We apply diferent polarization imaging techniques for cancerous liver tissues,and compare the relative contrasts for difference polarization imaging(DPI),degree of polarization imaging(DOPI)and rotating linear polariz...We apply diferent polarization imaging techniques for cancerous liver tissues,and compare the relative contrasts for difference polarization imaging(DPI),degree of polarization imaging(DOPI)and rotating linear polarization imaging(RLPI).Experimental results show that a number of polarization imaging parameters are capable of differentiating cancerous cells in isotropic liver tisues.To analyze the contrast mechanism of the cancer:-sensitive polarization imaging parameters,we propose a scattering model cont aining two types of spherical scatterers and carry on Monte Carlo simula tions based on this bi-component model.Both the experimental and Monte Carlo simulated results show that the RLPI technique can provide a good imaging contrast of cancerous tissues.The bi-component scattering model provides a useful tool to ana-lyze the contrast mechanism of polarization imaging of cancerous tissues.展开更多
We developed a model to describe polarized photon scattering in biological tissues.In this model,tissues are simplified to a mixture of scatterers and surrounding mpdium.There are t wo types ofscatterers in the model:...We developed a model to describe polarized photon scattering in biological tissues.In this model,tissues are simplified to a mixture of scatterers and surrounding mpdium.There are t wo types ofscatterers in the model:solid spheres and infinitely long solid cylinders.Variables related to thescatterers include:the densities and sizes of the spheres and cylinders,the orientation and angulardistribution of cylinders.Variables related to the surrounding medium include:the refractiveindex,absorption coeficient and birefringence.In this paper,as a development we introduce anoptical activity effct to the model.By comparing experiments and Monte Carlo simulations,we analyze the backscater ing Mueller matrix patterms of several tissue-like media,and summarizethe different effects coming from anisotropic scattering and optical properties.In addition,wepropose a possible method to extract the optical activity values for tissues.Both the experimentaland simulated results show that,by analyzing the Mueller matrix patterns,the microstructureand optical properties of the medium can be obtained.The characteristic features of Muellermatrix patterns are potentilly powerful tools for studying the contrast mechanisms of polari-zation imaging for medical diagnosis.展开更多
基金supported by the National Natural Science Foundation of China(NSFC)Grants No.10974114,11174178,41106034Open Fund of Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes,Jinan University.
文摘We apply diferent polarization imaging techniques for cancerous liver tissues,and compare the relative contrasts for difference polarization imaging(DPI),degree of polarization imaging(DOPI)and rotating linear polarization imaging(RLPI).Experimental results show that a number of polarization imaging parameters are capable of differentiating cancerous cells in isotropic liver tisues.To analyze the contrast mechanism of the cancer:-sensitive polarization imaging parameters,we propose a scattering model cont aining two types of spherical scatterers and carry on Monte Carlo simula tions based on this bi-component model.Both the experimental and Monte Carlo simulated results show that the RLPI technique can provide a good imaging contrast of cancerous tissues.The bi-component scattering model provides a useful tool to ana-lyze the contrast mechanism of polarization imaging of cancerous tissues.
基金supported by National Natural Science China(NSFC)Foundation of Grants No.10974114,11174178,41106034Open Fund of Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes,Jinan University.
文摘We developed a model to describe polarized photon scattering in biological tissues.In this model,tissues are simplified to a mixture of scatterers and surrounding mpdium.There are t wo types ofscatterers in the model:solid spheres and infinitely long solid cylinders.Variables related to thescatterers include:the densities and sizes of the spheres and cylinders,the orientation and angulardistribution of cylinders.Variables related to the surrounding medium include:the refractiveindex,absorption coeficient and birefringence.In this paper,as a development we introduce anoptical activity effct to the model.By comparing experiments and Monte Carlo simulations,we analyze the backscater ing Mueller matrix patterms of several tissue-like media,and summarizethe different effects coming from anisotropic scattering and optical properties.In addition,wepropose a possible method to extract the optical activity values for tissues.Both the experimentaland simulated results show that,by analyzing the Mueller matrix patterns,the microstructureand optical properties of the medium can be obtained.The characteristic features of Muellermatrix patterns are potentilly powerful tools for studying the contrast mechanisms of polari-zation imaging for medical diagnosis.
