Aim The purpose of this study was to develop a mathe-matical model to quantitatively describe the passive trans-port of macromolecules within dental biofilms. Methodology Fluorescently labeled dextrans with different ...Aim The purpose of this study was to develop a mathe-matical model to quantitatively describe the passive trans-port of macromolecules within dental biofilms. Methodology Fluorescently labeled dextrans with different molecular mass (3 kD,10 kD,40 kD,70 kD,2 000 kD) were used as a series of diffusion probes. Streptococcus mutans,Streptococcus sanguinis,Actinomyces naeslundii and Fusobacterium nucleatum were used as inocula for biofilm formation. The diffusion processes of different probes through the in vitro biofilm were recorded with a confocal laser microscope. Results Mathematical function of biofilm penetration was constructed on the basis of the inverse problem method. Based on this function,not only the relationship between average concentration of steady-state and molecule weights can be analyzed,but also that between penetrative time and molecule weights. Conclusion This can be used to predict the effective concentration and the penetrative time of anti-biofilm medicines that can diffuse through oral biofilm. Further-more,an improved model for large molecule is proposed by considering the exchange time at the upper boundary of the dental biofilm.展开更多
In this paper,we consider the inverse problem for identifying the source term of the time-fractional equation with a hyper-Bessel operator.First,we prove that this inverse problem is ill-posed,and give the conditional...In this paper,we consider the inverse problem for identifying the source term of the time-fractional equation with a hyper-Bessel operator.First,we prove that this inverse problem is ill-posed,and give the conditional stability.Then,we give the optimal error bound for this inverse problem.Next,we use the fractional Tikhonov regularization method and the fractional Landweber iterative regularization method to restore the stability of the ill-posed problem,and give corresponding error estimates under different regularization parameter selection rules.Finally,we verify the effectiveness of the method through numerical examples.展开更多
In this paper,we consider a Cauchy problem of the time fractional diffusion equation(TFDE)in x∈[0,L].This problem is ubiquitous in science and engineering applications.The illposedness of the Cauchy problem is explai...In this paper,we consider a Cauchy problem of the time fractional diffusion equation(TFDE)in x∈[0,L].This problem is ubiquitous in science and engineering applications.The illposedness of the Cauchy problem is explained by its solution in frequency domain.Furthermore,the problem is formulated into a minimization problem with a modified Tikhonov regularization method.The gradient of the regularization functional based on an adjoint problem is deduced and the standard conjugate gradient method is presented for solving the minimization problem.The error estimates for the regularized solutions are obtained under Hp norm priori bound assumptions.Finally,numerical examples illustrate the effectiveness of the proposed method.展开更多
In this paper,we mainly study an inverse source problem of time fractional diffusion equation in a bounded domain with an over-specified terminal condition at a fixed time.A novel regularization method,which we call t...In this paper,we mainly study an inverse source problem of time fractional diffusion equation in a bounded domain with an over-specified terminal condition at a fixed time.A novel regularization method,which we call the exponential Tikhonov regularization method with a parameter γ,is proposed to solve the inverse source problem,and the corresponding convergence analysis is given under a-priori and a-posteriori regularization parameter choice rules.Whenγis less than or equal to zero,the optimal convergence rate can be achieved and it is independent of the value of γ.However,when γ is greater than zero,the optimal convergence rate depends on the value of γ which is related to the regularity of the unknown source.Finally,numerical experiments are conducted for showing the effectiveness of the proposed exponential regularization method.展开更多
In this paper,an inverse source problem for the time-fractional diffusion equation is investigated.The observational data is on the final time and the source term is assumed to be temporally independent and with a spa...In this paper,an inverse source problem for the time-fractional diffusion equation is investigated.The observational data is on the final time and the source term is assumed to be temporally independent and with a sparse structure.Here the sparsity is understood with respect to the pixel basis,i.e.,the source has a small support.By an elastic-net regularization method,this inverse source problem is formulated into an optimization problem and a semismooth Newton(SSN)algorithm is developed to solve it.A discretization strategy is applied in the numerical realization.Several one and two dimensional numerical examples illustrate the efficiency of the proposed method.展开更多
The inverse estimation of a source location of pollutant released into a turbulent flow is a probability problem instead of a deterministic one, as the turbulent flow is chaotic and irreversible. However, researches c...The inverse estimation of a source location of pollutant released into a turbulent flow is a probability problem instead of a deterministic one, as the turbulent flow is chaotic and irreversible. However, researches can be conducted to provide helpful instructions to the possible source location with corresponding uncertainty. This study aims to propose a method of inverse estimation of a passive-scalar source location. Experimental investigation of the dye plume characteristics released into a fully-developed turbulent flow is performed in a water channel. A planar laser-induced fluorescence (PLIF) technique is used to obtain two-dimensional images of spreading dye plumes at a bulk Reynolds number of 20,000. The distributions of high concentration areas in the PLIF images are chosen as features that characterize the traveling (diffusion) distance or time from the dye source. Graphical analysis is used to extract these high concentration areas. The procedure of graphical analysis has three steps: 1) binarization using a threshold to extract high concentration dye patches;2) labeling individual high-concentration dye patches in the binarized images;and 3) pixel-counting to measure the area and perimeter of each dye patch. We examine the variations of fractal dimension of patches, and the fractal dimension is observed to be almost constant irrespective of the distance from the source. The kurtosis of the probability density function curve of the logarithm dimensionless dye patch areas is found to be related with the downstream diffusion distance, based on which an inverse estimation method to locate a passive-scalar point source is proposed and evaluated.展开更多
Machine learning-based modeling of reactor physics problems has attracted increasing interest in recent years.Despite some progress in one-dimensional problems,there is still a paucity of benchmark studies that are ea...Machine learning-based modeling of reactor physics problems has attracted increasing interest in recent years.Despite some progress in one-dimensional problems,there is still a paucity of benchmark studies that are easy to solve using traditional numerical methods albeit still challenging using neural networks for a wide range of practical problems.We present two networks,namely the Generalized Inverse Power Method Neural Network(GIPMNN)and Physics-Constrained GIPMNN(PC-GIPIMNN)to solve K-eigenvalue problems in neutron diffusion theory.GIPMNN follows the main idea of the inverse power method and determines the lowest eigenvalue using an iterative method.The PC-GIPMNN additionally enforces conservative interface conditions for the neutron flux.Meanwhile,Deep Ritz Method(DRM)directly solves the smallest eigenvalue by minimizing the eigenvalue in Rayleigh quotient form.A comprehensive study was conducted using GIPMNN,PC-GIPMNN,and DRM to solve problems of complex spatial geometry with variant material domains from the fleld of nuclear reactor physics.The methods were compared with the standard flnite element method.The applicability and accuracy of the methods are reported and indicate that PC-GIPMNN outperforms GIPMNN and DRM.展开更多
An inverse problem of reconstructing the initial condition for a time fractional diffusion equation is investigated.On the basis of the optimal control framework,the uniqueness and first order necessary optimality co...An inverse problem of reconstructing the initial condition for a time fractional diffusion equation is investigated.On the basis of the optimal control framework,the uniqueness and first order necessary optimality condition of the minimizer for the objective functional are established,and a time-space spectral method is proposed to numerically solve the resulting minimization problem.The contribution of the paper is threefold:1)a priori error estimate for the spectral approximation is derived;2)a conjugate gradient optimization algorithm is designed to efficiently solve the inverse problem;3)some numerical experiments are carried out to show that the proposed method is capable to find out the optimal initial condition,and that the convergence rate of the method is exponential if the optimal initial condition is smooth.展开更多
Time-fractional diffusion equations are of great interest and importance on describing the power law decay for diffusion in porous media. In this paper, to identify the diffusion rate, i.e., the heterogeneity of mediu...Time-fractional diffusion equations are of great interest and importance on describing the power law decay for diffusion in porous media. In this paper, to identify the diffusion rate, i.e., the heterogeneity of medium, the authors consider an inverse coefficient problem utilizing finite measurements and obtain a local HSlder type conditional stability based upon two Carleman estimates for the corresponding differential equations of integer orders.展开更多
This article deals with numerical inversion for the initial distribution in the multi-term time-fractional diffusion equation using final observations.The inversion problem is of instability,but it is uniquely solvabl...This article deals with numerical inversion for the initial distribution in the multi-term time-fractional diffusion equation using final observations.The inversion problem is of instability,but it is uniquely solvable based on the solution’s expression for the forward problem and estimation to the multivariate Mittag-Leffler function.From view point of optimality,solving the inversion problem is transformed to minimizing a cost functional,and existence of a minimum is proved by the weakly lower semi-continuity of the functional.Furthermore,the homotopy regularization algorithm is introduced based on the minimization problem to perform numerical inversions,and the inversion solutions with noisy data give good approximations to the exact initial distribution demonstrating the efficiency of the inversion algorithm.展开更多
In this paper, a novel reconstruction method is presented for Near Infrared (NIR) 2-D imaging to recover optical absorption coefficients from laboratory phantom data. The main body of this work validates a new generat...In this paper, a novel reconstruction method is presented for Near Infrared (NIR) 2-D imaging to recover optical absorption coefficients from laboratory phantom data. The main body of this work validates a new generation of highly efficient reconstruction algorithms called “Globally Convergent Method” (GCM) based upon actual measurements taken from brain-shape phantoms. It has been demonstrated in earlier studies using computer-simulated data that this type of reconstructions is stable for imaging complex distributions of optical absorption. The results in this paper demonstrate the excellent capability of GCM in working with experimental data measured from optical phantoms mimicking a rat brain with stroke.展开更多
This paper focuses on the high intensity filaments (dye patches) embedded in dye plumes in a wall-bounded shear flow, to investigate the shear effect on the dye patch distribution. Motivated by the widely concerned in...This paper focuses on the high intensity filaments (dye patches) embedded in dye plumes in a wall-bounded shear flow, to investigate the shear effect on the dye patch distribution. Motivated by the widely concerned inverse estimation of the source location, we try extracting useful information to know the source location from down-stream dye patches. Accordingly, we changed the dye injection location at different distances from the wall and made observations at different downstream (diffusion) distances from the source. The orientation angle and roundness of dye patches were concerned to examine the shear effect and dye patch characteristics. To capture the dye plume images, a planar laser induced fluorescence (PLIF) technique was used. The orientation and roundness of each dye patch were calculated by least-square fitting. The statistics of both the orientation angle and the roundness were compared with those in homogeneous turbulent cases to reveal the shear effect. Different from uniformly-orientated dye patches in the homogeneous flow, larger occurrence probabilities with positive orientation angles of dye patches are observed in wall-bounded shear flow, in particular, when the injection location is near the wall. As with information extraction for the inverse estimation of source location, it is found that the orientation distribution of dye patches is independent of the diffusion distance, but related with the injection location from the wall. While for the homogeneous flow cases, a strong dependence on the diffusion distance is observed in the orientation distribution profiles. As for the roundness, similar aspects are found regarding the dependencies on the injection location in shear flow and on diffusion distance in homogeneous flow.展开更多
For the backward diffusion equation,a stable discrete energy regularization algorithm is proposed.Existence and uniqueness of the numerical solution are given.Moreover,the error between the solution of the given backw...For the backward diffusion equation,a stable discrete energy regularization algorithm is proposed.Existence and uniqueness of the numerical solution are given.Moreover,the error between the solution of the given backward diffusion equation and the numerical solution via the regularization method can be estimated.Some numerical experiments illustrate the efficiency of the method,and its application in image deblurring.展开更多
基金supported by a grant from the National Natural Science Foundation of China (NSFC) No. 81070826/30872886/30400497Sponsored by Shanghai Rising-Star Program No. 09QA1403700+1 种基金funded by Shanghai Leading Academic Discipline Project (Project Number: S30206)the Science and Technology Commission of Shanghai (08DZ2271100)
文摘Aim The purpose of this study was to develop a mathe-matical model to quantitatively describe the passive trans-port of macromolecules within dental biofilms. Methodology Fluorescently labeled dextrans with different molecular mass (3 kD,10 kD,40 kD,70 kD,2 000 kD) were used as a series of diffusion probes. Streptococcus mutans,Streptococcus sanguinis,Actinomyces naeslundii and Fusobacterium nucleatum were used as inocula for biofilm formation. The diffusion processes of different probes through the in vitro biofilm were recorded with a confocal laser microscope. Results Mathematical function of biofilm penetration was constructed on the basis of the inverse problem method. Based on this function,not only the relationship between average concentration of steady-state and molecule weights can be analyzed,but also that between penetrative time and molecule weights. Conclusion This can be used to predict the effective concentration and the penetrative time of anti-biofilm medicines that can diffuse through oral biofilm. Further-more,an improved model for large molecule is proposed by considering the exchange time at the upper boundary of the dental biofilm.
基金supported by the National Natural Science Foundation of China(11961044)the Doctor Fund of Lan Zhou University of Technologythe Natural Science Foundation of Gansu Provice(21JR7RA214)。
文摘In this paper,we consider the inverse problem for identifying the source term of the time-fractional equation with a hyper-Bessel operator.First,we prove that this inverse problem is ill-posed,and give the conditional stability.Then,we give the optimal error bound for this inverse problem.Next,we use the fractional Tikhonov regularization method and the fractional Landweber iterative regularization method to restore the stability of the ill-posed problem,and give corresponding error estimates under different regularization parameter selection rules.Finally,we verify the effectiveness of the method through numerical examples.
基金Supported by the National Natural Science Foundation of China(Grant No.11471253 and No.11571311)
文摘In this paper,we consider a Cauchy problem of the time fractional diffusion equation(TFDE)in x∈[0,L].This problem is ubiquitous in science and engineering applications.The illposedness of the Cauchy problem is explained by its solution in frequency domain.Furthermore,the problem is formulated into a minimization problem with a modified Tikhonov regularization method.The gradient of the regularization functional based on an adjoint problem is deduced and the standard conjugate gradient method is presented for solving the minimization problem.The error estimates for the regularized solutions are obtained under Hp norm priori bound assumptions.Finally,numerical examples illustrate the effectiveness of the proposed method.
基金supported by National Natural Science Foundation of China(11961002,11761007,11861007)Key Project of the Natural Science Foundation of Jiangxi Province(20212ACB201001).
文摘In this paper,we mainly study an inverse source problem of time fractional diffusion equation in a bounded domain with an over-specified terminal condition at a fixed time.A novel regularization method,which we call the exponential Tikhonov regularization method with a parameter γ,is proposed to solve the inverse source problem,and the corresponding convergence analysis is given under a-priori and a-posteriori regularization parameter choice rules.Whenγis less than or equal to zero,the optimal convergence rate can be achieved and it is independent of the value of γ.However,when γ is greater than zero,the optimal convergence rate depends on the value of γ which is related to the regularity of the unknown source.Finally,numerical experiments are conducted for showing the effectiveness of the proposed exponential regularization method.
基金supported by National Science Foundation of China No.11171305 and No.91230203 and the work of X.Lu is partially supported by National Science Foundation of China No.11471253,the Fundamental Research Funds for the Central Universities(13lgzd07)and the PSTNS of Zhu Jiang in Guangzhou city(2011J2200099).
文摘In this paper,an inverse source problem for the time-fractional diffusion equation is investigated.The observational data is on the final time and the source term is assumed to be temporally independent and with a sparse structure.Here the sparsity is understood with respect to the pixel basis,i.e.,the source has a small support.By an elastic-net regularization method,this inverse source problem is formulated into an optimization problem and a semismooth Newton(SSN)algorithm is developed to solve it.A discretization strategy is applied in the numerical realization.Several one and two dimensional numerical examples illustrate the efficiency of the proposed method.
文摘The inverse estimation of a source location of pollutant released into a turbulent flow is a probability problem instead of a deterministic one, as the turbulent flow is chaotic and irreversible. However, researches can be conducted to provide helpful instructions to the possible source location with corresponding uncertainty. This study aims to propose a method of inverse estimation of a passive-scalar source location. Experimental investigation of the dye plume characteristics released into a fully-developed turbulent flow is performed in a water channel. A planar laser-induced fluorescence (PLIF) technique is used to obtain two-dimensional images of spreading dye plumes at a bulk Reynolds number of 20,000. The distributions of high concentration areas in the PLIF images are chosen as features that characterize the traveling (diffusion) distance or time from the dye source. Graphical analysis is used to extract these high concentration areas. The procedure of graphical analysis has three steps: 1) binarization using a threshold to extract high concentration dye patches;2) labeling individual high-concentration dye patches in the binarized images;and 3) pixel-counting to measure the area and perimeter of each dye patch. We examine the variations of fractal dimension of patches, and the fractal dimension is observed to be almost constant irrespective of the distance from the source. The kurtosis of the probability density function curve of the logarithm dimensionless dye patch areas is found to be related with the downstream diffusion distance, based on which an inverse estimation method to locate a passive-scalar point source is proposed and evaluated.
基金partially supported by the National Natural Science Foundation of China(No.11971020)Natural Science Foundation of Shanghai(No.23ZR1429300)Innovation Funds of CNNC(Lingchuang Fund)。
文摘Machine learning-based modeling of reactor physics problems has attracted increasing interest in recent years.Despite some progress in one-dimensional problems,there is still a paucity of benchmark studies that are easy to solve using traditional numerical methods albeit still challenging using neural networks for a wide range of practical problems.We present two networks,namely the Generalized Inverse Power Method Neural Network(GIPMNN)and Physics-Constrained GIPMNN(PC-GIPIMNN)to solve K-eigenvalue problems in neutron diffusion theory.GIPMNN follows the main idea of the inverse power method and determines the lowest eigenvalue using an iterative method.The PC-GIPMNN additionally enforces conservative interface conditions for the neutron flux.Meanwhile,Deep Ritz Method(DRM)directly solves the smallest eigenvalue by minimizing the eigenvalue in Rayleigh quotient form.A comprehensive study was conducted using GIPMNN,PC-GIPMNN,and DRM to solve problems of complex spatial geometry with variant material domains from the fleld of nuclear reactor physics.The methods were compared with the standard flnite element method.The applicability and accuracy of the methods are reported and indicate that PC-GIPMNN outperforms GIPMNN and DRM.
基金The work of X.Y was partially supported by the Natural Science Foundation of Fujian Province,China(Grant No.2012J01013)The work of C.X.was partially supported by National NSF of China(Grants 11071203 and 91130002).
文摘An inverse problem of reconstructing the initial condition for a time fractional diffusion equation is investigated.On the basis of the optimal control framework,the uniqueness and first order necessary optimality condition of the minimizer for the objective functional are established,and a time-space spectral method is proposed to numerically solve the resulting minimization problem.The contribution of the paper is threefold:1)a priori error estimate for the spectral approximation is derived;2)a conjugate gradient optimization algorithm is designed to efficiently solve the inverse problem;3)some numerical experiments are carried out to show that the proposed method is capable to find out the optimal initial condition,and that the convergence rate of the method is exponential if the optimal initial condition is smooth.
基金supported by the National Natural Science Foundation of China(No.11101093)Shanghai Science and Technology Commission(Nos.11ZR1402800,11PJ1400800)
文摘Time-fractional diffusion equations are of great interest and importance on describing the power law decay for diffusion in porous media. In this paper, to identify the diffusion rate, i.e., the heterogeneity of medium, the authors consider an inverse coefficient problem utilizing finite measurements and obtain a local HSlder type conditional stability based upon two Carleman estimates for the corresponding differential equations of integer orders.
基金This work is supported by the National Natural Science Foundation of China(Nos.11371231 and 11071148).
文摘This article deals with numerical inversion for the initial distribution in the multi-term time-fractional diffusion equation using final observations.The inversion problem is of instability,but it is uniquely solvable based on the solution’s expression for the forward problem and estimation to the multivariate Mittag-Leffler function.From view point of optimality,solving the inversion problem is transformed to minimizing a cost functional,and existence of a minimum is proved by the weakly lower semi-continuity of the functional.Furthermore,the homotopy regularization algorithm is introduced based on the minimization problem to perform numerical inversions,and the inversion solutions with noisy data give good approximations to the exact initial distribution demonstrating the efficiency of the inversion algorithm.
文摘In this paper, a novel reconstruction method is presented for Near Infrared (NIR) 2-D imaging to recover optical absorption coefficients from laboratory phantom data. The main body of this work validates a new generation of highly efficient reconstruction algorithms called “Globally Convergent Method” (GCM) based upon actual measurements taken from brain-shape phantoms. It has been demonstrated in earlier studies using computer-simulated data that this type of reconstructions is stable for imaging complex distributions of optical absorption. The results in this paper demonstrate the excellent capability of GCM in working with experimental data measured from optical phantoms mimicking a rat brain with stroke.
文摘This paper focuses on the high intensity filaments (dye patches) embedded in dye plumes in a wall-bounded shear flow, to investigate the shear effect on the dye patch distribution. Motivated by the widely concerned inverse estimation of the source location, we try extracting useful information to know the source location from down-stream dye patches. Accordingly, we changed the dye injection location at different distances from the wall and made observations at different downstream (diffusion) distances from the source. The orientation angle and roundness of dye patches were concerned to examine the shear effect and dye patch characteristics. To capture the dye plume images, a planar laser induced fluorescence (PLIF) technique was used. The orientation and roundness of each dye patch were calculated by least-square fitting. The statistics of both the orientation angle and the roundness were compared with those in homogeneous turbulent cases to reveal the shear effect. Different from uniformly-orientated dye patches in the homogeneous flow, larger occurrence probabilities with positive orientation angles of dye patches are observed in wall-bounded shear flow, in particular, when the injection location is near the wall. As with information extraction for the inverse estimation of source location, it is found that the orientation distribution of dye patches is independent of the diffusion distance, but related with the injection location from the wall. While for the homogeneous flow cases, a strong dependence on the diffusion distance is observed in the orientation distribution profiles. As for the roundness, similar aspects are found regarding the dependencies on the injection location in shear flow and on diffusion distance in homogeneous flow.
基金National Natural Science Foundation of China(No.10471073)。
文摘For the backward diffusion equation,a stable discrete energy regularization algorithm is proposed.Existence and uniqueness of the numerical solution are given.Moreover,the error between the solution of the given backward diffusion equation and the numerical solution via the regularization method can be estimated.Some numerical experiments illustrate the efficiency of the method,and its application in image deblurring.