Three-dimensional cell culture systems as an in vitro platform for cancer and stem cell modeling

Three-dimensional(3D)culture systems are becoming increasingly popular due to their ability to mimic tissue-like structures more effectively than the monolayer cultures.In cancer and stem cell research,the natural cell characteristics and architectures are closely mimicked by the 3D cell models.Thus,the 3D cell cultures are promising and suitable systems for various proposes,ranging from disease modeling to drug target identification as well as potential therapeutic substances that may transform our lives.This review provides a comprehensive compendium of recent advancements in culturing cells,in particular cancer and stem cells,using 3D culture techniques.The major approaches highlighted here include cell spheroids,hydrogel embedding,bioreactors,scaffolds,and bioprinting.In addition,the progress of employing 3D cell culture systems as a platform for cancer and stem cell research was addressed,and the prominent studies of 3D cell culture systems were discussed.

SHEsis,a powerful software platform for analyses of linkage disequi-librium,haplotype construction,and genetic association at polymor-phism loci

The authors want to changed the web link of the software platform in this Briefing.Page 97,section 'INTRODUCTION',the web link of SHEsis is changed from http://www.nhgg.org/analysis tohttp://analysis.bio-x.

DPOI: Distributed Software System Development Platform for Ocean Information Service

Ocean information management is of great importance as it has been employed in many areas of ocean science and technology. However, the developments of Ocean Information Systems(OISs) often suffer from low efficiency because of repetitive work and continuous modifications caused by dynamic requirements. In this paper, the basic requirements of OISs are analyzed first, and then a novel platform DPOI is proposed to improve development efficiency and enhance software quality of OISs by providing off-the-shelf resources. In the platform, the OIS is decomposed hierarchically into a set of modules, which can be reused in different system developments. These modules include the acquisition middleware and data loader that collect data from instruments and files respectively, the database that stores data consistently, the components that support fast application generation, the web services that make the data from distributed sources syntactical by use of predefined schemas and the configuration toolkit that enables software customization. With the assistance of the development platform, the software development needs no programming and the development procedure is thus accelerated greatly. We have applied the development platform in practical developments and evaluated its efficiency in several development practices and different development approaches. The results show that DPOI significantly improves development efficiency and software quality.

Study of Software Radio Receiver Development Platform

The Paper introduces an IF software radio receiver development Platform based on high-speed monolithic A/D Converter AD6640, Progranunable Digital Down-converter AD6620 and high-speed DSP chip TMSC320C6701. The implementation method is described as well as AD6620 parameter setting analysis. It also presents a flow chart of the on-line programming with the help of PC. The algorithm for demodulation AM signal is discussed.

Telecom-Oriented Embedded Software Support Platform

This paper presents an embedded software platform used in the telecom field.The platform consists of the Virtual Operating System (VOS)layer,core layer, protection layer and module layer.It supports and simplifies upper application software of telecom systems.In addition to basic modules and functions, its instance scheduling model and distributed process communication are detailed in the paper.

Analysis and Design of Quality Management Platform for the Entire Process of Characteristic Software Talent Training

At the end of 2021 to create a new model of characteristic software talent training for independent and controllable key software fields,the Ministry of Education and the Ministry of Industry and Information Technology jointly approved the establishment of the first batch of 33 Characteristic Pilot Schools of software.As a member of characteristic software schools,the HIT School of Software has been approved and will focus on the construction of 2 characteristic directions,which are large-scale industrial software and industrial professional application software.In order to achieve the goal,it is urgent to develop a comprehensive management platform to control the entire process of talent training,so that we can standardize,modelling,and digitized the entire process of characteristic software talent training.By relating all aspects of student training with and implementing the ability-index mechanisms,we will continuously collect big-data of the entire process of student growth,and generate multidimensional student ability portraits for evaluating the effect of talent training,and adjust as well as optimizing the growth path for students themselves during their studying.Employers will be able to identify talents accurately and provide effective reference for colleges to adjust training plans.This paper will analyze the needs of the platform,provide demand analysis of the platform,extract the correlation model between training,conclude the relations between ability-index activities and ability indicators,and give a reasonable overall system design scheme.

Research on the Computer Software Testing Method Based on Multiple Platforms

Informationization plays an important role in modern life and production.And various software is one of the bases for it.Before it goes into service,software needs to go through many steps,including software development,design,etc.In software development,test is the key to identify and control bugs and errors in the software.Therefore,software companies often test the software to ensure that it is qualified.In recent years,more attention has been paid to a multi-platform computer software testing method,which can make up for defects in traditional testing methods to improve test accuracy.Firstly,this paper illustrates the connotation and features of software testing.Secondly,common software testing platforms and their requirements are analyzed.Finally,this paper proposes software testing method based on multiple platforms.

Integration system research and development for three-dimensional laser scanning information visualization in goaf

An integration processing system of three-dimensional laser scanning information visualization in goaf was developed. It is provided with multiple functions, such as laser scanning information management for goaf, cloud data de-noising optimization, construction, display and operation of three-dimensional model, model editing, profile generation, calculation of goaf volume and roof area, Boolean calculation among models and interaction with the third party soft ware. Concerning this system with a concise interface, plentiful data input/output interfaces, it is featured with high integration, simple and convenient operations of applications. According to practice, in addition to being well-adapted, this system is favorably reliable and stable.

Research on Software Radio Fuze

The functions and characteristics of software radio are discussed. Using techniques and method of software radio, the concept and advantages of a new kind of radio fuze, software radio fuze, are analysed. Several kinds of hardware platform structures of the software radio fuze are studied and the key techniques are analysed. The software radio fuze will become the most promising radio fuze techniques in 21st century.

Knowledge Management of Software Productivity and Development Time

In this paper, we identify a set of factors that may be used to forecast software productivity and software development time. Software productivity was measured in function points per person hours, and software development time was measured in number of elapsed days. Using field data on over 130 field software projects from various industries, we empirically test the impact of team size, integrated computer aided software engineering (ICASE) tools, software development type, software development platform, and programming language type on the software development productivity and development time. Our results indicate that team size, software development type, software development platform, and programming language type significantly impact software development productivity. However, only team size significantly impacts software development time. Our results indicate that effective management of software development teams, and using different management strategies for different software development type environments may improve software development productivity.

An Embedded Software Modeling and Process by Using Aspect-Oriented Approach

In recent years, mobile devices have become widespread and refined, and they have offered increased convenience in human life. For these reasons, a variety of embedded systems have been designed. Therefore, improving methods for developing of embedded software systematically has become an important issue. Platform-based design is one example of an embedded-system design method that can reduce the design cost via improving a design’s abstraction level. However, platform-based design lacks precise definitions for platforms and design processes. This paper provides an approach that combines the aspects and platform-based design methods for developing embedded software. The approach is built on platform-based design methodology and uses the separating of concerns (SoC) concept to define the aspects and to reduce the crosscutting concerns in embedded system modeling. For aspect issues, we use the extended UML notation with aspects to describe both the static structure and the dynamic structure of the embedded system. We used an example of a digital photo frame system to demonstrate our approach.

Transforming Digital Experiences: The Evolution of Digital Experience Platforms (DXPs) from Monoliths to Microservices: A Practical Guide

The research aims to explore the transition from monolithic Digital Experience Platforms (DXPs) to Microservices-based DXPs, addressing scalability challenges. The study systematically decomposes monolithic structures into Microservices, emphasizing business capability and subdomain decomposition. Concrete insights, challenges, and solutions encountered during this transformation process are presented. The research contributes valuable insights into the challenges and benefits of adopting Microservices in DXPs. Results highlight the importance of architectural patterns and strategic scaling dimensions for improved performance and scalability. The case study on Backbase’s Engagement Banking Platform showcases successful implementation, providing flexibility, integration, and efficient development in the evolving DXP landscape.

makeTwin:A reference architecture for digital twin software platform

Digital twin is currently undergoing a significant transformation from the conceptual and theoretical research phase to the implementation and application phase.However,a universally adaptable research and development platform for digital twin is critically needed to meet the development requirements.Specifically,a publicly accessible simulation,testing,and validation platform which can support digital twin model building,data processing,algorithm design,configuration,etc.,is urgently required for researchers.Furthermore,for developers from the industry,a lowcode development platform that can offer a customizable suite of functions such as model creation,data management,protocol configuration,and visualization is urgently needed.Meanwhile,for enterprise users,there is a lack of an application management platform that can be configured and migrated for various application scenarios,functions,and modes.Therefore,based on the system research of digital twin theories and key technologies by the authors(such as the five-dimension digital twin model,digital twin modeling and digital twin data theory,digital twin standards,and so on),a digital twin software platform reference architecture,namely make Twin,is proposed and designed,as well as its ten core functions.The workflow of the make Twin and the interaction mechanisms among its core functions are described.Finally,a digital twin application system for a chemical fiber textile shop floor(CFTS)which was developed according to make Twin,is introduced,which validates the proposed reference architecture.

Biomaterial-based platforms for cancer stem cell enrichment and study

Cancer stem cells(CSCs)are a relatively rare subpopulation of tumor cell with self-renewal and tumorigenesis capabilities.CSCs are associated with cancer recurrence,progression,and chemoradiotherapy resistance.Establishing a reliable platform for CSC enrichment and study is a prerequisite for understanding the characteristics of CSCs and discovering CSC-related therapeutic strategies.Certain strategies for CSC enrichment have been used in laboratory,particularly fluorescence-activated cell sorting(FACS)and mammosphere culture.However,these methods fail to recapitulate the in vivo chemical and physical conditions in tumors,thus potentially decreasing the malignancy of CSCs in culture and yielding unreliable research results.Accumulating research suggests the promise of a biomaterial-based three-dimensional(3 D)strategy for CSC enrichment and study.This strategy has an advantage over conventional methods in simulating the tumor microenvironment,thus providing a more effective and predictive model for CSC laboratory research.In this review,we first briefly discuss the conventional methods for CSC enrichment and study.We then summarize the latest advances and challenges in biomaterial-based 3 D CSC platforms.Design strategies for materials,morphology,and chemical and physical cues are highlighted to provide direction for the future construction of platforms for CSC enrichment and study.

The IRIS Development Platform and Proposed Object-Oriented Data Base

Various code development platforms, such as the ATHENA Framework [1] of the ATLAS [2] experiment encounter lengthy compilation/linking times. To augment this situation, the IRIS Development Platform was built as a software development framework acting as compiler, cross-project linker and data fetcher, which allow hot-swaps in order to compare various versions of software under test. The flexibility fostered by IRIS allowed modular exchange of software libraries among developers, making it a powerful development tool. The IRIS platform used input data ROOT-ntuples [3];however a new data model is sought, in line with the facilities offered by IRIS. The schematic of a possible new data structuring—as a user implemented object oriented data base, is presented.

Intelligent decision support platform of new energy vehicles

New energy vehicles(NEVs) are gaining wider acceptance as the transportation sector is developing more environmentally friendly and sustainable technology. To solve problems of complex application scenarios and multi-sources heterogenous data for new energy vehicles and weak platform scalability,the framework of an intelligent decision support platform is proposed in this paper. The principle of software and hardware system is introduced. Hadoop is adopted as the software system architecture of the platform. Master-standby redundancy and dual-line redundancy ensure the reliability of the hardware system. In addition, the applications on the intelligent decision support platform in usage patterns recognition, energy consumption, battery state of health and battery safety analysis are also described.

The Practice-oriented Platform of“Data Structure and Algorithm”Curriculum

"Data Structure and Algorithm",which is an important major subject in computer science,has a lot of problems in teaching activity.This paper introduces and analyzes the situation and problems in this course study.A "programming factory" method is then brought out which is indeed a practice-oriented platform of the teachingstudy process.Good results are obtained by this creative method.

Platform LSF软件在高性能计算集群中的实施与应用

随着信息处理技术的精度、可靠度等要求的进一步提高,采用高性能计算集群系统已经成为数字化制造中的关键技术之一。本文结合高性能计算应用现状的不足,阐述了Platform LSF软件设计思想和目标,介绍了该软件的实施与应用情况。

eHealth Management Platform for Screening and Prediction of Down’s Syndrome in the Republic of Panama

Through engineering projects, we have integrated software engineering, geographical information systems and HL7 standard to propose a model of an eHealth management platform for Down’s syndrome screening, replicable in all the country. It will use real time sample information acquired from the local population and will geographically reference this information in the territory of Panama for future research.

油田开发中精细油藏描述成果平台建设研究

精细油藏描述是油田开发最基础的工作之一,历来受到研究者的高度重视。目前精细油藏描述中存在的突出问题主要包括研究成果继承性差、基础资料存储不规范、专业软件需求缺口大、成果应用需加强和成果存储管理不规范等5方面。文章通过精细油藏描述成果平台建设,可以从基础数据的整理准备、专业软件共享和协同研究、成果标准规范化存储管理等方面解决上述问题。精细油藏描述数据管理主要包括项目整体数据信息的统计和分析、项目研究数据的整理和统计、成果平台与其他数据平台的对接和数据调用等。精细油藏描述协同研究过程主要包括专业软件的平台实现和使用、不同专业软件之间中间成果的转换和调用、研究工作的自动化实现和完成。精细油藏描述成果存储和管理主要包括成果上传管理中格式的统一规范、成果存储上传中的质量控制、成果生产应用中的跟踪和更新。