Eighty-two patients with supraventricular tachycardia undergoing radiofrequency catheter ablation (RFCA) were studied to observe the inhibition effect of aspirin and ticlopidine on platelet aggregability (PAG) and thr...Eighty-two patients with supraventricular tachycardia undergoing radiofrequency catheter ablation (RFCA) were studied to observe the inhibition effect of aspirin and ticlopidine on platelet aggregability (PAG) and thromboxane B 2(TXB 2) of the blood samples. Patients were divided into aspirin group A, ticlopidine group B, aspirin+ticlopidine group C and control group D. PAG and TXB 2 were increased clearly after RFCA in all groups (P<0.001). Treatment with aspirin or ticlopidine before operation could reduce the platelet aggregability caused by RFCA and the joint effect of two drugs(change rate of group A:52.51±12.51%; group B:54.78±11.27%;group C: 30.51±10.59%;group D:91.75±21.43%; P<0.05)was studied. The much decreased platelet aggregability after antiplatelet therapy was evidence of the potential benefit of the treatment in preventing thromboembolism after ablation. Pretreatment with aspirin and ticlopidine together is a good way to decrease palatelet aggregability after RFCA.展开更多
The aim of this study was to investigate the initial time of platelet inhibiting effect of aspirin (ASA) and the effects of different doses on equilibrium of prostacyclin(PGI 2)-thromboxane B 2(TXB 2). The effects of ...The aim of this study was to investigate the initial time of platelet inhibiting effect of aspirin (ASA) and the effects of different doses on equilibrium of prostacyclin(PGI 2)-thromboxane B 2(TXB 2). The effects of 100 mg and 300 mg ASA on Platelet count, platelet aggregation rate, TXB 2 and PGI 2 were investigated using cross-compare way for 40 aspirin ingestion patients. The results showed that the platelet counts decreased to 33% after 30 minutes of single-dose ASA ingestion of 100 mg and to 25.6% after 60 minutes. TXB 2 and PGI 2 also decreased meanwhile. The platelet counts decreased to 39.5%, 35.5% and 26.6%, respectively with dose of 300 mg on day 1, 2 and 3. The platelet counts decreased to 38.1% and 39.5%, respectively, after 120 minutes with 100 and 300 mg ASA ingestion, without significent difference. In conclusion ASA begins to inhibit platelet function after 30 minutes of ingestion, and gives the strongest inhibition after 60 minutes. Continuous ASA ingestion accumulates the inhibitory effect. The single-dose ASA ingestion of 100 and 300 mg have nearly the same inhibitory effects.展开更多
文摘Eighty-two patients with supraventricular tachycardia undergoing radiofrequency catheter ablation (RFCA) were studied to observe the inhibition effect of aspirin and ticlopidine on platelet aggregability (PAG) and thromboxane B 2(TXB 2) of the blood samples. Patients were divided into aspirin group A, ticlopidine group B, aspirin+ticlopidine group C and control group D. PAG and TXB 2 were increased clearly after RFCA in all groups (P<0.001). Treatment with aspirin or ticlopidine before operation could reduce the platelet aggregability caused by RFCA and the joint effect of two drugs(change rate of group A:52.51±12.51%; group B:54.78±11.27%;group C: 30.51±10.59%;group D:91.75±21.43%; P<0.05)was studied. The much decreased platelet aggregability after antiplatelet therapy was evidence of the potential benefit of the treatment in preventing thromboembolism after ablation. Pretreatment with aspirin and ticlopidine together is a good way to decrease palatelet aggregability after RFCA.
文摘The aim of this study was to investigate the initial time of platelet inhibiting effect of aspirin (ASA) and the effects of different doses on equilibrium of prostacyclin(PGI 2)-thromboxane B 2(TXB 2). The effects of 100 mg and 300 mg ASA on Platelet count, platelet aggregation rate, TXB 2 and PGI 2 were investigated using cross-compare way for 40 aspirin ingestion patients. The results showed that the platelet counts decreased to 33% after 30 minutes of single-dose ASA ingestion of 100 mg and to 25.6% after 60 minutes. TXB 2 and PGI 2 also decreased meanwhile. The platelet counts decreased to 39.5%, 35.5% and 26.6%, respectively with dose of 300 mg on day 1, 2 and 3. The platelet counts decreased to 38.1% and 39.5%, respectively, after 120 minutes with 100 and 300 mg ASA ingestion, without significent difference. In conclusion ASA begins to inhibit platelet function after 30 minutes of ingestion, and gives the strongest inhibition after 60 minutes. Continuous ASA ingestion accumulates the inhibitory effect. The single-dose ASA ingestion of 100 and 300 mg have nearly the same inhibitory effects.
