目的对叶酸、维生素B_(12)(VB_(12))、二甲双胍联用对2型糖尿病(T2DM)患者的治疗作用。方法选取2021年2月至2023年3月浙江省医疗健康集团长兴医院收治的112例T2DM患者,采用随机数字表法分为对照组(VB_(12)^(+)二甲双胍,56例)和研究组(叶...目的对叶酸、维生素B_(12)(VB_(12))、二甲双胍联用对2型糖尿病(T2DM)患者的治疗作用。方法选取2021年2月至2023年3月浙江省医疗健康集团长兴医院收治的112例T2DM患者,采用随机数字表法分为对照组(VB_(12)^(+)二甲双胍,56例)和研究组(叶酸^(+)VB_(12)^(+)二甲双胍,56例)。对比血糖、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)水平、胰岛素抵抗指数(HOMA-IR)和同型半胱氨酸(Hcy)水平、临床疗效、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平、Th1、Th17、Th1/Th17水平,不良反应及并发症。结果治疗后,研究组空腹血糖(FPG)、餐后2 h血糖(2 h PG)、HOMA-IR、HbA1c、FINS和Hcy均低于治疗前与对照组(P<0.05);研究组总有效率更高(P<0.05);治疗后研究组CD4^(+)、CD4^(+)/CD8^(+)均高于治疗前和对照组(P<0.05),CD8^(+)低于治疗前和对照组(P<0.05);治疗后,研究组Th1、Th17水平低于治疗前和对照组(P<0.05),Th1/Th17高于治疗前和对照组(P<0.05);2组患者不良反应发生率比较差异无统计学意义(P>0.05);研究组并发症发生率低于对照组(P<0.05)。结论叶酸与VB_(12)、二甲双胍联用治疗T2DM有助于控糖,还可提高免疫,调节Th1/Th17平衡,且安全可靠,有助于减少并发症。展开更多
The wetting behavior of molten Cu on the B_(4)C-xTiB_(2)ceramic composites was investigated in this work.The results show that the contact angle of molten Cu alloy on B_(4)C-TiB_(2)ceramic composites is linear with th...The wetting behavior of molten Cu on the B_(4)C-xTiB_(2)ceramic composites was investigated in this work.The results show that the contact angle of molten Cu alloy on B_(4)C-TiB_(2)ceramic composites is linear with the composition rate of TiB_(2)or B_(4)C while the temperature is in the range of 1300 to 1350℃,consistent with the expectation of the commonly used theoretical method.However,a nonlinear relationship between the contact angle and the composition rate unexpectedly occurred at temperatures ranging from 1400 to 1500℃.The big difference of the contact angles between the molten metal and the components in the composites was found to be the key point.This result identifies that the commonly used theoretical method only works at a limited difference of the contact angle of the liquid on the different phases in the composites,and fails at a big difference.展开更多
文摘目的对叶酸、维生素B_(12)(VB_(12))、二甲双胍联用对2型糖尿病(T2DM)患者的治疗作用。方法选取2021年2月至2023年3月浙江省医疗健康集团长兴医院收治的112例T2DM患者,采用随机数字表法分为对照组(VB_(12)^(+)二甲双胍,56例)和研究组(叶酸^(+)VB_(12)^(+)二甲双胍,56例)。对比血糖、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)水平、胰岛素抵抗指数(HOMA-IR)和同型半胱氨酸(Hcy)水平、临床疗效、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平、Th1、Th17、Th1/Th17水平,不良反应及并发症。结果治疗后,研究组空腹血糖(FPG)、餐后2 h血糖(2 h PG)、HOMA-IR、HbA1c、FINS和Hcy均低于治疗前与对照组(P<0.05);研究组总有效率更高(P<0.05);治疗后研究组CD4^(+)、CD4^(+)/CD8^(+)均高于治疗前和对照组(P<0.05),CD8^(+)低于治疗前和对照组(P<0.05);治疗后,研究组Th1、Th17水平低于治疗前和对照组(P<0.05),Th1/Th17高于治疗前和对照组(P<0.05);2组患者不良反应发生率比较差异无统计学意义(P>0.05);研究组并发症发生率低于对照组(P<0.05)。结论叶酸与VB_(12)、二甲双胍联用治疗T2DM有助于控糖,还可提高免疫,调节Th1/Th17平衡,且安全可靠,有助于减少并发症。
基金Funded by National Natural Science Foundation of China(Nos.51521001,51832003,and 51911530153)。
文摘The wetting behavior of molten Cu on the B_(4)C-xTiB_(2)ceramic composites was investigated in this work.The results show that the contact angle of molten Cu alloy on B_(4)C-TiB_(2)ceramic composites is linear with the composition rate of TiB_(2)or B_(4)C while the temperature is in the range of 1300 to 1350℃,consistent with the expectation of the commonly used theoretical method.However,a nonlinear relationship between the contact angle and the composition rate unexpectedly occurred at temperatures ranging from 1400 to 1500℃.The big difference of the contact angles between the molten metal and the components in the composites was found to be the key point.This result identifies that the commonly used theoretical method only works at a limited difference of the contact angle of the liquid on the different phases in the composites,and fails at a big difference.
