Objective: To study the correlation between three-dimensional speckle tracking imaging (3D-STI) parameter global area strain (GAS) and the cardiotoxicity of chemotherapeutics in patients with lung cancer chemotherapy....Objective: To study the correlation between three-dimensional speckle tracking imaging (3D-STI) parameter global area strain (GAS) and the cardiotoxicity of chemotherapeutics in patients with lung cancer chemotherapy. Methods: Patients with lung cancer who underwent chemotherapy in the Second Affiliated Hospital of Xi'an Medical University between February 2016 and May 2017 were selected as the chemotherapy group, the healthy subjects who received physical examination during the same period were selected as the control group, the 3D-STI examination was performed and GAS was calculated;the serum was collected to determine the contents of cardiotoxicity markers as well as apoptosis and oxidative stress indexes, and the peripheral blood was collected to determine the expression of apoptosis and oxidative stress molecules. Results: GAS level, serum ALDH2 and CAT contents as well as peripheral blood Keap1 and Bcl-2 expression intensity of chemotherapy group were lower than those of control group whereas serum Copeptin, CK-MB, cTnI, cMyBP-c, sTWEAK, sFas, MDA and 8-isoPGF2α contents as well as peripheral blood Nrf-2, gp91phox, p22 phox and Caspase-3 expression intensity were significantly higher than those of control group;the GAS level in chemotherapy group was negatively correlated with serum Copeptin, CK-MB, cTnI, cMyBP-c, sTWEAK, sFas, MDA and 8-isoPGF2α contents as well as peripheral blood Nrf-2, gp91phox, p22 phox and Caspase-3 expression intensity, and positively correlated with serum ALDH2 and CAT contents as well as peripheral blood Keap1 and Bcl-2 expression intensity. Conclusion: The changes of 3D-STI parameter GAS in patients with lung cancer chemotherapy can reflect the degree of cardiotoxicity induced by oxidative stress and apoptosis.展开更多
Three-dimensional speckle tracking echocardiography was employed to evaluate the changes of left ventricular systolic strain in 23 heart transplant recipients at 1 st, 3rd, 6th and 12th month after heart transplantati...Three-dimensional speckle tracking echocardiography was employed to evaluate the changes of left ventricular systolic strain in 23 heart transplant recipients at 1 st, 3rd, 6th and 12th month after heart transplantation, and 23 healthy subjects served as controls. The three-dimensional full-volume echocardiographic images of left ventricle were recorded and then were analyzed using EchoPAC software. The strain curves and peak systolic strain values for each segment and overall left ventricular wall were obtained. Left ventricular global peak longitudinal strain （GPSL）, global peak radial strain （GPSR）, global peak circumferential strain （GPSC） and global peak area strain （GPSA） were measured and then statistically analyzed. There were no significant differences in left ventricular ejection fraction （LVEF） and cardiac output （CO） between heart transplant recipients and controls. The GPSL in heart transplant recipients at 1st month after surgery was significantly lower than that in controls, but close to the normal value at 3rd month after surgery and later. The GPSC, GPSA and GPSR were significantly lower in heart transplant recipients at 1 st, 3rd, 6th and 12th month after surgery than those in controls. It is suggested that three-dimensional speckle tracking echocardiography can be used for monitoring changes of left ventricular systolic strains and evaluating left ventricular systolic function in cardiac allograft.展开更多
Background Two-dimensional speckle tracking imaging （2D-STI） and real-time three-dimensional echocardiography （RT-3DE） have more advantages in evaluating left ventricular （LV） systolic dyssynchrony than traditio...Background Two-dimensional speckle tracking imaging （2D-STI） and real-time three-dimensional echocardiography （RT-3DE） have more advantages in evaluating left ventricular （LV） systolic dyssynchrony than traditional echocardiographic techniques. The study aimed to evaluate LV dyssynchrony parameters by both 2D-STI and RT-3DE, and the correlation between these two techniques. Methods A total of 43 chronic heart failure （CHF） patients and 27 healthy volunteers were enrolled. There were 23 dyssynchrony parameters selected to evaluate left ventricular systolic synchronization, involving 15 from 2D-STI and 8 from RT-3DE. Results Few of the dyssynchrony parametersshowednegative correlations with LV ejection fraction （LVEF） in the CHF group. The difference between time to peak-systolic radial strain of the anteroseptal and posterior segments at the level of papillary muscles [AS-P（RS）] from 2D-STI showed positive correlations with parts of the parameters from RT-3DE （P 〈 0.05）. Conclusions LV systolic dysfunction does not correlate with dyssynchrony. Moreover, there is a weak association between 2D-STI and RT-3DE in assessment of left ventricular dyssynchrony.展开更多
目的探讨四维超声自动左心房定量技术(Automatic left atrial quantification with four-dimensional ultrasound,4DAutoVQ)、三维斑点追踪成像技术(Three-dimensional speckle tracking imaging technology,3D-STI)在老年慢性心力衰竭(...目的探讨四维超声自动左心房定量技术(Automatic left atrial quantification with four-dimensional ultrasound,4DAutoVQ)、三维斑点追踪成像技术(Three-dimensional speckle tracking imaging technology,3D-STI)在老年慢性心力衰竭(Chronic heart failure,CHF)患者心功能评价中的应用价值。方法选取2020年1月至2022年4月重庆大学附属沙坪坝医院重庆市沙坪坝区人民医院心血管内科收治的老年CHF患者167例设为研究组,另选取同期健康体检者167例设为对照组。采集两组受检者性别、年龄、体质量指数(Body mass index,BMI)、舒张压、收缩压、研究组美国纽约心脏病学会(New York Heart Association,NYHA)分级等资料,实施3D-STI、4DAutoVQ检查。比较研究组与对照组、研究组不同NYHA分级患者4DAutoVQ、3D-STI参数,分析4DAutoVQ、3D-STI参数与研究组NYHA分级的关联性。结果(1)研究组左心室整体径向收缩期峰值应变(Global radial systolic peak strain of left ventricle,GRS)、整体环向收缩期峰值应变(Global circumferential peak systolic strain,GCS)、整体纵向收缩期峰值应变(Overall longitudinal peak systolic strain,GLS)、左房排空容积(Left atrial emptying volume,LAEV)、左房射血分数(Left atrial ejection fraction,LAEF)、左房被动射血分数(Left atrial passive ejection fraction,LAPEF)、左房主动射血分数(Left atrial active ejection fraction,LAAEF)、左房储备期纵向应变(Longitudinal strain of left atrial reserve,LASr)、左房储备期圆周应变(Peripheral strain of left atrial reserve period,LASr-c)低于对照组,左房最大容积指数(Maximum left atrial volume index,LAVImax)、左房最小容积(Minimum left atrial volume,LAVmin)、左房收缩前容积(Left atrial pre systolic volume,LAVpreA)、左房最大容积(Maximum left atrial volume,LAVmax)、左房通道期纵向应变(Longitudinal strain of left atrial passage,LAScd)、左房收缩期纵向应变(Longitudinal strain of left atrium during systole,LASct)、左房收缩期圆周应变(Left atrial systolic circumferential strain,LASct-c)、左房通道期圆周应变(Circumferential strain of left atrial passage,LAScd-c)高于对照组,差异有统计学意义(P<0.05)。(2)研究组不同NYHA分级患者4DAutoVQ、3D-STI参数比较,差异有统计学意义(P<0.05),且随着NYHA分级增高,GRS、GCS、GLS、LAEV、LAEF、LAPEF、LAAEF、LASr、LASr-c呈降低趋势,LAVImax、LAVmin、LAVpreA、LAVmax、LAScd、LASct、LASct-c、LAScd-c呈增高趋势,差异有统计学意义(P<0.05)。(3)Spearman相关性分析结果显示,GRS、GCS、GLS、LAEV、LAEF、LAPEF、LAAEF、LASr、LASr-c与CHF病情分级存在负相关关系,LAVImax、LAVmin、LAVpreA、LAVmax、LAScd、LASct、LASct-c、LAScd-c与CHF病情分级存在显著正相关关系(P<0.05)。(4)Logistic分析结果显示,GRS、GCS、GLS、LAEV、LAEF、LAPEF、LAAEF、LASr、LASr-c、LAVImax、LAVmin、LAVpreA、LAVmax、LAScd、LASct、LASct-c、LAScd-c均是CHF重要影响因素(P<0.05)。结论通过4DAutoVQ、3D-STI检查可评估老年CHF患者心功能及结构状态,相关参数增高或降低程度与疾病病情关系密切,可评估疾病NYHA分级。展开更多
文摘Objective: To study the correlation between three-dimensional speckle tracking imaging (3D-STI) parameter global area strain (GAS) and the cardiotoxicity of chemotherapeutics in patients with lung cancer chemotherapy. Methods: Patients with lung cancer who underwent chemotherapy in the Second Affiliated Hospital of Xi'an Medical University between February 2016 and May 2017 were selected as the chemotherapy group, the healthy subjects who received physical examination during the same period were selected as the control group, the 3D-STI examination was performed and GAS was calculated;the serum was collected to determine the contents of cardiotoxicity markers as well as apoptosis and oxidative stress indexes, and the peripheral blood was collected to determine the expression of apoptosis and oxidative stress molecules. Results: GAS level, serum ALDH2 and CAT contents as well as peripheral blood Keap1 and Bcl-2 expression intensity of chemotherapy group were lower than those of control group whereas serum Copeptin, CK-MB, cTnI, cMyBP-c, sTWEAK, sFas, MDA and 8-isoPGF2α contents as well as peripheral blood Nrf-2, gp91phox, p22 phox and Caspase-3 expression intensity were significantly higher than those of control group;the GAS level in chemotherapy group was negatively correlated with serum Copeptin, CK-MB, cTnI, cMyBP-c, sTWEAK, sFas, MDA and 8-isoPGF2α contents as well as peripheral blood Nrf-2, gp91phox, p22 phox and Caspase-3 expression intensity, and positively correlated with serum ALDH2 and CAT contents as well as peripheral blood Keap1 and Bcl-2 expression intensity. Conclusion: The changes of 3D-STI parameter GAS in patients with lung cancer chemotherapy can reflect the degree of cardiotoxicity induced by oxidative stress and apoptosis.
基金supported by Innovation Research Fund of Huazhong University of Science and Technology,China(No.2012QN183)
文摘Three-dimensional speckle tracking echocardiography was employed to evaluate the changes of left ventricular systolic strain in 23 heart transplant recipients at 1 st, 3rd, 6th and 12th month after heart transplantation, and 23 healthy subjects served as controls. The three-dimensional full-volume echocardiographic images of left ventricle were recorded and then were analyzed using EchoPAC software. The strain curves and peak systolic strain values for each segment and overall left ventricular wall were obtained. Left ventricular global peak longitudinal strain （GPSL）, global peak radial strain （GPSR）, global peak circumferential strain （GPSC） and global peak area strain （GPSA） were measured and then statistically analyzed. There were no significant differences in left ventricular ejection fraction （LVEF） and cardiac output （CO） between heart transplant recipients and controls. The GPSL in heart transplant recipients at 1st month after surgery was significantly lower than that in controls, but close to the normal value at 3rd month after surgery and later. The GPSC, GPSA and GPSR were significantly lower in heart transplant recipients at 1 st, 3rd, 6th and 12th month after surgery than those in controls. It is suggested that three-dimensional speckle tracking echocardiography can be used for monitoring changes of left ventricular systolic strains and evaluating left ventricular systolic function in cardiac allograft.
文摘Background Two-dimensional speckle tracking imaging （2D-STI） and real-time three-dimensional echocardiography （RT-3DE） have more advantages in evaluating left ventricular （LV） systolic dyssynchrony than traditional echocardiographic techniques. The study aimed to evaluate LV dyssynchrony parameters by both 2D-STI and RT-3DE, and the correlation between these two techniques. Methods A total of 43 chronic heart failure （CHF） patients and 27 healthy volunteers were enrolled. There were 23 dyssynchrony parameters selected to evaluate left ventricular systolic synchronization, involving 15 from 2D-STI and 8 from RT-3DE. Results Few of the dyssynchrony parametersshowednegative correlations with LV ejection fraction （LVEF） in the CHF group. The difference between time to peak-systolic radial strain of the anteroseptal and posterior segments at the level of papillary muscles [AS-P（RS）] from 2D-STI showed positive correlations with parts of the parameters from RT-3DE （P 〈 0.05）. Conclusions LV systolic dysfunction does not correlate with dyssynchrony. Moreover, there is a weak association between 2D-STI and RT-3DE in assessment of left ventricular dyssynchrony.
文摘目的探讨四维超声自动左心房定量技术(Automatic left atrial quantification with four-dimensional ultrasound,4DAutoVQ)、三维斑点追踪成像技术(Three-dimensional speckle tracking imaging technology,3D-STI)在老年慢性心力衰竭(Chronic heart failure,CHF)患者心功能评价中的应用价值。方法选取2020年1月至2022年4月重庆大学附属沙坪坝医院重庆市沙坪坝区人民医院心血管内科收治的老年CHF患者167例设为研究组,另选取同期健康体检者167例设为对照组。采集两组受检者性别、年龄、体质量指数(Body mass index,BMI)、舒张压、收缩压、研究组美国纽约心脏病学会(New York Heart Association,NYHA)分级等资料,实施3D-STI、4DAutoVQ检查。比较研究组与对照组、研究组不同NYHA分级患者4DAutoVQ、3D-STI参数,分析4DAutoVQ、3D-STI参数与研究组NYHA分级的关联性。结果(1)研究组左心室整体径向收缩期峰值应变(Global radial systolic peak strain of left ventricle,GRS)、整体环向收缩期峰值应变(Global circumferential peak systolic strain,GCS)、整体纵向收缩期峰值应变(Overall longitudinal peak systolic strain,GLS)、左房排空容积(Left atrial emptying volume,LAEV)、左房射血分数(Left atrial ejection fraction,LAEF)、左房被动射血分数(Left atrial passive ejection fraction,LAPEF)、左房主动射血分数(Left atrial active ejection fraction,LAAEF)、左房储备期纵向应变(Longitudinal strain of left atrial reserve,LASr)、左房储备期圆周应变(Peripheral strain of left atrial reserve period,LASr-c)低于对照组,左房最大容积指数(Maximum left atrial volume index,LAVImax)、左房最小容积(Minimum left atrial volume,LAVmin)、左房收缩前容积(Left atrial pre systolic volume,LAVpreA)、左房最大容积(Maximum left atrial volume,LAVmax)、左房通道期纵向应变(Longitudinal strain of left atrial passage,LAScd)、左房收缩期纵向应变(Longitudinal strain of left atrium during systole,LASct)、左房收缩期圆周应变(Left atrial systolic circumferential strain,LASct-c)、左房通道期圆周应变(Circumferential strain of left atrial passage,LAScd-c)高于对照组,差异有统计学意义(P<0.05)。(2)研究组不同NYHA分级患者4DAutoVQ、3D-STI参数比较,差异有统计学意义(P<0.05),且随着NYHA分级增高,GRS、GCS、GLS、LAEV、LAEF、LAPEF、LAAEF、LASr、LASr-c呈降低趋势,LAVImax、LAVmin、LAVpreA、LAVmax、LAScd、LASct、LASct-c、LAScd-c呈增高趋势,差异有统计学意义(P<0.05)。(3)Spearman相关性分析结果显示,GRS、GCS、GLS、LAEV、LAEF、LAPEF、LAAEF、LASr、LASr-c与CHF病情分级存在负相关关系,LAVImax、LAVmin、LAVpreA、LAVmax、LAScd、LASct、LASct-c、LAScd-c与CHF病情分级存在显著正相关关系(P<0.05)。(4)Logistic分析结果显示,GRS、GCS、GLS、LAEV、LAEF、LAPEF、LAAEF、LASr、LASr-c、LAVImax、LAVmin、LAVpreA、LAVmax、LAScd、LASct、LASct-c、LAScd-c均是CHF重要影响因素(P<0.05)。结论通过4DAutoVQ、3D-STI检查可评估老年CHF患者心功能及结构状态,相关参数增高或降低程度与疾病病情关系密切,可评估疾病NYHA分级。
