Osteonecrosis of the femoral head is a common disability disease of the hip joint in China,and osteonecrosis of the femoral head caused by hormone factors is the most common,which is related to the gradual increase in...Osteonecrosis of the femoral head is a common disability disease of the hip joint in China,and osteonecrosis of the femoral head caused by hormone factors is the most common,which is related to the gradual increase in the utilization rate of glucocorticoids in recent years.It is a refractory disease in orthopaedics with a poor prognosis.For this disease,the treatment of traditional Chinese medicine has certain advantages.In view of this,the author reads,analyzes and summarizes its materials by searching China Journal full-text Database and Wanfang Database.This paper reviews the mechanism and clinical research progress of tonifying kidney and activating blood circulation in the prevention and treatment of steroid-induced osteonecrosis of the femoral head,hoping to provide help for the clinical treatment of hormone-related osteonecrosis of the femoral head.展开更多
Objective: To explore the mechanism of treating endometriosis by tonifying Kidney and removing blood stasis with Neiyixiao recipe, ( , NYXR).Methods: One hundred and three patients of endometriosis were divided rando...Objective: To explore the mechanism of treating endometriosis by tonifying Kidney and removing blood stasis with Neiyixiao recipe, ( , NYXR).Methods: One hundred and three patients of endometriosis were divided randomly into the NYXR group (58 cases, treated with NYXR) and the control group (45 cases, treaed with danazol) and were reviewed for the improvement of clinical symptoms, serum level of FSH, LH, PRL, E2, P and T, humoral and cellular immunity (C3, C4, CD3, CD4, CD8), and plasma prostaglandin after treatment.Results: There was no significant difference in effect between the NYXR group and the control group in relief of dysmenorrhea and degradation of elevated plasma prostaglandin (x2 = 0.71,P >0.05). But there was significant difference between the two groups in curing infertility (x2 = 14.77, P<0. 01), and the effect of NYXR in regulating endocrine and immunity was significantly better than that of danazol.Conclusion: By tonifying Kidney and removing blood stasis, NYXR is multi-effective and being one of effective methods in clinical practice for treatment of endometriosis.展开更多
目的研究养阴益气活血方药对培养人脐静脉内皮细胞抗凝和纤溶功能的作用。方法养阴益气活血方由生地黄、黄芪、川芎各等份组成;活血方由川芎一味组成。采用血清药理学方法观察养阴益气活血方和活血方对培养人脐静脉内皮细胞抗凝、纤溶...目的研究养阴益气活血方药对培养人脐静脉内皮细胞抗凝和纤溶功能的作用。方法养阴益气活血方由生地黄、黄芪、川芎各等份组成;活血方由川芎一味组成。采用血清药理学方法观察养阴益气活血方和活血方对培养人脐静脉内皮细胞抗凝、纤溶功能的作用。结果与对照组比较,养阴益气活血方和活血方均有显著增高培养人脐静脉内皮细胞中6-酮-前列环素F1α(6-keto-PGF1α)含量〔(412.5±42.7)ng/L和(231.7±30.1)ng/L比(137.6±13.5)ng/L〕、提高组织型纤溶酶原激活物(t-PA)的活性〔(0.920±0.072)kU/L和(0.679±0.062)kU/L比(0.516±0.052)kU/L〕、抑制组织型纤溶酶原激活物抑制物(PA I)活性〔(0.622±0.071)kAU/L和(0.851±0.085)kAU/L比(0.934±0.076)kAU/L〕、降低内皮素(ET)含量〔(35.7±4.9)ng/L和(46.8±5.1)ng/L比(58.6±6.2)ng/L〕、提高一氧化氮(NO)含量〔(21.68±2.26)mm o l/L和(15.15±1.73)mm o l/L比(8.67±1.24)mm o l/L〕的作用,差异均有统计学意义(P<0.05或P<0.01),且养阴益气活血方的作用显著优于活血方(P均<0.05)。结论养阴、益气、活血方药的相互配伍在抗栓、溶栓方面具有协同作用;养阴生津是治疗血瘀证的重要法则。展开更多
Erhuang capsule, a typical formula based on traditional Chinese medicine theory, is widely used to ameliorate multiple sclerosis, inflammation and side effects of glucocortJcoid treatment. Oligodendrocyte precursor ce...Erhuang capsule, a typical formula based on traditional Chinese medicine theory, is widely used to ameliorate multiple sclerosis, inflammation and side effects of glucocortJcoid treatment. Oligodendrocyte precursor cells are neural stem cells that are important for myelin repair and regeneration. In the present study, Erhuang capsule effectively improved clinical symptoms and neurological function scores, reduced mortality and promoted recovery of neurological functions of mice with experimental autoimmune encephalomyelitis. The mechanism of action involved significant increases in oligodendrocyte precursor cell proliferation in specific regions of the brain and spinal cord, increased oligodendrocyte lineage gene 2 expression and enhanced oligodendrocyte precursor cell differentiation.展开更多
文摘Osteonecrosis of the femoral head is a common disability disease of the hip joint in China,and osteonecrosis of the femoral head caused by hormone factors is the most common,which is related to the gradual increase in the utilization rate of glucocorticoids in recent years.It is a refractory disease in orthopaedics with a poor prognosis.For this disease,the treatment of traditional Chinese medicine has certain advantages.In view of this,the author reads,analyzes and summarizes its materials by searching China Journal full-text Database and Wanfang Database.This paper reviews the mechanism and clinical research progress of tonifying kidney and activating blood circulation in the prevention and treatment of steroid-induced osteonecrosis of the femoral head,hoping to provide help for the clinical treatment of hormone-related osteonecrosis of the femoral head.
文摘Objective: To explore the mechanism of treating endometriosis by tonifying Kidney and removing blood stasis with Neiyixiao recipe, ( , NYXR).Methods: One hundred and three patients of endometriosis were divided randomly into the NYXR group (58 cases, treated with NYXR) and the control group (45 cases, treaed with danazol) and were reviewed for the improvement of clinical symptoms, serum level of FSH, LH, PRL, E2, P and T, humoral and cellular immunity (C3, C4, CD3, CD4, CD8), and plasma prostaglandin after treatment.Results: There was no significant difference in effect between the NYXR group and the control group in relief of dysmenorrhea and degradation of elevated plasma prostaglandin (x2 = 0.71,P >0.05). But there was significant difference between the two groups in curing infertility (x2 = 14.77, P<0. 01), and the effect of NYXR in regulating endocrine and immunity was significantly better than that of danazol.Conclusion: By tonifying Kidney and removing blood stasis, NYXR is multi-effective and being one of effective methods in clinical practice for treatment of endometriosis.
文摘目的研究养阴益气活血方药对培养人脐静脉内皮细胞抗凝和纤溶功能的作用。方法养阴益气活血方由生地黄、黄芪、川芎各等份组成;活血方由川芎一味组成。采用血清药理学方法观察养阴益气活血方和活血方对培养人脐静脉内皮细胞抗凝、纤溶功能的作用。结果与对照组比较,养阴益气活血方和活血方均有显著增高培养人脐静脉内皮细胞中6-酮-前列环素F1α(6-keto-PGF1α)含量〔(412.5±42.7)ng/L和(231.7±30.1)ng/L比(137.6±13.5)ng/L〕、提高组织型纤溶酶原激活物(t-PA)的活性〔(0.920±0.072)kU/L和(0.679±0.062)kU/L比(0.516±0.052)kU/L〕、抑制组织型纤溶酶原激活物抑制物(PA I)活性〔(0.622±0.071)kAU/L和(0.851±0.085)kAU/L比(0.934±0.076)kAU/L〕、降低内皮素(ET)含量〔(35.7±4.9)ng/L和(46.8±5.1)ng/L比(58.6±6.2)ng/L〕、提高一氧化氮(NO)含量〔(21.68±2.26)mm o l/L和(15.15±1.73)mm o l/L比(8.67±1.24)mm o l/L〕的作用,差异均有统计学意义(P<0.05或P<0.01),且养阴益气活血方的作用显著优于活血方(P均<0.05)。结论养阴、益气、活血方药的相互配伍在抗栓、溶栓方面具有协同作用;养阴生津是治疗血瘀证的重要法则。
基金supported by the Key Combination Program of Capital Medical Development Foundation,No.2005-SF-I-001the Natural Science Foundation of Beijing,No.7102051,7092014+1 种基金the Beijing Science and Technology Development Foundation of Traditional Chinese Medicine,No.JJ2009-27the National Natural Science Foundation of China,No. 81072765,30873230
文摘Erhuang capsule, a typical formula based on traditional Chinese medicine theory, is widely used to ameliorate multiple sclerosis, inflammation and side effects of glucocortJcoid treatment. Oligodendrocyte precursor cells are neural stem cells that are important for myelin repair and regeneration. In the present study, Erhuang capsule effectively improved clinical symptoms and neurological function scores, reduced mortality and promoted recovery of neurological functions of mice with experimental autoimmune encephalomyelitis. The mechanism of action involved significant increases in oligodendrocyte precursor cell proliferation in specific regions of the brain and spinal cord, increased oligodendrocyte lineage gene 2 expression and enhanced oligodendrocyte precursor cell differentiation.
