This paper presents a fully-differential CMOS dynamic comparator for use in high-speed pipelined ADCs with low stage resolution. Because the architecture is based on the coupled current sources and differential input ...This paper presents a fully-differential CMOS dynamic comparator for use in high-speed pipelined ADCs with low stage resolution. Because the architecture is based on the coupled current sources and differential input pairs, this comparator's threshold voltage can be adjusted to a desired level. Compared with traditional comparators, this one shows significant improvement in area,power,and speed. Fabricated in 0.35μm CMOS technology,it occupies only 30μm × 70μm. Simulation and measurement results indicate the comparator has a sampling frequency up to 1GHz with 2Vpp differential input signal range and only 181μW power consumption under a 3.3V supply. The speed/power ratio reaches up to 5524GS/J.展开更多
A conventional multi-channel pulse amplitude analyzer acquires single energy spectrum,but provides no information on its tendency with time.To address the limitation,we propose a scheme of time-sharing multichannel pu...A conventional multi-channel pulse amplitude analyzer acquires single energy spectrum,but provides no information on its tendency with time.To address the limitation,we propose a scheme of time-sharing multichannel pulse amplitude analyzer(TSMCA).A dual-port random access memory is divided into two storage spaces,one for current energy spectrum data acquisition and another for previous energy spectrum data storage.The two tasks can be performed simultaneously,and the time-related variation tendency of energy spectrum can be obtained.A prototype system of TSMCA is designed.It performs nicely,with maximum channel number of 4096 in capacity of 2^(32)/Ch,minimal time-sharing slice of 25 ms,the differential nonlinearity of <1.5%,and the integral nonlinearity of <0.3%.展开更多
The high-speed reciprocating motion of a detaching roller limits the velocity of a cotton comber and affects the quality of comber slivers. The article has proposed a controllable time-sharing unidirectional hybrid dr...The high-speed reciprocating motion of a detaching roller limits the velocity of a cotton comber and affects the quality of comber slivers. The article has proposed a controllable time-sharing unidirectional hybrid drive mechanism after analyzing detaching roller's current numerical control drive method. The analysis focuses on the detaching roller motion required according to cotton comber's velocity and process. The double-servo motors of the mechanism consists of differential gear trains. The mechanism addresses the problem of increased servo motor power,and failure of promptly responded to the positive inversion process of mechanism driven by servo motors. A velocity calculation model of the detaching roller controllable drive mechanism will be generated by using superposition method and design of differential gear trains. The accuracy of the model will be verified using the test platform. This study has presented a reliable and practical high-speed drive mechanism and can be a reference to future studies on high-speed reciprocating motion drive.展开更多
This paper presents an energy efficient successive-approximation register(SAR)analog-to-digital converter(ADC)for low-power applications.To improve the overall energy-efficiency,a skipping-window technique is used to ...This paper presents an energy efficient successive-approximation register(SAR)analog-to-digital converter(ADC)for low-power applications.To improve the overall energy-efficiency,a skipping-window technique is used to bypass corresponding conversion steps when the input falls in a window indicated by a time-domain comparator,which can provide not only the polarity of the input,but also the amount information of the input.The timedomain comparator,which is based on the edge pursing principle,consists of delay cells,two NAND gates,two D-flip-flop register-based phase detectors and a counter.The digital characteristic of the comparator makes the design more flexible,and the comparator can achieve noise and power optimization automatically by simply adjusting the delay cell number.An energy efficient digital-to-analog converter(DAC)control scheme suitable for the skipping window technique is also developed to reduce the switching energy during SAR conversion.Together with the skipping-window technique,the linearity and the power consumption of the SAR ADC are improved.The impact of different window sizes on comparison cycles,DAC switching energy and the overall energy efficiency is analyzed.Simulation results show that the proposed skipping-window technique can improve the overall energy-efficiency of the SAR ADC,as well as the linearity,and the optimized window size for the overall energy efficiency will vary with the DAC switching energy.展开更多
The design of a new type of latching voltage comparator ZJ03 is described.Thecommon voltage comparators consist of multistage DC amplifiers,for which it is difficult to realizehigh speed and high precision.The ZJ03 co...The design of a new type of latching voltage comparator ZJ03 is described.Thecommon voltage comparators consist of multistage DC amplifiers,for which it is difficult to realizehigh speed and high precision.The ZJ03 comparator contains a controlled positive feedbackamplifier.Therefore,it is capable of realizing high speed and high precision.For improving theperformance and producibility,the tolerance extension,design centering and potential adaptingtechniques are used in the design of comparator ZJ03.展开更多
The effects of stage numbers on power dissipation of pipeline analog-to-digital converter (ADC) are studied and a novel design method aiming for power optimization is presented. In this method, a minimum comparator ...The effects of stage numbers on power dissipation of pipeline analog-to-digital converter (ADC) are studied and a novel design method aiming for power optimization is presented. In this method, a minimum comparator number algorithm (MCNA) is first introduced, and then the optimum distribution of resolutions through pipeline ADC stages is deduced by MCNA. Based on the optimum stage-resolution distribution, an optimization method is established, which examines the precise function between ADC power and stage resolutions with a parameter of power ratio (Rp). For 10-bit pipeline ADC with scaling down technology, the simulation results by using MATLAB CAD tools show that an eight-stage topology with 1-bit RSD correction achieves the power optimization indicated by the power reduction ratio.展开更多
A novel design of multiplex differential voltage comparators(MDVC) is presented for reducing current and power dissipation. According to the special properties of relational operation and logical operation, parts of t...A novel design of multiplex differential voltage comparators(MDVC) is presented for reducing current and power dissipation. According to the special properties of relational operation and logical operation, parts of the comparators are redundant in some instances, and thus can be turned off. By selecting and switching the current routes, several effective differential pairs are biased by a single tail current stage-by-stage and the redundant comparators are turned off by cutting their tail currents. As a result, the quiescent current and power consumption are greatly decreased. The switching of current is achieved by the input differential pair transistors themselves and hence no extra switches are required. When a MDVC is used in a flash analog-to-digital converter(ADC), its current dissipation is much lower than that of the conventional comparators. This architecture can also be used in window-comparators, maximum or minimum comparators, and comparators for logical operations. The power dissipation in all these cases could be reduced significantly.展开更多
Understanding gene expression variations between species is pivotal for deciphering the evolutionary diversity in phenotypes. Rhesus macaques(Macaca mulatta, MMU)and crab-eating macaques(M. fascicularis, MFA) serve as...Understanding gene expression variations between species is pivotal for deciphering the evolutionary diversity in phenotypes. Rhesus macaques(Macaca mulatta, MMU)and crab-eating macaques(M. fascicularis, MFA) serve as crucial nonhuman primate biomedical models with different phenotypes. To date, however, large-scale comparative transcriptome research between these two species has not yet been fully explored. Here, we conducted systematic comparisons utilizing newly sequenced RNA-seq data from84 samples(41 MFA samples and 43 MMU samples)encompassing 14 common tissues. Our findings revealed a small fraction of genes(3.7%) with differential expression between the two species, as well as 36.5% of genes with tissue-specific expression in both macaques. Comparison of gene expression between macaques and humans indicated that 22.6% of orthologous genes displayed differential expression in at least two tissues. Moreover,19.41% of genes that overlapped with macaque-specific structural variants showed differential expression between humans and macaques. Of these, the FAM220A gene exhibited elevated expression in humans compared to macaques due to lineage-specific duplication. In summary,this study presents a large-scale transcriptomic comparison between MMU and MFA and between macaques and humans. The discovery of gene expression variations not only enhances the biomedical utility of macaque models but also contributes to the wider field of primate genomics.展开更多
A low-voltage, high-speed flash ADC is designed. The bottleneck of the operation speed in the low-voltage region is the delay time increase of the comparator. The temporarily boosted comparator is proposed to address ...A low-voltage, high-speed flash ADC is designed. The bottleneck of the operation speed in the low-voltage region is the delay time increase of the comparator. The temporarily boosted comparator is proposed to address this problem. The proposed circuit only boosts the supply voltage in the comparison phase, and therefore, can reduce the delay time while keeping the power overhead to a minimum. Moreover, the body bias control calibration is combined with the temporarily boosted technique. This helps to create a low-power and high-precision comparator. A 0.5-V, 6-bit flash ADC was designed by using 65-nm CMOS technology to demonstrate the effectiveness of the proposed technique. The simulation results showed a high sampling frequency of 1.2 GHz, a low power consumption of 1.4 mW, and an FOM of 28 fJ/conv.-step even at a low supply voltage of 0.5 V.展开更多
The rapid global outbreak of coronavirus disease 2019(COVID-19)and the surge of infected patients have led to the verge of exhaustion of critical care medicine resources worldwide,especially with regard to critical ca...The rapid global outbreak of coronavirus disease 2019(COVID-19)and the surge of infected patients have led to the verge of exhaustion of critical care medicine resources worldwide,especially with regard to critical care staff.A holistic care model on time-sharing management for severe and critical COVID-19 patients is proposed,which includes formulation of individualized care objectives and plans,identification of care tasks in each shift and making detailed checklist,and management of quality of care.This study was conducted in the COVID-19 treatment center of Harbin,Heilongjiang Province.The data collected from the treatment center were recorded and analyzed.From the results we can deduce that it is especially suitable for non-intensive care unit(non-ICU)nurses to adapt care management mode of ICU as soon as possible and ensure the quality and efficiency of care during the epidemic.The holistic care model on time-sharing management for severe and critical cases with COVID-19 proposed based on our daily work experiences can assist in improving the quality and efficiency of care,thus reducing the mortality rate of patients in ICU.展开更多
This paper presents a two-dimension time-domain comparator suitable for low power successive-approximation register(SAR)analog-to-digital converters(ADCs).The proposed two-dimension time-domain comparator consists of ...This paper presents a two-dimension time-domain comparator suitable for low power successive-approximation register(SAR)analog-to-digital converters(ADCs).The proposed two-dimension time-domain comparator consists of a ring oscillator collapse-based comparator and a counter.The propagation delay of a voltage controlled ring oscillator depends on the input.Thus,the comparator can automatically change the comparison time according to its input difference,which can adjust the power consumption of the comparator dynamically without any control logic.And a counter is utilized to count the cycle needed to finish a comparison when the input difference is small.Thus,the proposed comparator can not only provide the polarity of the input,but also the amount information of the input,which helps to skip most of the SAR cycles when the initial input is small.Thus,most energy can be saved when the initial input is small.The proposed time-domain comparator is designed in 0.18μm CMOS technology.Simulation results demonstrate that the comparator can not only save power consumption,but also give the design flexibility,and the current is only nA level when the supply voltage is 0.6 V.展开更多
In recent studies, reversible logic has emerged as a great scene of research, having applications in low power CMOS circuits, optical computing, quantum computing and nanotechnology. The classical logic gates such as ...In recent studies, reversible logic has emerged as a great scene of research, having applications in low power CMOS circuits, optical computing, quantum computing and nanotechnology. The classical logic gates such as AND, OR, EXOR and EXNOR are not reversible. In the existing literature, reversible sequential circuits designs are offered that are improved for the number of the garbage outputs and reversible gates. Minimizing the number of garbage is very noticeable. In the present paper, we show a design of the reversible comparator based on the quantum gates implementation of the reversible DG gate. The reversible DG gate is designed by using 3 × 3 quantum gates such as NOT, CNOT, Controlled-V and Controlled-V+ gates. Also, we have used the TR gate and various types of quantum gates in the implementation results. Low power three-bit comparator is designed using DG Gate, New Gate and Fredkin Gate. In order to evaluate the benefit of using the DG gate proposed in this paper, one-bit comparator is constructed. The design is useful for the future computing techniques like quantum computers. The proposed designs are implemented using VHDL and functionally investigated using Quartus II simulator.展开更多
BACKGROUND Among the most frequent hip fractures are trochanteric fractures,which usually occur from low-energy trauma like minor falls,especially in older people with osteoporotic bones.AIM To evaluate the treatment ...BACKGROUND Among the most frequent hip fractures are trochanteric fractures,which usually occur from low-energy trauma like minor falls,especially in older people with osteoporotic bones.AIM To evaluate the treatment efficacy of dynamic condylar screws(DCS)and proximal femoral nails(PFN)for unstable intertrochanteric fractures.METHODS To find pertinent randomized controlled trials and retrospective observational studies comparing PFN with DCS for the management of unstable femoral intertrochanteric fractures,a thorough search was carried out.For research studies published between January 1996 and April 2024,PubMed,EMBASE,Scopus,Web of Science,Cochrane Library,and Google Scholar were all searched.The complete texts of the papers were retrieved,vetted,and independently examined by two investigators.Disputes were settled by consensus,and any disagreements that persisted were arbitrated by a third author.RESULTS This study included six articles,comprising a total of 173 patients.Compared to the DCS,the PFN had a shorter operation time[mean difference(MD):-41.7 min,95%confidence interval(95%CI):-63.04 to-20.35,P=0.0001],higher success rates with closed reduction techniques[risk ratio(RR):34.05,95%CI:11.12-104.31,P<0.00001],and required less intraoperative blood transfusion(MD:-1.4 units,95%CI:-1.80 to-1.00,P<0.00001).Additionally,the PFN showed shorter fracture union time(MD:-6.92 wk,95%CI:-10.27 to-3.57,P<0.0001)and a lower incidence of reoperation(RR:0.37,95%CI:0.17-0.82,P=0.01).However,there was no discernible variation regarding hospital stay,implant-related complications,and infections.CONCLUSION Compared to DCS,PFN offers shorter operative times,reduces the blood transfusions requirements,achieves higher closed reduction success,enables faster fracture healing,and lowers reoperation incidence.展开更多
To fill the continuous needs for faster processing elements with less power consumption causes large pressure on the complementary metal oxide semiconductor(CMOS)technology developers.The scaling scenario is not an op...To fill the continuous needs for faster processing elements with less power consumption causes large pressure on the complementary metal oxide semiconductor(CMOS)technology developers.The scaling scenario is not an option nowadays and other technologies need to be investigated.The quantum-dot cellular automata(QCA)technology is one of the important emerging nanotechnologies that have attracted much researchers’attention in recent years.This technology has many interesting features,such as high speed,low power consumption,and small size.These features make it an appropriate alternative to the CMOS technique.This paper suggests three novel structures of XNOR gates in the QCA technology.The presented structures do not follow the conventional approaches to the logic gates design but depend on the inherent capabilities of the new technology.The proposed structures are used as the main building blocks for a single-bit comparator.The resulted circuits are simulated for the verification purpose and then compared with existing counterparts in the literature.The comparison results are encouraging to append the proposed structures to the library of QCA gates.展开更多
There are magnetic interference problems in the applications of DC current comparator. Analysis on the magnetic effectiveness which is applied by the external magnetic field is introduced in this paper. The effectiven...There are magnetic interference problems in the applications of DC current comparator. Analysis on the magnetic effectiveness which is applied by the external magnetic field is introduced in this paper. The effectiveness is proved by the actual results which are compared with the magnetic- circuit method and the finite element method. In addition, the reference comment is given which can be used in the practical work of DC current comparator shield design.展开更多
There is instability in the distributed energy storage cloud group end region on the power grid side.In order to avoid large-scale fluctuating charging and discharging in the power grid environment and make the capaci...There is instability in the distributed energy storage cloud group end region on the power grid side.In order to avoid large-scale fluctuating charging and discharging in the power grid environment and make the capacitor components showa continuous and stable charging and discharging state,a hierarchical time-sharing configuration algorithm of distributed energy storage cloud group end region on the power grid side based on multi-scale and multi feature convolution neural network is proposed.Firstly,a voltage stability analysis model based onmulti-scale and multi feature convolution neural network is constructed,and the multi-scale and multi feature convolution neural network is optimized based on Self-OrganizingMaps(SOM)algorithm to analyze the voltage stability of the cloud group end region of distributed energy storage on the grid side under the framework of credibility.According to the optimal scheduling objectives and network size,the distributed robust optimal configuration control model is solved under the framework of coordinated optimal scheduling at multiple time scales;Finally,the time series characteristics of regional power grid load and distributed generation are analyzed.According to the regional hierarchical time-sharing configuration model of“cloud”,“group”and“end”layer,the grid side distributed energy storage cloud group end regional hierarchical time-sharing configuration algorithm is realized.The experimental results show that after applying this algorithm,the best grid side distributed energy storage configuration scheme can be determined,and the stability of grid side distributed energy storage cloud group end region layered timesharing configuration can be improved.展开更多
Desmodus rotundus and Diphylla ecaudata, both of which are mammals of the order Chiroptera, Desmodontidae family, their diet consisting exclusively of blood. D. rotundus is the main vector and transmitter of the rabie...Desmodus rotundus and Diphylla ecaudata, both of which are mammals of the order Chiroptera, Desmodontidae family, their diet consisting exclusively of blood. D. rotundus is the main vector and transmitter of the rabies virus, which affects human beings as well as several livestock species so the study of this bat species is of high importance within the fields of animal agriculture and public health. The present study describes and compares the histologic characteristics of the urinary system of two hematophagous bat species. A total of 5 bats from each species were captured in the municipalities of Progreso de Obregón, Hidalgo (D. rotundus), and Huayacocotla, Veracruz (D. ecaudata). Organs belonging to the urinary system were extracted: kidneys, ureters, urinary bladder, and urethra;samples were fixed using 10% formalin and processed by the paraffin embedding technique, obtaining sections of 5 µm thickness, which in turn were stained using hematoxylin-eosin (H-E) and Gomori trichrome (GT) stains. From the obtained histologic preparations, a descriptive and comparative analysis of the structural organography of the urinary system of both species was made, and no noteworthy histological differences between samples were noted. The present research is intended to provide a framework for future studies of these species’ currently understudied microscopic anatomy.展开更多
Geological maps encode vast amounts of data about rock types,ages,chemistry,orogenic architecture and deep-time history or different tectonic units,yet these are often difficult to extract because of the way different...Geological maps encode vast amounts of data about rock types,ages,chemistry,orogenic architecture and deep-time history or different tectonic units,yet these are often difficult to extract because of the way different geologists portray their results at various scales.To understand orogenesis in 4D,it is essential to uniformly integrate map data,together with geophysical data and deep geochemical mapping(Wang et al.,2023).展开更多
Rice and wheat provide nearly 40%of human calorie and protein requirements.They share a common ancestor and belong to the Poaceae(grass)family.Characterizing their genetic homology is crucial for developing new cultiv...Rice and wheat provide nearly 40%of human calorie and protein requirements.They share a common ancestor and belong to the Poaceae(grass)family.Characterizing their genetic homology is crucial for developing new cultivars with enhanced traits.Several wheat genes and gene families have been characterized based on their rice orthologs.Rice–wheat orthology can identify genetic regions that regulate similar traits in both crops.Rice–wheat comparative genomics can identify candidate wheat genes in a genomic region identified by association or QTL mapping,deduce their putative functions and biochemical pathways,and develop molecular markers for marker-assisted breeding.A knowledge of gene homology facilitates the transfer between crops of genes or genomic regions associated with desirable traits by genetic engineering,gene editing,or wide crossing.展开更多
Recent research on the genome of Bifidobacterium bifidum has mainly focused on the isolation sources(intestinal tract niche)recently,but reports on the isolation region are limited.This study analyzed the differences ...Recent research on the genome of Bifidobacterium bifidum has mainly focused on the isolation sources(intestinal tract niche)recently,but reports on the isolation region are limited.This study analyzed the differences in the genome of B.bifidum isolated from different geographical populations by comparative genomic analysis.Results at the genome level indicated that the GC content of American isolates was significantly higher than that of Chinese and Russian isolates.The phylogenetic tree,based on 919 core genes showed that B.bifidum might be related to the geographical characteristics of isolation region.Furthermore,functional annotation analysis demonstrated that copy numbers of carbohydrate-active enzymes(CAZys)involved in the degradation of polysaccharide from plant and host sources in B.bifidum were high,and 18 CAZys showed significant differences across different geographical populations,indicating that B.bifidum had adapted to the human intestinal environment,especially in the groups with diets rich in fiber.Dietary habits were one of the main reasons for the differences of B.bifidum across different geographical populations.Additionally,B.bifidum exhibited high diversity,evident in glycoside hydrolases,the CRISPR-Cas system,and prophages.This study provides a genetic basis for further research and development of B.bifidum.展开更多
文摘This paper presents a fully-differential CMOS dynamic comparator for use in high-speed pipelined ADCs with low stage resolution. Because the architecture is based on the coupled current sources and differential input pairs, this comparator's threshold voltage can be adjusted to a desired level. Compared with traditional comparators, this one shows significant improvement in area,power,and speed. Fabricated in 0.35μm CMOS technology,it occupies only 30μm × 70μm. Simulation and measurement results indicate the comparator has a sampling frequency up to 1GHz with 2Vpp differential input signal range and only 181μW power consumption under a 3.3V supply. The speed/power ratio reaches up to 5524GS/J.
基金supported by the National Natural Science Foundation of China(Nos.11375195,11375263,and 11105143)the project of National Magnetic Confinement Fusion Energy Development Research(No.2013GB104003)
文摘A conventional multi-channel pulse amplitude analyzer acquires single energy spectrum,but provides no information on its tendency with time.To address the limitation,we propose a scheme of time-sharing multichannel pulse amplitude analyzer(TSMCA).A dual-port random access memory is divided into two storage spaces,one for current energy spectrum data acquisition and another for previous energy spectrum data storage.The two tasks can be performed simultaneously,and the time-related variation tendency of energy spectrum can be obtained.A prototype system of TSMCA is designed.It performs nicely,with maximum channel number of 4096 in capacity of 2^(32)/Ch,minimal time-sharing slice of 25 ms,the differential nonlinearity of <1.5%,and the integral nonlinearity of <0.3%.
基金National Basic Research Program of China(973 Program)(No.2010CB334711)the Applied Basic Research of China National Textile and Apparel Council (Textile Vision Science and Education Fund of China in 2012)
文摘The high-speed reciprocating motion of a detaching roller limits the velocity of a cotton comber and affects the quality of comber slivers. The article has proposed a controllable time-sharing unidirectional hybrid drive mechanism after analyzing detaching roller's current numerical control drive method. The analysis focuses on the detaching roller motion required according to cotton comber's velocity and process. The double-servo motors of the mechanism consists of differential gear trains. The mechanism addresses the problem of increased servo motor power,and failure of promptly responded to the positive inversion process of mechanism driven by servo motors. A velocity calculation model of the detaching roller controllable drive mechanism will be generated by using superposition method and design of differential gear trains. The accuracy of the model will be verified using the test platform. This study has presented a reliable and practical high-speed drive mechanism and can be a reference to future studies on high-speed reciprocating motion drive.
基金This work was supported partly by the National Natural Science Foundation of China under Grant No.61704015the General program of Chongqing Natural Science Foundation(a special program for the fundamental and frontier research)under Grant No.cstc2019jcyj-msxmX0108.
文摘This paper presents an energy efficient successive-approximation register(SAR)analog-to-digital converter(ADC)for low-power applications.To improve the overall energy-efficiency,a skipping-window technique is used to bypass corresponding conversion steps when the input falls in a window indicated by a time-domain comparator,which can provide not only the polarity of the input,but also the amount information of the input.The timedomain comparator,which is based on the edge pursing principle,consists of delay cells,two NAND gates,two D-flip-flop register-based phase detectors and a counter.The digital characteristic of the comparator makes the design more flexible,and the comparator can achieve noise and power optimization automatically by simply adjusting the delay cell number.An energy efficient digital-to-analog converter(DAC)control scheme suitable for the skipping window technique is also developed to reduce the switching energy during SAR conversion.Together with the skipping-window technique,the linearity and the power consumption of the SAR ADC are improved.The impact of different window sizes on comparison cycles,DAC switching energy and the overall energy efficiency is analyzed.Simulation results show that the proposed skipping-window technique can improve the overall energy-efficiency of the SAR ADC,as well as the linearity,and the optimized window size for the overall energy efficiency will vary with the DAC switching energy.
文摘The design of a new type of latching voltage comparator ZJ03 is described.Thecommon voltage comparators consist of multistage DC amplifiers,for which it is difficult to realizehigh speed and high precision.The ZJ03 comparator contains a controlled positive feedbackamplifier.Therefore,it is capable of realizing high speed and high precision.For improving theperformance and producibility,the tolerance extension,design centering and potential adaptingtechniques are used in the design of comparator ZJ03.
基金Supported by the National Natural Science Foundation of China (No. 60072004)
文摘The effects of stage numbers on power dissipation of pipeline analog-to-digital converter (ADC) are studied and a novel design method aiming for power optimization is presented. In this method, a minimum comparator number algorithm (MCNA) is first introduced, and then the optimum distribution of resolutions through pipeline ADC stages is deduced by MCNA. Based on the optimum stage-resolution distribution, an optimization method is established, which examines the precise function between ADC power and stage resolutions with a parameter of power ratio (Rp). For 10-bit pipeline ADC with scaling down technology, the simulation results by using MATLAB CAD tools show that an eight-stage topology with 1-bit RSD correction achieves the power optimization indicated by the power reduction ratio.
基金National Natural Science Foundation of China(60172004)PhD Subject Research Foundation of Ministry of Education of China(20010701003)
文摘A novel design of multiplex differential voltage comparators(MDVC) is presented for reducing current and power dissipation. According to the special properties of relational operation and logical operation, parts of the comparators are redundant in some instances, and thus can be turned off. By selecting and switching the current routes, several effective differential pairs are biased by a single tail current stage-by-stage and the redundant comparators are turned off by cutting their tail currents. As a result, the quiescent current and power consumption are greatly decreased. The switching of current is achieved by the input differential pair transistors themselves and hence no extra switches are required. When a MDVC is used in a flash analog-to-digital converter(ADC), its current dissipation is much lower than that of the conventional comparators. This architecture can also be used in window-comparators, maximum or minimum comparators, and comparators for logical operations. The power dissipation in all these cases could be reduced significantly.
基金supported by the National Natural Science Foundation of China (82021001 and 31825018 to Q.S., 32370658 to Y.M.,82001372 to X.Y.)National Key Research and Development Program of China (2022YFF0710901)+2 种基金National Science and Technology Innovation2030 Major Program (2021ZD0200900) to Q.S.Shanghai Pujiang Program (22PJ1407300)Shanghai Jiao Tong University 2030 Initiative (WH510363001-7) to Y.M。
文摘Understanding gene expression variations between species is pivotal for deciphering the evolutionary diversity in phenotypes. Rhesus macaques(Macaca mulatta, MMU)and crab-eating macaques(M. fascicularis, MFA) serve as crucial nonhuman primate biomedical models with different phenotypes. To date, however, large-scale comparative transcriptome research between these two species has not yet been fully explored. Here, we conducted systematic comparisons utilizing newly sequenced RNA-seq data from84 samples(41 MFA samples and 43 MMU samples)encompassing 14 common tissues. Our findings revealed a small fraction of genes(3.7%) with differential expression between the two species, as well as 36.5% of genes with tissue-specific expression in both macaques. Comparison of gene expression between macaques and humans indicated that 22.6% of orthologous genes displayed differential expression in at least two tissues. Moreover,19.41% of genes that overlapped with macaque-specific structural variants showed differential expression between humans and macaques. Of these, the FAM220A gene exhibited elevated expression in humans compared to macaques due to lineage-specific duplication. In summary,this study presents a large-scale transcriptomic comparison between MMU and MFA and between macaques and humans. The discovery of gene expression variations not only enhances the biomedical utility of macaque models but also contributes to the wider field of primate genomics.
文摘A low-voltage, high-speed flash ADC is designed. The bottleneck of the operation speed in the low-voltage region is the delay time increase of the comparator. The temporarily boosted comparator is proposed to address this problem. The proposed circuit only boosts the supply voltage in the comparison phase, and therefore, can reduce the delay time while keeping the power overhead to a minimum. Moreover, the body bias control calibration is combined with the temporarily boosted technique. This helps to create a low-power and high-precision comparator. A 0.5-V, 6-bit flash ADC was designed by using 65-nm CMOS technology to demonstrate the effectiveness of the proposed technique. The simulation results showed a high sampling frequency of 1.2 GHz, a low power consumption of 1.4 mW, and an FOM of 28 fJ/conv.-step even at a low supply voltage of 0.5 V.
基金Supported by The National Natural Science Foundation of China,No.81770276and Nn10 Program of Harbin Medical University Cancer Hospital and Scientific Research Project of Heilongjiang Health and Family Planning Commission,No.2018086.
文摘The rapid global outbreak of coronavirus disease 2019(COVID-19)and the surge of infected patients have led to the verge of exhaustion of critical care medicine resources worldwide,especially with regard to critical care staff.A holistic care model on time-sharing management for severe and critical COVID-19 patients is proposed,which includes formulation of individualized care objectives and plans,identification of care tasks in each shift and making detailed checklist,and management of quality of care.This study was conducted in the COVID-19 treatment center of Harbin,Heilongjiang Province.The data collected from the treatment center were recorded and analyzed.From the results we can deduce that it is especially suitable for non-intensive care unit(non-ICU)nurses to adapt care management mode of ICU as soon as possible and ensure the quality and efficiency of care during the epidemic.The holistic care model on time-sharing management for severe and critical cases with COVID-19 proposed based on our daily work experiences can assist in improving the quality and efficiency of care,thus reducing the mortality rate of patients in ICU.
基金This work was supported partly by the National Natural Science Foundation of China under grant No.61704015the General program of Chongqing Natural Science Foundation(a special program for the fundamental and frontier research)under grant No.cstc2019jcyj-msxmX0108.
文摘This paper presents a two-dimension time-domain comparator suitable for low power successive-approximation register(SAR)analog-to-digital converters(ADCs).The proposed two-dimension time-domain comparator consists of a ring oscillator collapse-based comparator and a counter.The propagation delay of a voltage controlled ring oscillator depends on the input.Thus,the comparator can automatically change the comparison time according to its input difference,which can adjust the power consumption of the comparator dynamically without any control logic.And a counter is utilized to count the cycle needed to finish a comparison when the input difference is small.Thus,the proposed comparator can not only provide the polarity of the input,but also the amount information of the input,which helps to skip most of the SAR cycles when the initial input is small.Thus,most energy can be saved when the initial input is small.The proposed time-domain comparator is designed in 0.18μm CMOS technology.Simulation results demonstrate that the comparator can not only save power consumption,but also give the design flexibility,and the current is only nA level when the supply voltage is 0.6 V.
文摘In recent studies, reversible logic has emerged as a great scene of research, having applications in low power CMOS circuits, optical computing, quantum computing and nanotechnology. The classical logic gates such as AND, OR, EXOR and EXNOR are not reversible. In the existing literature, reversible sequential circuits designs are offered that are improved for the number of the garbage outputs and reversible gates. Minimizing the number of garbage is very noticeable. In the present paper, we show a design of the reversible comparator based on the quantum gates implementation of the reversible DG gate. The reversible DG gate is designed by using 3 × 3 quantum gates such as NOT, CNOT, Controlled-V and Controlled-V+ gates. Also, we have used the TR gate and various types of quantum gates in the implementation results. Low power three-bit comparator is designed using DG Gate, New Gate and Fredkin Gate. In order to evaluate the benefit of using the DG gate proposed in this paper, one-bit comparator is constructed. The design is useful for the future computing techniques like quantum computers. The proposed designs are implemented using VHDL and functionally investigated using Quartus II simulator.
文摘BACKGROUND Among the most frequent hip fractures are trochanteric fractures,which usually occur from low-energy trauma like minor falls,especially in older people with osteoporotic bones.AIM To evaluate the treatment efficacy of dynamic condylar screws(DCS)and proximal femoral nails(PFN)for unstable intertrochanteric fractures.METHODS To find pertinent randomized controlled trials and retrospective observational studies comparing PFN with DCS for the management of unstable femoral intertrochanteric fractures,a thorough search was carried out.For research studies published between January 1996 and April 2024,PubMed,EMBASE,Scopus,Web of Science,Cochrane Library,and Google Scholar were all searched.The complete texts of the papers were retrieved,vetted,and independently examined by two investigators.Disputes were settled by consensus,and any disagreements that persisted were arbitrated by a third author.RESULTS This study included six articles,comprising a total of 173 patients.Compared to the DCS,the PFN had a shorter operation time[mean difference(MD):-41.7 min,95%confidence interval(95%CI):-63.04 to-20.35,P=0.0001],higher success rates with closed reduction techniques[risk ratio(RR):34.05,95%CI:11.12-104.31,P<0.00001],and required less intraoperative blood transfusion(MD:-1.4 units,95%CI:-1.80 to-1.00,P<0.00001).Additionally,the PFN showed shorter fracture union time(MD:-6.92 wk,95%CI:-10.27 to-3.57,P<0.0001)and a lower incidence of reoperation(RR:0.37,95%CI:0.17-0.82,P=0.01).However,there was no discernible variation regarding hospital stay,implant-related complications,and infections.CONCLUSION Compared to DCS,PFN offers shorter operative times,reduces the blood transfusions requirements,achieves higher closed reduction success,enables faster fracture healing,and lowers reoperation incidence.
文摘To fill the continuous needs for faster processing elements with less power consumption causes large pressure on the complementary metal oxide semiconductor(CMOS)technology developers.The scaling scenario is not an option nowadays and other technologies need to be investigated.The quantum-dot cellular automata(QCA)technology is one of the important emerging nanotechnologies that have attracted much researchers’attention in recent years.This technology has many interesting features,such as high speed,low power consumption,and small size.These features make it an appropriate alternative to the CMOS technique.This paper suggests three novel structures of XNOR gates in the QCA technology.The presented structures do not follow the conventional approaches to the logic gates design but depend on the inherent capabilities of the new technology.The proposed structures are used as the main building blocks for a single-bit comparator.The resulted circuits are simulated for the verification purpose and then compared with existing counterparts in the literature.The comparison results are encouraging to append the proposed structures to the library of QCA gates.
文摘There are magnetic interference problems in the applications of DC current comparator. Analysis on the magnetic effectiveness which is applied by the external magnetic field is introduced in this paper. The effectiveness is proved by the actual results which are compared with the magnetic- circuit method and the finite element method. In addition, the reference comment is given which can be used in the practical work of DC current comparator shield design.
基金supported by State Grid Corporation Limited Science and Technology Project Funding(Contract No.SGCQSQ00YJJS2200380).
文摘There is instability in the distributed energy storage cloud group end region on the power grid side.In order to avoid large-scale fluctuating charging and discharging in the power grid environment and make the capacitor components showa continuous and stable charging and discharging state,a hierarchical time-sharing configuration algorithm of distributed energy storage cloud group end region on the power grid side based on multi-scale and multi feature convolution neural network is proposed.Firstly,a voltage stability analysis model based onmulti-scale and multi feature convolution neural network is constructed,and the multi-scale and multi feature convolution neural network is optimized based on Self-OrganizingMaps(SOM)algorithm to analyze the voltage stability of the cloud group end region of distributed energy storage on the grid side under the framework of credibility.According to the optimal scheduling objectives and network size,the distributed robust optimal configuration control model is solved under the framework of coordinated optimal scheduling at multiple time scales;Finally,the time series characteristics of regional power grid load and distributed generation are analyzed.According to the regional hierarchical time-sharing configuration model of“cloud”,“group”and“end”layer,the grid side distributed energy storage cloud group end regional hierarchical time-sharing configuration algorithm is realized.The experimental results show that after applying this algorithm,the best grid side distributed energy storage configuration scheme can be determined,and the stability of grid side distributed energy storage cloud group end region layered timesharing configuration can be improved.
文摘Desmodus rotundus and Diphylla ecaudata, both of which are mammals of the order Chiroptera, Desmodontidae family, their diet consisting exclusively of blood. D. rotundus is the main vector and transmitter of the rabies virus, which affects human beings as well as several livestock species so the study of this bat species is of high importance within the fields of animal agriculture and public health. The present study describes and compares the histologic characteristics of the urinary system of two hematophagous bat species. A total of 5 bats from each species were captured in the municipalities of Progreso de Obregón, Hidalgo (D. rotundus), and Huayacocotla, Veracruz (D. ecaudata). Organs belonging to the urinary system were extracted: kidneys, ureters, urinary bladder, and urethra;samples were fixed using 10% formalin and processed by the paraffin embedding technique, obtaining sections of 5 µm thickness, which in turn were stained using hematoxylin-eosin (H-E) and Gomori trichrome (GT) stains. From the obtained histologic preparations, a descriptive and comparative analysis of the structural organography of the urinary system of both species was made, and no noteworthy histological differences between samples were noted. The present research is intended to provide a framework for future studies of these species’ currently understudied microscopic anatomy.
基金supported by the National Natural Science Foundation of China(Grant Nos.41888101,41890834,91755213)the Most Special Fund(MSFGPMR02-3)from the State Key Laboratory of Geological Processes and Mineral Resources,China University of Geosciences,Wuhana contribution to the IUGS International Lithosphere Program(2023-TF1)“Formation,Character,History and Behavior of Earth’s Oldest Lithospheres”。
文摘Geological maps encode vast amounts of data about rock types,ages,chemistry,orogenic architecture and deep-time history or different tectonic units,yet these are often difficult to extract because of the way different geologists portray their results at various scales.To understand orogenesis in 4D,it is essential to uniformly integrate map data,together with geophysical data and deep geochemical mapping(Wang et al.,2023).
文摘Rice and wheat provide nearly 40%of human calorie and protein requirements.They share a common ancestor and belong to the Poaceae(grass)family.Characterizing their genetic homology is crucial for developing new cultivars with enhanced traits.Several wheat genes and gene families have been characterized based on their rice orthologs.Rice–wheat orthology can identify genetic regions that regulate similar traits in both crops.Rice–wheat comparative genomics can identify candidate wheat genes in a genomic region identified by association or QTL mapping,deduce their putative functions and biochemical pathways,and develop molecular markers for marker-assisted breeding.A knowledge of gene homology facilitates the transfer between crops of genes or genomic regions associated with desirable traits by genetic engineering,gene editing,or wide crossing.
基金the National Key R&D Program of China(2022YFD21007002)the National Natural Science Foundation of China(32325040)+1 种基金Inner Mongolia Science&Technology planning project(2022YFSJ0017)the earmarked fund for CARS36.
文摘Recent research on the genome of Bifidobacterium bifidum has mainly focused on the isolation sources(intestinal tract niche)recently,but reports on the isolation region are limited.This study analyzed the differences in the genome of B.bifidum isolated from different geographical populations by comparative genomic analysis.Results at the genome level indicated that the GC content of American isolates was significantly higher than that of Chinese and Russian isolates.The phylogenetic tree,based on 919 core genes showed that B.bifidum might be related to the geographical characteristics of isolation region.Furthermore,functional annotation analysis demonstrated that copy numbers of carbohydrate-active enzymes(CAZys)involved in the degradation of polysaccharide from plant and host sources in B.bifidum were high,and 18 CAZys showed significant differences across different geographical populations,indicating that B.bifidum had adapted to the human intestinal environment,especially in the groups with diets rich in fiber.Dietary habits were one of the main reasons for the differences of B.bifidum across different geographical populations.Additionally,B.bifidum exhibited high diversity,evident in glycoside hydrolases,the CRISPR-Cas system,and prophages.This study provides a genetic basis for further research and development of B.bifidum.