Iridoid glycosides extracted from Zhizi(Fructus Gardeniae)decrease collagen-induced platelet aggregation and reduce carotid artery thrombosis in an invivo rat model

OBJECTIVE: To investigate the anti-platelet aggregation and antithrombotic effects in rats of iridoid glycosides extracted from Zhizi (FructusGardeniae). METHODS: The present study evaluated the antithrombotic activity of iridoid glycosides (IGs) in a rat model of carotid artery thrombosis. The effects on coagulation, such as thromboplastin time (APTT), thrombin time (TT) and prothrombin time (PT), and the effect on collagen-induced platelet aggregation in vivo were investigated. Rats were intragastrically administered IGs (50, 100 or 200 mg/ kg) twice daily for 3 days. RESULTS: IGs were shown for the first time to have an antithrombotic action through the inhibition of platelet aggregation, with little effect on the coagulation time of peripheral blood. Our results also showed that IGs may significantly and dose-dependently reduce arterial thrombus load in a model of carotid artery thrombosis and inhibit collagen-induced platelet aggregation in rats. IGs (100or 200 mg/kg) had no significant effect on APTT and PT, but did lengthenTT at a higher dose. CONCLUSION: These data, together with the previously reported neuroprotective effects of IGs in rats with cerebral ischemia, suggest that the antithrombotic action of IGs may potentially contribute to the treatment of cerebral ischemic diseases, including cerebral apoplexy.

A maximum flow algorithm for buffer-limited delay tolerant networks

Deep space networks,satellite networks,ad hoc networks,and the Internet can be modeled as DTNs(Delay Tolerant Networks).As a fundamental problem,the maximum flow problem is of vital importance for routing and service scheduling in networks.However,there exists no permanent end-to-end path since the topology and the characteristics of links are time-variant,resulting in a crucial maximum flow problem in DTNs.In this paper,we focus on the single-source-single-sink maximum flow problem of buffer-limited DTNs,followed by a valid algorithm to solve it.First,the BTAG(Buffer-limited Time Aggregated Graph)is constructed for modeling the buffer-limited DTN.Then,on the basis of BTAG,the two-way cache transfer series and the relevant transfer rules are designed,and thus a BTAG-based maximum flow algorithm is proposed to solve the maximum flow problem in buffer-limited DTNs.Finally,a numerical example is given to demonstrate the effectiveness of the proposed algorithm.