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The single-cell transcriptomic landscape of the topological differences in mammalian auditory receptors
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作者 Xiangyu Ma Xin Chen +10 位作者 Yuwei Che Siyao Zhu Xinlin Wang Shan Gao Jiheng Wu Fanliang Kong Cheng Cheng Yunhao Wu Jiamin Guo Jieyu Qi Renjie Chai 《Science China(Life Sciences)》 SCIE CAS CSCD 2024年第11期2398-2410,共13页
Mammalian hair cells(HCs)are arranged spirally along the cochlear axis and correspond to different frequency ranges.Serving as primary sound detectors,HCs spatially segregate component frequencies into a topographical... Mammalian hair cells(HCs)are arranged spirally along the cochlear axis and correspond to different frequency ranges.Serving as primary sound detectors,HCs spatially segregate component frequencies into a topographical map.HCs display significant diversity in anatomical and physiological characteristics,yet little is known about the organization of the cochleotopic map of HCs or the molecules involved in this process.Using single-cell RNA sequencing,we determined the distinct molecular profiles of inner hair cells and outer hair cells,and we identified numerous position-dependent genes that were expressed as gradients.Newly identified genes such as Ptn,Rxra,and Nfe2l2 were found to be associated with tonotopy.We employed the SCENIC algorithm to predict the transcription factors that potentially shape these tonotopic gradients.Furthermore,we confirmed that Nfe2l2,a tonotopy-related transcription factor,is critical in mice for sensing low-tomedium sound frequencies in vivo.the analysis of cell-cell communication revealed potential receptor-ligand networks linking inner hair cells to spiral ganglion neurons,including pathways such as BDNF-Ntrk and PTN-Scd4,which likely play essential roles in tonotopic maintenance.Overall,these findings suggest that molecular gradients serve as the organizing principle for maintaining the selection of sound frequencies by HCs. 展开更多
关键词 tonotopic axis hair cell auditory receptor scRNA-seq
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