and ameliorate the consequences of liver failure.Furthermore,we explored the challenges in transitioning these innovative strategies from preclinical studies to clinical applications.The collective insights presented herein highlight the significance of 3D cell-based strategies as a transformative paradigm for liver regeneration and improved patient care.展开更多
Spinal cord injury is considered one of the most difficult injuries to repair and has one of the worst prognoses for injuries to the nervous system.Following surgery,the poor regenerative capacity of nerve cells and t...Spinal cord injury is considered one of the most difficult injuries to repair and has one of the worst prognoses for injuries to the nervous system.Following surgery,the poor regenerative capacity of nerve cells and the generation of new scars can make it very difficult for the impaired nervous system to restore its neural functionality.Traditional treatments can only alleviate secondary injuries but cannot fundamentally repair the spinal cord.Consequently,there is a critical need to develop new treatments to promote functional repair after spinal cord injury.Over recent years,there have been seve ral developments in the use of stem cell therapy for the treatment of spinal cord injury.Alongside significant developments in the field of tissue engineering,three-dimensional bioprinting technology has become a hot research topic due to its ability to accurately print complex structures.This led to the loading of three-dimensional bioprinting scaffolds which provided precise cell localization.These three-dimensional bioprinting scaffolds co uld repair damaged neural circuits and had the potential to repair the damaged spinal cord.In this review,we discuss the mechanisms underlying simple stem cell therapy,the application of different types of stem cells for the treatment of spinal cord injury,and the different manufa cturing methods for three-dimensional bioprinting scaffolds.In particular,we focus on the development of three-dimensional bioprinting scaffolds for the treatment of spinal cord injury.展开更多
A toroidal soft x-ray imaging(T-SXRI)system has been developed to investigate threedimensional(3D)plasma physics on J-TEXT.This T-SXRI system consists of three sets of SXR arrays.Two sets are newly developed and locat...A toroidal soft x-ray imaging(T-SXRI)system has been developed to investigate threedimensional(3D)plasma physics on J-TEXT.This T-SXRI system consists of three sets of SXR arrays.Two sets are newly developed and located on the vacuum chamber wall at toroidal positionsφof 126.4°and 272.6°,respectively,while one set was established previously atφ=65.50.Each set of SXR arrays consists of three arrays viewing the plasma poloidally,and hence can be used separately to obtain SXR images via the tomographic method.The sawtooth precursor oscillations are measured by T-SXRI,and the corresponding images of perturbative SXR signals are successfully reconstructed at these three toroidal positions,hence providing measurement of the 3D structure of precursor oscillations.The observed 3D structure is consistent with the helical structure of the m/n=1/1 mode.The experimental observation confirms that the T-SXRI system is able to observe 3D structures in the J-TEXT plasma.展开更多
BACKGROUND Acetabular component positioning in total hip arthroplasty(THA)is of key importance to ensure satisfactory post-operative outcomes and to minimize the risk of complications.The majority of acetabular compon...BACKGROUND Acetabular component positioning in total hip arthroplasty(THA)is of key importance to ensure satisfactory post-operative outcomes and to minimize the risk of complications.The majority of acetabular components are aligned freehand,without the use of navigation methods.Patient specific instruments(PSI)and three-dimensional(3D)printing of THA placement guides are increasingly used in primary THA to ensure optimal positioning.AIM To summarize the literature on 3D printing in THA and how they improve acetabular component alignment.METHODS PubMed was used to identify and access scientific studies reporting on different 3D printing methods used in THA.Eight studies with 236 hips in 228 patients were included.The studies could be divided into two main categories;3D printed models and 3D printed guides.RESULTS 3D printing in THA helped improve preoperative cup size planning and post-operative Harris hip scores between intervention and control groups(P=0.019,P=0.009).Otherwise,outcome measures were heterogeneous and thus difficult to compare.The overarching consensus between the studies is that the use of 3D guidance tools can assist in improving THA cup positioning and reduce the need for revision THA and the associated costs.CONCLUSION The implementation of 3D printing and PSI for primary THA can significantly improve the positioning accuracy of the acetabular cup component and reduce the number of complications caused by malpositioning.展开更多
Identifying a device and detecting a change in its position is critical for secure devices management in the Internet of Things(IoT).In this paper,a device management system is proposed to track the devices by using a...Identifying a device and detecting a change in its position is critical for secure devices management in the Internet of Things(IoT).In this paper,a device management system is proposed to track the devices by using audio-based location distinction techniques.In the proposed scheme,traditional cryptographic techniques,such as symmetric encryption algorithm,RSA-based signcryption scheme,and audio-based secure transmission,are utilized to provide authentication,non-repudiation,and confidentiality in the information interaction of the management system.Moreover,an audio-based location distinction method is designed to detect the position change of the devices.Specifically,the audio frequency response(AFR)of several frequency points is utilized as a device signature.The device signature has the features as follows.(1)Hardware Signature:different pairs of speaker and microphone have different signatures;(2)Distance Signature:in the same direction,the signatures are different at different distances;and(3)Direction Signature:at the same distance,the signatures are different in different directions.Based on the features above,amovement detection algorithmfor device identification and location distinction is designed.Moreover,a secure communication protocol is also proposed by using traditional cryptographic techniques to provide integrity,authentication,and non-repudiation in the process of information interaction between devices,Access Points(APs),and Severs.Extensive experiments are conducted to evaluate the performance of the proposed method.The experimental results show that the proposedmethod has a good performance in accuracy and energy consumption.展开更多
Microseismic source location is crucial for the early warning of rockburst risks.However,the conventional methods face challenges in terms of the microseismic wave velocity and arrival time accuracy.Intelligent techni...Microseismic source location is crucial for the early warning of rockburst risks.However,the conventional methods face challenges in terms of the microseismic wave velocity and arrival time accuracy.Intelligent techniques,such as the full convolutional neural network(FCNN),can capture spatial information but struggle with complex microseismic sequence.Combining the FCNN with the long shortterm memory(LSTM)network enables better time-series signal classification by integrating multiscale information and is therefore suitable for waveform location.The LSTM-FCNN model does not require extensive data preprocessing and it simplifies the microseismic source location through feature extraction.In this study,we utilized the LSTM-FCNN as a regression learning model to locate the seismic focus.Initially,the method of short-time-average/long-time-average(STA/LTA)arrival time picking was employed to augment spatiotemporal information.Subsequently,oversampling the on-site data was performed to address the issue of data imbalance,and finally,the performance of LSTM-FCNN was tested.Meanwhile,we compared the LSTM-FCNN model with previous deep-learning models.Our results demonstrated remarkable location capabilities with a mean absolute error(MAE)of only 7.16 m.The model can realize swift training and high accuracy,thereby significantly improving risk warning of rockbursts.展开更多
BACKGROUND The management of hepatoblastoma(HB)becomes challenging when the tumor remains in close proximity to the major liver vasculature(PMV)even after a full course of neoadjuvant chemotherapy(NAC).In such cases,e...BACKGROUND The management of hepatoblastoma(HB)becomes challenging when the tumor remains in close proximity to the major liver vasculature(PMV)even after a full course of neoadjuvant chemotherapy(NAC).In such cases,extreme liver resection can be considered a potential option.AIM To explore whether computer-assisted three-dimensional individualized extreme liver resection is safe and feasible for children with HB who still have PMV after a full course of NAC.METHODS We retrospectively collected data from children with HB who underwent surgical resection at our center from June 2013 to June 2023.We then analyzed the detailed clinical and three-dimensional characteristics of children with HB who still had PMV after a full course of NAC.RESULTS Sixty-seven children diagnosed with HB underwent surgical resection.The age at diagnosis was 21.4±18.8 months,and 40 boys and 27 girls were included.Fifty-nine(88.1%)patients had a single tumor,39(58.2%)of which was located in the right lobe of the liver.A total of 47 patients(70.1%)had PRE-TEXT III or IV.Thirty-nine patients(58.2%)underwent delayed resection.After a full course of NAC,16 patients still had close PMV(within 1 cm in two patients,touching in 11 patients,compressing in four patients,and showing tumor thrombus in three patients).There were 6 patients of tumors in the middle lobe of the liver,and four of those patients exhibited liver anatomy variations.These 16 children underwent extreme liver resection after comprehensive preoperative evaluation.Intraoperative procedures were performed according to the preoperative plan,and the operations were successfully performed.Currently,the 3-year event-free survival of 67 children with HB is 88%.Among the 16 children who underwent extreme liver resection,three experienced recurrence,and one died due to multiple metastases.CONCLUSION Extreme liver resection for HB that is still in close PMV after a full course of NAC is both safe and feasible.This approach not only reduces the necessity for liver transplantation but also results in a favorable prognosis.Individualized three-dimensional surgical planning is beneficial for accurate and complete resection of HB,particularly for assessing vascular involvement,remnant liver volume and anatomical variations.展开更多
Drone logistics is a novel method of distribution that will become prevalent.The advantageous location of the logistics hub enables quicker customer deliveries and lower fuel consumption,resulting in cost savings for ...Drone logistics is a novel method of distribution that will become prevalent.The advantageous location of the logistics hub enables quicker customer deliveries and lower fuel consumption,resulting in cost savings for the company’s transportation operations.Logistics firms must discern the ideal location for establishing a logistics hub,which is challenging due to the simplicity of existing models and the intricate delivery factors.To simulate the drone logistics environment,this study presents a new mathematical model.The model not only retains the aspects of the current models,but also considers the degree of transportation difficulty from the logistics hub to the village,the capacity of drones for transportation,and the distribution of logistics hub locations.Moreover,this paper proposes an improved particle swarm optimization(PSO)algorithm which is a diversity-based hybrid PSO(DHPSO)algorithm to solve this model.In DHPSO,the Gaussian random walk can enhance global search in the model space,while the bubble-net attacking strategy can speed convergence.Besides,Archimedes spiral strategy is employed to overcome the local optima trap in the model and improve the exploitation of the algorithm.DHPSO maintains a balance between exploration and exploitation while better defining the distribution of logistics hub locations Numerical experiments show that the newly proposed model always achieves better locations than the current model.Comparing DHPSO with other state-of-the-art intelligent algorithms,the efficiency of the scheme can be improved by 42.58%.This means that logistics companies can reduce distribution costs and consumers can enjoy a more enjoyable shopping experience by using DHPSO’s location selection.All the results show the location of the drone logistics hub is solved by DHPSO effectively.展开更多
BACKGROUND Gastric cancer(GC)is a highly prevalent gastrointestinal tract tumor.Several trials have demonstrated that the location of GC can affect patient prognosis.However,the factors determining tumor location rema...BACKGROUND Gastric cancer(GC)is a highly prevalent gastrointestinal tract tumor.Several trials have demonstrated that the location of GC can affect patient prognosis.However,the factors determining tumor location remain unclear.AIM To investigate the tumor location of patients,we went on to study the influencing factors that lead to changes in the location of GC.METHODS A retrospective evaluation was carried out on 3287 patients who underwent gastrectomy for GC in Zhejiang Cancer Hospital.The patients were followed up post-diagnosis and post-gastrectomy.The clinicopathological variables and overall survival of the patients were recorded.By analyzing the location of GC,the tumor location was divided into four categories:“Upper”,“middle”,“lower”,and“total”.Statistical software was utilized to analyze the relationship of each variable with the location of GC.RESULTS A total of 3287 patients were included in this study.The clinicopathological indices of gender,age,serum levels of carcinoembryonic antigen(CEA),carbohydrate antigen(CA19-9)and CA72-4 levels,were significantly associated with tumor location in patients with GC.In addition,there was a strong correlation between GC location and the prognosis of postoperative patients.Specifically,patients with“lower”and“middle”GC demonstrated a better prognosis than those with tumors in other categories.CONCLUSION The five clinicopathological indices of gender,age,CEA,CA19-9 and CA72-4 levels exhibit varying degrees of influence on the tumor location.The tumor location correlates with patient prognosis following surgery.展开更多
Understanding the pore water pressure distribution in unsaturated soil is crucial in predicting shallow landslides triggered by rainfall,mainly when dealing with different temporal patterns of rainfall intensity.Howev...Understanding the pore water pressure distribution in unsaturated soil is crucial in predicting shallow landslides triggered by rainfall,mainly when dealing with different temporal patterns of rainfall intensity.However,the hydrological response of vegetated slopes,especially three-dimensional(3D)slopes covered with shrubs,under different rainfall patterns remains unclear and requires further investigation.To address this issue,this study adopts a novel 3D numerical model for simulating hydraulic interactions between the root system of the shrub and the surrounding soil.Three series of numerical parametric studies are conducted to investigate the influences of slope inclination,rainfall pattern and rainfall duration.Four rainfall patterns(advanced,bimodal,delayed,and uniform)and two rainfall durations(4-h intense and 168-h mild rainfall)are considered to study the hydrological response of the slope.The computed results show that 17%higher transpiration-induced suction is found for a steeper slope,which remains even after a short,intense rainfall with a 100-year return period.The extreme rainfalls with advanced(PA),bimodal(PB)and uniform(PU)rainfall patterns need to be considered for the short rainfall duration(4 h),while the delayed(PD)and uniform(PU)rainfall patterns are highly recommended for long rainfall durations(168 h).The presence of plants can improve slope stability markedly under extreme rainfall with a short duration(4 h).For the long duration(168 h),the benefit of the plant in preserving pore-water pressure(PWP)and slope stability may not be sufficient.展开更多
Ocean bottom node(OBN)data acquisition is the main development direction of marine seismic exploration;it is widely promoted,especially in shallow sea environments.However,the OBN receivers may move several times beca...Ocean bottom node(OBN)data acquisition is the main development direction of marine seismic exploration;it is widely promoted,especially in shallow sea environments.However,the OBN receivers may move several times because they are easily affected by tides,currents,and other factors in the shallow sea environment during long-term acquisition.If uncorrected,then the imaging quality of subsequent processing will be affected.The conventional secondary positioning does not consider the case of multiple movements of the receivers,and the accuracy of secondary positioning is insufficient.The first arrival wave of OBN seismic data in shallow ocean mainly comprises refracted waves.In this study,a nonlinear model is established in accordance with the propagation mechanism of a refracted wave and its relationship with the time interval curve to realize the accurate location of multiple receiver movements.In addition,the Levenberg-Marquart algorithm is used to reduce the influence of the first arrival pickup error and to automatically detect the receiver movements,identifying the accurate dynamic relocation of the receivers.The simulation and field data show that the proposed method can realize the dynamic location of multiple receiver movements,thereby improving the accuracy of seismic imaging and achieving high practical value.展开更多
In order to accurately measure an object’s three-dimensional surface shape,the influence of sampling on it was studied.First,on the basis of deriving spectra expressions through the Fourier transform,the generation o...In order to accurately measure an object’s three-dimensional surface shape,the influence of sampling on it was studied.First,on the basis of deriving spectra expressions through the Fourier transform,the generation of CCD pixels was analyzed,and its expression was given.Then,based on the discrete expression of deformation fringes obtained after sampling,its Fourier spectrum expression was derived,resulting in an infinitely repeated"spectra island"in the frequency domain.Finally,on the basis of using a low-pass filter to remove high-order harmonic components and retaining only one fundamental frequency component,the inverse Fourier transform was used to reconstruct the signal strength.A method of reducing the sampling interval,i.e.,reducing the number of sampling points per fringe,was proposed to increase the ratio between the sampling frequency and the fundamental frequency of the grating.This was done to reconstruct the object’s surface shape more accurately under the condition of m>4.The basic principle was verified through simulation and experiment.In the simulation,the sampling intervals were 8 pixels,4 pixels,2 pixels,and 1 pixel,the maximum absolute error values obtained in the last three situations were 88.80%,38.38%,and 31.50%in the first situation,respectively,and the corresponding average absolute error values are 71.84%,43.27%,and 32.26%.It is demonstrated that the smaller the sampling interval,the better the recovery effect.Taking the same four sampling intervals in the experiment as in the simulation can also lead to the same conclusions.The simulated and experimental results show that reducing the sampling interval can improve the accuracy of object surface shape measurement and achieve better reconstruction results.展开更多
To enhance the understanding of the geometry and characteristics of seismogenic faults in the Beijing-Tianjin-Hebei region,we relocated 14805 out of 16063 earthquakes(113°E-120°E,36°N-43°N)that occ...To enhance the understanding of the geometry and characteristics of seismogenic faults in the Beijing-Tianjin-Hebei region,we relocated 14805 out of 16063 earthquakes(113°E-120°E,36°N-43°N)that occurred between January 2008 and December 2020 using the double-difference tomography method.Based on the spatial variation in seismicity after relocation,the Beijing-Tianjin-Hebei region can be divided into three seismic zones:Xingtai-Wen'an,Zhangbei-Ninghexi,and Tangshan.(1)The Xingtai-Wen'an Seismic Zone has a northeastsouthwest strike.The depth profile of earthquakes perpendicular to the strike reveals three northeast-striking,southeast-dipping,high-angle deep faults(>10 km depth),including one below the shallow(<10 km depth)listric,northwest-dipping Xinghe fault in the Xingtai region.Two additional deep faults in the Wen'an region are suggested to be associated with the 2006 M 5.1 Wen'an Earthquake and the 1967 M 6.3 Dacheng earthquake;(2)The Zhangbei-Ninghexi Seismic Zone is oriented north-northwest.Multiple northeast-striking faults(10-20 km depth),inferred from the earthquake-intensive zones,exist beneath the shallow(<10 km depth)Xiandian Fault,Xiaotangshan Fault,Huailai-Zhuolu Basin North Fault,Yangyuan Basin Fault and Yanggao Basin North Fault;(3)In the Tangshan Seismic Zone,earthquakes are mainly concentrated near the northeast-striking Tangshan-Guye Fault,Lulong Fault,and northwest-striking Luanxian-Laoting Fault.An inferred north-south-oriented blind fault is present to the north of the Tangshan-Guye Fault.The 1976 M 7.8 Tangshan earthquake occurred at the junction of a shallow northwest-dipping fault and a deep southeast-dipping fault.This study emphasizes that earthquakes in the region are primarily associated with deep blind faults.Some deep blind faults have different geometries compared to shallow faults,suggesting a complex fault system in the region.Overall,this research provides valuable insights into the seismogenic faults in the Beijing–Tianjin–Hebei region.Further studies and monitoring of these faults are essential for earthquake mitigation efforts in this region.展开更多
Location prediction in social media,a growing research field,employs machine learning to identify users' locations from their online activities.This technology,useful in targeted advertising and urban planning,rel...Location prediction in social media,a growing research field,employs machine learning to identify users' locations from their online activities.This technology,useful in targeted advertising and urban planning,relies on natural language processing to analyze social media content and understand the temporal dynamics and structures of social networks.A key application is predicting a Twitter user's location from their tweets,which can be challenging due to the short and unstructured nature of tweet text.To address this challenge,the research introduces a novel machine learning model called the location-aware attention LSTM(LAA-LSTM).This hybrid model combines a Long Short-Term Memory(LSTM) network with an attention mechanism.The LSTM is trained on a dataset of tweets,and the attention network focuses on extracting features related to latitude and longitude,which are crucial for pinpointing the location of a user's tweet.The result analysis shows approx.10% improvement in accuracy over other existing machine learning approaches.展开更多
BACKGROUND Biliary stone disease is a highly prevalent condition and a leading cause of hospitalization worldwide.Hepatolithiasis with associated strictures has high residual and recurrence rates after traditional mul...BACKGROUND Biliary stone disease is a highly prevalent condition and a leading cause of hospitalization worldwide.Hepatolithiasis with associated strictures has high residual and recurrence rates after traditional multisession percutaneous transhepatic cholangioscopic lithotripsy(PTCSL).AIM To study one-step PTCSL using the percutaneous transhepatic one-step biliary fistulation(PTOBF)technique guided by three-dimensional(3D)visualization.METHODS This was a retrospective,single-center study analyzing,140 patients who,between October 2016 and October 2023,underwent one-step PTCSL for hepatolithiasis.The patients were divided into two groups:The 3D-PTOBF group and the PTOBF group.Stone clearance on choledochoscopy,complications,and long-term clearance and recurrence rates were assessed.RESULTS Age,total bilirubin,direct bilirubin,Child-Pugh class,and stone location were similar between the 2 groups,but there was a significant difference in bile duct strictures,with biliary strictures more common in the 3D-PTOBF group(P=0.001).The median follow-up time was 55.0(55.0,512.0)days.The immediate stone clearance ratio(88.6%vs 27.1%,P=0.000)and stricture resolution ratio(97.1%vs 78.6%,P=0.001)in the 3D-PTOBF group were significantly greater than those in the PTOBF group.Postoperative complication(8.6%vs 41.4%,P=0.000)and stone recurrence rates(7.1%vs 38.6%,P=0.000)were significantly lower in the 3D-PTOBF group.CONCLUSION Three-dimensional visualization helps make one-step PTCSL a safe,effective,and promising treatment for patients with complicated primary hepatolithiasis.The perioperative and long-term outcomes are satisfactory for patients with complicated primary hepatolithiasis.This minimally invasive method has the potential to be used as a substitute for hepatobiliary surgery.展开更多
The 2D limit equilibrium method is widely used for slope stability analysis.However,with the advancement of dump engineering,composite slopes often exhibit significant 3D mechanical effects.Consequently,it is of signi...The 2D limit equilibrium method is widely used for slope stability analysis.However,with the advancement of dump engineering,composite slopes often exhibit significant 3D mechanical effects.Consequently,it is of significant importance to develop an effective 3D stability calculation method for composite slopes to enhance the design and stability control of open-pit slope engineering.Using the composite slope formed by the mining stope and inner dump in Baiyinhua No.1 and No.2 open-pit coal mine as a case study,this research investigates the failure mode of composite slopes and establishes spatial shape equations for the sliding mass.By integrating the shear resistance and sliding force of each row of microstrip columns onto the bottom surface of the strip corresponding to the main sliding surface,a novel 2D equivalent physical and mechanical parameters analysis method for the strips on the main sliding surface of 3D sliding masses is proposed.Subsequently,a comprehensive 3D stability calculation method for composite slopes is developed,and the quantitative relationship between the coordinated development distance and its 3D stability coefficients is examined.The analysis reveals that the failure mode of the composite slope is characterized by cutting-bedding sliding,with the arc serving as the side interface and the weak layer as the bottom interface,while the destabilization mechanism primarily involves shear failure.The spatial form equation of the sliding mass comprises an ellipsoid and weak plane equation.The analysis revealed that when the coordinated development distance is 1500 m,the error rate between the 3D stability calculation result and the 2D stability calculation result of the composite slope is less than 8%,thereby verifying the proposed analytical method of equivalent physical and mechanical parameters and the 3D stability calculation method for composite slopes.Furthermore,the3D stability coefficient of the composite slope exhibits an exponential correlation with the coordinated development distance,with the coefficient gradually decreasing as the coordinated development distance increases.These findings provide a theoretical guideline for designing similar slope shape parameters and conducting stability analysis.展开更多
基金Projects(11447242,41272304,51209236,51274254)supported by the National Natural Science Foundation of ChinaProject(2015CB060200)supported by the National Basic Research Program of China
文摘To find analytical solutions of nonlinear systems for locating the acoustic emission/microseismic(AE/MS) source without knowing the wave velocity of structures, the sensor location coordinates were simplified as a cuboid monitoring network. Different locations of sensors on upper and lower surfaces were considered and used to establish nonlinear equations. Based on the proposed functions of time difference of arrivals, the analytical solutions were obtained using five sensors under three networks. The proposed analytical solutions were validated using authentic data of numerical tests and experiments. The results show that located results are consistent with authentic data, and the outstanding characteristics of the new solution are that the solved process is not influenced by the wave velocity knowledge and iterated algorithms.
基金Project (10872218) supported by the National Natural Science Foundation of ChinaProject (2010CB732004) supported by the National Basic Research Program of China+1 种基金Project (kjdb2010-6) supported by Doctoral Candidate Innovation Research Support Program of Science & Technology ReviewProject (201105) supported by Scholarship Award for Excellent Doctoral Student of Ministry of Education of China
文摘To find the analytical solution of the acoustic emission/microseismic(AE/MS) source location coordinates, the sensor location coordinates were optimized and simplified. A cube monitoring network of sensor location was selected, and the AE/MS source localization equations were established. A location method with P-wave velocity by analytical solutions (P-VAS) was obtained with these equations. The virtual location tests show that the relocation results of analytical method are fully consistent with the actual coordinates for events both inside and outside the monitoring network; whereas the location error of traditional time difference method is between 0.01 and 0.03 m for events inside the sensor array, and the location errors are larger, which is up to 1080986 m for events outside the sensor array. The broken pencil location tests were carried out in the cross section of 100 mm×98 mm, 350 mm-length granite rock specimen using five AE sensors. Five AE sources were relocated with the conventional method and the P-VAS method. For the four events outside monitoring network, the positioning accuracy by P-VAS method is higher than that by the traditional method, and the location accuracy of the larger one can be increased by 17.61 mm. The results of both virtual and broken pencil location tests show that the proposed analytical solution is effective to improve the positioning accuracy. It can locate the coordinates of AE/MS source only using simple four arithmetic operations, without determining the fitting initial value and iterative calculation, which can be solved by a conventional calculator or Microsoft Excel.
基金Project supported by the National Natural Science Foundation of China (No. 12072337)。
文摘Through combined applications of the transfer-matrix method and asymptotic expansion technique,we formulate a theory to predict the three-dimensional response of micropolar plates.No ad hoc assumptions regarding through-thickness assumptions of the field variables are made,and the governing equations are two-dimensional,with the displacements and microrotations of the mid-plane as the unknowns.Once the deformation of the mid-plane is solved,a three-dimensional micropolar elastic field within the plate is generated,which is exact up to the second order except in the boundary region close to the plate edge.As an illustrative example,the bending of a clamped infinitely long plate caused by a uniformly distributed transverse force is analyzed and discussed in detail.
基金supported by the National Natural Science Foundation of China (No. 52275291)the Fundamental Research Funds for the Central Universitiesthe Program for Innovation Team of Shaanxi Province,China (No. 2023-CX-TD-17)
文摘Hypoxia is a typical feature of the tumor microenvironment,one of the most critical factors affecting cell behavior and tumor progression.However,the lack of tumor models able to precisely emulate natural brain tumor tissue has impeded the study of the effects of hypoxia on the progression and growth of tumor cells.This study reports a three-dimensional(3D)brain tumor model obtained by encapsulating U87MG(U87)cells in a hydrogel containing type I collagen.It also documents the effect of various oxygen concentrations(1%,7%,and 21%)in the culture environment on U87 cell morphology,proliferation,viability,cell cycle,apoptosis rate,and migration.Finally,it compares two-dimensional(2D)and 3D cultures.For comparison purposes,cells cultured in flat culture dishes were used as the control(2D model).Cells cultured in the 3D model proliferated more slowly but had a higher apoptosis rate and proportion of cells in the resting phase(G0 phase)/gap I phase(G1 phase)than those cultured in the 2D model.Besides,the two models yielded significantly different cell morphologies.Finally,hypoxia(e.g.,1%O2)affected cell morphology,slowed cell growth,reduced cell viability,and increased the apoptosis rate in the 3D model.These results indicate that the constructed 3D model is effective for investigating the effects of biological and chemical factors on cell morphology and function,and can be more representative of the tumor microenvironment than 2D culture systems.The developed 3D glioblastoma tumor model is equally applicable to other studies in pharmacology and pathology.
基金This work was supported by grants fromthe Sichuan Science and Technology Program(2023NSFSC1877).
文摘Liver regeneration and the development of effective therapies for liver failure remain formidable challenges in modern medicine.In recent years,the utilization of 3D cell-based strategies has emerged as a promising approach for addressing these urgent clinical requirements.This review provides a thorough analysis of the application of 3D cell-based approaches to liver regeneration and their potential impact on patients with end-stage liver failure.Here,we discuss various 3D culture models that incorporate hepatocytes and stem cells to restore liver function and ameliorate the consequences of liver failure.Furthermore,we explored the challenges in transitioning these innovative strategies from preclinical studies to clinical applications.The collective insights presented herein highlight the significance of 3D cell-based strategies as a transformative paradigm for liver regeneration and improved patient care.
基金supported by the National Natural Science Foundation of China,No.82171380(to CD)Jiangsu Students’Platform for Innovation and Entrepreneurship Training Program,No.202110304098Y(to DJ)。
文摘Spinal cord injury is considered one of the most difficult injuries to repair and has one of the worst prognoses for injuries to the nervous system.Following surgery,the poor regenerative capacity of nerve cells and the generation of new scars can make it very difficult for the impaired nervous system to restore its neural functionality.Traditional treatments can only alleviate secondary injuries but cannot fundamentally repair the spinal cord.Consequently,there is a critical need to develop new treatments to promote functional repair after spinal cord injury.Over recent years,there have been seve ral developments in the use of stem cell therapy for the treatment of spinal cord injury.Alongside significant developments in the field of tissue engineering,three-dimensional bioprinting technology has become a hot research topic due to its ability to accurately print complex structures.This led to the loading of three-dimensional bioprinting scaffolds which provided precise cell localization.These three-dimensional bioprinting scaffolds co uld repair damaged neural circuits and had the potential to repair the damaged spinal cord.In this review,we discuss the mechanisms underlying simple stem cell therapy,the application of different types of stem cells for the treatment of spinal cord injury,and the different manufa cturing methods for three-dimensional bioprinting scaffolds.In particular,we focus on the development of three-dimensional bioprinting scaffolds for the treatment of spinal cord injury.
基金supported by the National Magnetic Confinement Fusion Energy R&D Program of China(Nos.2018YFE0309100 and 2019YFE03010004)National Natural Science Foundation of China(No.51821005)。
文摘A toroidal soft x-ray imaging(T-SXRI)system has been developed to investigate threedimensional(3D)plasma physics on J-TEXT.This T-SXRI system consists of three sets of SXR arrays.Two sets are newly developed and located on the vacuum chamber wall at toroidal positionsφof 126.4°and 272.6°,respectively,while one set was established previously atφ=65.50.Each set of SXR arrays consists of three arrays viewing the plasma poloidally,and hence can be used separately to obtain SXR images via the tomographic method.The sawtooth precursor oscillations are measured by T-SXRI,and the corresponding images of perturbative SXR signals are successfully reconstructed at these three toroidal positions,hence providing measurement of the 3D structure of precursor oscillations.The observed 3D structure is consistent with the helical structure of the m/n=1/1 mode.The experimental observation confirms that the T-SXRI system is able to observe 3D structures in the J-TEXT plasma.
文摘BACKGROUND Acetabular component positioning in total hip arthroplasty(THA)is of key importance to ensure satisfactory post-operative outcomes and to minimize the risk of complications.The majority of acetabular components are aligned freehand,without the use of navigation methods.Patient specific instruments(PSI)and three-dimensional(3D)printing of THA placement guides are increasingly used in primary THA to ensure optimal positioning.AIM To summarize the literature on 3D printing in THA and how they improve acetabular component alignment.METHODS PubMed was used to identify and access scientific studies reporting on different 3D printing methods used in THA.Eight studies with 236 hips in 228 patients were included.The studies could be divided into two main categories;3D printed models and 3D printed guides.RESULTS 3D printing in THA helped improve preoperative cup size planning and post-operative Harris hip scores between intervention and control groups(P=0.019,P=0.009).Otherwise,outcome measures were heterogeneous and thus difficult to compare.The overarching consensus between the studies is that the use of 3D guidance tools can assist in improving THA cup positioning and reduce the need for revision THA and the associated costs.CONCLUSION The implementation of 3D printing and PSI for primary THA can significantly improve the positioning accuracy of the acetabular cup component and reduce the number of complications caused by malpositioning.
基金This work is supported by Demonstration of Scientific and Technology Achievements Transform in Sichuan Province under Grant 2022ZHCG0036National Natural Science Foundation of China(62002047).
文摘Identifying a device and detecting a change in its position is critical for secure devices management in the Internet of Things(IoT).In this paper,a device management system is proposed to track the devices by using audio-based location distinction techniques.In the proposed scheme,traditional cryptographic techniques,such as symmetric encryption algorithm,RSA-based signcryption scheme,and audio-based secure transmission,are utilized to provide authentication,non-repudiation,and confidentiality in the information interaction of the management system.Moreover,an audio-based location distinction method is designed to detect the position change of the devices.Specifically,the audio frequency response(AFR)of several frequency points is utilized as a device signature.The device signature has the features as follows.(1)Hardware Signature:different pairs of speaker and microphone have different signatures;(2)Distance Signature:in the same direction,the signatures are different at different distances;and(3)Direction Signature:at the same distance,the signatures are different in different directions.Based on the features above,amovement detection algorithmfor device identification and location distinction is designed.Moreover,a secure communication protocol is also proposed by using traditional cryptographic techniques to provide integrity,authentication,and non-repudiation in the process of information interaction between devices,Access Points(APs),and Severs.Extensive experiments are conducted to evaluate the performance of the proposed method.The experimental results show that the proposedmethod has a good performance in accuracy and energy consumption.
基金financial support of the Fundamental Research Funds for the Central Universities(Grant No.2022XSCX35)the National Natural Science Foundation of China(Grant Nos.51934007 and 52104230).
文摘Microseismic source location is crucial for the early warning of rockburst risks.However,the conventional methods face challenges in terms of the microseismic wave velocity and arrival time accuracy.Intelligent techniques,such as the full convolutional neural network(FCNN),can capture spatial information but struggle with complex microseismic sequence.Combining the FCNN with the long shortterm memory(LSTM)network enables better time-series signal classification by integrating multiscale information and is therefore suitable for waveform location.The LSTM-FCNN model does not require extensive data preprocessing and it simplifies the microseismic source location through feature extraction.In this study,we utilized the LSTM-FCNN as a regression learning model to locate the seismic focus.Initially,the method of short-time-average/long-time-average(STA/LTA)arrival time picking was employed to augment spatiotemporal information.Subsequently,oversampling the on-site data was performed to address the issue of data imbalance,and finally,the performance of LSTM-FCNN was tested.Meanwhile,we compared the LSTM-FCNN model with previous deep-learning models.Our results demonstrated remarkable location capabilities with a mean absolute error(MAE)of only 7.16 m.The model can realize swift training and high accuracy,thereby significantly improving risk warning of rockbursts.
基金Supported by National Natural Science Foundation of China,No.82293665Anhui Provincial Department of Education University Research Project,No.2023AH051763.
文摘BACKGROUND The management of hepatoblastoma(HB)becomes challenging when the tumor remains in close proximity to the major liver vasculature(PMV)even after a full course of neoadjuvant chemotherapy(NAC).In such cases,extreme liver resection can be considered a potential option.AIM To explore whether computer-assisted three-dimensional individualized extreme liver resection is safe and feasible for children with HB who still have PMV after a full course of NAC.METHODS We retrospectively collected data from children with HB who underwent surgical resection at our center from June 2013 to June 2023.We then analyzed the detailed clinical and three-dimensional characteristics of children with HB who still had PMV after a full course of NAC.RESULTS Sixty-seven children diagnosed with HB underwent surgical resection.The age at diagnosis was 21.4±18.8 months,and 40 boys and 27 girls were included.Fifty-nine(88.1%)patients had a single tumor,39(58.2%)of which was located in the right lobe of the liver.A total of 47 patients(70.1%)had PRE-TEXT III or IV.Thirty-nine patients(58.2%)underwent delayed resection.After a full course of NAC,16 patients still had close PMV(within 1 cm in two patients,touching in 11 patients,compressing in four patients,and showing tumor thrombus in three patients).There were 6 patients of tumors in the middle lobe of the liver,and four of those patients exhibited liver anatomy variations.These 16 children underwent extreme liver resection after comprehensive preoperative evaluation.Intraoperative procedures were performed according to the preoperative plan,and the operations were successfully performed.Currently,the 3-year event-free survival of 67 children with HB is 88%.Among the 16 children who underwent extreme liver resection,three experienced recurrence,and one died due to multiple metastases.CONCLUSION Extreme liver resection for HB that is still in close PMV after a full course of NAC is both safe and feasible.This approach not only reduces the necessity for liver transplantation but also results in a favorable prognosis.Individualized three-dimensional surgical planning is beneficial for accurate and complete resection of HB,particularly for assessing vascular involvement,remnant liver volume and anatomical variations.
基金supported by the NationalNatural Science Foundation of China(No.61866023).
文摘Drone logistics is a novel method of distribution that will become prevalent.The advantageous location of the logistics hub enables quicker customer deliveries and lower fuel consumption,resulting in cost savings for the company’s transportation operations.Logistics firms must discern the ideal location for establishing a logistics hub,which is challenging due to the simplicity of existing models and the intricate delivery factors.To simulate the drone logistics environment,this study presents a new mathematical model.The model not only retains the aspects of the current models,but also considers the degree of transportation difficulty from the logistics hub to the village,the capacity of drones for transportation,and the distribution of logistics hub locations.Moreover,this paper proposes an improved particle swarm optimization(PSO)algorithm which is a diversity-based hybrid PSO(DHPSO)algorithm to solve this model.In DHPSO,the Gaussian random walk can enhance global search in the model space,while the bubble-net attacking strategy can speed convergence.Besides,Archimedes spiral strategy is employed to overcome the local optima trap in the model and improve the exploitation of the algorithm.DHPSO maintains a balance between exploration and exploitation while better defining the distribution of logistics hub locations Numerical experiments show that the newly proposed model always achieves better locations than the current model.Comparing DHPSO with other state-of-the-art intelligent algorithms,the efficiency of the scheme can be improved by 42.58%.This means that logistics companies can reduce distribution costs and consumers can enjoy a more enjoyable shopping experience by using DHPSO’s location selection.All the results show the location of the drone logistics hub is solved by DHPSO effectively.
基金Supported by the National Natural Science Foundation of China,No.82473195Natural Science Foundation of Zhejiang Province,No.LTGY23H160018+2 种基金Zhejiang Medical and Health Science and Technology Program,No.2024KY789Beijing Science and Technology Innovation Medical Development Foundation,No.KC2023-JX-0270-07National Natural Science Foundation of China,No.32370797.
文摘BACKGROUND Gastric cancer(GC)is a highly prevalent gastrointestinal tract tumor.Several trials have demonstrated that the location of GC can affect patient prognosis.However,the factors determining tumor location remain unclear.AIM To investigate the tumor location of patients,we went on to study the influencing factors that lead to changes in the location of GC.METHODS A retrospective evaluation was carried out on 3287 patients who underwent gastrectomy for GC in Zhejiang Cancer Hospital.The patients were followed up post-diagnosis and post-gastrectomy.The clinicopathological variables and overall survival of the patients were recorded.By analyzing the location of GC,the tumor location was divided into four categories:“Upper”,“middle”,“lower”,and“total”.Statistical software was utilized to analyze the relationship of each variable with the location of GC.RESULTS A total of 3287 patients were included in this study.The clinicopathological indices of gender,age,serum levels of carcinoembryonic antigen(CEA),carbohydrate antigen(CA19-9)and CA72-4 levels,were significantly associated with tumor location in patients with GC.In addition,there was a strong correlation between GC location and the prognosis of postoperative patients.Specifically,patients with“lower”and“middle”GC demonstrated a better prognosis than those with tumors in other categories.CONCLUSION The five clinicopathological indices of gender,age,CEA,CA19-9 and CA72-4 levels exhibit varying degrees of influence on the tumor location.The tumor location correlates with patient prognosis following surgery.
文摘Understanding the pore water pressure distribution in unsaturated soil is crucial in predicting shallow landslides triggered by rainfall,mainly when dealing with different temporal patterns of rainfall intensity.However,the hydrological response of vegetated slopes,especially three-dimensional(3D)slopes covered with shrubs,under different rainfall patterns remains unclear and requires further investigation.To address this issue,this study adopts a novel 3D numerical model for simulating hydraulic interactions between the root system of the shrub and the surrounding soil.Three series of numerical parametric studies are conducted to investigate the influences of slope inclination,rainfall pattern and rainfall duration.Four rainfall patterns(advanced,bimodal,delayed,and uniform)and two rainfall durations(4-h intense and 168-h mild rainfall)are considered to study the hydrological response of the slope.The computed results show that 17%higher transpiration-induced suction is found for a steeper slope,which remains even after a short,intense rainfall with a 100-year return period.The extreme rainfalls with advanced(PA),bimodal(PB)and uniform(PU)rainfall patterns need to be considered for the short rainfall duration(4 h),while the delayed(PD)and uniform(PU)rainfall patterns are highly recommended for long rainfall durations(168 h).The presence of plants can improve slope stability markedly under extreme rainfall with a short duration(4 h).For the long duration(168 h),the benefit of the plant in preserving pore-water pressure(PWP)and slope stability may not be sufficient.
基金funded by the National Natural Science Foundation of China (No.42074140)the Scientific Research and Technology Development Project of China National Petroleum Corporation (No.2021ZG02)。
文摘Ocean bottom node(OBN)data acquisition is the main development direction of marine seismic exploration;it is widely promoted,especially in shallow sea environments.However,the OBN receivers may move several times because they are easily affected by tides,currents,and other factors in the shallow sea environment during long-term acquisition.If uncorrected,then the imaging quality of subsequent processing will be affected.The conventional secondary positioning does not consider the case of multiple movements of the receivers,and the accuracy of secondary positioning is insufficient.The first arrival wave of OBN seismic data in shallow ocean mainly comprises refracted waves.In this study,a nonlinear model is established in accordance with the propagation mechanism of a refracted wave and its relationship with the time interval curve to realize the accurate location of multiple receiver movements.In addition,the Levenberg-Marquart algorithm is used to reduce the influence of the first arrival pickup error and to automatically detect the receiver movements,identifying the accurate dynamic relocation of the receivers.The simulation and field data show that the proposed method can realize the dynamic location of multiple receiver movements,thereby improving the accuracy of seismic imaging and achieving high practical value.
文摘In order to accurately measure an object’s three-dimensional surface shape,the influence of sampling on it was studied.First,on the basis of deriving spectra expressions through the Fourier transform,the generation of CCD pixels was analyzed,and its expression was given.Then,based on the discrete expression of deformation fringes obtained after sampling,its Fourier spectrum expression was derived,resulting in an infinitely repeated"spectra island"in the frequency domain.Finally,on the basis of using a low-pass filter to remove high-order harmonic components and retaining only one fundamental frequency component,the inverse Fourier transform was used to reconstruct the signal strength.A method of reducing the sampling interval,i.e.,reducing the number of sampling points per fringe,was proposed to increase the ratio between the sampling frequency and the fundamental frequency of the grating.This was done to reconstruct the object’s surface shape more accurately under the condition of m>4.The basic principle was verified through simulation and experiment.In the simulation,the sampling intervals were 8 pixels,4 pixels,2 pixels,and 1 pixel,the maximum absolute error values obtained in the last three situations were 88.80%,38.38%,and 31.50%in the first situation,respectively,and the corresponding average absolute error values are 71.84%,43.27%,and 32.26%.It is demonstrated that the smaller the sampling interval,the better the recovery effect.Taking the same four sampling intervals in the experiment as in the simulation can also lead to the same conclusions.The simulated and experimental results show that reducing the sampling interval can improve the accuracy of object surface shape measurement and achieve better reconstruction results.
基金supported by the Natural Science Foundation of China(U2034207)the Natural Science Foundation of Hebei Province(E2021210099)the Technical Development Project of Shuohuang Railway Development Co.,Ltd.(GJNY-20-230).
文摘To enhance the understanding of the geometry and characteristics of seismogenic faults in the Beijing-Tianjin-Hebei region,we relocated 14805 out of 16063 earthquakes(113°E-120°E,36°N-43°N)that occurred between January 2008 and December 2020 using the double-difference tomography method.Based on the spatial variation in seismicity after relocation,the Beijing-Tianjin-Hebei region can be divided into three seismic zones:Xingtai-Wen'an,Zhangbei-Ninghexi,and Tangshan.(1)The Xingtai-Wen'an Seismic Zone has a northeastsouthwest strike.The depth profile of earthquakes perpendicular to the strike reveals three northeast-striking,southeast-dipping,high-angle deep faults(>10 km depth),including one below the shallow(<10 km depth)listric,northwest-dipping Xinghe fault in the Xingtai region.Two additional deep faults in the Wen'an region are suggested to be associated with the 2006 M 5.1 Wen'an Earthquake and the 1967 M 6.3 Dacheng earthquake;(2)The Zhangbei-Ninghexi Seismic Zone is oriented north-northwest.Multiple northeast-striking faults(10-20 km depth),inferred from the earthquake-intensive zones,exist beneath the shallow(<10 km depth)Xiandian Fault,Xiaotangshan Fault,Huailai-Zhuolu Basin North Fault,Yangyuan Basin Fault and Yanggao Basin North Fault;(3)In the Tangshan Seismic Zone,earthquakes are mainly concentrated near the northeast-striking Tangshan-Guye Fault,Lulong Fault,and northwest-striking Luanxian-Laoting Fault.An inferred north-south-oriented blind fault is present to the north of the Tangshan-Guye Fault.The 1976 M 7.8 Tangshan earthquake occurred at the junction of a shallow northwest-dipping fault and a deep southeast-dipping fault.This study emphasizes that earthquakes in the region are primarily associated with deep blind faults.Some deep blind faults have different geometries compared to shallow faults,suggesting a complex fault system in the region.Overall,this research provides valuable insights into the seismogenic faults in the Beijing–Tianjin–Hebei region.Further studies and monitoring of these faults are essential for earthquake mitigation efforts in this region.
文摘Location prediction in social media,a growing research field,employs machine learning to identify users' locations from their online activities.This technology,useful in targeted advertising and urban planning,relies on natural language processing to analyze social media content and understand the temporal dynamics and structures of social networks.A key application is predicting a Twitter user's location from their tweets,which can be challenging due to the short and unstructured nature of tweet text.To address this challenge,the research introduces a novel machine learning model called the location-aware attention LSTM(LAA-LSTM).This hybrid model combines a Long Short-Term Memory(LSTM) network with an attention mechanism.The LSTM is trained on a dataset of tweets,and the attention network focuses on extracting features related to latitude and longitude,which are crucial for pinpointing the location of a user's tweet.The result analysis shows approx.10% improvement in accuracy over other existing machine learning approaches.
基金Supported by The Key Medical Specialty Nurturing Program of Foshan During The 14th Five-Year Plan Period,No.FSPY145205The Medical Research Project of Foshan Health Bureau,No.20230814A010024+1 种基金The Guangzhou Science and Technology Plan Project,No.202102010251the Guangdong Science and Technology Program,No.2017ZC0222.
文摘BACKGROUND Biliary stone disease is a highly prevalent condition and a leading cause of hospitalization worldwide.Hepatolithiasis with associated strictures has high residual and recurrence rates after traditional multisession percutaneous transhepatic cholangioscopic lithotripsy(PTCSL).AIM To study one-step PTCSL using the percutaneous transhepatic one-step biliary fistulation(PTOBF)technique guided by three-dimensional(3D)visualization.METHODS This was a retrospective,single-center study analyzing,140 patients who,between October 2016 and October 2023,underwent one-step PTCSL for hepatolithiasis.The patients were divided into two groups:The 3D-PTOBF group and the PTOBF group.Stone clearance on choledochoscopy,complications,and long-term clearance and recurrence rates were assessed.RESULTS Age,total bilirubin,direct bilirubin,Child-Pugh class,and stone location were similar between the 2 groups,but there was a significant difference in bile duct strictures,with biliary strictures more common in the 3D-PTOBF group(P=0.001).The median follow-up time was 55.0(55.0,512.0)days.The immediate stone clearance ratio(88.6%vs 27.1%,P=0.000)and stricture resolution ratio(97.1%vs 78.6%,P=0.001)in the 3D-PTOBF group were significantly greater than those in the PTOBF group.Postoperative complication(8.6%vs 41.4%,P=0.000)and stone recurrence rates(7.1%vs 38.6%,P=0.000)were significantly lower in the 3D-PTOBF group.CONCLUSION Three-dimensional visualization helps make one-step PTCSL a safe,effective,and promising treatment for patients with complicated primary hepatolithiasis.The perioperative and long-term outcomes are satisfactory for patients with complicated primary hepatolithiasis.This minimally invasive method has the potential to be used as a substitute for hepatobiliary surgery.
基金supported by the National Natural Science Foundation of China (No.52374124)National Youth Science Foundation of China (No.52204135)+3 种基金Xing Liao Talent Plan (No.XLYC2202004)Young Elite Scientists Sponsorship Program by CAST (No.2023QNRC001)Liaoning Province International Science and Technology Cooperation Plan (No.2022JH2/1070004)Liaoning Natural Science Foundation Program (No.2022-BS-327)。
文摘The 2D limit equilibrium method is widely used for slope stability analysis.However,with the advancement of dump engineering,composite slopes often exhibit significant 3D mechanical effects.Consequently,it is of significant importance to develop an effective 3D stability calculation method for composite slopes to enhance the design and stability control of open-pit slope engineering.Using the composite slope formed by the mining stope and inner dump in Baiyinhua No.1 and No.2 open-pit coal mine as a case study,this research investigates the failure mode of composite slopes and establishes spatial shape equations for the sliding mass.By integrating the shear resistance and sliding force of each row of microstrip columns onto the bottom surface of the strip corresponding to the main sliding surface,a novel 2D equivalent physical and mechanical parameters analysis method for the strips on the main sliding surface of 3D sliding masses is proposed.Subsequently,a comprehensive 3D stability calculation method for composite slopes is developed,and the quantitative relationship between the coordinated development distance and its 3D stability coefficients is examined.The analysis reveals that the failure mode of the composite slope is characterized by cutting-bedding sliding,with the arc serving as the side interface and the weak layer as the bottom interface,while the destabilization mechanism primarily involves shear failure.The spatial form equation of the sliding mass comprises an ellipsoid and weak plane equation.The analysis revealed that when the coordinated development distance is 1500 m,the error rate between the 3D stability calculation result and the 2D stability calculation result of the composite slope is less than 8%,thereby verifying the proposed analytical method of equivalent physical and mechanical parameters and the 3D stability calculation method for composite slopes.Furthermore,the3D stability coefficient of the composite slope exhibits an exponential correlation with the coordinated development distance,with the coefficient gradually decreasing as the coordinated development distance increases.These findings provide a theoretical guideline for designing similar slope shape parameters and conducting stability analysis.