Thymus is the primary lymphoid organ involved in the development of thymocytes.Maturation related events of thymocytes within thymus,especially the widely discussed directional migration of thymocytes,is regulated by ...Thymus is the primary lymphoid organ involved in the development of thymocytes.Maturation related events of thymocytes within thymus,especially the widely discussed directional migration of thymocytes,is regulated by chemokines via chemokine receptors mediated signaling pathway.Multiple types of chemokines and chemokine receptors,as components of the network-interaction within thymic microenvironment,are involved in the thymopoiesis.It appears that these chemokines are functionally redundant and such phenomenon may be explained not only by the promiscuous,non-one-to-one matching between ligands-receptors within CXC or CC chemokine subfamily,but also by the various spatio-temporal expression patterns within different cell types and developmental stages.The redundancy and regulation of thymus expressed chemokines and chemokine receptors during thymocyte development are herein discussed.Cellular & Molecular Immunology. 2004;1(4):266-273.展开更多
Small animal models with functional human lymphohematopoietic systems are highly valuable for the study of human immune function under physiological and pathological conditions. Over the last two decades, numerous eff...Small animal models with functional human lymphohematopoietic systems are highly valuable for the study of human immune function under physiological and pathological conditions. Over the last two decades, numerous efforts have been devoted towards the development of such humanized mouse models. This review is focused on human lymphohematopoietic reconstitution and immune function in humanized mice by cotransplantation of human fetal thymic tissue and CD34＋ cells. The potential use of these humanized mice in translational biomedical research is also discussed.展开更多
文摘Thymus is the primary lymphoid organ involved in the development of thymocytes.Maturation related events of thymocytes within thymus,especially the widely discussed directional migration of thymocytes,is regulated by chemokines via chemokine receptors mediated signaling pathway.Multiple types of chemokines and chemokine receptors,as components of the network-interaction within thymic microenvironment,are involved in the thymopoiesis.It appears that these chemokines are functionally redundant and such phenomenon may be explained not only by the promiscuous,non-one-to-one matching between ligands-receptors within CXC or CC chemokine subfamily,but also by the various spatio-temporal expression patterns within different cell types and developmental stages.The redundancy and regulation of thymus expressed chemokines and chemokine receptors during thymocyte development are herein discussed.Cellular & Molecular Immunology. 2004;1(4):266-273.
文摘Small animal models with functional human lymphohematopoietic systems are highly valuable for the study of human immune function under physiological and pathological conditions. Over the last two decades, numerous efforts have been devoted towards the development of such humanized mouse models. This review is focused on human lymphohematopoietic reconstitution and immune function in humanized mice by cotransplantation of human fetal thymic tissue and CD34＋ cells. The potential use of these humanized mice in translational biomedical research is also discussed.
