Obesity (Ob) is an accepted major risk factor for the metabolic syndrome (MetS), a combination of at least three of five risk factors, which predispose to high oxidative stress (OS), but all obese do not show symptoms...Obesity (Ob) is an accepted major risk factor for the metabolic syndrome (MetS), a combination of at least three of five risk factors, which predispose to high oxidative stress (OS), but all obese do not show symptoms of MetS. There is dearth of data comparing OS homeostasis of severely obese adults with and without MetS, and need for biomarkers to help in differential diagnosis. Erythrocytic lipid and protein damage markers, malondialdehyde (MDA) and protein carbonyl (PCO), antioxidant enzymes erythrocytic superoxide dismutase(SOD), catalase (CAT), plasma glutathione peroxidase (GPX), and total antioxidant capacity (TAC) as ferric-reducing-ability-of-plasma (FRAP) were compared to understand OS homeostasis among 102 severely Ob (body mass index > 30), 102 Ob with severe (z-score > 2) MetS as per National Cholesterol Education Program-Adult Treatment Panel III guidelines and 100 healthy non-obese Controls. MDA/PCO and all antioxidant enzymes were lowest for ObMetS, followed by Ob, indicating greater damage to protein moieties of the erythrocytic membrane. Multiple regression analysis confirmed z-scores > 2 as significant predictor of lowered enzymes and TAC. Receiver Operator Curve analysis predicted that TAC was the most potential biomarker for the diagnosis and prognosis of MetS with an Odds Ratio of 88.5 indicating the high probability that FRAP would be low for ObMetS (z-score > 2) than for Ob with BMI > 30, but z-scores < 1. TAC is qualified as the most effective biomarker to distinguish between severely obese respondents with and without metabolic syndrome, and as a useful candidate for study of homeostatic breakdown in metabolic syndrome and the importance of z-score in assessment of MetS in obese respondents.展开更多
目的探讨膝骨关节炎患者全膝关节置换术后关节功能的影响因素。方法对我院2018年1月—2019年1月行全膝关节置换术的膝骨关节炎患者100例进行回顾性分析,对患者进行术后1年膝关节评分(hospital for special surgery knee score,HSS),根...目的探讨膝骨关节炎患者全膝关节置换术后关节功能的影响因素。方法对我院2018年1月—2019年1月行全膝关节置换术的膝骨关节炎患者100例进行回顾性分析,对患者进行术后1年膝关节评分(hospital for special surgery knee score,HSS),根据评分数据进行患者分组,HSS评分≥70分的患者设置为研究组,共58例,HSS评分<70分的患者设置为对照组,共42例。比较两组患者一般资料与病历资料,对患者术后关节功能影响因素进行分析。结果患者术后关节功能的影响因素中,患者年龄、体质量指数、术前VAS评分(是否行疼痛管理)、术前ROM、术中是否采用鸡尾酒治疗方法皆能够作为影响因素,两组患者上述指标有显著数据差异有统计学意义(P <0.05)。结论膝骨关节炎患者行全膝关节置换术后,关节功能恢复受到不同因素的影响,其中包括患者年龄、未使用鸡尾酒治疗方法、术前未进行疼痛管理等因素,还需要对各类影响因素采取积极干预,以提高患者术后关节功能恢复效果。展开更多
文摘Obesity (Ob) is an accepted major risk factor for the metabolic syndrome (MetS), a combination of at least three of five risk factors, which predispose to high oxidative stress (OS), but all obese do not show symptoms of MetS. There is dearth of data comparing OS homeostasis of severely obese adults with and without MetS, and need for biomarkers to help in differential diagnosis. Erythrocytic lipid and protein damage markers, malondialdehyde (MDA) and protein carbonyl (PCO), antioxidant enzymes erythrocytic superoxide dismutase(SOD), catalase (CAT), plasma glutathione peroxidase (GPX), and total antioxidant capacity (TAC) as ferric-reducing-ability-of-plasma (FRAP) were compared to understand OS homeostasis among 102 severely Ob (body mass index > 30), 102 Ob with severe (z-score > 2) MetS as per National Cholesterol Education Program-Adult Treatment Panel III guidelines and 100 healthy non-obese Controls. MDA/PCO and all antioxidant enzymes were lowest for ObMetS, followed by Ob, indicating greater damage to protein moieties of the erythrocytic membrane. Multiple regression analysis confirmed z-scores > 2 as significant predictor of lowered enzymes and TAC. Receiver Operator Curve analysis predicted that TAC was the most potential biomarker for the diagnosis and prognosis of MetS with an Odds Ratio of 88.5 indicating the high probability that FRAP would be low for ObMetS (z-score > 2) than for Ob with BMI > 30, but z-scores < 1. TAC is qualified as the most effective biomarker to distinguish between severely obese respondents with and without metabolic syndrome, and as a useful candidate for study of homeostatic breakdown in metabolic syndrome and the importance of z-score in assessment of MetS in obese respondents.
文摘目的探讨膝骨关节炎患者全膝关节置换术后关节功能的影响因素。方法对我院2018年1月—2019年1月行全膝关节置换术的膝骨关节炎患者100例进行回顾性分析,对患者进行术后1年膝关节评分(hospital for special surgery knee score,HSS),根据评分数据进行患者分组,HSS评分≥70分的患者设置为研究组,共58例,HSS评分<70分的患者设置为对照组,共42例。比较两组患者一般资料与病历资料,对患者术后关节功能影响因素进行分析。结果患者术后关节功能的影响因素中,患者年龄、体质量指数、术前VAS评分(是否行疼痛管理)、术前ROM、术中是否采用鸡尾酒治疗方法皆能够作为影响因素,两组患者上述指标有显著数据差异有统计学意义(P <0.05)。结论膝骨关节炎患者行全膝关节置换术后,关节功能恢复受到不同因素的影响,其中包括患者年龄、未使用鸡尾酒治疗方法、术前未进行疼痛管理等因素,还需要对各类影响因素采取积极干预,以提高患者术后关节功能恢复效果。
