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Synchronous multiple primary malignant neoplasms in breast,kidney,and bilateral thyroid:A case report
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作者 Miao-Miao Jia Bin Yang +3 位作者 Chao Ding Ya-Rong Yao Jun Guo Hai-Bo Yang 《World Journal of Clinical Cases》 SCIE 2023年第7期1513-1520,共8页
BACKGROUND Multiple primary malignant neoplasms(MPMNs)are rare,while synchronous MPMNs(SMPMNs)are even less common.Owing to the progression of medical technology and the extension of life expectancy,its incidence is g... BACKGROUND Multiple primary malignant neoplasms(MPMNs)are rare,while synchronous MPMNs(SMPMNs)are even less common.Owing to the progression of medical technology and the extension of life expectancy,its incidence is gradually increasing.CASE SUMMARY Although reports of breast and thyroid dual cancers are common,cases of an additional diagnosis of kidney primary cancer within the same individual are rare.CONCLUSION We present a case of simultaneous MPMN of three endocrine organs,reviewing the relevant literature to enhance our understanding of SMPMNs while emphasizing the increasingly important need for accurate diagnosis and multidisciplinary management whenever this challenging situation arises. 展开更多
关键词 SYNCHRONOUS Multiple primary malignant neoplasms Breast cancer Kidney cancer Bilateral thyroid cancer Tumor neoplasm Case report
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Expressions and clinical significances of mannose-binding lectin(MBL) and MBL-associated serine protease 2(MASP-2) in patients with thyroid neoplasm
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作者 Yanping Shi Geling Liu +5 位作者 Huiqin Zhang Fang Yu Xiuxiu Xiang Yifang Lu Xiaomei Dong Xiaohua Li 《The Chinese-German Journal of Clinical Oncology》 CAS 2013年第3期106-108,共3页
Objective: The aim of the study was to detect the levels of mannose-binding lectin (MBL), MBL-associated serine protease 2 (MASP-2) and explore the clinical significances of them in patients with primary thyroid ... Objective: The aim of the study was to detect the levels of mannose-binding lectin (MBL), MBL-associated serine protease 2 (MASP-2) and explore the clinical significances of them in patients with primary thyroid neoplasms. Methods: By using ELISA method, we detected the serum levels of MBL and MASP-2 in 26 patients with papillary thyroid carcinoma (PTC), 30 patients with thyroid adenoma (TA) and 26 healthy people, respectively. Results: Serum MBL level was (565.23 ± 76.70) μg/L in PTCs higher than (324.267 ±24.74) μg/L in TAs, and (152.69± 16.95) IJg/L in healthy of controlling group. There was statistical significance between PTC and TA (P 〈 0.05), however there was no difference between TA and healthy (P 〉 0.05). Serum MASP-2 level was (726.153± 78.88) pg/L in PTCs higher than (379.266 ± 30.26) μg/L in TAs, and (203.846 ± 29.09) μg/L in healthy. Serum MASP-2 level was higher in PTCs than TAs, and the difference had statistical significance (P 〈 0.01). But no difference was observed between in TAs and healthy. Conclusion: These findings might reflect inflammatory processes induced by defense mechanisms, in response to the development of the turnout. MBL may also be involved in the elimination of possible tumourigenic pathogens. 展开更多
关键词 thyroid neoplasm mannose-binding lectin (MBL) MBL-associated serine protease 2 (MASP-2) DETECTION
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Factors influencing postoperative anxiety and depression following Iodine-131 treatment in patients with differentiated thyroid cancer:A cross-sectional study 被引量:4
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作者 Ying-Rui Su Xiao-Peng Yu +2 位作者 Li-Qun Huang Long Xie Jin-Shun Zha 《World Journal of Psychiatry》 SCIE 2023年第7期486-494,共9页
BACKGROUND Differentiated thyroid cancer(DTC)often seriously impacts patients’lives.Radionuclide Iodine-131(131I)is widely used in treating patients with DTC.However,most patients know little about radionuclide thera... BACKGROUND Differentiated thyroid cancer(DTC)often seriously impacts patients’lives.Radionuclide Iodine-131(131I)is widely used in treating patients with DTC.However,most patients know little about radionuclide therapy,and the treatment needs to be performed in a special isolation ward,which can cause anxiety and depression.AIM To explore anxiety and depression status and their influencing factors after 131I treatment in patients with DTC.METHODS A questionnaire survey was conducted among postoperative patients with DTC who received 131I treatment at our hospital from June 2020 to December 2022.General patient data were collected using a self-administered demographic characteristics questionnaire.The self-rating depression scale and self-rating anxiety scale were used to determine whether patients were worried about their symptoms and the degree of anxiety and depression.The patients were categorized into anxiety,non-anxiety,depression,and non-depression groups.Singlevariable and multiple-variable analyses were used to determine the risk factors for anxiety and depression in patients with thyroid cancer after surgery.RESULTS A total of 144 patients were included in this study.The baseline mean score of self-rating anxiety and depression scales were 50.06±16.10 and 50.96±16.55,respectively.Notably,48.62%(70/144)had anxiety and 47.22%(68/144)of the patients had depression.Sex,age,education level,marital status,household income,underlying diseases,and medication compliance significantly differed among groups(P<0.05).Furthermore,multivariate logistic regression analysis showed that education level,per capita monthly household income,and medication compliance level affected anxiety(P=0.015,0.001,and 0.001 respectively).Patient’s sex,marital status,and underlying diseases affected depression(P=0.007,0.001,and 0.009,respectively).CONCLUSION Nursing interventions aiming at reducing the risk of anxiety and depression should target unmarried female patients with low education level,low family income,underlying diseases,and poor adherence to medications. 展开更多
关键词 IODINE-131 thyroid gland neoplasms ANXIETY DEPRESSION PROGNOSIS
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Primary hyperparathyroidism in a woman with multiple tumors: A case report
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作者 Can-Can Hui Xue Zhang +1 位作者 Jian-Ran Sun Da-Tong Deng 《World Journal of Clinical Cases》 SCIE 2019年第19期3132-3137,共6页
BACKGROUND Parathyroid adenoma(PTA)is known as an adenomatous hyperparathyroidism syndrome.At earlier times,the major symptoms of this disease included high blood calcium and low phosphorus.PTA is a benign neuroendocr... BACKGROUND Parathyroid adenoma(PTA)is known as an adenomatous hyperparathyroidism syndrome.At earlier times,the major symptoms of this disease included high blood calcium and low phosphorus.PTA is a benign neuroendocrine neoplasm.We have reviewed the literature and found that it is rare for patients with hyperparathyroidism to have benign tumors with multiple organs at the same time.This report describes a patient with a PTA and four nonfunctional adenomas.CASE SUMMARY We report a case of primary hyperparathyroidism in a 39-year-old woman with multiple organ tumors.The patient was admitted to hospital because of hypercalcemia.Laboratory,imaging,and histological examinations confirmed a left parathyroid neoplasm.Right thyroid adenoma was discovered during hospitalization.She had a medical history of uterine fibroids,right benign mammary gland tumor,and meningioma.The patient recovered after surgical and conservative treatments.CONCLUSION Primary hyperparathyroidism with multiple organ tumors is uncommon,and further studies should be conducted to determine if there is genetic heterogeneity. 展开更多
关键词 Primary HYPERpaRAthyroidISM paRAthyroid neoplasm thyroid ADENOMA MENINGIOMA Breast neoplasm Case report
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A study of pathological changes and their mechanisms of the thyroid after severe burns in rats
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作者 金晓岚 陈意生 《Journal of Medical Colleges of PLA(China)》 CAS 1993年第4期349-355,共7页
Full thickness burns of 30% TBSA by napalm was inflicted to rats and the pathologi-cal changes of the thyroid were observed with optical and electron microscopy and with peroxi-dase histoehemistry for 15 days postburn... Full thickness burns of 30% TBSA by napalm was inflicted to rats and the pathologi-cal changes of the thyroid were observed with optical and electron microscopy and with peroxi-dase histoehemistry for 15 days postburn.Dynamic changes of the serum level of T<sub>3</sub> and T<sub>4</sub> wereobserved concomitantly.It was found that the postburn pathological changes of the thyroid couldbe distinguished into 3 phases as follows:The phase of injury inhibition.This lasted from the 2nd to the 24th hour postburn and wascharacterized by marked damage of the follicular epithelium.The phase of structural and functional recovery.This lasted from the 3rd to 6th day post-burn and was characterized by abated damage of the thyroid and a tendency to recover.The phase of active function.This lasted from the 10th to the 15th day postburn.The syn-thesizing and releasing organellae of the thyroid were well-restored.The changes of T<sub>4</sub> were parallel to the pathological changes of the thyroid in all the stages,while T<sub>3</sub> level was continously inhibited because of the low serum level of T<sub>4</sub>,the metabolic dis-turbance of T<sub>4</sub> deiodination,and the inhibition of thyroid secretion in the early postburn stage andthe metabolic disturbance of T<sub>4</sub> deiodination in the middle and late postburn stages.In the earlypostburn stage,the inhibition on thyroid peroxidase was an important factor to inhibit the func-tion of the thyroid. 展开更多
关键词 thyroid gland/pa and UL BURNS PEROXIDASE
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Middle thyroid vein tumor thrombus in metastatic papillary thyroid microcarcinoma:A case report and review of literature
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作者 Yan Gui Jun-Yi Wang Xu-Dong Wei 《World Journal of Clinical Cases》 SCIE 2022年第10期3213-3221,共9页
BACKGROUND Although papillary thyroid microcarcinoma(PTMC)is not considered a threatening tumor,in some cases,it can be aggressive.Metastatic thrombosis of papillary thyroid carcinoma,follicular thyroid carcinoma,H... BACKGROUND Although papillary thyroid microcarcinoma(PTMC)is not considered a threatening tumor,in some cases,it can be aggressive.Metastatic thrombosis of papillary thyroid carcinoma,follicular thyroid carcinoma,Hürthle cell carcinoma,poorly differentiated thyroid carcinoma and anaplastic thyroid carcinoma have been reported in the literature,but there have been no reports about PTMC.CASE SUMMARY A 45-year-old woman presented with a thyroid mass and thrombosis in a middle thyroid vein during a physical examination.She had no symptoms,and the physical examination showed no positive signs.Subsequent ultrasonographyguided fine-needle aspiration biopsy results indicated an atypical lesion of ambiguous significance,with some actively growing cells(TBSRTCⅢ)and the BRAFV600E mutation not present.This patient underwent left thyroidectomy,isthmus lobectomy,prophylactic central lymph node dissection and thromboembolectomy.Postoperative pathology showed papillary microcarcinoma of the left thyroid,and the thrombus in the middle thyroid vein was a tumor thrombus.CONCLUSION Middle thyroid vein tumor thrombus is an extremely rare condition in PTMC,but it does exist.Lobectomy and thromboembolectomy may be an option for patients with thrombi in the middle vein of the thyroid,and we strongly suggest close follow-up of these patients. 展开更多
关键词 thyroid neoplasms papillary carcinoma thyroid vein Venous thrombosis SURGERY Case report
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Late recurrence of papillary thyroid cancer from needle tract implantation after core needle biopsy: A case report
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作者 Yon-Hee Kim In-Ho Choi +4 位作者 Jong-Eun Lee Zisun Kim Sun-Wook Han Sung-Mo Hur Jihyoun Lee 《World Journal of Clinical Cases》 SCIE 2021年第1期218-223,共6页
BACKGROUND Papillary thyroid cancer(PTC)has good prognosis so that the local recurrence or distant metastasis can occur later on the lifetime follow up.In this study,we report recurrence of PTC in subcutaneous area co... BACKGROUND Papillary thyroid cancer(PTC)has good prognosis so that the local recurrence or distant metastasis can occur later on the lifetime follow up.In this study,we report recurrence of PTC in subcutaneous area combined with lymph node metastasis.A suspicion of needle tract implantation after core needle biopsy was found.CASE SUMMARY A 66-year-old female patients who underwent right thyroid lobectomy for PTC complained of palpable nodule on anterior neck area.The location of the palpable nodule was not associated with her postoperative scar.After excision of the skin tumor,it was diagnosed as recurrence of PTC.Furthermore,results of subsequent imaging showed lymph node metastasis on her right cervical area.According to the previous medical records,the patient received core needle biopsy through the neck of the patient midline and hematoma was noted after the procedure.The time interval from the first diagnosis to local recurrence or metastasis to the skin and lymph nodes was ten years.As treatment,the patient underwent lymph node dissection in the right and completion thyroidectomy for radioisotope treatment.CONCLUSION Needle tract implantation can occur after core needle biopsy.Further studies are needed to compare core-needle biopsy and fine-needle aspiration. 展开更多
关键词 thyroid cancer paPILLARY neoplasm seeding BIOPSY Large-core needle neoplasm recurrence Local Case report Image-guided biopsy
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Papillary thyroid microcarcinoma with contralateral lymphatic skip metastasis and breast cancer: A case report
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作者 Min Ding Ya-Hui Kong +2 位作者 Jian-Hua Gu Rong-Li Xie Jian Fei 《World Journal of Clinical Cases》 SCIE 2022年第11期3609-3614,共6页
BACKGROUND The recognized pattern of cervical lymph node metastasis(CLNM)of papillary thyroid carcinoma involves a stepwise route.Contralateral lymph node skip metastasis is very rare.In addition,the patient in our ca... BACKGROUND The recognized pattern of cervical lymph node metastasis(CLNM)of papillary thyroid carcinoma involves a stepwise route.Contralateral lymph node skip metastasis is very rare.In addition,the patient in our case report also suffered from a breast carcinoma accompanied by left supraclavicular lymphadenopathy,which made it difficult to distinguish the origin of the CLNM.Based on this case,we recommended that more detailed physical and imaging examinations are needed for patients with uncommon cervical lymphatic metastasis of primary cancer.CASE SUMMARY A 53-year-old women was admitted to the hospital for a neck mass in the left cervical region that had existed for 2 mo.The neck mass was suspected to be an enlarged lateral LN originating from papillary thyroid microcarcinoma of the contralateral thyroid lobe,according to ultrasound and ultrasound-guided fine needle aspiration biopsy.The patient underwent total thyroidectomy and radical cervical LN dissection.Postoperative pathology confirmed the diagnosis of papillary thyroid microcarcinoma with contralateral lymphatic skip metastasis.Unfortunately,a breast cancer was discovered 4 mo later,which was accompanied by ipsilateral supraclavicular LN metastasis.She accepted neoadjuvant chemotherapy and subsequent left modified radical mastectomy for treatment.The patient is currently receiving postoperative radiotherapy,and no local recurrence was observed in the 6-mo follow-up after surgery.CONCLUSIONWe present a rare case of papillary thyroid microcarcinoma with contralateral lymphatic skipmetastasis and breast cancer with supraclavicular lymphatic metastasis. 展开更多
关键词 thyroid cancer paPILLARY Breast neoplasms Lymphatic metastasis Skip metastasis Contralateral metastasis Case report
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Advances in BRAF gene mutations in papillary thyroid carcinoma
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作者 ZHANG Xu-xu MA Su-mei 《Journal of Hainan Medical University》 2022年第17期77-80,共4页
Thyroid cancer is the most common endocrine system tumor.Ultrasound guided fine needle puncture(FNA)can identify benign and malignant thyroid nodules.However,due to the limitation of cytological detection,some thyroid... Thyroid cancer is the most common endocrine system tumor.Ultrasound guided fine needle puncture(FNA)can identify benign and malignant thyroid nodules.However,due to the limitation of cytological detection,some thyroid nodules are difficult to distinguish benign and malignant.BRAF gene mutation is a common human oncogenic mutation and the highest mutation frequency in papillary thyroid carcinoma.The combination of FNA and BRAF gene detection can significantly improve the diagnostic rate of benign and malignant thyroid nodules and make up for the deficiency of single diagnosis of cytology.Moreover,while the incidence of thyroid cancer is growing rapidly worldwide,its mortality remains stable.The problem of overdiagnosis and overtreatment of thyroid cancer is becoming more and more obvious.However,due to the limitations of current studies on BRAF genes,its prognostic value for papillary thyroid carcinoma remains controversial.Therefore,in order to reduce the adverse effects of overdiagnosis and treatment,the relationship between gene and tumor biological behavior needs further study in the future. 展开更多
关键词 papillary thyroid carcinoma neoplasm invasiveness Proto-oncogene proteins BRAF Telomerase reverse transcriptase
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黄腐酚通过Notch信号通路对甲状腺癌细胞B-CPAP增殖及凋亡的影响
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作者 亓军 孙勇 +3 位作者 张远鹏 鹿彬 李涛 张延涛 《中国现代普通外科进展》 CAS 2024年第4期282-285,共4页
目的:探讨黄腐酚通过Notch信号通路对甲状腺癌B-CPAP细胞增殖及凋亡影响。方法:体外培养甲状腺癌B-CPAP细胞,以不同浓度黄腐酚干预培养。根据黄腐酚浓度不同分为对照组(0μmol/L)、低剂量组(10μmol/L)、中剂量组(20μmol/L)、高剂量组... 目的:探讨黄腐酚通过Notch信号通路对甲状腺癌B-CPAP细胞增殖及凋亡影响。方法:体外培养甲状腺癌B-CPAP细胞,以不同浓度黄腐酚干预培养。根据黄腐酚浓度不同分为对照组(0μmol/L)、低剂量组(10μmol/L)、中剂量组(20μmol/L)、高剂量组(40μmol/L)。采用MTT法检测黄腐酚对B-CPAP细胞的增殖抑制率。采用Hoechst 33258染色方法,应用荧光显微镜观察不同组别B-CPAP细胞形态的变化。采用Annexin V-FITC/PI双染法流式细胞术检测B-CPAP细胞凋亡率。采用Western-blot法测定Notch信号通路相关蛋白变化。结果:MTT检测结果表明,低剂量组、中剂量组及高剂量组分别处理24、48、72 h后,细胞增殖抑制率差异均有统计学意义(P<0.05);同剂量组处理24、48、72 h后,细胞增殖抑制率逐渐增高,差异有统计学意义(F=204.51、169.64、183.15,P<0.05)。与对照组比较,高剂量组荧光显微镜下显示出典型细胞凋亡的形态学改变。流式细胞术检测B-CPAP细胞经不同剂量黄腐酚处理72 h后,凋亡率比较差异有统计学意义(F=1235.54,P<0.05),高剂量组凋亡率更高。Western-blot法结果显示,处理72 h,与对照组比较,低剂量组、中剂量组、高剂量组Notch1、Hes1、Bcl-2蛋白表达明显降低,而Cleaved caspase-3表达明显增高,差异均有统计学意义(P<0.05)。结论:黄腐酚可能通过Notch信号通路抑制B-CPAP细胞增殖及诱导凋亡。 展开更多
关键词 甲状腺肿瘤 黄腐酚 NOTCH信号通路
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COX-2、u-PA和TSP-1在胃癌及周围淋巴结中的表达及意义 被引量:3
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作者 张富花 周永宁 +6 位作者 张锦华 庄剑波 李强 李高中 陆斌 张志镒 吴正奇 《第二军医大学学报》 CAS CSCD 北大核心 2009年第7期771-774,共4页
目的:研究COX-2、u-PA和TSP-1在胃癌及周围淋巴结中的表达状况,探讨它们在胃癌浸润和淋巴结转移中的作用和意义。方法:用组织芯片技术和免疫组化法检测COX-2、u-PA和TSP-1的表达。结果:COX-2、u-PA和TSP-1在胃癌组阳性表达率分别为67.7%... 目的:研究COX-2、u-PA和TSP-1在胃癌及周围淋巴结中的表达状况,探讨它们在胃癌浸润和淋巴结转移中的作用和意义。方法:用组织芯片技术和免疫组化法检测COX-2、u-PA和TSP-1的表达。结果:COX-2、u-PA和TSP-1在胃癌组阳性表达率分别为67.7%、78.1%和78.6%,均显著高于对照组(40.0%、6.7%和40.0%,P<0.05)。COX-2表达与浸润深度有关(P<0.05)。u-PA表达与浸润深度和淋巴结转移均有关(P<0.05)。TSP-1表达与浸润深度和淋巴结转移均无关(P>0.05)。COX-2、u-PA和TSP-1在转移淋巴结和对应癌组织间的表达差异无显著性(P>0.05)。COX-2和u-PA、TSP-1的表达呈正相关,u-PA和TSP-1的表达无相关关系。结论:胃癌中COX-2、u-PA和TSP-1高表达;COX-2表达与胃癌的浸润深度有关,u-PA表达与浸润深度和淋巴结转移有关。 展开更多
关键词 胃肿瘤 COX-2 U-pa TSP-1 淋巴结 肿瘤浸润 淋巴转移
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EPAS1、VEGF在胰腺癌中表达及其相关性 被引量:6
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作者 朱东明 李德春 +1 位作者 张子祥 张晓懿 《江苏医药》 CAS CSCD 北大核心 2008年第5期433-435,F0002,共4页
目的研究胰腺癌组织中缺氧诱导因子2(EPAS1/HIF-2α)、血管内皮生长因子(VEGF)和微血管密度(MVD)的表达及与临床病理特征之间的关系。方法应用逆转录聚合酶链反应(RT-PCR)、免疫印迹Western blot、免疫组化SP法检测60例胰腺癌及相应正... 目的研究胰腺癌组织中缺氧诱导因子2(EPAS1/HIF-2α)、血管内皮生长因子(VEGF)和微血管密度(MVD)的表达及与临床病理特征之间的关系。方法应用逆转录聚合酶链反应(RT-PCR)、免疫印迹Western blot、免疫组化SP法检测60例胰腺癌及相应正常胰腺组织中EPAS1、VEGF mRNA和蛋白的表达和分布,同时检测MVD作为判断血管生成的指标,分析其间的相关性以及与肿瘤临床病理特征之间的关系。结果EPAS1、VEGF和MVD在胰腺癌组织中的表达明显高于正常胰腺组织,VEGF在mRNA和蛋白水平均增高(P<0.01),但EPAS1只在蛋白水平增高(P<0.01)。此外,三者之间的表达具有显著相关性(P<0.01)。EPAS1和VEGF的阳性表达与胰腺癌的TNM分期、肿瘤大小有关。结论胰腺癌组织中EPAS1和VEGF呈过量表达,且EPAS1的表达与VEGF及MVD呈显著正相关。EPAS1可通过上调VEGF表达来促进胰腺癌血管生成从而在胰腺癌的发生、发展中起重要作用。 展开更多
关键词 胰腺癌 缺氧诱导因子2 血管内皮生长因子
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甲状腺肿瘤原位细胞凋亡检测与PPARγ表达的研究 被引量:3
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作者 梁华晟 钟宇华 +3 位作者 梁秀就 周少碧 黄宇 詹松 《实用医学杂志》 CAS 2007年第8期1145-1146,共2页
目的:研究原位细胞凋亡指数(apoptosis index,AI)及核转录因子过氧化物酶体增殖物激活受体γ(peroxisome proliferator-activated receptorγ,PPARγ)在原发性甲状腺肿瘤中的表达及其与病变的关系。方法:对87例原发性甲状腺肿瘤组织(乳... 目的:研究原位细胞凋亡指数(apoptosis index,AI)及核转录因子过氧化物酶体增殖物激活受体γ(peroxisome proliferator-activated receptorγ,PPARγ)在原发性甲状腺肿瘤中的表达及其与病变的关系。方法:对87例原发性甲状腺肿瘤组织(乳头状腺癌38例,滤泡性腺癌21例,未分化癌5例,腺瘤23例)分别应用原位细胞凋亡检测(TuNEL)试剂盒测定AI及应用免疫组化方法检测PPARγ表达情况。结果:AI及PPARγ蛋白在各甲状腺肿瘤组织均有表达,AI在腺癌表达高于腺瘤(P<0.01),PPARγ在滤泡性腺癌及腺瘤表达显著高于乳头状腺癌及未分化癌(P<0.01);AI及PPARγ有正相关性(r=0.554,P<0.01)。结论:AI及PPARγ的表达与甲状腺肿瘤显著相关,检测AI及PPARγ水平对于鉴别原发性甲状腺滤泡癌具有重要参考意义。 展开更多
关键词 甲状腺肿瘤 细胞凋亡 Ppa 诊断 鉴别
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甲状腺乳头状癌中Paxillin与Ezrin的表达及意义 被引量:2
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作者 张永生 刘西林 +2 位作者 韩洁 朱晓玲 高萍 《临床与实验病理学杂志》 CAS CSCD 北大核心 2013年第11期1202-1205,共4页
目的探讨Paxillin、Ezrin在甲状腺乳头状癌(papillary thyroid carcinomas,PTC)组织中的表达及意义。方法采用免疫组化MaxVision两步法检测50例PTC组织、22例甲状腺腺瘤组织和28例正常甲状腺组织中Paxillin、Ezrin的表达,分析二者表达与... 目的探讨Paxillin、Ezrin在甲状腺乳头状癌(papillary thyroid carcinomas,PTC)组织中的表达及意义。方法采用免疫组化MaxVision两步法检测50例PTC组织、22例甲状腺腺瘤组织和28例正常甲状腺组织中Paxillin、Ezrin的表达,分析二者表达与PTC临床病理特征的关系及其相关性。结果 Paxillin、Ezrin在PTC组织的阳性率均明显高于甲状腺腺瘤及正常甲状腺组织,且其高表达与肿瘤淋巴结转移密切相关(P<0.05);Paxillin与Ezrin表达呈正相关(P<0.05)。结论 Paxillin和Ezrin的过表达可能与PTC的发生、发展、侵袭转移有关,二者有望成为判定PTC及预测其侵袭转移能力的指标。 展开更多
关键词 甲状腺肿瘤 乳头状癌 paXILLIN EZRIN 侵袭转移
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基质降解酶u-PA、PAI-1与人口腔鳞状细胞癌细胞侵袭转移的相关性研究 被引量:1
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作者 金晓明 李雅馨 +2 位作者 李金荣 李宁毅 贾暮云 《现代口腔医学杂志》 CAS CSCD 2003年第5期398-400,共3页
目的 探讨体外培养细胞系TSCCa和GNM细胞的u -PA及PAI - 1活性和表达与口腔鳞状细胞癌侵袭转移的关系。方法 采用酶联免疫反应法和免疫组化法测定了两细胞系中u -PA及PAI - 1的活性和表达 ,同时对GNM细胞在BALB/CA裸鼠皮下种植瘤组织... 目的 探讨体外培养细胞系TSCCa和GNM细胞的u -PA及PAI - 1活性和表达与口腔鳞状细胞癌侵袭转移的关系。方法 采用酶联免疫反应法和免疫组化法测定了两细胞系中u -PA及PAI - 1的活性和表达 ,同时对GNM细胞在BALB/CA裸鼠皮下种植瘤组织的u -PA及PAI - 1抗原表达进行了测定。结果 两细胞系均能产生u -PA及PAI- 1,但u -PA在两细胞系中的表达不同 ,在GNM细胞u -PA为高表达 ,在TSCCa细胞中u -PA为低表达 ,PAI- 1在两细胞系中均为高表达 ;种植瘤组织中u -PA呈阳性~强阳性表达 ,PAI- 1为阴性表达。结论 u 展开更多
关键词 口腔鳞状细胞癌 基质降解酶 U-pa paI-1 酶联免疫反应法 免疫组化法
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凋亡相关蛋白Livin及Caspase-3在膀胱移行细胞癌中的表达及临床意义 被引量:1
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作者 祝兴旺 宋彦 +1 位作者 张明明 宋永胜 《医学临床研究》 CAS 2008年第11期1955-1957,1960,共4页
【目的】探讨凋亡相关蛋白Livin及Caspase-3在膀胱移形细胞癌(BTCC)中的表达及其临床意义。【方法】应用SP免疫组织化学法检测55例膀胱移行细胞癌及10例正常膀胱黏膜组织石蜡切片中Livin和Caspase-3表达的情况,结合临床资料进行分析,并... 【目的】探讨凋亡相关蛋白Livin及Caspase-3在膀胱移形细胞癌(BTCC)中的表达及其临床意义。【方法】应用SP免疫组织化学法检测55例膀胱移行细胞癌及10例正常膀胱黏膜组织石蜡切片中Livin和Caspase-3表达的情况,结合临床资料进行分析,并探讨两者相关性。【结果】Livin在膀胱移形细胞癌标本中的表达阳性率为76.4%(42/55),而正常对照组中无一例呈阳性表达;Caspase-3在膀胱移行细胞癌标本中的表达阳性率为32.7%(18/55),与对照组阳性率90%(9/10)相比差异有统计学意义(P<0.05)。Livin的表达与膀胱移行细胞癌的初发和复发显著相关(P<0.05),但与组织学分级、临床病理分期、转移与否、肿瘤数目无关;Caspase-3的表达与膀胱移行细胞癌的初发复发、组织学分级、临床病理分期、转移与否、肿瘤数目均无关。相关性分析表明,膀胱移行细胞癌中的Livin表达与Caspase-3表达呈负相关。【结论】Livin蛋白与膀胱癌的发生和复发有关,可作为BTCC早期诊断和评判术后高复发风险的一项重要指标,且Livin的高表达和Caspase-3蛋白的低表达在膀胱移行细胞癌的发生发展起着重要作用。 展开更多
关键词 移行性细胞/病理学 膀胱肿瘤/病理学 脱噬作用 Caspase类/分析
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膀胱移行细胞癌组织中HPA、VEGF基因的表达及其意义 被引量:1
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作者 黄江波 黄健 +4 位作者 刘思平 曾嵘 罗志刚 魏建华 林立国 《医学临床研究》 CAS 2009年第9期1600-1602,共3页
【目的】研究膀胱移行细胞癌(BTCC)组织中乙酰肝素酶(HPA)及血管内皮细胞生长因子(VEGFmRNA)的表达及其临床意义。【方法】应用RT—PCR技术检测62例BTCC组织中HPAmRNA及VEGF mRNA表达,并以12例正常膀胱组织作对照,分析HPAmRNA... 【目的】研究膀胱移行细胞癌(BTCC)组织中乙酰肝素酶(HPA)及血管内皮细胞生长因子(VEGFmRNA)的表达及其临床意义。【方法】应用RT—PCR技术检测62例BTCC组织中HPAmRNA及VEGF mRNA表达,并以12例正常膀胱组织作对照,分析HPAmRNA表达与肿瘤部分临床、病理学特征的关系,并分析HPA与VEGF表达的相关性。【结果】12例正常膀胱组织未发现HPAmRNA阳性表达,BTCC组织中HPAmRNA阳性表达率为58.06%(36/62)。其表达与肿瘤的病理分级、临床分期、淋巴结转移及复发明显相关。而且,HPA与VEGF二者的表达具有明显相关性(r=0.501,P〈0.01)。【结论]HPAmRNA阳性表达与BTCC侵袭转移密切相关,HPA在BTCC组织中过度表达可能通过释放VEGF促进肿瘤血管生成。 展开更多
关键词 移行性细胞/病理学 膀胱肿瘤/病理学 内皮生长因子/生物合成
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PAX8、ASAH1、Cullin7在脑胶质瘤患者癌组织与癌旁组织中的蛋白表达及与生存状况的相关性分析 被引量:2
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作者 张莞萍 李长生 《医学临床研究》 CAS 2021年第3期413-415,420,共4页
【目的】探究配对盒基因8(PAX8)、酸性神经酰胺酶(ASAH1)、Cullin7在脑胶质瘤(GC)患者癌组织与癌旁组织中的蛋白表达情况及与生存状况的相关性。【方法】选取2014年1月至2017年7月本院收治的75例GC患者,均行手术切除,比较癌组织与癌旁... 【目的】探究配对盒基因8(PAX8)、酸性神经酰胺酶(ASAH1)、Cullin7在脑胶质瘤(GC)患者癌组织与癌旁组织中的蛋白表达情况及与生存状况的相关性。【方法】选取2014年1月至2017年7月本院收治的75例GC患者,均行手术切除,比较癌组织与癌旁组织中PAX8、ASAH1、Cullin7蛋白表达情况,分析三者表达之间相关性,并分析三者与临床病理特征的相关性。分析PAX8、ASAH1、Cullin7蛋白表达与患者3年生存率的相关性。【结果】癌组织中PAX8、ASAH1、Cullin7蛋白阳性表达率高于癌旁组织,差异有统计学意义(P<0.05);PAX8蛋白与ASAH1蛋白呈正相关,ASAH1蛋白与Cullin7蛋白呈正相关,Cullin7蛋白与PAX8蛋白呈正相关(P<0.05);PAX8、ASAH1、Cullin7蛋白与GC患者病理类型、病理分级、分化程度、浸润深度、瘤周水肿显著相关(P<0.05);PAX8、ASAH1、Cullin7蛋白阳性表达与3年生存率呈负相关(P<0.05)。【结论】GC患者癌组织PAX8蛋白、ASAH1蛋白、Cullin7蛋白均呈阳性表达,并与生存状况存在负相关性。 展开更多
关键词 脑肿瘤/病理学 神经胶质瘤/病理学 免疫组织化学 预后 存活率
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甲状腺乳头状癌uPA表达和微血管密度与颈部淋巴结转移的关系 被引量:2
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作者 陈一峰 张白凌 连云宗 《中华肿瘤防治杂志》 CAS 2006年第19期1479-1481,共3页
目的探讨血管新生和(或)尿激酶型纤溶酶原激活物(urokinase-typeplasmino-genactivator,uPA)的表达与甲状腺乳头状癌(papillarythyroidcarcinoma,PTC)颈部淋巴结转移的关系。方法应用免疫组织化学SP法检测PTC中uPA的表达和以CD105抗体... 目的探讨血管新生和(或)尿激酶型纤溶酶原激活物(urokinase-typeplasmino-genactivator,uPA)的表达与甲状腺乳头状癌(papillarythyroidcarcinoma,PTC)颈部淋巴结转移的关系。方法应用免疫组织化学SP法检测PTC中uPA的表达和以CD105抗体标志的微血管密度(microvesseldensity,MVD)。结果有颈部淋巴结转移和无淋巴结转移的PTC的uPA阳性表达率分别为72.89%(43/59)和38.71%(12/31),两组间差异有统计学意义,χ2=9.96,P=0.002。59例有颈部淋巴结转移PTC的MVD值(76.18±4.98)显著高于31例无淋巴结转移者的MVD值(38.01±3.92),t=37.03,P=0.000。uPA阳性表达且具有高MVD的PTC的淋巴结转移率为92.50%,明显高于uPA阳性表达但具有低MVD组(46.67%)、uPA阴性表达但具有高MVD组(50.00%)和uPA阴性表达且具有低MVD组(40.74%),χ2=23.45,P=0.000。结论活跃的血管生成和uPA的过表达与PTC颈部淋巴结转移的发生密切相关,PTC中uPA过表达且具高MVD者越容易发生颈部淋巴结转移,这对临床筛选高危淋巴结转移病例具有重要的指导意义。 展开更多
关键词 甲状腺肿瘤/病理学 尿激酶型纤溶酶原激活物 CD105 微血管密度 免疫组织化学 淋巴结转移
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TBX2和PAX9在甲状腺乳头状癌中的表达及临床意义探讨 被引量:1
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作者 张卫东 李弘 江虹 《当代医学》 2012年第36期26-28,共3页
目的探讨TBX2和PAX9在甲状腺乳头状癌中的表达及临床病理学意义。方法取得60例甲状腺乳头状癌组织及20例癌旁正常甲状腺组织标本,用免疫组化法检测TBX2和PAX9的蛋白表达情况,用RT-PCR法检测TBX2 mRNA和PAX9 mRNA的相对表达量,并分析两... 目的探讨TBX2和PAX9在甲状腺乳头状癌中的表达及临床病理学意义。方法取得60例甲状腺乳头状癌组织及20例癌旁正常甲状腺组织标本,用免疫组化法检测TBX2和PAX9的蛋白表达情况,用RT-PCR法检测TBX2 mRNA和PAX9 mRNA的相对表达量,并分析两者与患者临床病理因素之间的关系。结果免疫组化和RT-PCR结果均显示TBX2和PAX9在甲状腺乳头状癌组织中的表达明显高于正常甲状腺组织,差异有统计学意义(P<0.01);TBX2和PAX9的表达与分化程度、病理分期(pTMN)及淋巴转移密切相关(P<0.05);并且甲状腺乳头状癌组织中TBX2蛋白与PAX9蛋白的表达呈正相关(r=0.471,P<0.01)。结论 TBX2和PAX9参与了人类甲状腺乳头状癌的发生、发展,表达水平随着甲状腺乳头状癌组织恶性程度的增高而增高,可作为衡量食管鳞状细胞癌恶性程度的肿瘤分子标志物。 展开更多
关键词 甲状腺乳头状癌 TBX2 paX9
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