Currently,due to improvements in living standards,people are paying more attention to all-around disease prevention and health care.Self-powered implantable“tissue batteries”integrated with electrochemical materials...Currently,due to improvements in living standards,people are paying more attention to all-around disease prevention and health care.Self-powered implantable“tissue batteries”integrated with electrochemical materials are essential for disease prevention,diagnosis,treatment,postoperative therapy,and healthcare applications.We propose and define new concepts of“tissue batteries”-self-powered tissue batteries(SPTBs)-are flexible self-powered implantable systems or platforms based on electroactive biomaterials,acting at the interface of biological tissue.Based on the electrical phenomenon of living organisms in life activities,there has been an increased attention to SPTBs for tissue repair promotion.SPTBs take advantages of both the preeminent biocompatibility of biomaterials and the promotion of time-honored electrical stimulation therapy for tissue recovery,which are very promising for human illness treatment.However,studies on clinical applications of SPTBs are impeded by a lack of comprehensive cognitive assessment of SPTBs.Herein,SPTBs for life and health applications are comprehensively reviewed.First,electrochemical materials and their across-the-board applications for several types of SPTBs are introduced and compared with regard to disease prevention,diagnosis,precision therapy,and personalized health monitoring.Then,the potential mechanisms for SPTBs for tissue repair promotion are discussed.Finally,the prospective challenges are summarized and recommendations for future research are provided.This review elucidates on the significance and versatility of SPTBs for various medical applications.展开更多
This study presents the development and evaluation of a poly(3-hydroxybutyrate-co-4-hydroxybutyrate)(P34HB)ultrafine fiber slow-release system for in vivo osteogenic induction of human umbilical cord mesenchymal stem ...This study presents the development and evaluation of a poly(3-hydroxybutyrate-co-4-hydroxybutyrate)(P34HB)ultrafine fiber slow-release system for in vivo osteogenic induction of human umbilical cord mesenchymal stem cells(HUCMSCs).Utilizing dual-nozzle and cell electrospinning techniques,the system encapsulates L-ascorbic acid-2-phosphate magnesium(AsP),βB-glycerophosphate sodium and dexamethasone(DEX)within the'fbers,ensuring sustained osteogenic differentiation.The scaffold's morphology,characterization,hydrophilicity,mechanical properties and cellular behavior were examined.Immediate subcutaneous implantation in rabbits was con-ducted to observe its ectopic osteogenic induction effect.Successfully fabricated P34HB ultrafine fiber slow-release sys-tem.Charact ization med.theuniform distribution of HUCMSCs and inducing components within the scaffold,with no chemical reactions affecting the active components.In vitro tests showcased a prolonged release of DEX and ASP,while biocompatibility assays highlighted the scaffold's suitability for cellular growth.Alizarin Red,type I collagen,and osteopontin(OPN)staining verifed the scaffold's potent osteogenic induction effect on HUCMsCs.Notably,immediate implantation into New Zealand White rabbits led to significant new bone formation within 8 weeks.These findings underscore the system's potential for immediate in vivo implantation without prior in vitro induction,marking a promising advancement in bone tissue engineering.展开更多
基金the National Natural Science Foundation of China(Nos.22278257 and 21804084)the Key R&D Program of Shaanxi Province(No.2022GY-272)+2 种基金the Scientific Research Program Funded by Shaanxi Provincial Education Department(No.22JY013)the Chinese Postdoctoral Science Foundation(No.2021M692000)Young Talent Support Program Project of Shaanxi University Science and Technology Association(No.20200424)for the funding the research.
文摘Currently,due to improvements in living standards,people are paying more attention to all-around disease prevention and health care.Self-powered implantable“tissue batteries”integrated with electrochemical materials are essential for disease prevention,diagnosis,treatment,postoperative therapy,and healthcare applications.We propose and define new concepts of“tissue batteries”-self-powered tissue batteries(SPTBs)-are flexible self-powered implantable systems or platforms based on electroactive biomaterials,acting at the interface of biological tissue.Based on the electrical phenomenon of living organisms in life activities,there has been an increased attention to SPTBs for tissue repair promotion.SPTBs take advantages of both the preeminent biocompatibility of biomaterials and the promotion of time-honored electrical stimulation therapy for tissue recovery,which are very promising for human illness treatment.However,studies on clinical applications of SPTBs are impeded by a lack of comprehensive cognitive assessment of SPTBs.Herein,SPTBs for life and health applications are comprehensively reviewed.First,electrochemical materials and their across-the-board applications for several types of SPTBs are introduced and compared with regard to disease prevention,diagnosis,precision therapy,and personalized health monitoring.Then,the potential mechanisms for SPTBs for tissue repair promotion are discussed.Finally,the prospective challenges are summarized and recommendations for future research are provided.This review elucidates on the significance and versatility of SPTBs for various medical applications.
基金supported by National Natural Science Foundation of China[81960416(C.Y.)and 82260428(L.Y.)]Department of Science and Technology of Guizhou Province[2020]6013-2(C.Y.)+1 种基金Doctor start-up Fund of Affiliated Hospital of Guizhou Medical University[gyfybsky-2022-13(L.Y.)]Excellent Reserve talents Fund of Affiliated Hospital of Guizhou Medical University[gyfyxkrc-2023-11(L.Y.)].
文摘This study presents the development and evaluation of a poly(3-hydroxybutyrate-co-4-hydroxybutyrate)(P34HB)ultrafine fiber slow-release system for in vivo osteogenic induction of human umbilical cord mesenchymal stem cells(HUCMSCs).Utilizing dual-nozzle and cell electrospinning techniques,the system encapsulates L-ascorbic acid-2-phosphate magnesium(AsP),βB-glycerophosphate sodium and dexamethasone(DEX)within the'fbers,ensuring sustained osteogenic differentiation.The scaffold's morphology,characterization,hydrophilicity,mechanical properties and cellular behavior were examined.Immediate subcutaneous implantation in rabbits was con-ducted to observe its ectopic osteogenic induction effect.Successfully fabricated P34HB ultrafine fiber slow-release sys-tem.Charact ization med.theuniform distribution of HUCMSCs and inducing components within the scaffold,with no chemical reactions affecting the active components.In vitro tests showcased a prolonged release of DEX and ASP,while biocompatibility assays highlighted the scaffold's suitability for cellular growth.Alizarin Red,type I collagen,and osteopontin(OPN)staining verifed the scaffold's potent osteogenic induction effect on HUCMsCs.Notably,immediate implantation into New Zealand White rabbits led to significant new bone formation within 8 weeks.These findings underscore the system's potential for immediate in vivo implantation without prior in vitro induction,marking a promising advancement in bone tissue engineering.
