The observation of oxygen(O)-and nitrogen(N)-bearing molecules gives an idea about the complex prebiotic chemistry in the interstellar medium.Recent millimeter and submillimeter wavelength observations have shown the ...The observation of oxygen(O)-and nitrogen(N)-bearing molecules gives an idea about the complex prebiotic chemistry in the interstellar medium.Recent millimeter and submillimeter wavelength observations have shown the presence of complex O-and N-bearing molecules in the star formation regions.So,the investigation of those molecules is crucial to understanding the chemical complexity in the star-forming regions.In this article,we present the identification of the rotational emission lines of N-bearing molecules ethyl cyanide(C_(2)H_(5)CN)and cyanoacetylene(HC_(3)N),and O-bearing molecule methyl formate(CH_(3)OCHO)toward high-mass protostar IRAS18089–1732 using the Atacama Compact Array.We also detected the emission lines of both the N-and O-bearing molecule formamide(NH_(2)CHO)in the envelope of IRAS 18089–1732.We have detected the v=0 and 1 state rotational emission lines of CH_(3)OCHO.We also detected the two vibrationally excited states of HC_(3)N(v7=1 and v7=2).The estimated fractional abundances of C_(2)H_(5)CN,HC_(3)N(v7=1),HC_(3)N(v7=2),and NH_(2)CHO toward IRAS 18089–1732 are(1.40±0.5)×10^(-10),(7.5±0.7)×10^(-11),(3.1±0.4)×10^(-11),and(6.25±0.82)×10^(-11)respectively.Similarly,the estimated fractional abundances of CH_(3)OCHO(v=0)and CH_(3)OCHO(v=1)are(1.90±0.9)×10^(-9)and(8.90±0.8)×10^(-10),respectively.We also created the integrated emission maps of the detected molecules,and the observed molecules may have originated from the extended envelope of the protostar.We show that C_(2)H_(5)CNand HC_(3)N are most probably formed via the subsequential hydrogenation of the CH_(2)CHCNand the reaction between C_(2)H_(2)and CN on the grain surface of IRAS 18089–1732.We found that NH_(2)CHO is probably produced due to the reaction between NH_(2)and H_(2)CO in the gas phase.Similarly,CH_(3)OCHO is possibly created via the reaction between radical CH_(3)O and radical HCO on the grain surface of IRAS 18089–1732.展开更多
目的:探讨免疫检查点抑制剂(ICI)治疗非小细胞肺癌(NSCLC)患者发生免疫检查点抑制剂相关性肺炎(CIP)的发生情况和免疫治疗疗效的关系,分析接受ICI治疗的NSCLC患者的预后相关因素。方法:回顾性分析2020年3月至2023年3月在新疆医科大学附...目的:探讨免疫检查点抑制剂(ICI)治疗非小细胞肺癌(NSCLC)患者发生免疫检查点抑制剂相关性肺炎(CIP)的发生情况和免疫治疗疗效的关系,分析接受ICI治疗的NSCLC患者的预后相关因素。方法:回顾性分析2020年3月至2023年3月在新疆医科大学附属肿瘤医院接受ICI治疗145例NSCLC患者的临床资料,将患者分为CIP组和非CIP组,随后将发生CIP的患者分为轻度(1、2级)CIP和重度(3、4级)CIP两个亚组,通过Kaplan-Meier法比较生存曲线,分析CIP的发生及严重程度对于患者PFS及OS的影响。通过单因素及多因素COX风险比例回归模型分析与PFS和OS相关的预后因素。结果:145例患者中有26例患者出现CIP,发生率为17.93%,重度CIP发生率为3.45%。CIP组患者PFS明显长于非CIP组患者(12.3 vs 7.6个月,P<0.05),CIP组与非CIP组的OS比较差异无统计学意义(16.2 vs 15.8个月,P>0.05)。亚组分析显示,轻度CIP和重度CIP相比,PFS(12.2vs 12.9个月)及OS(16.1 vs 17.8个月)均无统计学意义(均P>0.05)。多因素COX回归分析显示,CIP[HR=0.55,95%CI(0.33,0.90),P=0.02]、免疫疗程>6个[HR=0.51,95%CI(0.31,0.85),P=0.01]是影响患者PFS的有利预后因素,免疫疗程>6个[HR=0.4,95%CI(0.18,0.88),P=0.02]是影响OS的有利预后因素。结论:CIP的发生率为17.93%,CIP的发生与PFS的延长密切相关。免疫疗程>6个是影响NSCLC患者PFS、OS的有利预后因素。展开更多
基金the Swami Vivekananda Merit-cum-Means Scholarship(SVMCM)for financial support for this research。
文摘The observation of oxygen(O)-and nitrogen(N)-bearing molecules gives an idea about the complex prebiotic chemistry in the interstellar medium.Recent millimeter and submillimeter wavelength observations have shown the presence of complex O-and N-bearing molecules in the star formation regions.So,the investigation of those molecules is crucial to understanding the chemical complexity in the star-forming regions.In this article,we present the identification of the rotational emission lines of N-bearing molecules ethyl cyanide(C_(2)H_(5)CN)and cyanoacetylene(HC_(3)N),and O-bearing molecule methyl formate(CH_(3)OCHO)toward high-mass protostar IRAS18089–1732 using the Atacama Compact Array.We also detected the emission lines of both the N-and O-bearing molecule formamide(NH_(2)CHO)in the envelope of IRAS 18089–1732.We have detected the v=0 and 1 state rotational emission lines of CH_(3)OCHO.We also detected the two vibrationally excited states of HC_(3)N(v7=1 and v7=2).The estimated fractional abundances of C_(2)H_(5)CN,HC_(3)N(v7=1),HC_(3)N(v7=2),and NH_(2)CHO toward IRAS 18089–1732 are(1.40±0.5)×10^(-10),(7.5±0.7)×10^(-11),(3.1±0.4)×10^(-11),and(6.25±0.82)×10^(-11)respectively.Similarly,the estimated fractional abundances of CH_(3)OCHO(v=0)and CH_(3)OCHO(v=1)are(1.90±0.9)×10^(-9)and(8.90±0.8)×10^(-10),respectively.We also created the integrated emission maps of the detected molecules,and the observed molecules may have originated from the extended envelope of the protostar.We show that C_(2)H_(5)CNand HC_(3)N are most probably formed via the subsequential hydrogenation of the CH_(2)CHCNand the reaction between C_(2)H_(2)and CN on the grain surface of IRAS 18089–1732.We found that NH_(2)CHO is probably produced due to the reaction between NH_(2)and H_(2)CO in the gas phase.Similarly,CH_(3)OCHO is possibly created via the reaction between radical CH_(3)O and radical HCO on the grain surface of IRAS 18089–1732.
文摘目的:探讨免疫检查点抑制剂(ICI)治疗非小细胞肺癌(NSCLC)患者发生免疫检查点抑制剂相关性肺炎(CIP)的发生情况和免疫治疗疗效的关系,分析接受ICI治疗的NSCLC患者的预后相关因素。方法:回顾性分析2020年3月至2023年3月在新疆医科大学附属肿瘤医院接受ICI治疗145例NSCLC患者的临床资料,将患者分为CIP组和非CIP组,随后将发生CIP的患者分为轻度(1、2级)CIP和重度(3、4级)CIP两个亚组,通过Kaplan-Meier法比较生存曲线,分析CIP的发生及严重程度对于患者PFS及OS的影响。通过单因素及多因素COX风险比例回归模型分析与PFS和OS相关的预后因素。结果:145例患者中有26例患者出现CIP,发生率为17.93%,重度CIP发生率为3.45%。CIP组患者PFS明显长于非CIP组患者(12.3 vs 7.6个月,P<0.05),CIP组与非CIP组的OS比较差异无统计学意义(16.2 vs 15.8个月,P>0.05)。亚组分析显示,轻度CIP和重度CIP相比,PFS(12.2vs 12.9个月)及OS(16.1 vs 17.8个月)均无统计学意义(均P>0.05)。多因素COX回归分析显示,CIP[HR=0.55,95%CI(0.33,0.90),P=0.02]、免疫疗程>6个[HR=0.51,95%CI(0.31,0.85),P=0.01]是影响患者PFS的有利预后因素,免疫疗程>6个[HR=0.4,95%CI(0.18,0.88),P=0.02]是影响OS的有利预后因素。结论:CIP的发生率为17.93%,CIP的发生与PFS的延长密切相关。免疫疗程>6个是影响NSCLC患者PFS、OS的有利预后因素。
