Evaluation of the Left Ventricular Remodeling in Patients with Myocardial Infarction after Revascularization with Intravenous Real-time Myocardial Contrast Echocardiography

In order to evaluate the left ventricular remodeling in patients with myocardial infarction after revascularization with intravenous real-time myocardial contrast echocardiography （RT-MCE）, intravenous RT-MCE was performed on 20 patients with myocardial infarction before coronary revascularization. Follow-up echocardiography was performed 3 months after coronary revascularization. Segmental wall motion was assessed using 18-segment LV model and classified as normal, hypokinesis, akinesis and dyskinesis. Myocardial perfusion was assessed by visual interpretation and divided into 3 conditions： homogeneous opacification=l; partial or reduced opaciflcation or subendocardial contrast defect=2; constrast defect=3. Myocardial perfusion score index （MPSI） was calculated by dividing the total sum of contrast score by the total number of segments with abnormal wall motion. Twenty patients were classified into 2 groups according to the MPSI： MPSI≤I.5 as good myocardial perfusion, MPSI〉1.5 as poor myocardial perfusion. To assess the left ventricular remodeling, the following comparisons were carried out： （1） Comparisons of left ventricular ejection fraction （LVEF）, left ventricular end-systolic volume （LVESV） and left ventricular end-diastolic volume （LVEDV） before and 3 months after revascularization in two groups;（2） Comparisons of LVEF, LVESV and LVEDV pre-revascularization between two groups and comparisons of these 3 months post-revascularization between two groups; （3） Comparisons of the differences in LVEF, LVESV and LVEDV between 3 months post-and pre-revascularization （ALVEF, ALVESV and ALVEDV） between two groups; （4） The linear regression analysis between ALVEF, ALVESV, ALVEDV and MPSI. The results showed that the LVEF obtained 3 months after revascularization in patients with MPSI〉1.5 was obviously lower than that in those with MPSI〈1.5. The LVEDV obtained 3 months post-revascularization in patients with MPSI〉1.5 was obviously larger than that in those with MPSI≤1.5 （P=0.002 and 0.04）. The differences in ALVEF and ALVEDV between patients with MPSI〉I.5 and those with MPSI≤1.5 were significant （P=0.002 and 0.001, respectively）. Linear regression analysis revealed that MPSI had a negative correlation with ALVEF and a positive correlation with ALVESV, ALVEDV （P=0.004, 0.008, and 0.016, respectively）. It was concluded that RT-MCE could accurately evaluate the left ventricular remodeling in patients with myocardial infarction after revascularization.

Quantitative Assessment of Coronary Flow Reserve by the Variables of Time-Intensity Curve with Myocardial Contrast Echocardiography

The reliability and reliable indexes of q ua ntitative assessment of coronary flow reserve (CFR) by using time intensity cur ve (TIC) via myocardial contrast echocardiography were investigated. The TIC var iables were obtained by employing acoustic densitometry (AD) technique before an d after acetylcholine (Ach) injection in 12 dogs. Meanwhile, the correlation be tween these variables and CFR was analyzed. Among the variables derived from TIC , peak intensity (PI), area under the curve (AUC) and descending slope (DS) were increased significantly ( P <0.05) with the increase of coronary blood flow a fter Ach injection. Conversely, time to peak (TP), half time of descent (HT) , and mean transit time (MTT) were decreased remarkably ( P <0.0001). Th e P I and AUC ratios from post to pre Ach injection were strongly associated with CFR with the correlation coefficient (r) being 0.8366 and 0.8824, respectively. It is reliable by using the variables derived from TIC with myocardial contrast echocardiography to quantitatively evaluate regional myocardial CFR. The PI an d AUC ratios from post to pre Ach injection are the reliable indexes for quan titative assessment of CFR.

Quantitative Assessment of Right Ventricular Systolic Function by the Analysis of Right Ventricular Contrast Time-intensity Curve

Summary: To study reliability and reliable indices of quantitative assessment of right ventricular systolic function by time-intensity curve (TIC) with right ventricular contrast, 5 % sonicated human albumin was injected intravenously at a does of 0.08 ml/kg into 10 dogs at baseline status and cardiac insufficiency. Apical four-chamber view was observed for washin and washout of contrast agent from right ventricle. The parameters of TIC were obtained by curve fitting. The differences of parameters were analyzed in different states of cardiac functions. Among the parameters derived from TIC, the time constant (k) was decreased significantly with decline of cardiac function (P<0.001). But half-time of decent of peak intensity (HT) and mean-transit-time (MTT) of washout were increased significantly (P<0.001). The k was strongly related to cardiac output of right ventricle (CO) and ejection fraction (EF) of left ventricle and fractional shortening (FS) of left ventricle. Right ventricular systolic function could be assessed reliably by the parameters derived from TIC with right ventricular contrast echocardiography. The k, HT and MTT are reliable indices for quantitative assessment of right ventricular systolic function.

Quantitative Analysis of Myocaridal Perfusion in Rabbits by Tansthoracic Real-time Myocardial Contrast Echocardiography

To evaluate the feasibility of real-time myocardial contrast echocardiography （RTMCE） by quantitative analysis of myocardial perfusion in rabbits, transthoracic RTMCE was performed in 10 healthy rabbits by using continuous infusion of SonoVue into the auricular vein. The short axis view at the papillary muscle level was obtained. The duration of the time that the contrast took to appear in right heart, left heart and myocardium was recorded. The regional myocardial signal intensity （SI） versus re-filling time plots were fitted to an exponential function： y（t） =A（1–e–β（t–t0）） ＋ C, where y is SI at any given time, A is the SI plateau that reflects myocardial blood volume, and β is the slope of the refilling curve that reflects myocardial microbubble velocity. The A, β and A×β values at different infusion rate of SonoVue were analyzed and the A, β and A×β values in each segment in the short axis view at the papillary muscle level were compared. All the animal experiments were successful and high-quality im-ages were obtained. The best intravenous infusion rate for SonoVue was 30 mL/h. The contrast appeared in right heart, left heart and myocardium at 7.5±2.2 s, 9.1±2.4 s and 12.2±1.6 s respectively. After 16.6±2.3s, myocardial opacification reached a steady state. The mean A, β and A×β value in the short axis view at the papillary muscle level were 9.8±3.0 dB, 1.4±0.5 s-1 and 13.5±3.6 dB×s-1 respectively. A, β and A×β values showed no significant differences among 6 segments. It was suggested that RTMCE was feasible for quantitative analysis of myocardial perfusion in rabbits. It provides a non-invasive method to evaluate the myocardial perfusion in rabbit disease models.

融合时频特征的多粒度时间序列对比学习方法

现有的时间序列对比学习方法存在增强样本构造方式过于依赖人工经验、泛化能力不足、正样本的定义方式不够通用、对比度量方式存在粗粒度表征等问题,使得整体的时序表示效果较差。为此,提出了一种融合时频特征的多粒度时间序列对比学习方法(Temporal-Spectral Deep Contrastive Network, TSDC)。该方法通过季节-趋势生成网络在时域内产生具有稳定变化的时序增强样本,通过多频带融合扰动操作在频域内产生非稳定变化的时序增强样本,两种增强样本通过实例级别的粗粒度对比以及维度级别的细粒度对比方式进行对比学习,使得模型在获得较好表征的同时能够较好地适应于下游不同类型的时序任务。在多个时间序列公开数据集上进行的分类、预测以及异常检测实验表明,由TSDC方法所得的表征用于下游任务的结果优于典型基线模型。

MRI动态增强TIC联合DWI在乳腺癌诊断中的应用价值

目的 探究磁共振(MRI)动态增强时间-信号强度曲线(DCE-TIC)联合扩散加权成像(DWI)在乳腺癌诊断中的应用价值。方法 对本院2020年10月至20 23年10月纳入的90例乳腺病变患者的诊疗资料(病理结果、 DCE-TIC、DWI影像学资料)进行回顾性分析,以病理结果为“金标准”,分析DCETIC联合DWI在乳腺癌诊断中的价值。结果 90例患者检出乳腺癌56例(62.22%),乳腺良性病变34例(37.78%),不同病灶性质患者在DCE-TIC、DWI中的差异均有统计学意义(P<0.05);DCE-TIC合DWI诊断乳腺癌与病理结果的Kappa值0.858(P<0.05),高于二者单独诊断的Kappa值0.613、0.622(P<0.05);DCE-TIC联合DWI检查在乳腺癌诊断中的灵敏度、特异度等均高于单一方法检测。结论 DCE-TIC与DWI联合检查可有效提高乳腺癌的诊断效能,临床应用价值较高。

Transit time ultrasound perivascular flow probe technology is superior to MR imaging on hepatic blood flow measurement in a porcine model

Background: The hepatic hemodynamics is an essential parameter in surgical planning as well as in various disease processes. The transit time ultrasound(TTUS) perivascular flow probe technology is widely used in clinical practice to evaluate the hepatic inflow, yet invasive. The phase-contrast-MRI(PC-MRI) is not invasive and potentially applicable in assessing the hepatic blood flow. In the present study, we compared the hepatic inflow rates using the PC-MRI and the TTUS probe, and evaluated their predictive value of post-hepatectomy adverse events. Methods: Eighteen large white pigs were anaesthetized for PC-MRI and approximately 75% hepatic resection was performed under a unified protocol. The blood flow was measured in the hepatic artery(Qha), the portal vein(Qpv), and the aorta above the celiac trunk(Qca) using PC-MRI, and was compared to the TTUS probe. The Bland-Altman method was conducted and a partial least squares regression(PLS) model was implemented. Results: The mean Qpv measured in PC-MRI was 0.55 ± 0.12 L/min, and in the TTUS probe was 0.74 ± 0.17 L/min. Qca was 1.40 ± 0.47 L/min in the PC-MRI and 2.00 ± 0.60 L/min in the TTUS probe. Qha was 0.17 ± 0.10 L/min in the PC-MRI, and 0.13 ± 0.06 L/min in the TTUS probe. The Bland-Altman method revealed that the estimated bias of Qca in the PC-MRI was 32%(95% CI:-49% to 15%); Qha 17%(95% CI:-15% to 51%); and Qpv 40%(95% CI:-62% to 18%). The TTUS probe had a higher weight in predicting adverse outcomes after 75% resection compared to the PC-MRI( β= 0.35 and 0.43 vs β = 0.22 and 0.07, for tissue changes and premature death, respectively). Conclusions: There is a tendency of the PC-MRI to underestimate the flow measured by the TTUS probes. The TTUS probe measures are more predictive of relevant post-hepatectomy outcomes.

Diagnostic performance of contrast-enhanced ultrasound and enhanced magnetic resonance for breast nodules

In the current study, we sought to evaluate the diagnostic efficacies of conventional ultrasound（US）, contrastenhanced US（CEUS）, combined US and CEUS and magnetic resonance imaging（MRI） in detecting focal solid breast lesions. Totally 117 patients with 120 BI-RADS category 4A-5 breast lesions were evaluated by conventional US and CEUS, and MRI, respectively. SonoVue was used as contrast agent in CEUS and injected as an intravenous bolus; nodule scan was performed 4 minutes after bolus injection. A specific sonographic quantification software was used to obtain color-coded maps of perfusion parameters for the investigated lesion, namely the time-intensity curve.The pattern of contrast enhancement and related indexes regarding the time-intensity curve were used to describe the lesions, comparatively with pathological results. Histopathologic examination revealed 46 benign and 74 malignant lesions. Sensitivity, specificity, and accuracy of US in detecting malignant breast lesions were 90.14%, 95.92%, and 92.52%, respectively. Meanwhile, CE-MRI showed sensitivity, specificity, and accuracy of 88.73%, 95.92%, and91.67%, respectively. The area under the ROC curve for combined US and CEUS in discriminating benign from malignant breast lesions was 0.936, while that of MRI was 0.923, with no significant difference between them, as well as among groups. The time-intensity curve of malignant hypervascular fibroadenoma and papillary lesions mostly showed a fast-in/fast-out pattern, with no good correlation between them（kappa 〈0.20）. In conclusion, the combined use of conventional US and CEUS displays good agreement with MRI in differentiating benign from malignant breast lesions.

Can semi-quantitative evaluation of uncertain (type II) time-intensity curves improve diagnosis in breast DCE-MRI?

Objective/Background: Qualitative assessment of uncertain (type II) time-intensity curves (TICs) in breast DCE-MRI is problematic and operator dependent. The aim of this work is to evaluate if a semi-quantitative assessment of uncertain TICs could improve overall diagnostic performance. Methods: In this study 49 lesions from 44 patients were retrospectively analysed. Per each lesion one region-of-interest (ROI)- averaged TIC was qualitatively evaluated by two radiologists in consensus: all the ROIs resulted in type II (uncertain) TIC. The same TICs were semi-quantitatively re-classified on the basis of the difference between the signal intensities of the last-time-point and of the peak: this difference was classified according to two different cut-off ranges (±5% and ±3%). All patients were cytological or histological biopsy proven. Fisher test and McNemar test were performed to evaluate if results were statistically significant (p < 0.05). Results: Using ±5% cut-off 16 TICs were reclassified as type III and 12 as type I while 21 were reclassified again as type II. Using ±3% 22 TICs were reclassified as type III and 16 as type I while 11 were reclassified again as type II. The semi-quantitative classification was compared to the histological-cytological results: the sensitivity, specificity, positive and negative predictive values obtained with ±3% were 77%, 91%, 91% and 78% respectively while using ±5% were 58%, 96%, 94% and 68% respectively. Using the ±5% cut-off 26/28 (93%) TICs were correctly reclassified while using the ±3% cut-off 34/38 (90%) TICs were correctly reclassified (p < 0.05). Conclusions: Semi-quantitative methods in kinetic curve assessment on DCE-MRI could improve classification of qualitatively uncertain TICs, leading to a more accurate classification of suspicious breast lesions.

Cerebral blood flow volume measurements of the carotid artery and ipsilateral branches using two-dimensional phase-contrast magnetic resonance angiography

The optimal velocity encoding of phase-contrast magnetic resonance angiography （PC MRA） in measuring cerebral blood flow volume （BFV） ranges from 60 to 80 cm/s. To verify the accuracy of two-dimensional （2D） PC MRA, the present study localized the region of interest at blood vessels of the neck using PC MRA based on three-dimensional time-of-flight sequences, and the velocity encoding was set to 80 cm/s. Results of the measurements showed that the error rate was 7.0±6.0% in the estimation of BFV in the internal carotid artery, the external carotid artery and the ipsilateral common carotid artery. There was no significant difference, and a significant correlation in BFV between internal carotid artery ＋ external carotid artery and ipsilateral common carotid artery. In addition, the BFV of the common carotid artery was correlated with that of the ipsilateral internal carotid artery. The main error was attributed to the external carotid artery and its branches. Therefore, after selecting the appropriate scanning parameters and protocols, 2D PC MRA is more accurate in the determination of BFV in the carotid arteries.

超声造影时间-强度曲线相关参数鉴别诊断肝细胞癌与转移性肝癌价值研究

目的探讨超声造影(CEUS)时间-强度曲线(TIC)相关参数鉴别诊断肝细胞癌(HCC)与转移性肝癌的价值。方法2021年3月~2023年3月我院诊治的106例肝癌患者,均接受CEUS检查,记录造影剂到达时间(AT)、达峰时间(TTP)、峰值强度(PI)和上升斜率(RS)等TIC相关参数,均进行肝穿刺组织病理学检查。绘制受试者工作特征(ROC)曲线,以曲线下面积(AUC)评估TIC参数的鉴别诊断效能。结果在106例肝癌患者中,经病理学检查诊断为HCC者44例(41.5%)和转移性肝癌者62例(58.5%);HCC病灶AT和PI分别为(9.1±2.2)s和(41.7±5.1)dB,均显著低于转移性肝癌病灶【分别为(13.4±2.6)s和(45.8±5.5)dB,P<0.05】,而TTP为(24.8±4.7)s,显著慢于转移性肝癌病灶【(18.9±3.4)s,P<0.05】;HCC患者血清AFP水平为(226.7±37.5)ng/mL,显著高于转移性肝癌患者【(73.1±14.6)ng/mL,P<0.05】;ROC曲线分析显示,采用AT、TTP和PI联合诊断HCC的AUC为0.89(95%CI:0.83~0.96),其敏感度(Se)和特异度(Sp)分别为70.5%和95.2%,显著优于血清AFP诊断【其AUC为0.78(95%CI:0.68~0.79),其Se和Sp分别为56.8%和78.8%,P<0.05】。结论使用CEUS检测的TIC相关参数鉴别诊断HCC与转移性肝癌有一定的临床应用价值,值得进一步研究。

实时剪切波弹性成像联合超声造影参数在鉴别甲状腺实性结节良恶性的诊断价值研究

目的 评估实时剪切波弹性成像(SWE)杨氏模量联合超声造影(CEUS)参数在鉴别甲状腺结节良恶性中的诊断价值。方法 以2020年6月至2022年11月在宝鸡市人民医院经细针穿刺活检或手术病理证实的甲状腺结节病人为研究对象,按照研究目标设定的纳入/排除标准,最终纳入106例共106个结节,行常规超声及SWE检查,记录结节超声特征及弹性参数,后行CEUS检查,并对结节动态造影图像进行定量参数分析,获取造影时间-强度曲线(TIC)图及相关CEUS参数。比较SWE参数Еmax、Еmin、Еmean与CEUS参数PI、TTP、MTT、超声造影TIC曲线下面积(AUC)及联合参数在鉴别甲状腺结节良恶性中的诊断价值。结果 106例甲状腺结节中,甲状腺良性结节(TBN)组60例和恶性结节(TMN)组46例;两组结节一般资料比较中,病人年龄平均值TBN组(42.37±5.54)岁与TMN组(39.56±4.69)岁相比差异有统计学意义(P<0.05),结节血流分布差异有统计学意义(P<0.05);两组结节SWE杨氏模量Emax、Emin、Emean平均值中,TBN组平均值分别为(39.29±12.59)Kp、(14.19±4.60)Kp、(23.01±7.93)Kp,TMN组平均值分别为(104.35±35.62)Kp、(35.09±17.53)Kp、(62.13±22.94)Kp,两组相比差异有统计学意义(P<0.05);两组结节CEUS定性及定量各参数PI、TTP、AUC平均值中,TBN组各参数平均值分别为(45.88±4.22)dB、(22.02±1.97)s、(4177.58±426.29)dB·s,TMN组各参数平均值分别为(35.64±4.16)dB、(24.98±3.91)s、(3280.94±315.76)dB·s,TMN组PI、AUC均低于TBN组,而TMN组TTP长于TBN组,两组相比差异有统计学意义(P<0.05);SWE及CEUS参数联合诊断受试者操作特征(ROC)曲线下面积(AUC)、准确性及对应的灵敏度、特异度均高于各参数单独诊断,且均差异有统计学意义(P<0.05)。SWE各参数单独及联合诊断ROC曲线成对比较,Еmax比Еmin、Еmean比Еmin成对比较差异有统计学意义(Z=2.60、3.00,P<0.05)。CEUS各参数单独及联合诊断ROC曲线成对比较,TTP与联合诊断成对比较差异有统计学意义(Z=2.35,P<0.05)。Emean截断值为32.21 KPa时,SWE-Emean联合CEUS特征鉴别甲状腺结节良恶性的诊断效能均优于SWE-Emean或CEUS单独诊断。结论SWE杨氏模量联合CEUS参数可提高甲状腺结节诊断准确性。

Usefulness of contrast enhanced ultrasound in monitoring therapeutic response after hepatocellular carcinoma treatment

In the last years, the development in the oncology field has been huge and rapid. In particular, the evaluation of response to anti-tumour treatments has been being object of intense research, producing significant changes. Response assessment after therapy in solid neoplasias has always used radiological imaging techniques, with tumour size reduction representing a presumed therapeutic efficacy. However, with the introduction of anti-angiogenetic drugs the evaluation of tumour size has become unsuitable because some tumours, under treatment, show only tumour perfusion changes rather than lesion shrinkage. Between different imaging techniques with contrast-enhancement, contrastenhanced ultrasound(CEUS) and, in particular, dynamic CEUS have arisen as a promising and non-invasive device for monitoring cancer treatments. Moreover, the introduction of perfusion software has even more refined the technique since it is able to provide quantitative parameters related to blood flow and blood volume that can be associated with tumour response and clinical outcome such as the progression free survival and the overall survival. Here, we give an overview of the current status of CEUS in monitoring hepatocellular carcinoma response to different kind of treatments.

基于二维光子晶体全光逻辑门的设计

在二维光子晶体中嵌入了线缺陷,利用线性干涉效应和波导耦合,设计了一种基于二维光子晶体的同或门和与非门结构。主要采用平面波展开法对该二维光子晶体的能带结构进行分析,采用时域有限差分法,结合线性干涉效应,在Rsoft平台对所设计的同或门和与非门进行稳定电场图和归一化功率仿真。仿真结果标明:设计的同或门对比度高达29.5 dB,响应时间为0.073 ps,数据传输速率为13.7 Tbit/s;设计的与非门对比度高达24.15 dB,响应时间为0.08 ps,数据传输速率为12.5 Tbit/s。这些结果表明所设计的结构对比度高、响应时间短和数据传输速率快。

经阴道子宫输卵管实时三维超声造影与X线碘油造影术对女性不孕症的诊断价值

目的:探讨经阴道子宫输卵管实时三维超声造影(RT-3D-HyCoSy)与X线碘油造影术(HSG)对女性不孕症的诊断价值。方法:选取70例(140条输卵管)不孕症患者为研究对象,按照影像学检查方式不同分为对照组和观察组,每组各35例。对照组患者行HSG检查;观察组患者行RT-3D-HyCoS检查,并于检查后次月月经干净后3~7 d行腹腔镜输卵管通液术(CLP)。比较两种影像学检查方法与CLP检查结果的符合率;以CLP检查结果为“金标准”,分析HSG与3D-HyCoSy检查对不孕症的诊断价值。结果:HSG和RT-3D-HyCoSy检查与CLP结果相符合的输卵管条数分别为52条和65条,两种检查方式与CLP的符合率比较,差异有统计学意义(74.29%vs.92.86%,χ^(2)=8.792,P=0.003)。以CLP检查结果为“金标准”,RT-3D-HyCoSy检查的敏感性、阴性预测值及准确性高于HSG检查(P<0.05);两种检查的特异性、阳性预测值比较,差异无统计学意义(P>0.05)。结论:相较传统HSG,RT-3D-HyCoSy是诊断女性不孕症更有效的方法,值得临床推广。

More Peripheral Visualization of Hepatic Arteries by Using Respiratory-Triggered 3D True Steady-State Free-Precession Projection Magnetic Resonance Angiographic Sequences with Time-Spatial Labeling Inversion Pulse

Purpose: To evaluate respiratory-triggered three-dimensional (3D) true steady-state free-precession (SSFP) projection magnetic resonance angiographic sequences with time-spatial labeling inversion pulse (Time-SLIP) for visualizing the hepatic arteries and to optimize the image acquisition protocol. Materials and Methods: A 1.5-T clinical magnetic resonance imager was used to perform abdominal magnetic resonance angiography (MRA) in 25 consecutive patients before transcatheter arterial chemoembolization or surgery. We compared two selective space-labeling inversion pulse (tag pulse) patterns (Patterns I and II, oblique and parallel tag pulses, respectively). Two experienced radiologists evaluated the number of hepatic arterial branches visible on the acquired MRA images, and the results were referenced with those on images from intra-arterial digital subtraction angiography. Results: Images were acquired from all patients. The two radiologists clearly visualized branches of the left and right hepatic arteries. More peripheral hepatic arterial branches were identified in MRA images captured by using tag pulse Pattern I than in those acquired by using Pattern II (P P > 0.05). Conclusion: Non-contrast-enhanced Time-SLIP hepatic MRA with true SSFP allowed selective visualization of peripheral hepatic vessels.

超声造影下峰值强度、平均渡越时间在子宫内膜癌患者中的检测意义

目的:探讨超声造影下峰值强度(PI)、平均渡越时间(MTT)在子宫内膜癌(EC)患者中的检测意义。方法:选取2020年1月—2023年10月江西中医药大学附属医院收治的60例EC患者作为EC组,另选取同期本院收治的子宫内膜良性病变患者60例作为良性病变(BL)组。所有患者均行超声造影,比较EC组和BL组及深肌层浸润组和无或浅肌层浸润组PI、MTT、达峰时间(TTP)、到达时间(AT),并分析上述指标对EC及深肌层浸润的诊断价值。结果:EC组PI高于BL组,MTT短于BL组(t=6.315、3.177,P<0.05);ROC曲线显示,PI、MTT联合诊断EC的AUC为0.861,高于PI的0.799、MTT的0.694(Z=2.015、3.780,P<0.05);深肌层浸润组PI高于无或浅肌层浸润组,MTT短于无或浅肌层浸润组(t=3.901、3.854,P<0.05);ROC曲线显示,PI、MTT联合诊断EC深肌层浸润的AUC为0.902,高于PI的0.792、MTT的0.764(Z=2.345、2.226,P<0.05)。结论:超声造影下PI、MTT对EC及深肌层浸润有一定的诊断价值。

经直肠超声造影评估前列腺癌新辅助内分泌治疗反应的价值

目的:探讨经直肠超声造影(contrast-enhanced transrectal ultrasound)时间-强度曲线(time-intensity curve,TIC)参数评估前列腺癌(prostate cancer,PCa)患者对新辅助内分泌治疗(neoadjuvant hormonal therapy,NHT)的反应程度。方法:纳入27例接受NHT的PCa患者的临床资料,根据术后病理学检查结果分为有效组(n=16)和无效组(n=11)。对比两组患者临床病理学特征、治疗前后血清前列腺特异性抗原(prostate-specific antigen,PSA)和CETRUS检查指标及其变化率,以筛选与NHT反应性有关的潜在指标。进一步采用相关性分析评价其在评估患者对NHT反应方面的价值。结果:有效组和无效组在临床病理学特征、治疗前的血清PSA和C E T R U S检查指标方面的差异无统计学意义(均P>0.05)。治疗后,仅有效组的TIC曲线下面积(area under curve,AUC)低于无效组(560 dB·s vs 710 dB·s),其变化率大于无效组(-27.1%vs-5.3%)(均P<0.05)。相关性分析显示AUC变化率与组织学反应评分之间的相关性略高于治疗后AUC(r为-0.690 vs-0.630)。结论:CETRUS TIC参数中,NHT后的AUC及其变化率在评估PCa患者对NHT反应方面具有较好的价值。其中,AUC变化率可能与治疗反应程度更相关。

甲状腺癌患者超声造影参数与淋巴结转移的关系探讨

目的:分析甲状腺癌(TC)患者超声造影(CEUS)参数与淋巴结转移的关系。方法:选取2021年1月—2024年5月沛县人民医院收治的135例TC患者为研究对象,以病理诊断结果提示是否发生淋巴结转移,将患者分为转移组71例与无转移组64例。均行CEUS检查,对比两组超声造影特征及定量参数,并分析CEUS参数与甲状腺癌淋巴结转移的关系。结果:两组CEUS灌注特征比较差异无统计学意义(P>0.05);转移组肿瘤直径大于无转移组,差异有统计学意义(P<0.05);两组上升时间(RT)、上升斜率(WIS)、峰值降半时间(TPH)及达峰时间(TTP)水平比较,差异无统计学意义(P>0.05);转移组平均渡越时间(MTT)低于无转移组,峰值强度(PI)高于无转移组,差异有统计学意义(P<0.05);Pearson相关性分析显示,MTT与甲状腺癌患者淋巴结转移呈负相关,PI与甲状腺癌患者淋巴结转移呈正相关(P<0.05)。结论:TC患者淋巴结转移与癌结节大小、CEUS参数MTT及PI有关,通过测定CEUS参数可准确评估淋巴结转移情况,以指导临床治疗。

两款非球面散光镜片配戴清晰度和舒适度研究

采用前瞻性随机双盲对照实验,对比2款非球面散光镜片的配戴清晰度、舒适度、清晰视野感觉宽广度和适应时间。采用调查问卷量表评估刚开始配戴及戴镜1周后的清晰度、舒适度、清晰视野感觉宽广度以及适应时间的主观评价;采用配对t检验比较2组对象的平均客观视力;采用配对秩和检验比较2组对象的主观评价情况。在客观评价中,反向曲率组拥有更好的视觉分辨能力,且2组数据差异都具有统计学意义;在主观评价中,反向曲率组镜片的评分均高于标准非球面组,且差异具有统计学意义。而在日间看近、夜间看近、夜间活动的配戴舒适度评价和眼镜适应时间的评价中,尽管反向曲率组的评分也高于标准非球面组,但差异不具有统计学意义。反向曲率修正设计镜片相比于传统标准非球面设计镜片,可在快速适应的同时,提供更好的配戴清晰度、舒适度和清晰视野感觉宽广度。