Let G = (V,E) be a simple graph without isolated vertices. For positive integer k, a 3-valued function f : V → {-1,0,1} is said to be a minus total k-subdominating function (MTkSF) if sum from (u∈N(v)) to f(u)≥1 fo...Let G = (V,E) be a simple graph without isolated vertices. For positive integer k, a 3-valued function f : V → {-1,0,1} is said to be a minus total k-subdominating function (MTkSF) if sum from (u∈N(v)) to f(u)≥1 for at least k vertices v in G, where N(v) is the open neighborhood of v. The minus total k-subdomination number γkt(G) equals the minimum weight of an MTkSF on G. In this paper, the values on the minus total k-subdomination number of some special graphs are investigated. Several lower bounds on γkt of general graphs and trees are obtained.展开更多
目的观察骨碎补总黄酮对去卵巢大鼠骨质疏松模型组织蛋白酶K(Cathepsin K)的血清浓度和左胫骨干骺端基因表达的影响,探讨骨碎补总黄酮防治骨质疏松的机制。方法选取3月龄雌性SD大鼠72只,随机分为6组:高剂量骨碎补总黄酮组[治疗组1,12只...目的观察骨碎补总黄酮对去卵巢大鼠骨质疏松模型组织蛋白酶K(Cathepsin K)的血清浓度和左胫骨干骺端基因表达的影响,探讨骨碎补总黄酮防治骨质疏松的机制。方法选取3月龄雌性SD大鼠72只,随机分为6组:高剂量骨碎补总黄酮组[治疗组1,12只大鼠,切除双侧卵巢,给药剂量0.216 g/(kg·d)];中剂量骨碎补总黄酮组[治疗组2,12只大鼠,切除双侧卵巢,给药剂量0.108 g/(kg·d)];低剂量骨碎补总黄酮组[治疗组3,12只大鼠,给药剂量0.054 g/(kg·d)];雌激素组(12只大鼠,切除双侧卵巢,给予结合雌激素片0.1 mg/kg);假手术组(12只大鼠,仅切除腹腔少量脂肪和软组织,以5 mL蒸馏水灌胃);正常组(12只大鼠,不做特殊处理,以5 mL蒸馏水灌胃)。各组均在去卵巢造模成功后开始灌胃,并于造模成功后即刻、3个月、6个月每组处死4只大鼠,无菌条件下抽取静脉血,检测血清Cathepsin K浓度。取左胫骨近端干骺端标本,荧光定量PCR测定Cathepsin K mRNA表达量,用SPSS13.0软件进行数据分析。结果各治疗组、正常组与雌激素组大鼠血清Cathepsin K浓度间差异均有统计学意义(P<0.05)。各治疗组与雌激素组左胫骨干骺端Cathepsin K mRNA表达量相比有统计学意义(P<0.05)。各治疗组、假手术组与正常组左胫骨干骺端Cathepsin K mRNA表达量相比均有统计学意义(P<0.01)。结论骨碎补总黄酮抑制去卵巢大鼠血清Cathepsin K浓度、降低左胫骨干骺端Cathepsin K mRNA表达量的作用,可能是其治疗骨质疏松症的机制之一。展开更多
基金supported by the National Natural Science Foundation of China (Grant No.10571117)the Development Foundation of Shanghai Municipal Education Commission (Grant No.05AZ04)
文摘Let G = (V,E) be a simple graph without isolated vertices. For positive integer k, a 3-valued function f : V → {-1,0,1} is said to be a minus total k-subdominating function (MTkSF) if sum from (u∈N(v)) to f(u)≥1 for at least k vertices v in G, where N(v) is the open neighborhood of v. The minus total k-subdomination number γkt(G) equals the minimum weight of an MTkSF on G. In this paper, the values on the minus total k-subdomination number of some special graphs are investigated. Several lower bounds on γkt of general graphs and trees are obtained.
文摘目的观察骨碎补总黄酮对去卵巢大鼠骨质疏松模型组织蛋白酶K(Cathepsin K)的血清浓度和左胫骨干骺端基因表达的影响,探讨骨碎补总黄酮防治骨质疏松的机制。方法选取3月龄雌性SD大鼠72只,随机分为6组:高剂量骨碎补总黄酮组[治疗组1,12只大鼠,切除双侧卵巢,给药剂量0.216 g/(kg·d)];中剂量骨碎补总黄酮组[治疗组2,12只大鼠,切除双侧卵巢,给药剂量0.108 g/(kg·d)];低剂量骨碎补总黄酮组[治疗组3,12只大鼠,给药剂量0.054 g/(kg·d)];雌激素组(12只大鼠,切除双侧卵巢,给予结合雌激素片0.1 mg/kg);假手术组(12只大鼠,仅切除腹腔少量脂肪和软组织,以5 mL蒸馏水灌胃);正常组(12只大鼠,不做特殊处理,以5 mL蒸馏水灌胃)。各组均在去卵巢造模成功后开始灌胃,并于造模成功后即刻、3个月、6个月每组处死4只大鼠,无菌条件下抽取静脉血,检测血清Cathepsin K浓度。取左胫骨近端干骺端标本,荧光定量PCR测定Cathepsin K mRNA表达量,用SPSS13.0软件进行数据分析。结果各治疗组、正常组与雌激素组大鼠血清Cathepsin K浓度间差异均有统计学意义(P<0.05)。各治疗组与雌激素组左胫骨干骺端Cathepsin K mRNA表达量相比有统计学意义(P<0.05)。各治疗组、假手术组与正常组左胫骨干骺端Cathepsin K mRNA表达量相比均有统计学意义(P<0.01)。结论骨碎补总黄酮抑制去卵巢大鼠血清Cathepsin K浓度、降低左胫骨干骺端Cathepsin K mRNA表达量的作用,可能是其治疗骨质疏松症的机制之一。
