Shanxi Tongzhi,written during the reign of Emperor Guangxu in the Qing Dynasty,is a typical example of the printed version of ancient Chinese books.Through the textual research of relevant cultural and historical mate...Shanxi Tongzhi,written during the reign of Emperor Guangxu in the Qing Dynasty,is a typical example of the printed version of ancient Chinese books.Through the textual research of relevant cultural and historical materials,combined with the research on the publishing background and the formal binding system,this paper shows that“Shanxi Tongzhi”during Qing Guangxu has four editions since the original edition was compiled and published in 1892.With development and changes,its content has been continuously deepened and expanded.The version inherits the ancient system and extensive collection,the printing form is rigorous,and the binding is simple and exquisite,which has essential historical research value.At the same time,the traditional and straightforward Chinese-style aesthetics of the ancient printed version of“Shanxi Tongzhi”published during Qing Guangxu has a very high reference value for the exploration and development of the new connotation of the modern book form.展开更多
Zhiyi Tongzhi Recipe(治疫通治方) in Traditional Chinese Medicine plays an important role in the history of anti-epidemic. When an epidemic is widespread, formulating accurate prescriptions will play a key role in cont...Zhiyi Tongzhi Recipe(治疫通治方) in Traditional Chinese Medicine plays an important role in the history of anti-epidemic. When an epidemic is widespread, formulating accurate prescriptions will play a key role in controlling the spread of the epidemic, improving clinical symptoms, preventing the spread of the disease, and promoting prognosis and recovery. This paper performed an objective analysis of the historical role played by Zhiyi Tongzhi Recipe in the history of infectious diseases in China, and summed up the experience and lessons of the application of Zhiyi Tongzhi Recipe. Meanwhile, this paper conducted a theoretical discussion on how to ensure the efficacy of Zhiyi Tongzhi Recipe, with a view to provide useful enlightenment for the better application of Zhiyi Tongzhi Recipe to fight against epidemics in the future.展开更多
目的观察痰瘀同治方对心肌缺血再灌注损伤(MI/RI)大鼠核因子(NF)-κB通路及心肌自噬、凋亡的影响,探讨该方抗MI/RI作用机制。方法 40只SD大鼠随机分为假手术组、模型组、吡咯烷二硫代甲酸铵(PDTC)干预组及痰瘀同治组。可逆性冠脉左前降...目的观察痰瘀同治方对心肌缺血再灌注损伤(MI/RI)大鼠核因子(NF)-κB通路及心肌自噬、凋亡的影响,探讨该方抗MI/RI作用机制。方法 40只SD大鼠随机分为假手术组、模型组、吡咯烷二硫代甲酸铵(PDTC)干预组及痰瘀同治组。可逆性冠脉左前降支结扎缺血30 min、再灌注2 h复制MI/RI模型。造模前,痰瘀同治组每日予痰瘀同治方水煎液灌胃,其他各组给予生理盐水灌胃,连续3周。RT-PCR检测各组大鼠心肌NF-κB、自噬基因Beclin-1表达,Western blot检测心肌促凋亡蛋白Bax和抗凋亡蛋白Bcl-2表达。结果与假手术组比较,模型组大鼠心肌NF-κB、Beclin-1 m RNA及Bax蛋白表达均显著增强,且Bcl-2蛋白降低(均P<0.01);与模型组比较,痰瘀同治组能抑制再灌注后NF-κB、Beclin-1 m RNA及Bax蛋白高表达(均P<0.01),且作用与PDTC干预组相当(P>0.05),痰瘀同治组能显著上调心肌Bcl-2表达,且作用优于PDTC干预组(P<0.01)。结论痰瘀同治方通过抑制NF-κB活化,改善心肌细胞凋亡,抑制自噬而达到保护心肌的作用。展开更多
文摘Shanxi Tongzhi,written during the reign of Emperor Guangxu in the Qing Dynasty,is a typical example of the printed version of ancient Chinese books.Through the textual research of relevant cultural and historical materials,combined with the research on the publishing background and the formal binding system,this paper shows that“Shanxi Tongzhi”during Qing Guangxu has four editions since the original edition was compiled and published in 1892.With development and changes,its content has been continuously deepened and expanded.The version inherits the ancient system and extensive collection,the printing form is rigorous,and the binding is simple and exquisite,which has essential historical research value.At the same time,the traditional and straightforward Chinese-style aesthetics of the ancient printed version of“Shanxi Tongzhi”published during Qing Guangxu has a very high reference value for the exploration and development of the new connotation of the modern book form.
基金Research Project of Independent Topic Selection of Fundamental Scientific Research Business Expenses of China Academy of Chinese Medical Sciences (YZ-202001):Cognitive Research on Chinese Medicine Theory of COVID-19。
文摘Zhiyi Tongzhi Recipe(治疫通治方) in Traditional Chinese Medicine plays an important role in the history of anti-epidemic. When an epidemic is widespread, formulating accurate prescriptions will play a key role in controlling the spread of the epidemic, improving clinical symptoms, preventing the spread of the disease, and promoting prognosis and recovery. This paper performed an objective analysis of the historical role played by Zhiyi Tongzhi Recipe in the history of infectious diseases in China, and summed up the experience and lessons of the application of Zhiyi Tongzhi Recipe. Meanwhile, this paper conducted a theoretical discussion on how to ensure the efficacy of Zhiyi Tongzhi Recipe, with a view to provide useful enlightenment for the better application of Zhiyi Tongzhi Recipe to fight against epidemics in the future.
文摘目的观察痰瘀同治方对心肌缺血再灌注损伤(MI/RI)大鼠核因子(NF)-κB通路及心肌自噬、凋亡的影响,探讨该方抗MI/RI作用机制。方法 40只SD大鼠随机分为假手术组、模型组、吡咯烷二硫代甲酸铵(PDTC)干预组及痰瘀同治组。可逆性冠脉左前降支结扎缺血30 min、再灌注2 h复制MI/RI模型。造模前,痰瘀同治组每日予痰瘀同治方水煎液灌胃,其他各组给予生理盐水灌胃,连续3周。RT-PCR检测各组大鼠心肌NF-κB、自噬基因Beclin-1表达,Western blot检测心肌促凋亡蛋白Bax和抗凋亡蛋白Bcl-2表达。结果与假手术组比较,模型组大鼠心肌NF-κB、Beclin-1 m RNA及Bax蛋白表达均显著增强,且Bcl-2蛋白降低(均P<0.01);与模型组比较,痰瘀同治组能抑制再灌注后NF-κB、Beclin-1 m RNA及Bax蛋白高表达(均P<0.01),且作用与PDTC干预组相当(P>0.05),痰瘀同治组能显著上调心肌Bcl-2表达,且作用优于PDTC干预组(P<0.01)。结论痰瘀同治方通过抑制NF-κB活化,改善心肌细胞凋亡,抑制自噬而达到保护心肌的作用。
