Evaluation of the diagnostic value of total bile acids/platelets in HBV related liver fibrosis

Objective:Explore the diagnostic value of total bile acids/platelets in HBV related liver fibrosis.Methods:160 patients with chronic HBV infection admitted to the Infection Department of the First Affiliated Hospital of Hainan Medical College from February 2021 to December 2022 were selected.They were divided into two groups based on the degree of liver fibrosis detected by liver biopsy:significant liver fibrosis group and non-significant liver fibrosis group.The total bile acid/blood platelet levels and their correlation with liver fibrosis in the two groups were compared and observed,and the efficacy of other non-invasive liver fibrosis diagnostic models was evaluated.Results:(1)Compared with the non-significant liver fibrosis group,the significant liver fibrosis group showed an increase in total bile acid levels,a decrease in platelet levels,and a significant increase in total bile acid/platelet levels(P<0.05).(2)Platelets decrease with the increase of liver fibrosis degree,total bile acids increase with the increase of liver fibrosis degree,and total bile acids/platelets increase with the increase of liver fibrosis degree.(3)The area under the curve(AUC)of total bile acid/platelet,APRI,FIB-4,and elastography in diagnosing the degree of liver fibrosis were 0.69,0.57,0.56,and 0.68,respectively.Conclusions:The diagnostic efficacy of total bile acids/platelets in diagnosing HBV related liver fibrosis is no less than that of other liver fibrosis diagnostic methods,and it is non-invasive,simple,and convenient,which is worthy of further clinical promotion and validation.

Analyze the Performance of Electroactive Anticorrosion Coating of Medical Magnesium Alloy Using Deep Learning

Electroactive anticorrosion coatings are specialized surface treatments that prevent or minimize corrosion. Thestudy employs strategic thermodynamic equilibriumcalculations to pioneer a novel factor in corrosion protection.A first-time proposal, the total acidity (TA) potential of the hydrogen (pH) concept significantly shapes medicalmagnesium alloys. These coatings are meticulously designed for robust corrosion resistance, blending theoreticalinsights and practical applications to enhance our grasp of corrosion prevention mechanisms and establisha systematic approach to coating design. The groundbreaking significance of this study lies in its innovativeintegration of the TA/pH concept,which encompasses the TA/pH ratio of the chemical environment. This approachsurpasses convention by acknowledging the intricate interplay between the acidity and pH levels within thecoating formulation, thereby optimizing metal-phosphate-based conversion coatings and transforming corrosionmitigation strategies. To authenticate the TA/pH concept, the study comprehensively compares its findings withexisting research, rigorously validating the theoretical framework and reinforcing the correlates among TA/pHvalues and observed corrosion resistance in the coatings. The influence of mutations that occur naturally inthe detergent solution on persistent phosphorus changes is shown by empirical confirmation, which improvescorrosion resistance. This realization advances the field ofmaterials and the field’s knowledge of coated generation,particularly anticorrosion converter layers.

Antioxidant Activity and Phytochemical Screening in Acacia rigidula Benth. Leaves

This study aimed to compare the total phenolic content (TPC) and antioxidant activities of A. rigidula extracts. It also aimed to identify phenolic acids present in the extracts. The 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), and ferric thiocyanate lipid peroxidation antioxidant assays were performed. High performance liquid chromatography was used to identify phenolic acids. There was no solvent effect on TPC nor on scavenging activities, and inhibition of lipid peroxidation (p > 0.05) among solvent extracts. On the other hand, 1:1:3 water: acetone: methanol extract (10.22 mg GAE/g sample) had significantly higher reducing potential than 50% ethanol extract (EE) (9.259 mg GAE/g sample) (p < 0.05);but EE was not significantly different from 80% methanol extract (9.781 mg GAE/g sample) (p > 0.05). Phenolic fraction designated as fraction 4 had the highest antioxidant activity (p < 0.05) with 69.49% ABTS scavenging activity and FRAP reducing potential, 22.26 mg of GAE/g sample. DPPH scavenging activities of fractions 4 (55.59%) and 5 (55.64%) were significantly higher than the other fractions (p A. rigidula extracts contain gallic, caffeic, vanillic, p-coumaric, salicylic acids and vanillin.

Changes of Petroleum Acid Distribution Characterized by FT-ICR MS in Heavy Acidic Crude Oil after True Boiling Point Distillation

The molecular transformations of carboxylic acids in heavy acidic SL crude before and after true boiling point distillation were examined by ultra-high resolution negative-ion electrospray ionization(ESI) Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR MS). The acid class(heteroatom number), type(z numbers) and carbon number distributions were positively characterized. It was found out that the total acid number(TAN) of SL crude decreased after true boiling point distillation, and the abundance of O2 class in mass spectra was also found to be reduced from 67.6% to 34.5% in SL TBP mixed crude as measured by MS spectra, indicating to a potential carboxylic acid decomposition. However, it was interesting that the carboxylic acids type distribution in both oils was almost the same although their relative abundance in SL TBP mixed crude turned to be much lower, suggesting that various petroleum carboxylic acid types have the similar thermal decomposition reaction behavior. Furthermore, for each O2 type of acids in SL TBP mixed crude, the abundance of carboxylic acids with carbon number higher than 35 was reduced greatly, especially for those with carbon number higher than 60, the mass peaks of which were nearly totally removed, indicating that the large carboxylic acid molecules in heavy fractions decomposed more significantly because of longer heating time during the true boiling point distillation process. As a result, the reduction of TAN may be caused by the thermal decomposition of carboxylic acids especially those with high carbon number, suggesting that quick distillation or much lower pressure is required to avoid the thermal decomposition.

Clinical Application Value of Combined Detection of CG and TBA in Differential Diagnosis of Hepatobiliary System Diseases

Objective: To understand the clinical value of combined detection of cholyglycine CG and TBA in differential diagnosis of hepatobiliary diseases. Methods: Serum samples from 50 healthy people were collected as healthy control group. According to the latest disease diagnosis and treatment plan, 58 cases of HBV asymptomatic carrier group, 17 cases of viral hepatitis group, 49 cases of cirrhosis group, 50 cases of primary liver cancer group and 50 cases of other hepatobiliary diseases groups were collected respectively. The concentration levels of cholyglycine and total bile acid in each group were detected, and the differences among each group were compared. Results: By statistical analysis, serum CG concentration in viral hepatitis group, cirrhosis group, primary liver cancer group and other hepatobiliary diseases group was significantly higher than that in asymptomatic HEPATITIS B carriers and healthy control group, the differences were statistically significant (p 0.05). There was no significant difference in CG concentration among viral hepatitis group, liver cirrhosis group, primary liver cancer group and other hepatobiliary diseases group (p > 0.05). The serum TBA levels of asymptomatic carriers, viral hepatitis group, cirrhosis group, primary liver cancer group and other hepatobiliary system diseases group were significantly higher than those of healthy control group, the difference was statistically significant, p 0.05. Conclusion: Serum CG expression can not only detect liver lesions, but also distinguish different liver lesions. The positive rate of CG combined with TBA detection in patients with hepatobiliary diseases is significantly higher than that of single CG index detection. CG combined with TBA detection can significantly improve the sensitivity and accuracy of the diagnosis of hepatobiliary diseases, which is worthy of popularization and application.

放电对变压器油特性的影响(英文)

Petroleum based oils,the so-called mineral oils,are used for impregnating solid insulations or filling products of very large number of electric materials:transformers,reactors,cables,bushings,circuit breakers,tap changers, etc.In these equipments,oil is exposed to electrical stress and may experience electrical discharges under certain circumstances.Since the electrical stress is unavoidable in power equipments,the ability of oil to resist decomposition under electrical stress is of great importance for the safety of these devices.Electrical stress together with heat and moisture,in the presence of oxygen,oxidises the oil producing free radicals,acids and sludge that are deleterious to the transformer.In this paper,the effect of electrical discharges on oil properties is reported.The results indicate that quality of oil is considerably affected with increasing voltage stress.Comparing oil properties before and after voltage application allows assessing the outcome of random secondary chemical reactions between large oil born free radicals.

Fermented Spirulina products with Saccharomyces and non- Saccharomyces yeasts:Special reference to their microbial,physico-chemical and sensory characterizations

Innovative products produced from various sources through fermentation processes have been a resurgence of interest.This study was designed to determine the performance of fermented Spirulina (FS) products by three different yeast species including Debaryomyces hansenii ,Kluyveromyces marxianus and Saccharomyces cerevisiae and investigate the microbial,physicochemical and sensory characteristics of products.The results showed that the increase in yeast cell number was around 3 log after 48 h fermentation in Spirulina medium without additional carbon source.Protein bands with a molecular weight of ∼51 kDa seemed less visible and bands 14–22 kDa disappeared after 48 h fermentation by K.marxianus showed strong hydrolysis of proteins during fermentation.The amino acid compositions of the three kinds of FS were different also compared to unfermented Spirulina (unFS).Glutamic acid,methionine,lysine,isoleucine and valine became more dominant in FS samples.According to GC–MS analysis,there was a decrease in the concentration of pyrazine,ketone and aldehyde compounds of FS compared to unFS.The flavor notes of “seaweed”,“cardboard”,“earthy/muddy” and “cereal/straw” were found to be the highest in unFS than in FS detected by panelists during sensory evaluations.FS by K.marxianus is highly characterized as having the lowest “seaweed” and “umami” flavor attributes and higher “fermented” and “rose” attributes.Finally,the current study revealed that the potential of Spirulina biomass to be a suitable substrate for yeasts and fermentation of Spirulina with different yeast species led to different kinds of products.