Tiacumicin B(also known as fidaxomicin or difimicin)is a marketed 18-membered macrolide antibiotic for the treatment of Clostridium difficile infections.Tiacumicin B is structurally characterized with two chlorine ato...Tiacumicin B(also known as fidaxomicin or difimicin)is a marketed 18-membered macrolide antibiotic for the treatment of Clostridium difficile infections.Tiacumicin B is structurally characterized with two chlorine atoms substituted on the aromatic ring,which is installed by the halogenase Tia M.During the study on halide compatibility of Tia M,a facile and nonenzymatic iodination method of didechlorotiacumicin B was discovered,requiring Na I,acid and air for iodination at room temperature.This method was also amenable to other 9 aromatic substrates with electron-rich sites for iodination.展开更多
基金the Key Science and Technology Project of Hainan Province(Key Science and Technology Project ZDKJ202018)the Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou,2019ZD0406)+2 种基金the Chinese Academy of Sciences(QYZDJ-SSW-DQC004)the National Natural Science Foundation of China(81872778,31630004,41911530078)the Ministry of Science and Technology of China(2018YFC1406705)。
文摘Tiacumicin B(also known as fidaxomicin or difimicin)is a marketed 18-membered macrolide antibiotic for the treatment of Clostridium difficile infections.Tiacumicin B is structurally characterized with two chlorine atoms substituted on the aromatic ring,which is installed by the halogenase Tia M.During the study on halide compatibility of Tia M,a facile and nonenzymatic iodination method of didechlorotiacumicin B was discovered,requiring Na I,acid and air for iodination at room temperature.This method was also amenable to other 9 aromatic substrates with electron-rich sites for iodination.
