Is it time to rethink the Alzheimer's disease drug development strategy by targeting its silent phase?

Alzheimer＇s disease （AD） is the most frequent cause of dementia in the western world. In clinical terms, AD is characterized by progres- sive cognitive decline that usually begins with memory impairment. As the disease progresses, AD inevitably affects all intellectual functions including executive functions, leading to complete dependence for basic activities of daily life and premature death.

An Integrated Scheduling Algorithm for the Same Equipment Process Sequencing Based on the Root-Subtree Vertical and Horizontal Pre-Scheduling

Given the existing integrated scheduling algorithms,all processes are ordered and scheduled overall,and these algorithms ignore the influence of the vertical and horizontal characteristics of the product process tree on the product scheduling effect.This paper presents an integrated scheduling algorithm for the same equipment process sequencing based on the Root-Subtree horizontal and vertical pre-scheduling to solve the above problem.Firstly,the tree decomposition method is used to extract the root node to split the process tree into several Root-Subtrees,and the Root-Subtree priority is set from large to small through the optimal completion time of vertical and horizontal pre-scheduling.All Root-Subtree processes on the same equipment are sorted into the stack according to the equipment process pre-start time,and the stack-top processes are combined with the schedulable process set to schedule and dispatch the stack.The start processing time of each process is determined according to the dynamic start processing time strategy of the equipment process,to complete the fusion operation of the Root-Subtree processes under the constraints of the vertical process tree and the horizontal equipment.Then,the root node is retrieved to form a substantial scheduling scheme,which realizes scheduling optimization by mining the vertical and horizontal characteristics of the process tree.Verification by examples shows that,compared with the traditional integrated scheduling algorithms that sort the scheduling processes as an overall,the integrated scheduling algorithmin this paper is better.The proposed algorithmenhances the process scheduling compactness,reduces the length of the idle time of the processing equipment,and optimizes the production scheduling target,which is of universal significance to solve the integrated scheduling problem.

Delay Time Measurement and Comparison of Protection Strategies with One-Link Failed Domestic Optical Fiber Networks in Taiwan

In this paper, we study the protection strategies of domestic optical fiber networks in Taiwan. Delay time experiment of two one-link failed cases are also reported and compared. We can get best protection strategy and bypass the optical transmission signal at shortest delay time.

Design and evaluation of control strategies in urban drainage systems in Kunming city

Real time control （RTC） of urban drainage systems （UDSs） is an important measure to reduce combined sewer overflow （CSO） and urban flooding, helping achieve the aims of ＂Sponge City＇. Application of RTC requires three main steps： strategy design, simulation-based evaluation and field test. But many of published RTC studies are system-specific, lacking discussions on how to design a strategy step by step. In addition, the existing studies are prone to use hydrologic model to evaluated strategics, but a more precise and dynamic insight into strategy performance is needed. To fill these knowledge gaps, based on a case UDS in Kunming city, a studio on RTC strategy design and Management Model （SWMM） - uncier four typical rainfall events characterized by different return periods （1-year or 0.5 year） and different spatial distributions （uniform or uneven）. The equal filling strategy outperformss other two strategies and it can achieve 10% more CSO reduction and 5% more flooding reduction relative to the no-tank case.