In vivo label-free measurement of blood flow velocity symmetry based on dual line scanning third-harmonic generation microscopy excited at the 1700 nm window

Measurement of bloodflow velocity is key to understanding physiology and pathology in vivo.While most measurements are performed at the middle of the blood vessel,little research has been done on characterizing the instantaneous bloodflow velocity distribution.This is mainly due to the lack of measurement technology with high spatial and temporal resolution.Here,we tackle this problem with our recently developed dual-wavelength line-scan third-harmonic generation(THG)imaging technology.Simultaneous acquisition of dual-wavelength THG line-scanning signals enables measurement of bloodflow velocities at two radially symmetric positions in both venules and arterioles in mouse brain in vivo.Our results clearly show that the instantaneous bloodflow velocity is not symmetric under general conditions.

Flow characteristics and regime transition of aqueous foams in porous media over a wide range of quality,velocity,and surfactant concentration

Aqueous foam is broadly applicable to enhanced oil recovery(EOR).The rheology of foam as a function of foam quality,gas and liquid velocities,and surfactant concentration constitute the foundation of its application.The great variations of the above factors can affect the effectiveness of N2 foam in EOR continuously in complex formations,which is rarely involved in previous relevant studies.This paper presents an experimental study of foam flow in porous media by injecting pre-generated N2 foam into a sand pack under the conditions of considering a wide range of gas and liquid velocities and surfactant concentrations.The results show that in a wide range of gas and liquid velocities,the pressure gradient contours are L-shaped near the coordinate axes,but V-shaped in other regions.And the surfactant concentration is a strong factor influencing the trend of pressure gradient contours.Foam flow resistance is very sensitive to the surfactant concentration in both the high-and low-foam quality regime,especially when the surfactant concentration is less than CMC.The foam quality is an important variable to the flow resistance obtained.There exists a transition point from low-to high-quality regime in a particular flow system,where has the maximum flow resistance,the corresponding foam quality is called transition foam quality,which increases as the surfactant concentration increases.The results can add to our knowledge base of foam rheology in porous media,and can provide a strong basis for the field application of foams.

Simultaneous measurement of velocity profile and liquid film thickness in horizontal gas–liquid slug flow by using ultrasonic Doppler method

Horizontal gas-liquid two-phase flows widely exist in chemical engineering,oil/gas production and other important industrial processes.Slug flow pattern is the main form of horizontal gas-liquid flows and characterized by intermittent motion of film region and slug region.This work aims to develop the ultrasonic Doppler method to realize the simultaneous measurement of the velocity profile and liquid film thickness of slug flow.A single-frequency single-channel transducer is adopted in the design of the field-programmable gate array based ultrasonic Doppler system.A multiple echo repetition technology is used to improve the temporal-spatial resolution for the velocity profile.An experiment of horizontal gas-liquid two-phase flow is implemented in an acrylic pipe with an inner diameter of 20 mm.Considering the aerated characteristics of the liquid slug,slug flow is divided into low-aerated slug flow,high-aerated slug flow and pseudo slug flow.The temporal-spatial velocity distributions of the three kinds of slug flows are reconstructed by using the ultrasonic velocity profile measurement.The evolution characteristics of the average velocity profile in slug flows are investigated.A novel method is proposed to derive the liquid film thickness based on the instantaneous velocity profile.The liquid film thickness can be effectively measured by detecting the position and the size of the bubbles nearly below the elongated gas bubble.Compared with the time of flight method,the film thickness measured by the Doppler system shows a higher accuracy as a bubble layer occurs in the film region.The effect of the gas distribution on the film thickness is uncovered in three kinds of slug flows.

FeatureMatching Combining Variable Velocity Model with Reverse Optical Flow

The ORB-SLAM2 based on the constant velocity model is difficult to determine the search window of the reprojection of map points when the objects are in variable velocity motion,which leads to a false matching,with an inaccurate pose estimation or failed tracking.To address the challenge above,a new method of feature point matching is proposed in this paper,which combines the variable velocity model with the reverse optical flow method.First,the constant velocity model is extended to a new variable velocity model,and the expanded variable velocity model is used to provide the initial pixel shifting for the reverse optical flow method.Then the search range of feature points is accurately determined according to the results of the reverse optical flow method,thereby improving the accuracy and reliability of feature matching,with strengthened interframe tracking effects.Finally,we tested on TUM data set based on the RGB-D camera.Experimental results show that this method can reduce the probability of tracking failure and improve localization accuracy on SLAM(Simultaneous Localization and Mapping)systems.Compared with the traditional ORB-SLAM2,the test error of this method on each sequence in the TUM data set is significantly reduced,and the root mean square error is only 63.8%of the original system under the optimal condition.

CFD numerical simulation of flow velocity characteristics of hydrocyclone

A CFD based numerical simulation of flow velocity of hydrocyclone was conducted with different structural and operational parameters to investigate its distribution characteristics and influencing mechanism. The results show there exist several unsymmetrical envelopes of equal vertical velocities in both upward inner flows and downward outer flows in the hydrocyclone, and the cone angle and apex diameter have remarkable influence on the vertical location of the cone bottom of the envelope of zero vertical velocity. It is also found that the tangential velocity isolines exist in the horizontal planes located in the effective separation region of hydrocyclone. The increase of feed pressure has almost no effect on the distribution characteristics of both vertical velocity and tangential velocity in hydrocyclone, but the magnitude and gradient of tangential velocity are increased obviously to make the motion velocity of high density particles to the wall increased and to make the cyclonic separation effect improved.

Pore structure and liquid flow velocity distribution in water-saturated porous media probed by MRI

Magnetic resonance imaging （MRI） was used to probe the structure and flow velocity within the interparticle space of a packed bed of agar beads under water-saturated condition. The images of the velocity field at three different flow rates were obtained. To determine the pore-parameter of the porous media, the internal structure of the bed was also obtained using image processing technique. The results show that the porosity of the sample is 31.28% and the fitting curve for the distribution of pore equivalent diameter follows Gaussian distribution. The velocity profiles do shift as the flow rate varies and the solution flow through the void space is not a homogeneous flow in any pores. The velocity distributions within the pore are roughly parabolic with the local maximum being near the center. About half of the velocity components are in the class of 0-1 cm/s. The frequency of lower velocity components is lower at higher flow rate, but to higher velocity components, it is just the opposite.

Ultrasonic method for measuring water holdup of low velocity and high-water-cut oil-water two-phase flow

Oil reservoirs with low permeability and porosity that are in the middle and late exploitation periods in China＇s onshore oil fields are mostly in the high-water-cut production stage.This stage is associated with severely non-uniform local-velocity flow profiles and dispersed-phase concentration（of oil droplets） in oil-water two-phase flow,which makes it difficult to measure water holdup in oil wells.In this study,we use an ultrasonic method based on a transmission-type sensor in oil-water two-phase flow to measure water holdup in lowvelocity and high water-cut conditions.First,we optimize the excitation frequency of the ultrasonic sensor by calculating the sensitivity of the ultrasonic field using the finite element method for multiphysics coupling.Then we calculate the change trend of sound pressure level attenuation ratio with the increase in oil holdup to verify the feasibility of the employed diameter for the ultrasonic sensor.Based on the results,we then investigate the effects of oildroplet diameter and distribution on the ultrasonic field.To further understand the measurement characteristics of the ultrasonic sensor,we perform a flow loop test on vertical upward oilwater two-phase flow and measure the responses of the optimized ultrasonic sensor.The results show that the ultrasonic sensor yields poor resolution for a dispersed oil slug in water flow（D OS/W flow）,but the resolution is favorable for dispersed oil in water flow（D O/W flow） and very fine dispersed oil in water flow（VFD O/W flow）.This research demonstrates the potential application of a pulsed-transmission ultrasonic method for measuring the fraction of individual components in oil-water two-phase flow with a low mixture velocity and high water cut.

EXPERIMENTAL INVESTIGATION ON INDUCED FLOW VELOCITY OF PLASMA AERODYNAMIC ACTUATION

Plasma flow control is an active flow control technology that based on the plasma aerodynamic actuation. It can be used to enhance the aerodynamic characteristics of aircraft and propulsion systems. To study the phenomena occurring in plasma aerodynamic actuation and the mechanism of plasma flow control, the induced flow velocity of the plasma aerodynamic actuator is experimentally investigated under a variety of parameter conditions. The results indicate that plasma aerodynamic actuation accelerates the near surface air at velocities of a few meters per second, and there is an angle about 5° between the mainstream and the actuator wall and a spiral vortex is formed when the induced flow is moving along the wall. Besides, with the fixed frequency, the induced flow velocity increases linearly with the applied voltage, but it is insensitive to the frequency when the applied voltage is fixed. And the configuration is an effective factor for the performance of the plasma aerodynamic actuator.

Effect of flow velocity on corrosion behavior of AZ91D magnesium alloy at elbow of loop system

A loop system was used to investigate the effect of flow velocity on corrosion behavior of AZ91 D magnesium alloy at an elbow of loop system based on array electrode technology by polarization, computational fluid dynamics(CFD) simulation and surface analysis. The experimental results showed that the corrosion rate increased with increasing flow velocity, and a critical flow velocity could exist in the corrosion of AZ91 D magnesium alloy. When flow velocity exceeded the critical flow velocity, fluid hydrodynamics was dominant in the corrosion of AZ91 D magnesium alloy. On the contrary, the electrochemical factors were dominant.

3D FEM simulation of flow velocity field for 5052 aluminum alloy multi-row sprocket in cold semi-precision forging process

Based on the design of the multi-row sprocket with a new tooth profile,a cold semi-precision forging process for manufacturing 5052 aluminum alloy multi-row sprocket was presented.Through simulating the forging process of 5052 aluminum alloy sprocket billet with 3D rigid-viscoplastic FEM,both the distributions of flow velocity field in axial(U_Z),radial(U_R) and circumferential(U_θ) directions and the curves of velocity component in different deformation regions were respectively obtained.By comparison and analysis of the velocity varying curves,the velocity component relation conditions for filling the die cavity were clarified.It shows that when the die cavity is almost fully filled,the circumferential velocity U_θ increases sharply,implying that U_θplays a key role in fully filling the die cavity.

Submerged flexible vegetation impact on open channel flow velocity distribution: An analytical modelling study on drag and friction

In this paper,an analytical model that represents the streamwise velocity distribution for open channel flow with submerged flexible vegetation is studied.In the present vegetated flow modelling,the whole flow field has been separated into two layers vertically: a vegetated layer and a non-vegetated free-water layer.Within the vegetated layer,an analysis of the mechanisms affecting water flow through flexible vegetation has been conducted.In the non-vegetated layer,a modified log-law equation that represents the velocity profile varying with vegetation height has been investigated.Based on the studied analytical model,a sensitivity analysis has been conducted to assess the influences of the drag (CD) and friction (Cf ) coefficients on the flow velocity.The investigated ranges of CD and Cf have also been compared to published values.The findings suggest that the CD and Cf values are non-constant at different depths and vegetation densities,unlike the constant values commonly suggested in literature.This phenomenon is particularly clear for flows with flexible vegetation,which is characterised by large deflection.

Planar Velocity Distribution of Viscous Debris Flow at Jiangjia Ravine,Yunnan,China:A Field Measurement Using Two Radar Velocimeters

Characteristics of planar velocity distribution of viscous debris flow were analyzed using the measured data at Jiangjia Ravine, Yunnan, China. The velocity data were measured through using two radar velocimeters. The cross-sectional mean velocities were calculated and used to examine Kang et al＇s （2004） relationship, which was established for converting the flow velocity at river centerline measured by a radar velocimeter into the mean velocity based on the stop-watch method. The velocity coefficient, K, defined by the ratio of the mean velocity to the maximum velocity, ranges from 0.2 to 0.6. Kang et al＇s （2004） relationship was found being inapplicable to flows with K smaller than 0.43. This paper contributes to show the complexity of the planar velocity distribution of viscous debris flows and the applicability of Kang et al＇s relationship.

Experimental study on influence of boundary on location of maximum velocity in open channel flows

The velocity dip phenomenon may occur in a part of or in the whole flow field of open channel flows due to the secondary flow effect. Based on rectangular flume experiments and the laser Doppler velocimetry, the influence of the distance to the sidewall and the aspect ratio on the velocity dip is investigated. Through application of statistical methods to the experimental results, it is proposed that the flow field may be divided into two regions, the relatively strong sidewall region and the relatively weak sidewall region. In the former region, the distance to the sidewall greatly affects the location of maximum velocity, and, in the latter region, both the distance to the sidewall and the aspect ratio influence the location of the maximum velocity.

Measuring the Internal Velocity of Debris Flows Using Impact Pressure Detecting in the Flume Experiment

Measuring the internal velocity of debris flows is very important for debris flow dynamics research and designing debris flow control works. However, there is no appropriate method for measuring the internal velocity because of the destructive power of debris flow process. In this paper, we address this problem by using the relationship between velocity and kinetic pressure, as described by surface velocity and surface kinetic pressure data. Kinetic pressure is the difference of impact pressure and static pressure. The former is detected by force sensors installed in the flow direction at the sampling section. Observations show that static pressure can be computed using the formula for static water pressure by simply substituting water density for debris flow density. We describe the relationship between surface velocity and surface kinetic pressure using data from seven laboratory flume experiments. It is consistent with the relationship for single phase flow, which is the measurement principle of the Pitot tube.

Numerical investigation of velocity distribution of turbulent flow through vertically double-layered vegetation

The velocity structures of flow through vertically double-layered vegetation(VDLV)as well as single-layered rigid vegetation(SLV)were investigated computationally with a three-dimensional(3D)Reynolds stress turbulence model,using the computational fluid dynamics(CFD)code FLUENT.The detailed velocity distribution was explored with a varying initial Froude number(Fr),with consideration of the steady subcritical flow conditions of an inland tsunami.In VDLV flows,the numerical model successfully captured the inflection point in the profiles of mean streamwise velocities in the mixing-layer region around the top of short submerged vegetation.An upward and downward movement of flow occurred at the positions located just behind the tall and short vegetation,respectively.Overall,higher streamwise velocities were observed in the upper vegetation layer due to high porosity,with Pr=98%(sparse vegetation,where Pr is the porosity),as compared to those in the lower vegetation layer,which had comparatively low porosity,with Pr=91%(dense vegetation).A rising trend of velocities was found as the flow passed through the vegetation region,followed by a clear sawtooth distribution,as compared to the regions just upstream and downstream of vegetation where the flow was almost uniform.In VDLV flows,a rising trend in the flow resistance was observed with the increase in the initial Froude number,i.e.,Fr?0.67,0.70,and 0.73.However,the flow resistance in the case of SLV was relatively very low.The numerical results also show the flow structures within the vicinity of short and tall vegetation,which are difficult to attain through experimental measurements.

Mass-front velocity of dry granular flows influenced by the angle of the slope to the runout plane and particle size gradation

The mass-front velocities of granular flows results from the joint action of particle size gradations and the underlying surfaces.However,because of the complexity of friction during flow movement,details such as the slope-toe impedance effects and momentum-transfer mechanisms have not been completely explained by theoretical analyses,numerical simulations,or field investigations.To study the mass-front velocity of dry granular flows influenced by the angle of the slope to the runout plane and particle size gradations we conducted model experiments that recorded the motion of rapid and long-runout rockslides or avalanches.Flume tests were conducted using slope angles of 25°,35°,45°,and 55° and three particle size gradations.The resulting mass-front motions consisted of three stages:acceleration,velocity maintenance,and deceleration.The existing methods of velocity prediction could not explain the slowing effect of the slope toe or the momentum-transfer steady velocity stage.When the slope angle increased from 25° to 55°,the mass-front velocities dropped significantly to between 44.4% and59.6% of the peak velocities and energy lossesincreased from 69.1% to 83.7% of the initial,respectively.The velocity maintenance stages occurred after the slope-toe and mass-front velocity fluctuations.During this stage,travel distances increased as the angles increased,but the average velocity was greatest at 45°.At a slope angle of 45°,as the median particle size increased,energy loss around the slope toe decreased,the efficiency of momentum transfer increased,and the distance of the velocity maintenance stage increased.We presented an improved average velocity formula for granular flow and a geometrical model of the energy along the flow line.

Effect of slope gradient on the subsurface water flow velocity of sand layer profile

Subsurface water flow velocity influences the hydrodynamic characteristics of soil seepage and the interaction between subsurface water flow and surface runoff during soil erosion and sediment transport.A visualized method and equipment was adopted in this study to observe the subsurface water flow.Quartz sand was used as the test material of subsurface water flow and fluorescent dye was used as the indicator for tracing subsurface water flow.Water was supplied at the same flow discharge to the three parts at the bottom of the test flume,and the subsurface water flow were determined with four slope gradients(4°,8°,10°,and 12°).The results showed that the seepage velocity gradually increased with increasing slope gradient.The pore water velocity at different depths of sand layer profile increased with increasing slope gradient,whereas the thickness of the flow front gradually decreased.For the same slope gradient,the pore water velocity in the lower layer was the largest,whereas the thickness of the flow front was the smallest.Comparative analysis of the relationship between seepage velocity and pore water velocity at different depths of sand layer profile showed that the maximum relative difference between the measured pore water velocity and the computational pore water velocity at different depths of sand profile in the experiment was 4.38%.Thus,the test method for measuring the subsurface water flow velocity of sand layer profile adopted in this study was effective and feasible.The development of this experiment and the exploration of research methods would lay a good test foundation for future studies on the variation law of subsurface water flow velocity and the determination of flow velocity in purple soils,thus contributing to the improvement of the hydrodynamic mechanism of purple soils.

Prediction of velocity distribution in straight open-channel flow with partial vegetation by singular perturbation method

A numerical analysis model based on two-dimensional shallow water differential equations is presented for straight open-channel flow with partial vegetation across the channel. Both the drag force acting on vegetation and the momentum exchange between the vegetation and non-vegetation zones are considered. The depth-averaged streamwise velocity is solved by the singular perturbation method, while the Reynolds stress is calculated based on the results of the streamwise velocity. Comparisons with the experimental data indicate that the accuracy of prediction is significantly improved by introducing a term for the secondary current in the model. A sensitivity analysis shows that a sound choice of the secondary current intensity coefficient is important for an accurate prediction of the depth-averaged streamwise velocity near the vegetation and non-vegetation interfaces, and the drag force coefficient is crucial for predictions in the vegetation zone.

Assessment of Coronary Flow Velocity Reserve by Noninvasive Transthoracic Doppler Echocardiography in Patients with Angiographically Normal Coronary Arteries

Summary： The measurement of coronary flow velocity reserve （CFVR） by transthoracic Doppler echocardiography （TTDE） with invasive intracoronary Doppler flow wire technique （ICD） was validated and the pathological factors which influence CFVR in patients with angiographically normal coronary arteries were analyzed. CFVR was determined successfully in left anterior descending artery （LAD） in 37 of 40 patients with angiographically normal coronary arteries （men 22, women 15, age 20-75 years, mean age 54±12 years）. Coronary flow velocity was measured in the distal LAD by TTDE with contrast enhancement at baseline and during intravenous adenosine infusion of 110 μg/ kg per min within 48 h after ICD technique. Average peak velocity at baseline （APVb）, average peak velocity during hyperemia （APVh） and CFVR determined from TTDE were correlated closely with those from ICD measurements （APVb： y= 0. 64x＋ 5. 04, r=0. 86, P〈0. 001; APVh： y=0. 63x＋14. 36, r=0.82, P〈0.001; CFVR： y=0.65xq-0.92, r=0.88, P〈0.001）. For CFVR measurements, the mean differences between TTDE and ICD methods were 0. 12±0.39. CFVR in patients with history of hypertension was significantly lower than that in patients without history of hypertension （P〈0.05）. Intravascular ultrasound （IVUS） was performed in 34 patients. Plaque formation was found in LAD by IVUS in 17 （50%） patients. No significant difference in CFVR was found between the patients without plaque formation （3. 11±0. 49） and those with plaque formation （2. 76±0.53, P=0. 056）. It is suggested that TTDE with contrast enhancement provides reliable measurement of APV and CFVR in the distal I.AD. The early stage of atherosclerosis could be detected by IVUS, which may be normal in angiography. CFVR is impaired in patients with history of hypertension compared with that in patients without history of hypertension.

Three-dimensional mixed convection stagnation-point fow past a vertical surface with second-order slip velocity

This study is concerned with the three-dimensional(3D)stagnation-point for the mixed convection flow past a vertical surface considering the first-order and secondorder velocity slips.To the authors’knowledge,this is the first study presenting this very interesting analysis.Nonlinear partial differential equations for the flow problem are transformed into nonlinear ordinary differential equations(ODEs)by using appropriate similarity transformation.These ODEs with the corresponding boundary conditions are numerically solved by utilizing the bvp4c solver in MATLAB programming language.The effects of the governing parameters on the non-dimensional velocity profiles,temperature profiles,skin friction coefficients,and the local Nusselt number are presented in detail through a series of graphs and tables.Interestingly,it is reported that the reduced skin friction coefficient decreases for the assisting flow situation and increases for the opposing flow situation.The numerical computations of the present work are compared with those from other research available in specific situations,and an excellent consensus is observed.Another exciting feature for this work is the existence of dual solutions.An important remark is that the dual solutions exist for both assisting and opposing flows.A linear stability analysis is performed showing that one solution is stable and the other solution is not stable.We notice that the mixed convection and velocity slip parameters have strong effects on the flow characteristics.These effects are depicted in graphs and discussed in this paper.The obtained results show that the first-order and second-order slip parameters have a considerable effect on the flow,as well as on the heat transfer characteristics.