Model-based risk assessment on dynamic control of twin-column continuous capture under feedstock variations

Dynamic control is essential to guarantee the stable performance of continuous chromatography.AutoMAb dynamic control strategy has been developed to ensure a consistent protein load in twincolumn CaptureSMB continuous capture by integrating the UV signal of breakthrough.In this study,the process risk of CaptureSMB continuous capture under AutoMAb control towards the feedstock variations was assessed by a mechanistic model developed by us.The effects of target protein and impurities under the variation range of±10 mAU·min^(-1) on load amount,protein loss,process productivity,and resin capacity utilization were investigated.The results showed that the CaptureSMB process could be successfully controlled by AutoMAb towards increased or slightly decreased concentration of feedstock.However,the load process would be out of control with drastically decreased target protein or impurities,and the decreased impurities would lead to protein loss.It was found that AutoMAb control would cause 44.7%non-operational areas and 18.3%protein loss areas in the variation range of±10 mAU·min^(-1).To improve the stability of the CaptureSMB process,a modified AutoMAb control that would stop the load procedure when the absolute value of the integral area reached the preset value,was proposed to reduce the risk of protein loss and the non-operational area.

Utilising continuous glucose monitoring for glycemic control in diabetic kidney disease

In this editorial,we comment on the article by Zhang et al.Chronic kidney disease(CKD)presents a significant challenge in managing glycemic control,especially in diabetic patients with diabetic kidney disease undergoing dialysis or kidney transplantation.Conventional markers like glycated haemoglobin(HbA1c)may not accurately reflect glycemic fluctuations in these populations due to factors such as anaemia and kidney dysfunction.This comprehensive review discusses the limitations of HbA1c and explores alternative methods,such as continuous glucose monitoring(CGM)in CKD patients.CGM emerges as a promising technology offering real-time or retrospective glucose concentration measure-ments and overcoming the limitations of HbA1c.Key studies demonstrate the utility of CGM in different CKD settings,including hemodialysis and peritoneal dialysis patients,as well as kidney transplant recipients.Despite challenges like sensor accuracy fluctuation,CGM proves valuable in monitoring glycemic trends and mitigating the risk of hypo-and hyperglycemia,to which CKD patients are prone.The review also addresses the limitations of CGM in CKD patients,emphasizing the need for further research to optimize its utilization in clinical practice.Altogether,this review advocates for integrating CGM into managing glycemia in CKD patients,highlighting its superiority over traditional markers and urging clinicians to consider CGM a valuable tool in their armamentarium.

Analysis of the Causes of Continuous Cropping Obstacles for Atractylodes macrocephala Koidz in Pingjiang County and Its Control Methods

First at all, it introduced the concept and the damages of continuous cropping obstacle. Then, it analyzed the causes of continuous cropping obstacles for Atractylodes macrocephala Koidz. In the end, in order to provide guidance for pro- moting sustainable development of Atractylodes macrocephala Koidz industry in Pingjiang County, it put forward some control methods for eliminating continuous cropping obstacles of Atractylodes macrocephala Koidz, including breeding varieties with high resistance; applying rotation cropping and intercropping reasonable; rational fertilization and soil disinfection; introducing antagonistic bacterial and eliminating au- tointoxication.

Effect of Continuous Application of Controlled Release Nitrogen Fertilizer in Various Types of Soil in Dong-Ting Lake Region under Double Rice Cropping System

[Objective] This study aimed to explore the effects of continuous application of controlled release nitrogen fertilizer under double rice cropping system. [Method] By modeling three types of paddy soils in Dong-Ting Lake area, four treatments as no fertilizer （CK）, urea, controlled release nitrogen fertilizer （CRNF） and 70% controlled release nitrogen fertilizer （70% CRNF） were designed in the micro-plot trials from 2005 to 2008. [Result] The rice yield in treatment CRNF at N 150 kg/hm2 was increased by 10.3%, 8.0% and 2.4% compared with treatment of urea, in alluvial sandy loamy paddy soil （ALS）, purple calcareous clayey paddy soil （PCS）, and reddish yellow loamy paddy soil （RYS）, respectively; and the yield in treatment of 70% CRNF was increased by 6.1%, 2.6% and -0.8%, respectively. The ranking order of nitrogen uptake amount by plant in early rice and late rice was CRNF 70% CRNF urea CK in all three types of soil. Nitrogen utilization efficiency of CRNF in above three types of soil was 60.7%, 59.6% and 56.3%, increased by 23.8%, 19.4% and 16.3% compared with that in treatment of urea, respectively. Nitrogen utilization efficiency of CRNF in early rice was increased year by year, and was higher than that of 70% CRNF during the whole experiment stage, while that in late rice was increased first and then decreased from the 3rd year. [Conclusion] Continuous application CRNF could alleviate the decreasing of soil nitrogen fertility and organic carbon especially in ALS, increase rice yield and nitrogen utilization efficiency in double-rice cropping system.

EXACT CONTROLLABILITY AND CONTINUOUS DEPENDENCE OF FRACTIONAL NEUTRAL INTEGRO-DIFFERENTIAL EQUATIONS WITH STATE-DEPENDENT DELAY

In the present paper,with the help of the resolvent operator and some analytic methods,the exact controllability and continuous dependence are investigated for a fractional neutral integro-differential equations with state-dependent delay.As an application,we also give one example to demonstrate our results.

Temperature distribution and dynamic control of secondary cooling in slab continuous casting

To predict and optimize the temperature distribution of slab continuous casting in steady operational state, a three-dimensional model （named ＂offline model＂） based on the heat transfer and solidification theories was developed. Both heat transfer and flux distribution characteristics of the nozzle sprays on the slab were considered, and the complicated boundary conditions, such as spray cooling, natural convection, thermal radiation as well as contact cooling of individual rolls were involved in the model. By using the calibrated caster dependent model factors, the calculated temperature and shell thickness accorded well with the measured. Furthermore, a dynamic secondary water cooling control system was also developed on the basis of a two-dimensional transient heat transfer model （named ＂online model＂） and incremental PID control algorithm to reduce slab surface temperature fluctuation in unsteady state. Compared with the traditional spray table control method, the present online model and dynamic PID control demonstrate a higher capability and flexibility to adjust cooling water flowrate and reduce slab surface temperature fluctuation when the casting speed is changed.

STUDY ON CONTROL STRATEGY OF CLUTCH STARTING FOR CAR WITH A METAL PUSHING BELT-PLANETARY GEAR CONTINUOUSLY VARIABLE TRANSMISSION SYSTEM

The automatic control of clutch starting in car with a metal pushingbelt-planetary gear continuously variable transmission (CVT) is a complex problem. A suited controlstrategy is required to realize quick and smooth start. A simulation state space equation isestablished on clutch staring control of a car with CVT by bond graph theory. According to the fuzzycontrol method with the expert system, a fuzzy control system of car starting process to weaken thejerk motion is introduced. The simulation results indicate that the jerk motion of clutch startingis below 10 m/s^3.

Iterative Learning Model Predictive Control for a Class of Continuous/Batch Processes

An iterative learning model predictive control （ILMPC） technique is applied to a class of continuous/batch processes. Such processes are characterized by the operations of batch processes generating periodic strong disturbances to the continuous processes and traditional regulatory controllers are unable to eliminate these periodic disturbances. ILMPC integrates the feature of iterative learning control （ILC） handling repetitive signal and the flexibility of model predictive control （MPC）. By on-line monitoring the operation status of batch processes, an event-driven iterative learning algorithm for batch repetitive disturbances is initiated and the soft constraints are adjusted timely as the feasible region is away from the desired operating zone. The results of an industrial application show that the proposed ILMPC method is effective for a class of continuous/batch processes.

Vibration analysis of maglev three-span continuous guideway considering control system

The dynamic interaction between maglev vehicle and three-span continuous guideway is discussed. With the consideration of control system, the dynamic interaction model has been developed. Numerical simulation has been performed to study dynamic characteristics of the guideway. The results show that bending rigidity, vehicle speed, span ratio and primary frequency all have important influences on the dynamic characteristics of the guideway and there is no distinct trend towards resonance vibration when fl/（v/l） equals 1.0. The definite way is to control impact coefficient and acceleration of the guideway. The conclusions can serve the design of high-speed maglev three-span continuous guideway.

Simulation and control model for interactions among process parameters of directional solidification continuous casting

On the basis of analyzing the principles, equipment and control needs of directional solidification continuous casting (DSCC) process, the building and fulfilling methods of control model of DSCC procedure by neural network control (NNC) method were proposed and discussed. Combining the experimental researches, firstly the computer is used to simulate the effects of those solidification parameters on destination control variable (S/L interface) and the reactions among those parameters during DSCC procedure; secondly many training samples can be obtained. Moreover, after these samples are input into neural network software (NNs) and trained, the control model can be built.

Trigonometric Regularization and Continuation Method Based Time-Optimal Control of Hypersonic Vehicles

Aiming at the time-optimal control problem of hypersonic vehicles(HSV)in ascending stage,a trigonometric regularization method(TRM)is introduced based on the indirect method of optimal control.This method avoids analyzing the switching function and distinguishing between singular control and bang-bang control,where the singular control problem is more complicated.While in bang-bang control,the costate variables are unsmooth due to the control jumping,resulting in difficulty in solving the two-point boundary value problem(TPBVP)induced by the indirect method.Aiming at the easy divergence when solving the TPBVP,the continuation method is introduced.This method uses the solution of the simplified problem as the initial value of the iteration.Then through solving a series of TPBVP,it approximates to the solution of the original complex problem.The calculation results show that through the above two methods,the time-optimal control problem of HSV in ascending stage under the complex model can be solved conveniently.

THEORETICAL AND EXPERIMENTAL STUDY ON THE PRESSURE AND VACUUM CONTINUOUS CONTROL SYSTEM BASED ON HYBRID PUMP

A novel pressure and vacuum continuous control system, which adopts a hybrid pump as pressure and vacuum source, is presented. The mathematical model of the system is developed. The theoretical simulation and analysis on the system are implemented in order to study the relationships among the characteristics, parameters and working points of the system. The experimental investigations on the system characteristics are presented with the adoption ofa fuzzy-PID controller. The simulation and experimental results indicate that the pressure and vacuum continuous control system based on hybrid pump has good dynamic and static performance, strong robustness and satisfactory adaptability to various system parameters. According to the results, system can successfully gain high accuracy and fast response signal. Also, the mathematical model of system is also testified by the experimental results.

MODELING, VALIDATION AND OPTIMAL DESIGN OF THE CLAMPING FORCE CONTROL VALVE USED IN CONTINUOUSLY VARIABLE TRANSMISSION

Associated dynamic performance of the clamping force control valve used in continuously variable transmission （CVT） is optimized. Firstly, the structure and working principle of the valve are analyzed, and then a dynamic model is set up by means of mechanism analysis. For the purpose of checking the validity of the modeling method, a prototype workpiece of the valve is manufactured for comparison test, and its simulation result follows the experimental result quite well. An associated performance index is founded considering the response time, overshoot and saving energy, and five structural parameters are selected to adjust for deriving the optimal associated performance index. The optimization problem is solved by the genetic algorithm （GA） with necessary constraints. Finally, the properties of the optimized valve are compared with those of the prototype workpiece, and the results prove that the dynamic performance indexes of the optimized valve are much better than those of the prototype workpiece.

Control strategy of LCL-type three-phase photovoltaic grid connected inverter

The grid-connected inverter with LCL filter has the ability of easily attenuating high-frequency current harmonics. However, its suppression effect on the background harmonics in grid voltage is limited. A control strategy is presented, which is composed of an inner loop of capacitor current feedforward, an outer loop of grid-current feedforward and feedforward of grid voltage. The limitations and steps of parameters design for LCL filter are analyzed. Meanwhile, the capacitor current loop is employed to damp the resonant peak caused by the LCL filter and enhance the stability. The properties of different controllers are analyzed and compared, thereinto quasi-proportional-rasonant (PR) controller realizes the control with zero steady-state error of AC variables in static coordinates. In order to suppress the current distortion effected by the background harmonics in grid voltage, the feed-forward function is calculated for the grid-connected inverter with an LCL filter. After simplifying the block diagram, a full-feedforward control strategy for grid voltage is proposed. Theoretical analysis and Matlab/Simulink simulation results show that the proposed method has the advantages of high steady accuracy, fast dynamic response and strong robustness.

Continuous rotary motor electro-hydraulic servo system based on the improved repetitive controller

In order to suppress the periodic interference of the continuous rotary electro-hydraulic servo motor,this paper makes the motor tracking the periodic signals with high accuracy,and improves the influence of friction interference to the performance of continuous rotary electro-hydraulic servo motor.The mathematic model of the electro-hydraulic position servo system of the continuous rotary motor was established,and the compound control method was adopted based on the repetitive control,feed forward and PID to suppress the friction interference.Through the simulation,the result confirms that the compound control method decreases the tracking error of the system,increases the robust performance of the system and improves the performance of the continuous rotary electro-hydraulic servo motor.

Application of Continuous Compaction Technology in the Quality Control and Acceptance of High-Speed Railway Subgrade

On the basis of the theory of continuous compaction technology, we put forward the vibratory compaction value （VCV） index measured by a roller compactor, in order to evaluate the quality of continuously compacted subgrade. The relationships between the VCV index and the currently used indexes K30, Evd, Ev1 and Ev2, were explored by analyzing the experimental data collected from two test sections on the Beijing - Shanghai High-Speed Railway. The result shows that the VCV index has a linear relationship with the currently used indexes.

Research on improved active disturbance rejection control of continuous rotary motor electro-hydraulic servo system

In order to meet the precision requirements and tracking performance of the continuous rotary motor electro-hydraulic servo system under unknown strong non-linear and uncertain strong disturbance factors,such as dynamic uncertainty and parameter perturbation,an improved active disturbance rejection control(ADRC)strategy was proposed.The state space model of the fifth order closed-loop system was established based on the principle of valve-controlled hydraulic motor.Then the three parts of ADRC were improved by parameter perturbation and external disturbance;the fast tracking differentiator was introduced into linear and non-linear combinations;the nonlinear state error feedback was proposed using synovial control;the extended state observer was determined by nonlinear compensation.In addition,the grey wolf algorithm was used to set the parameters of the three parts.The simulation and experimental results show that the improved ADRC can realize the system frequency 12 Hz when the tracking accuracy and response speed meet the requirements of double ten indexes,which lay foundation for the motor application.

Continuous glucose monitoring metrics in pregnancy with type 1 diabetes mellitus

Managing diabetes during pregnancy is challenging,given the significant risk it poses for both maternal and foetal health outcomes.While traditional methods involve capillary self-monitoring of blood glucose level monitoring and periodic HbA1c tests,the advent of continuous glucose monitoring(CGM)systems has revolutionized the approach.These devices offer a safe and reliable means of tracking glucose levels in real-time,benefiting both women with diabetes during pregnancy and the healthcare providers.Moreover,CGM systems have shown a low rate of side effects and high feasibility when used in pregnancies complicated by diabetes,especially when paired with continuous subcutaneous insulin infusion pump as hybrid closed loop device.Such a combined approach has been demonstrated to improve overall blood sugar control,lessen the occurrence of preeclampsia and neonatal hypoglycaemia,and minimize the duration of neonatal intensive care unit stays.This paper aims to offer a comprehensive evaluation of CGM metrics specifically tailored for pregnancies impacted by type 1 diabetes mellitus.

Control strategy and methods for continuous direct compression processes

We presented a control strategy for tablet manufacturing processes based on continuous direct compression.The work was conducted by the experts of pharmaceutical companies,machine suppliers,academia,and regulatory authority in Japan.Among different items in the process,the component ratio and blended powder content were selected as the items requiring the control method specific to continuous manufacturing different from the conventional batch manufacturing.The control and management of the Loss in Weight(LIW)feeder were deemed the most important,and the Residence Time Distribution(RTD)model were regarded effective for setting the control range and for controlling of the LIW feeder.Based on these ideas,the concept of process control using RTD was summarized.

A Compensation Controller Based on a Nonlinear Wavelet Neural Network for Continuous Material Processing Operations

Continuous material processing operations like printing and textiles manufacturing are conducted under highly variable conditions due to changes in the environment and/or in the materials being processed.As such,the processing parameters require robust real-time adjustment appropriate to the conditions of a nonlinear system.This paper addresses this issue by presenting a hybrid feedforward-feedback nonlinear model predictive controller for continuous material processing operations.The adaptive feedback control strategy of the controller augments the standard feedforward control to ensure improved robustness and compensation for environmental disturbances and/or parameter uncertainties.Thus,the controller can reduce the need for manual adjustments.The controller applies nonlinear generalized predictive control to generate an adaptive control signal for attaining robust performance.A wavelet-based neural network model is adopted as the prediction model with high prediction precision and time-frequency localization characteristics.Online training is utilized to predict uncertain system dynamics by tuning the wavelet neural network parameters and the controller parameters adaptively.The performance of the controller algorithm is verified by both simulation,and in a real-time practical application involving a single-input single-output double-zone sliver drafting system used in textiles manufacturing.Both the simulation and practical results demonstrate an excellent control performance in terms of the mean thickness and coefficient of variation of output slivers,which verifies the effectiveness of this approach in improving the long-term uniformity of slivers.