Bone metastases(BM)are a common complication in advanced cancer patients,significantly contributing to morbidity and mortality due to their ability to cause pain,fractures,and spinal cord compression.Radiation therapy...Bone metastases(BM)are a common complication in advanced cancer patients,significantly contributing to morbidity and mortality due to their ability to cause pain,fractures,and spinal cord compression.Radiation therapy(RT)is vital in managing these complications by targeting metastatic lesions to ease pain,improve mobility,and reduce the risk of skeletal-related events such as fractures.Evidence supports the effectiveness of RT in pain relief,showing its ability to provide significant palliation and lessen the need for opioid painkillers,thereby enhancing the overall quality of life(QoL)for patients with BM.However,optimizing RT outcomes involves considerations such as the choice of radiation technique,dose fractionation schedules,and the integration of supportive care measures to mitigate treatment-related side effects like fatigue and skin reactions.These factors highlight the importance of personalized treatment planning tailored to individual patient needs and tumor characteristics.This mini-review aims to provide comprehensive insights into the multifaceted impacts of RT on pain management and QoL enhancement in BM patients,with implications for refining clinical practices and advancing patient care through the synthesis of findings from various studies.展开更多
Approximately 50%of breast cancer patients under hormone therapy experience osteoarticular pain,which increases the risk of treatment discontinuation and relapse.The aim of the study was to assess the feasibility of y...Approximately 50%of breast cancer patients under hormone therapy experience osteoarticular pain,which increases the risk of treatment discontinuation and relapse.The aim of the study was to assess the feasibility of yoga practice associated with patient education(PE)for at-home practice in breast cancer patients under hormone therapy.We also evaluated osteoarticular pain,flexibility and patients’satisfaction.In this study,intervention was split into two 6-week periods(P):P1 consisting of a supervised yoga-PE session of 90 minutes/week and 15-minutes of daily at-home yoga,and P2,involving daily autonomous athome yoga sessions.Feasibility was evaluated by patient adherence defined as completion of at least 4 out of the 6 supervised yoga-PE sessions and 70%or more of the at-home yoga sessions.Evaluations(at inclusion and at the end of each period)consisted in assessment of osteoarticular pain,forward flexibility and patient satisfaction.Twenty-four women with a median age of 53 years[36–72]were included.Feasibility was validated with a successful adherence rate reaching 83%,combined with a mean satisfaction score of 10/10[8–10].In addition,58%of patients reported reduced osteoarticular pain,with a 2-point reduction on the numerical rating scale.The forward flexibility also improved,with a median gain of 8 cm.Combined physiotherapy-yoga-PE intervention is a feasible strategy,increasing at-home yoga practice with potential benefit on pain,flexibility,and patient satisfaction.Evaluation of this innovative program is ongoing in a larger randomized multicenter trial.展开更多
BACKGROUND According to the World Health Organization analgesic ladder,cancer-related pain generally begins with pharmacotherapy in a stepwise approach.Nevertheless,some patients continue to experience poorly controll...BACKGROUND According to the World Health Organization analgesic ladder,cancer-related pain generally begins with pharmacotherapy in a stepwise approach.Nevertheless,some patients continue to experience poorly controlled pain despite medications,particularly when considering adverse effects and self-care quality.Percutaneous cervical cordotomy is an alternative interventional procedure for unremitting unilateral intractable cancer-related pain.CASE SUMMARY The patient was diagnosed with lung cancer with destruction of the brachial plexus and ribs.For 2 mo,the patient experienced progressive severe weakness and pain in the right upper extremity.Notably,the pain intensity reached an extreme level,particularly when lying supine,even under heavy sedation.This heightened pain response posed a significant challenge;as a result,the patient was unable to undergo further evaluation through magnetic resonance imaging.Ultimately,he underwent percutaneous cervical cordotomy for symptom relief,resulting in complete resolution of right arm pain.After a 3-mo follow-up,the pain did not recur,and only a flurbiprofen local patch was required for mild scapular tightness.CONCLUSION Cordotomy,under careful patient selection,appears to enhance the quality of life of patients with unilateral cancerrelated pain.展开更多
Cancer pain is the most common and serious symptom of cancer, which seriously affects the quality of life of cancer patients. the most widely used three-step analgesia has received good effects, but the toxic side eff...Cancer pain is the most common and serious symptom of cancer, which seriously affects the quality of life of cancer patients. the most widely used three-step analgesia has received good effects, but the toxic side effects at the same time can be ignored. As a complementary therapy increasingly accepted around the world, traditional Chinese medicine (TCM) also plays an important role in cancer pain treatment. Traditional Chinese non-drug therapy has a good effect for cancer pain. In this mini-review, the commonly used traditional Chinese non-drug therapies such as acupuncture, moxibustion, acupoint catgut embedding and injection, massage, ear point pressing with coxherb seeds therapy, traditional music therapy were introduced.展开更多
Objective: Under the guidance of the theory of Miao medicine, the technical norm scheme for intervention of acupuncture and moxibustion for the treatment of cancer pain is proposed. Methods: The standard operation pro...Objective: Under the guidance of the theory of Miao medicine, the technical norm scheme for intervention of acupuncture and moxibustion for the treatment of cancer pain is proposed. Methods: The standard operation procedure of the intervention of the acupuncture and moxibustion acupuncture therapy for cancer pain was formulated according to the selection of acupoints in the Miao medicine Tianying acupoint, sputum manipulation method, and the routine operations such as medicine, acupuncture and canning. Results: A set of technical specifications for the treatment of cancer pain in a mobilized Miao doctor was sorted out. Conclusion: The sputum acupuncture treatment technique specification for cancer pain is easy to operate and easy to be applied in clinical application.展开更多
Bone metastasis,a life-threatening complication of advanced breast cancer,is often accompanied by debilitating pain(cancer-induced bone pain,CIBP)that severely impairs life quality and survival.The concurrent treatmen...Bone metastasis,a life-threatening complication of advanced breast cancer,is often accompanied by debilitating pain(cancer-induced bone pain,CIBP)that severely impairs life quality and survival.The concurrent treatment of bone metastases and CIBP remains a clinical challenge because the therapeutic options are limited.In this study,we construct a near-infrared light-activated nano-therapeutic system to meet this conundrum.In detail,sorafenib(SRF)and photosensitizer(chlorin e6,Ce6)are encapsulated into mesoporous hydroxyapatite nanoparticles(HANPs),which are further functionalized with hyaluronic acid(HA)to obtain HA-SRF/Ce6@HANPs system.The designed nanoplatform destroys tumor cells in vitro and in vivo via the synergism of SRF(interrupting the exchange of cystine/glutamate by inhibiting SLC7A11)and photodynamic therapy(PDT,inducing reactive oxygen species generation).The decrease in tumor burden and reduction of extracellular glutamate significantly attenuate CIBP in mice model with developing bone cancer.Moreover,the combination of HA-SRF/Ce6@HANPs and PDT inhibit osteoclasts activation,promote osteoblast differentiation and accelerate bone repair.Overall,the nanoagent with good biocompatibility may provide an effective therapy method for the concurrent treatment of breast cancer bone metastasis and CIBP.展开更多
BACKGROUND Pain in the liver is a common symptom of liver cancer in late stages,and the pain incidence rate exceeds 50%[1].In serious cancer pain,morphine and other major analgesics have been commonly administrated fo...BACKGROUND Pain in the liver is a common symptom of liver cancer in late stages,and the pain incidence rate exceeds 50%[1].In serious cancer pain,morphine and other major analgesics have been commonly administrated for clinical treatments,and their effects are accurate,but with a high incidence of side effects,such as nausea,vomiting,constipation,and other conditions.Acupuncture is a traditional Chinese medicine therapy.There have been many randomized controlled trials addressing the safety and usefulness of different methods of acupuncture in alleviating liver cancer pain.However,which of these methods is the most effective method is still unclear.AIM To compare the effectiveness of different acupuncture methods for alleviating pain due to liver cancer.METHODS Eligible studies were retrieved from eight databases(the Cochrane Library,PubMed,EMBASE,Medline,CNKI,CBM,Chongqing VIP,and Wan Fang Database)up to March 31,2021 and screened based on the established inclusion and exclusion criteria.The quality of the include studies was evaluated.Stata software was applied for statistical analyses.Publication bias of the included studies was also determined.Finally,the network meta-analysis was carried out to evaluate the efficacy of acupuncture methods for relief of pain due to liver cancer.RESULTS A total of eight randomized controlled trials were included in the network metaanalysis.Eight trials(covering 5 treatments and 734 patients)provided data suitable for analysis.Most trials focused on short-term effects and many were classed as being of poor quality with a high risk of bias,commonly associated with lack of blinding(which was sometimes impossible to achieve).End of treatment results showed that four interventions,including wrist-ankle acupuncture,triple puncture and remaining needle acupuncture,Tian Yuan acupuncture,and block acupuncture,produced a statistically significant reduction in pain when compared with the three-step analgesic ladder therapy.The surface under the cumulative ranking sorting results showed that triple puncture and remaining needle acupuncture had a relatively high effective rate.CONCLUSION The network meta-analysis results indicate that the overall effectiveness of triple puncture and remaining needle acupuncture is better than the other therapies.展开更多
In clinic, most patients with middle-late cancer suffer from cancer pain, which seriously affects the confidence and compliance of treatment. However, the side effects of the three-step analgesic therapy, which is wid...In clinic, most patients with middle-late cancer suffer from cancer pain, which seriously affects the confidence and compliance of treatment. However, the side effects of the three-step analgesic therapy, which is widely used at present, are gradually manifested, aggravating patients' resistance to treatment. The role of Moxibustion in relieving pain has been gradually recognized and used in various professional fields. Because of its advantages of non-toxic side effects, simple operation, economic benefits, pain relief and immunity enhancement, moxibustion has been paid more and more attention.展开更多
Requirements for intervention measures for lung cancer have increased in number and difficulty due to the progress of patients and influence of complex groups of symptom.The cure rate for patients with lung cancer has...Requirements for intervention measures for lung cancer have increased in number and difficulty due to the progress of patients and influence of complex groups of symptom.The cure rate for patients with lung cancer has improved with the vigorous development of new technologies in modern medicine.However,their mental health status and physical quality of life have continued to warrant scholarly attention.The field of cognitive behavior therapy(CBT)provides innovative ideas for addressing this issue.Thus,the study reviews the origin and concept of CBT,CBT technology,and effect of its application to patients with lung cancer to provide a feasible reference for intervention on physical and mental adverse symptoms in patients with lung cancer.展开更多
目的评价不同康复锻炼方式改善乳腺癌术后肩关节功能的效果。方法检索中国知网、维普网、万方数据、SinoMed、PubMed、Embase、Cochrane Library、Web of Science数据库中关于锻炼方式改善乳腺癌术后患者肩关节功能的随机对照试验,检索...目的评价不同康复锻炼方式改善乳腺癌术后肩关节功能的效果。方法检索中国知网、维普网、万方数据、SinoMed、PubMed、Embase、Cochrane Library、Web of Science数据库中关于锻炼方式改善乳腺癌术后患者肩关节功能的随机对照试验,检索时限为建库至2024年1月,采用Stata17.0软件进行文献的质量评价与数据分析。结果共纳入13项研究,涉及9种锻炼方式和994例患者。网状Meta分析结果表明,在改善肩部屈曲功能方面,水疗法和渐进式康复操的效果优于常规护理(均P<0.05),其中以水疗法的效果最佳;在改善肩部伸展功能方面,渐进式康复操、本体感觉神经肌肉促进术、推拿的效果优于常规护理(均P<0.05),其中以渐进式康复操的效果最佳;在改善肩部外旋功能方面,渐进式康复操的效果优于常规护理(P<0.05);在改善肩部内旋功能方面,涉及的锻炼方式两两比较均未产生统计学差异;在缓解疼痛方面,抗阻力训练的干预效果优于常规护理(P<0.05)。结论水疗法能更好地改善肩部屈曲功能,渐进式康复操在改善肩部伸展、外旋功能方面更具优势,抗阻力训练改善肩部疼痛的效果最优。展开更多
文摘Bone metastases(BM)are a common complication in advanced cancer patients,significantly contributing to morbidity and mortality due to their ability to cause pain,fractures,and spinal cord compression.Radiation therapy(RT)is vital in managing these complications by targeting metastatic lesions to ease pain,improve mobility,and reduce the risk of skeletal-related events such as fractures.Evidence supports the effectiveness of RT in pain relief,showing its ability to provide significant palliation and lessen the need for opioid painkillers,thereby enhancing the overall quality of life(QoL)for patients with BM.However,optimizing RT outcomes involves considerations such as the choice of radiation technique,dose fractionation schedules,and the integration of supportive care measures to mitigate treatment-related side effects like fatigue and skin reactions.These factors highlight the importance of personalized treatment planning tailored to individual patient needs and tumor characteristics.This mini-review aims to provide comprehensive insights into the multifaceted impacts of RT on pain management and QoL enhancement in BM patients,with implications for refining clinical practices and advancing patient care through the synthesis of findings from various studies.
文摘Approximately 50%of breast cancer patients under hormone therapy experience osteoarticular pain,which increases the risk of treatment discontinuation and relapse.The aim of the study was to assess the feasibility of yoga practice associated with patient education(PE)for at-home practice in breast cancer patients under hormone therapy.We also evaluated osteoarticular pain,flexibility and patients’satisfaction.In this study,intervention was split into two 6-week periods(P):P1 consisting of a supervised yoga-PE session of 90 minutes/week and 15-minutes of daily at-home yoga,and P2,involving daily autonomous athome yoga sessions.Feasibility was evaluated by patient adherence defined as completion of at least 4 out of the 6 supervised yoga-PE sessions and 70%or more of the at-home yoga sessions.Evaluations(at inclusion and at the end of each period)consisted in assessment of osteoarticular pain,forward flexibility and patient satisfaction.Twenty-four women with a median age of 53 years[36–72]were included.Feasibility was validated with a successful adherence rate reaching 83%,combined with a mean satisfaction score of 10/10[8–10].In addition,58%of patients reported reduced osteoarticular pain,with a 2-point reduction on the numerical rating scale.The forward flexibility also improved,with a median gain of 8 cm.Combined physiotherapy-yoga-PE intervention is a feasible strategy,increasing at-home yoga practice with potential benefit on pain,flexibility,and patient satisfaction.Evaluation of this innovative program is ongoing in a larger randomized multicenter trial.
文摘BACKGROUND According to the World Health Organization analgesic ladder,cancer-related pain generally begins with pharmacotherapy in a stepwise approach.Nevertheless,some patients continue to experience poorly controlled pain despite medications,particularly when considering adverse effects and self-care quality.Percutaneous cervical cordotomy is an alternative interventional procedure for unremitting unilateral intractable cancer-related pain.CASE SUMMARY The patient was diagnosed with lung cancer with destruction of the brachial plexus and ribs.For 2 mo,the patient experienced progressive severe weakness and pain in the right upper extremity.Notably,the pain intensity reached an extreme level,particularly when lying supine,even under heavy sedation.This heightened pain response posed a significant challenge;as a result,the patient was unable to undergo further evaluation through magnetic resonance imaging.Ultimately,he underwent percutaneous cervical cordotomy for symptom relief,resulting in complete resolution of right arm pain.After a 3-mo follow-up,the pain did not recur,and only a flurbiprofen local patch was required for mild scapular tightness.CONCLUSION Cordotomy,under careful patient selection,appears to enhance the quality of life of patients with unilateral cancerrelated pain.
基金National Natural Science Foundation of China Regional Science Fund Project, Gehua Jieyu Recipe synergistically inhibits VEGF and Wnt signaling pathways to block the angiogenesis of liver cancer microenvironment in ethanol-induced HBV transgenic mice, project document number: 81673862The National Natural Science Foundation of China, based on the P53-GADD45 pathway, studied the regulation mechanism of Tujia medicine Oriental sputum on autophagy and apoptosis of hepatoma cells, project document number: 81660833+1 种基金National Natural Science Foundation of China Regional Science Fund Project: HIF-1a /SDF-1a axis regulates the role of Warburg effect in the inhibition of colorectal cancer liver metastasis by Qiling Ointment, project document number:81760814Guizhou Provincial Department of Education: Yang Zhu, Guizhou Province,"Traditional Chinese Medicine oncology" graduate tutor studio, project number: Teaching and research GZS [2016] 08, Guizhou Provincial Department of Science and Technology: Guizhou Province high-level innovative talent training program (100 levels), project number: Teaching and research (2016) 4032. Guizhou Provincial Organization Department: Guizhou Province TCM (traditional chinese medical) Tumor Inheritance and Technology Innovation Talent Base, Project number: Leading by Guizhou [2018] 3.
文摘Cancer pain is the most common and serious symptom of cancer, which seriously affects the quality of life of cancer patients. the most widely used three-step analgesia has received good effects, but the toxic side effects at the same time can be ignored. As a complementary therapy increasingly accepted around the world, traditional Chinese medicine (TCM) also plays an important role in cancer pain treatment. Traditional Chinese non-drug therapy has a good effect for cancer pain. In this mini-review, the commonly used traditional Chinese non-drug therapies such as acupuncture, moxibustion, acupoint catgut embedding and injection, massage, ear point pressing with coxherb seeds therapy, traditional music therapy were introduced.
文摘Objective: Under the guidance of the theory of Miao medicine, the technical norm scheme for intervention of acupuncture and moxibustion for the treatment of cancer pain is proposed. Methods: The standard operation procedure of the intervention of the acupuncture and moxibustion acupuncture therapy for cancer pain was formulated according to the selection of acupoints in the Miao medicine Tianying acupoint, sputum manipulation method, and the routine operations such as medicine, acupuncture and canning. Results: A set of technical specifications for the treatment of cancer pain in a mobilized Miao doctor was sorted out. Conclusion: The sputum acupuncture treatment technique specification for cancer pain is easy to operate and easy to be applied in clinical application.
基金financially supported by the National Natural Science Foundation of China(No.82001189)The Project Tackling of Key Scientific and Technical Problems of Henan Provine(No.232102311163).
文摘Bone metastasis,a life-threatening complication of advanced breast cancer,is often accompanied by debilitating pain(cancer-induced bone pain,CIBP)that severely impairs life quality and survival.The concurrent treatment of bone metastases and CIBP remains a clinical challenge because the therapeutic options are limited.In this study,we construct a near-infrared light-activated nano-therapeutic system to meet this conundrum.In detail,sorafenib(SRF)and photosensitizer(chlorin e6,Ce6)are encapsulated into mesoporous hydroxyapatite nanoparticles(HANPs),which are further functionalized with hyaluronic acid(HA)to obtain HA-SRF/Ce6@HANPs system.The designed nanoplatform destroys tumor cells in vitro and in vivo via the synergism of SRF(interrupting the exchange of cystine/glutamate by inhibiting SLC7A11)and photodynamic therapy(PDT,inducing reactive oxygen species generation).The decrease in tumor burden and reduction of extracellular glutamate significantly attenuate CIBP in mice model with developing bone cancer.Moreover,the combination of HA-SRF/Ce6@HANPs and PDT inhibit osteoclasts activation,promote osteoblast differentiation and accelerate bone repair.Overall,the nanoagent with good biocompatibility may provide an effective therapy method for the concurrent treatment of breast cancer bone metastasis and CIBP.
文摘BACKGROUND Pain in the liver is a common symptom of liver cancer in late stages,and the pain incidence rate exceeds 50%[1].In serious cancer pain,morphine and other major analgesics have been commonly administrated for clinical treatments,and their effects are accurate,but with a high incidence of side effects,such as nausea,vomiting,constipation,and other conditions.Acupuncture is a traditional Chinese medicine therapy.There have been many randomized controlled trials addressing the safety and usefulness of different methods of acupuncture in alleviating liver cancer pain.However,which of these methods is the most effective method is still unclear.AIM To compare the effectiveness of different acupuncture methods for alleviating pain due to liver cancer.METHODS Eligible studies were retrieved from eight databases(the Cochrane Library,PubMed,EMBASE,Medline,CNKI,CBM,Chongqing VIP,and Wan Fang Database)up to March 31,2021 and screened based on the established inclusion and exclusion criteria.The quality of the include studies was evaluated.Stata software was applied for statistical analyses.Publication bias of the included studies was also determined.Finally,the network meta-analysis was carried out to evaluate the efficacy of acupuncture methods for relief of pain due to liver cancer.RESULTS A total of eight randomized controlled trials were included in the network metaanalysis.Eight trials(covering 5 treatments and 734 patients)provided data suitable for analysis.Most trials focused on short-term effects and many were classed as being of poor quality with a high risk of bias,commonly associated with lack of blinding(which was sometimes impossible to achieve).End of treatment results showed that four interventions,including wrist-ankle acupuncture,triple puncture and remaining needle acupuncture,Tian Yuan acupuncture,and block acupuncture,produced a statistically significant reduction in pain when compared with the three-step analgesic ladder therapy.The surface under the cumulative ranking sorting results showed that triple puncture and remaining needle acupuncture had a relatively high effective rate.CONCLUSION The network meta-analysis results indicate that the overall effectiveness of triple puncture and remaining needle acupuncture is better than the other therapies.
基金National Natural Science Foundation of China(81673862,81660833,81760814).
文摘In clinic, most patients with middle-late cancer suffer from cancer pain, which seriously affects the confidence and compliance of treatment. However, the side effects of the three-step analgesic therapy, which is widely used at present, are gradually manifested, aggravating patients' resistance to treatment. The role of Moxibustion in relieving pain has been gradually recognized and used in various professional fields. Because of its advantages of non-toxic side effects, simple operation, economic benefits, pain relief and immunity enhancement, moxibustion has been paid more and more attention.
文摘Requirements for intervention measures for lung cancer have increased in number and difficulty due to the progress of patients and influence of complex groups of symptom.The cure rate for patients with lung cancer has improved with the vigorous development of new technologies in modern medicine.However,their mental health status and physical quality of life have continued to warrant scholarly attention.The field of cognitive behavior therapy(CBT)provides innovative ideas for addressing this issue.Thus,the study reviews the origin and concept of CBT,CBT technology,and effect of its application to patients with lung cancer to provide a feasible reference for intervention on physical and mental adverse symptoms in patients with lung cancer.
文摘目的评价不同康复锻炼方式改善乳腺癌术后肩关节功能的效果。方法检索中国知网、维普网、万方数据、SinoMed、PubMed、Embase、Cochrane Library、Web of Science数据库中关于锻炼方式改善乳腺癌术后患者肩关节功能的随机对照试验,检索时限为建库至2024年1月,采用Stata17.0软件进行文献的质量评价与数据分析。结果共纳入13项研究,涉及9种锻炼方式和994例患者。网状Meta分析结果表明,在改善肩部屈曲功能方面,水疗法和渐进式康复操的效果优于常规护理(均P<0.05),其中以水疗法的效果最佳;在改善肩部伸展功能方面,渐进式康复操、本体感觉神经肌肉促进术、推拿的效果优于常规护理(均P<0.05),其中以渐进式康复操的效果最佳;在改善肩部外旋功能方面,渐进式康复操的效果优于常规护理(P<0.05);在改善肩部内旋功能方面,涉及的锻炼方式两两比较均未产生统计学差异;在缓解疼痛方面,抗阻力训练的干预效果优于常规护理(P<0.05)。结论水疗法能更好地改善肩部屈曲功能,渐进式康复操在改善肩部伸展、外旋功能方面更具优势,抗阻力训练改善肩部疼痛的效果最优。
