A three-dimensional numerical calculation of the wind-driven thermohaline and tide-induced Lagrangian residual current in the Bohai Sea

On the basis of a three-dimensional weakly nonliear theory of Lagrangian residual current in the Baroclinic shallow seas, a diagnostic numerical calculation of wind-driven, thermohaline and tide-induced Lagrangian residual current in the Bohai Sea is made. The model involves the Richardson number in the eddy viscosity coefficient, wind, thcrmolialine and tidal effects in the focing terms. The runoff of the Huanghe River and a part of the Huanghai Warm Water coming from the Huanghai Sea through the Bohai Sea Strait is also considered. The velocity-splitting method is adopted. The wind-driven circu lation, thermohaline circulation and the tide-induced Lagrangian residual circulation are also obtained individually and analysed. The dynamics of the three main eddies in the Lagrangian mean circulation is discussed. Finally, the numerical result is partly verified with the observed data.

The Roles of Different Mechanisms Related to the Tide-induced Fronts in the Yellow Sea in Summer

In summer, the Yellow Sea Cold Water Mass （YSCWM） is a stable water mass of low temperature lying at the bottom of the central Yellow Sea （YS）. It is fringed by some typical tidal fronts, which separate deep, stratified water on the offshore side from the well-mixed, shallow water on the inshore side. Three striking fronts--Subei Bank Front （SBF）, Shandong Peninsula Front （SPF）, and Mokpo Front （MKF; a front off the southwestern tip of the Korean Peninsula）--have been iden- tified by various studies from both satellite observations and model results. Tide plays an important role in the formation and maintenance of these fronts. However, it is still a matter of debate as to the roles these two kinds of mechanisms of upwelling and tidal mixing play, and how importance they are in the maintenance processes of the above three fronts. Basing a nested high-resolution model HYCOM （the Hybrid Coordinate Ocean Model）, this study focuses on the different mechanisms of tidal effects on the thermal fronts in the YS in summertime. Through comparative experiments with and without tidal forcing, the results indicate that the MKF is mainly driven by tide-induced upwelling. For the SPF, tidal mixing is the dominant factor, when lower cold water is stirred upwards along the sloping topography of the western YS. Meanwhile, the combined effect of upwelling and tidal mixing is the main cause of the formation of the SBF. Diagnostic analysis of thermal balance shows that horizontal nonlinear advection induced by strong tidal currents also contributes to the thermal balance of frontal areas.

A harmonic analyzed parameterization of tide-induced mixing for ocean models

The tide-induced mixing plays an important role in the regulation of ocean circulation.Numerical simulation of continental shelf circulation is found to exhibit an unreasonable vertical thermohaline structure without consideration of tide effects.In this study,we establish a harmonic analyzed parameterization of tide-induced（HAT） mixing,by which means to derive time-depended function of mixing coefficient based on harmonic analysis of the vertical mixing coefficient.By employing HAT mixing parameterization scheme,a series of numerical experiments are conducted for the Yellow Sea.Numerical results show that an ocean circulation model with the HAT mixing involved is capable of reproducing the reasonable thermohaline structure of the Yellow Sea Cold Water Mass,similar to structures produced by explicit tidal forcing on the open boundary.The advantage of the HAT method is its faster computation time,compared with models that directly resolve explicit tidal motion.The HAT parameterization for the tide-induced mixing has potential to improve both the accuracy and efficiency of ocean circulation and climate models.

Impact of Wind on Tide-Induced Advective Salt Transport in A Well- Mixed Estuary

The tide-induced net advective salt flux in well-mixed estuaries consists of five terms according to the method from Kjerfve.The term resulted from the vertical variation in salinity can be negligible in well-mixed estuaries with four tide-induced salt flux terms,known as F1−F4.To explore the effects of wind on these salt fluxes,the current-salinity analytical model combined with the perturbation analysis is extended by including wind.Analytical expressions for the four salt fluxes are derived separately in the present model.Under the assumption that only the M_(2) tidal component is accounted for and the salt flux generated by diffusion is not studied,the tide-induced net advective salt flux Q_(sx) is in the seaward direction without the wind effect.By applying the Western Scheldt estuary case,the wind influence on the tidal advection salt flux(TASF)distribution in the F4 term was investigated.The phase difference between zero-order velocity and first-order salinity(Δφ)at the surface layer of the estuary is larger than 90°and smaller than 90°at the bottom layer,which leads to landward TASF in the surface layer and seaward TASF in the bottom layer.The distribution ofΔφis not uniform in the horizontal direction with wind included,which differs from the result without wind.In the case of seaward wind with the speed of 18 m/s,the decrease in the zeroth-order velocity phase(φu)at the surface layer is larger than that of the first-order salinity phase(φs)downstream,which leads to an abnormal seaward TASF in this region.Owing to the surface stress caused by wind,the Stokes compensation flow in the middle and lower reaches increases/decreases with the increase of the landward/seaward wind,while the upstream situation is opposite.Thus,the first-order velocity in the middle and lower reaches increases/decreases with the increase of the landward/seaward wind,while the upstream situation is also opposite.The first-order salinity also increases/decreases with the increase of landward/seaward wind,while the upstream salinity tends to zero.Therefore,the tide-induced net advective salt flux Q_(sx) increases/decreases with the increase of the landward/seaward wind,which is contrary to the usual recognition.

On the functions of astrocyte-mediated neuronal slow inward currents

Slow inward currents are known as neuronal excitatory currents mediated by glutamate release and activation of neuronal extra synaptic N-met hyl-D-aspartate receptors with the contribution of astrocytes.These events are significantly slower than the excitatory postsynaptic currents.Parameters of slow inward currents are determined by seve ral factors including the mechanisms of astrocytic activation and glutamate release,as well as the diffusion pathways from the release site towards the extra synaptic recepto rs.Astrocytes are stimulated by neuronal network activity,which in turn excite neurons,forming an astrocyte-neuron feedback loop.Mostly as a consequence of brain edema,astrocytic swelling can also induce slow inward currents under pathological conditions.There is a growing body of evidence on the roles of slow inward currents on a single neuron or local network level.These events often occur in synchro ny on neurons located in the same astrocytic domain.Besides synchronization of neuronal excitability,slow inward currents also set synaptic strength via eliciting timing-dependent synaptic plasticity.In addition,slow inward currents are also subject to non-synaptic plasticity triggered by long-la sting stimulation of the excitatory inputs.Of note,there might be important regionspecific differences in the roles and actions triggering slow inward currents.In greater networks,the pathophysiological roles of slow inward currents can be better understood than physiological ones.Slow inward currents are identified in the pathophysiological background of autism,as slow inward currents drive early hypersynchrony of the neural networks.Slow inward currents are significant contributors to paroxysmal depolarizational shifts/interictal spikes.These events are related to epilepsy,but also found in Alzheimer's disease,Parkinson's disease,and stroke,leading to the decline of cognitive functions.Events with features overlapping with slow inward currents(excitatory,N-methyl-Daspartate-receptor mediated currents with astrocytic contribution) as ischemic currents and spreading depolarization also have a well-known pathophysiological role in worsening consequences of stroke,traumatic brain injury,or epilepsy.One might assume that slow inward currents occurring with low frequency under physiological conditions might contribute to synaptic plasticity and memory formation.However,to state this,more experimental evidence from greater neuronal networks or the level of the individual is needed.In this review,I aimed to summarize findings on slow inward currents and to speculate on the potential functions of it.

Altered synaptic currents,mitophagy,mitochondrial dynamics in Alzheimer's disease models and therapeutic potential of Dengzhan Shengmai capsules intervention

Emerging research suggests a potential association of progression of Alzheimer's disease(AD)with alterations in synaptic currents and mitochondrial dynamics.However,the specific associations between these pathological changes remain unclear.In this study,we utilized Aβ42-induced AD rats and primary neural cells as in vivo and in vitro models.The investigations included behavioural tests,brain magnetic resonance imaging(MRI),liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis,Nissl staining,thioflavin-S staining,enzyme-linked immunosorbent assay,Golgi-Cox staining,transmission electron microscopy(TEM),immunofluorescence staining,proteomics,adenosine triphosphate(ATP)detection,mitochondrial membrane potential(MMP)and reactive oxygen species(ROS)assessment,mitochondrial morphology analysis,electrophysiological studies,Western blotting,and molecular docking.The results revealed changes in synaptic currents,mitophagy,and mitochondrial dynamics in the AD models.Remarkably,intervention with Dengzhan Shengmai(DZSM)capsules emerged as a pivotal element in this investigation.Aβ42-induced synaptic dysfunction was significantly mitigated by DZSM intervention,which notably amplified the frequency and amplitude of synaptic transmission.The cognitive impairment observed in AD rats was ameliorated and accompanied by robust protection against structural damage in key brain regions,including the hippocampal CA3,primary cingular cortex,prelimbic system,and dysgranular insular cortex.DZSM intervention led to increased IDE levels,augmented long-term potential(LTP)amplitude,and enhanced dendritic spine density and length.Moreover,DZSM intervention led to favourable changes in mitochondrial parameters,including ROS expression,MMP and ATP contents,and mitochondrial morphology.In conclusion,our findings delved into the realm of altered synaptic currents,mitophagy,and mitochondrial dynamics in AD,concurrently highlighting the therapeutic potential of DZSM intervention.

Current perspectives of viral hepatitis

Viral hepatitis represents a major danger to public health,and is a globally leading cause of death.The five liver-specific viruses:Hepatitis A virus,hepatitis B virus,hepatitis C virus,hepatitis D virus,and hepatitis E virus,each have their own unique epidemiology,structural biology,transmission,endemic patterns,risk of liver complications,and response to antiviral therapies.There remain few options for treatment,in spite of the increasing prevalence of viral-hepatitiscaused liver disease.Furthermore,chronic viral hepatitis is a leading worldwide cause of both liver-related morbidity and mortality,even though effective treatments are available that could reduce or prevent most patients’complications.In 2016,the World Health Organization released its plan to eliminate viral hepatitis as a public health threat by the year 2030,along with a discussion of current gaps and prospects for both regional and global eradication of viral hepatitis.Today,treatment is sufficiently able to prevent the disease from reaching advanced phases.However,future therapies must be extremely safe,and should ideally limit the period of treatment necessary.A better understanding of pathogenesis will prove beneficial in the development of potential treatment strategies targeting infections by viral hepatitis.This review aims to summarize the current state of knowledge on each type of viral hepatitis,together with major innovations.

Lift-Off Effect of Koch and Circular Differential Pickup Eddy Current Probes

A flexible or planar eddy current probe with a differential structure can suppress the lift-off noise during the inspection of defects.However,the extent of the lift-off effect on differential probes,including different coil structures,varies.In this study,two planar eddy current probes with differential pickup structures and the same size,Koch and circular probes,were used to compare lift-off effects.The eddy current distributions of the probes perturbed by 0°and 90°cracks were obtained by finite element analysis.The analysis results show that the 90°crack can impede the eddy current induced by the Koch probe even further at relatively low lift-off distance.The peak-to-peak values of the signal output from the two probes were compared at different lift-off distances using finite element analysis and experimental methods.In addition,the effects of different frequencies on the lift-off were studied experimentally.The results show that the signal peak-to-peak value of the Koch probe for the inspection of cracks in 90°orientation is larger than that of the circular probe when the lift-off distance is smaller than 1.2 mm.In addition,the influence of the lift-off distance on the peak-to-peak signal value of the two probes was studied via normalization.This indicates that the influence becomes more evident with an increase in excitation frequency.This research discloses the lift-off effect of differential planar eddy current probes with different coil shapes and proves the detection merit of the Koch probe for 90°cracks at low lift-off distances.

Evidence of guide field magnetic reconnection in flapping current sheets

Based on current sheet flapping motion on 27 August 2018 in the dusk flank magnetotail,as recorded by instruments aboard Magnetospheric Multiscale(MMS)spacecraft,we present the first study of guide field reconnection observed in the flux rope embedded in kink-like flapping current sheets near the dusk-side flank of the magnetotail.Unlike more common magnetotail reconnections,which are symmetric,these asymmetric small-scale(λ_(i)~650 km)reconnections were found in the highly twisted current sheet when the direction normal to the sheet changes from the Z direction into the Y direction.The unique feature of this unusual reconnection is that the reconnection jets are along the Z direction-different from outflow in the X direction,which is the more usual situation.This vertical reconnection jet is parallel or antiparallel to the up-and-down motion of the tail’s current sheet.The normalized reconnection rate R is estimated to be~0.1.Our results indicate that such asymmetric reconnections can significantly enlarge current sheet flapping,with large oscillation amplitudes.This letter presents direct evidence of guide field reconnection in a highly twisted current sheet,characterized by enlarged current sheet flapping as a consequence of the reconnection outflow.

Double-ring high-frequency common-mode switching oscillation current sensor for inverter-fed machine winding insulation monitoring

Insulation failure significantly contributes to the unpredictable shutdown of power equipment.Compared to the partial discharge and high-frequency(HF)injection methods,the HF common-mode(CM)leakage current method offers a non-intrusive and highly sensitive alternative.However,the detection of HF CM currents is susceptible to interference from differential-mode(DM)currents,which exhibit high-amplitude and multifrequency components during normal operation.To address this challenge,this paper proposes a double-ring current sensor based on the principle of magnetic shielding for inverter-fed machine winding insulation monitoring.The inner ring harnesses the magnetic aggregation effect to isolate the DM current magnetic field,whereas the outer ring serves as the magnetic core of the Rogowski current sensor,enabling HF CM current monitoring.First,the magnetic field distributions of the CM and DM currents were analyzed.Then,a correlation between the sensor parameters and signal-to-noise ratio of the target HF CM current was established.Finally,an experimental study was conducted on a 3-kW PMSM for verification.The results indicate that the proposed double-ring HF CM sensor can effectively mitigate DM current interference.Compared to a single-ring sensor,a reduction of approximately 40%in the DM component was achieved,which significantly enhanced the precision of online insulation monitoring.

Research and exploration of direct current power supply and distribution systems for Antarctic research stations

The power supply and distribution systems for Antarctic research stations have special characteristics.In light of a worldwide trend toward a gradual increase in the application of renewable energy,an analysis was performed to assess the feasibility of achieving a direct current power supply and distribution at Antarctic research stations by comparing the characteristics of direct current and alternating current electricity.Research was also performed on the status quo and future trends in direct current power supply and distribution systems in Antarctica research stations in combination with case studies.

Numerical analysis for the free-boundary current reversal equilibrium in the AC plasma current operation in a tokamak

In recent decades, tokamak discharges with zero total toroidal current have been reported in tokamak experiments, and this is one of the key problems in alternating current(AC) operations.An efficient free-boundary equilibrium code is developed to investigate such advanced tokamak discharges with current reversal equilibrium configuration. The calculation results show that the reversal current equilibrium can maintain finite pressure and also has considerable effects on the position of the X-point and the magnetic separatrix shape, and hence also on the position of the strike point on the divertor plates, which is extremely useful for magnetic design, MHD stability analysis, and experimental data analysis etc. for the AC plasma current operation on tokamaks.

Analysis of Sea Surface Temperature Cooling in Typhoon Events Passing the Kuroshio Current

The aim of this study is to investigate the sea surface temperature(SST) cooling as typhoons pass the Kuroshio Current.A numerical circulation model,denoted as the Stony Brook Parallel Ocean Model(sbPOM),was used to simulate the SST,which includes four wave-induced effect terms(i.e.,radiation stress,nonbreaking waves,Stokes drift,and breaking waves) simulated using the third-generation wave model,called WAVEWATCH-Ⅲ(WW3).The significant wave height(SWH) measurements from the Jason-2 altimeter were used to validate the WW3-simulated results,yielding a root mean square error(RMSE) of less than 0.50 m and a correlation coefficient(COR) of approximately 0.93.The water temperature measured from the Advanced Research and Global Observation Satellite was applied to validate the model simulation.Accordingly,the RMSE of the SST is 0.92℃ with a COR of approximately 0.99.As revealed in the sbPOM-simulated SST fields,a reduction in the SST at the Kuroshio Current region was observed as a typhoon passed,although the water temperature of the Kuroshio Current is relatively high.The variation of the SST is consistent with that of the current,whereas the maximum SST lagged behind the occurrence of the peak SWH.Moreover,the Stokes drift plays an important role in the SST cooling after analyzing four wave-induced terms in the background of the Kuroshio Current.The sensitivity experiment also showed that the accuracy of the water temperature was significantly reduced when including breaking waves,which play a negative role in the inside part of the ocean.The variation in the mean mixing layer depth(MLD) showed that a typhoon could enhance the mean MLD in the Kuroshio Current area in September and October,whereas a typhoon has little influence on the mean MLD in the Kuroshio Current area in May.Moreover,the mean MLD rapidly decreased with the weakening of the strong wind force and wave-induced effects when a typhoon crossed the Kuroshio Current.

Alternating current heating techniques for lithium-ion batteries in electric vehicles:Recent advances and perspectives

The significant decrease in battery performance at low temperatures is one of the critical challenges that electric vehicles(EVs)face,thereby affecting the penetration rate in cold regions.Alternating current(AC)heating has attracted widespread attention due to its low energy consumption and uniform heating advantages.This paper introduces the recent advances in AC heating from the perspective of practical EV applications.First,the performance degradation of EVs in low-temperature environments is introduced briefly.The concept of AC heating and its research methods are provided.Then,the effects of various AC heating methods on battery heating performance are reviewed.Based on existing studies,the main factors that affect AC heating performance are analyzed.Moreover,various heating circuits based on EVs are categorized,and their cost,size,complexity,efficiency,reliability,and heating rate are elaborated and compared.The evolution of AC heaters is presented,and the heaters used in brand vehicles are sorted out.Finally,the perspectives and challenges of AC heating are discussed.This paper can guide the selection of heater implementation methods and the optimization of heating effects for future EV applications.

Influence of Current Density on the Photocatalytic Activity of Nd:TiO_(2) Coatings

The Nd:TiO_(2 )PEO coatings were formed in a phosphate-based electrolyte with the addition of Nd_(2)O_(3 )under the current density of 150,200,250 and 300 m A/cm^(2).SEM results showed that the micropores decreased on quantity and increased on scale with the increasing current density.AFM results revealed that the roughness of the coatings increased with the increasing current density.Phase and composition analysis showed that the Nd:TiO_(2) coatings were mainly composed of anatase and rutile phase.And the anatase phase content has reached the maximum value at the current density of 250 m A/cm^(2).XPS results indicated that Ti2p spin-orbit components of the Nd:TiO_(2) coatings are shifted towards higher binding energy,compared with the pure TiO_(2) coating,suggesting that some of the Nd^(3+)ions are combined with TiO_(2) lattice and led to dislocation.Photocatalytic test showed that the photocatalytic activity of Nd:TiO_(2) coatings varied in the same pattern with the anatase content variation in Nd:TiO_(2) coatings.The photocatalytic experiment results show that the photocatalytic activity of Nd:TiO_(2) coatings can be greatly enhanced with moderate amount of Nd^(3+).However,excessive amount of Nd^(3+)does not have an effective impact on the photoctalytic activity improvement.

Recent advances in design of hydrogen evolution reaction electrocatalysts at high current density:A review

The electrolysis of water powered by renewable energy sources offers a promising method of"green hydrogen"production,which is considered to be at the heart of future carbon-neutral energy systems.In the past decades,researchers have reported a number of hydrogen evolution reaction(HER)electrocatalysts with activity comparable to that of commercial Pt/C,but most of them are tested within a small current density range,typically no more than 500 mA cm^(-2).To realize the industrial application of hydrogen production from water electrolysis,it is essential to develop high-efficiency HER electrocatalysts at high current density(HCD≥500 mA cm^(-2)).Nevertheless,it remains challenging and significant to rational design HCD electrocatalysts for HER.In this paper,the design strategy of HCD electrocatalysts is discussed,and some HCD electrocatalysts for HER are reviewed in seven categories(alloy,metal oxide,metal hydroxide,metal sulfide/selenide,metal nitride,metal phosphide and other derived electrocatalysts).At the end of this article,we also pro-pose some viewpoints and prospects for the future development and research directions of HCD electrocatalysts for HER.

Organic X-Ray Image Sensors Using a Medium Bandgap Polymer Donor with Low Dark Current

The development of portable X-ray detectors is necessary for diagnosing fractures in unconscious patients in emergency situations.However,this is quite challenging because of the heavy weight of the scintillator and silicon photodetectors.The weight and thickness of X-ray detectors can be reduced by replacing the silicon layer with an organic photodetectors.This study presents a novel bithienopyrroledione-based polymer donor that exhibits excellent photodetection properties even in a thick photoactive layer(~700 nm),owing to the symmetric backbone and highly soluble molecular structure of bithienopyrroledione.The ability of bithienopyrroledione-based polymer donor to strongly suppress the dark current density(Jd~10−10 A cm^(−2))at a negative bias(−2.0 V)while maintaining high responsivity(R=0.29 A W−1)even at a thickness of 700 nm results in a maximum shot-noise-limited specific detectivity of D_(sh)^(*)=2.18×10^(13)Jones in the organic photodetectors.Printed organic photodetectors are developed by slot-die coating for use in X-ray detectors,which exhibit D_(sh)^(*)=2.73×10^(12)Jones with clear rising(0.26 s)and falling(0.29 s)response times upon X-ray irradiation.Detection reliability is also proven by linear response of the X-ray detector,and the X-ray detection limit is 3 mA.

Plasma current tomography for HL-2A based on Bayesian inference

An accurate plasma current profile has irreplaceable value for the steady-state operation of the plasma.In this study,plasma current tomography based on Bayesian inference is applied to an HL-2A device and used to reconstruct the plasma current profile.Two different Bayesian probability priors are tried,namely the Conditional Auto Regressive(CAR)prior and the Advanced Squared Exponential(ASE)kernel prior.Compared to the CAR prior,the ASE kernel prior adopts nonstationary hyperparameters and introduces the current profile of the reference discharge into the hyperparameters,which can make the shape of the current profile more flexible in space.The results indicate that the ASE prior couples more information,reduces the probability of unreasonable solutions,and achieves higher reconstruction accuracy.

“Flow” Transcranial Direct Current Stimulation (tDCS) for Depression Treatment in a Primary Healthcare General Practice—An Open-Label Cohort Study Measuring Montgomery-Åsberg Depression Rating Scale (MADRS-S) Outcomes

Background: Flow FL-100 is a transcranial direct current stimulation (tDCS) device self-administered by a patient at home in combination with a software application delivered wellbeing behaviour therapy training. tDCS has evidence of effectiveness in treating symptoms of depression. Purpose/Aim: This post marketing study evaluated the effect of Flow on depression for primary care general practice patients with depression symptoms. Methods: Open-label patient cohort design with no control group. Inclusion criteria were aged 18 years or over and reporting depression symptoms. Participants self-administered five 30 minute tDCS sessions per week for the first three weeks, and then 3 sessions per week following this. Three, six and ten week assessment with participant self-report measure: Montgomery- Åsberg Depression Rating Scale (MADRS-S). Results: MADRS-S remission rates were between 29% - 30% at three weeks, 33% - 34% at six-weeks and 50% at 10-weeks treatment. There was a significant improvement in MADRS-S with large effect sizes at all time points. Conclusions: Flow tDCS can be delivered through a primary healthcare general practice service and patients will choose to use. Flow tDCS provides an effective depression treatment in addition and as an alternative to antidepressants and psychotherapy. tDCS has evidence as an effective depression treatment, and the widespread availability of tDCS in primary care general practice should be considered.

Fault Estimation for a Class of Markov Jump Piecewise-Affine Systems: Current Feedback Based Iterative Learning Approach

In this paper, the issues of stochastic stability analysis and fault estimation are investigated for a class of continuoustime Markov jump piecewise-affine(PWA) systems against actuator and sensor faults. Firstly, a novel mode-dependent PWA iterative learning observer with current feedback is designed to estimate the system states and faults, simultaneously, which contains both the previous iteration information and the current feedback mechanism. The auxiliary feedback channel optimizes the response speed of the observer, therefore the estimation error would converge to zero rapidly. Then, sufficient conditions for stochastic stability with guaranteed performance are demonstrated for the estimation error system, and the equivalence relations between the system information and the estimated information can be established via iterative accumulating representation.Finally, two illustrative examples containing a class of tunnel diode circuit systems are presented to fully demonstrate the effectiveness and superiority of the proposed iterative learning observer with current feedback.