Reported herein is an example of highly regio-, diastereo-and enantioselective Cu（I）-catalyzed intermolecular [3＋2] cycloaddition reaction of a-substituted iminoesters with α-trifluoromethyl α,β-unsaturated este...Reported herein is an example of highly regio-, diastereo-and enantioselective Cu（I）-catalyzed intermolecular [3＋2] cycloaddition reaction of a-substituted iminoesters with α-trifluoromethyl α,β-unsaturated esters. This novel strategy provided a facile access to pyrrolidines with two skipped （aza）quaternary stereocenters including a CF3 all-carbon quaternary stereocenter. A broad substrate scope was observed and high yields （up to 94%） with excellent diastereoselectivity （up to 〉20 ： 1 d.r.） and enantioselectivity （up to 98% ee） were obtained.展开更多
文摘Reported herein is an example of highly regio-, diastereo-and enantioselective Cu（I）-catalyzed intermolecular [3＋2] cycloaddition reaction of a-substituted iminoesters with α-trifluoromethyl α,β-unsaturated esters. This novel strategy provided a facile access to pyrrolidines with two skipped （aza）quaternary stereocenters including a CF3 all-carbon quaternary stereocenter. A broad substrate scope was observed and high yields （up to 94%） with excellent diastereoselectivity （up to 〉20 ： 1 d.r.） and enantioselectivity （up to 98% ee） were obtained.
