The Effects of Total Flavones of Hippophae Rhamnoides L. on Cardiac function and Hemodynamics of Normal Subjects

Healthy volunteers were randomly divided into TFH group(22 subjects) and placebo control group (20 subjects). We used double-blind method. The cardiac performance and hemodynamics of the subjects before and after administration of TFH or placebo were determined by Admittance and STI methods, Oral TFH in a dose of 10 mg could significantly decrease the PEP/LVET, ICT/LVET and ICT of the mormal subjects(P<0.05). Oral TFH could increase SV(P<0.05). CO, CI, SWI, CWI and LI also tended to increase. Oral TFH also markedly reduced TPR (P<0.05) and increasedc (P<0.05). After administration of TFH, HR and HP did not significantly change(P>0.05). After administration of placebo, the parameters observed did not significantly change(P>0.05). The above results show that TFH can strengthen myocardial contractility and pump function of the heart, reduce total peripheral vascular resistance and increase vascular clasticity in normal subjects.

沙棘总黄酮对正常人心功能及血流动力学的影响

自愿的健康受试者,被随机分为TFH组(22人)和安慰剂对照组(20人),采用双盲法,使用Admittance、STI方法测定服药前后心功能及血流动力学的变化。结果表明,口服TFH 10mg/次,能使正常人的PEP/LVET、ICT/LVET及ICT值显著缩小(P<0.05);SV显著增加(P<0.05),CO、CI、SWI、CWI及LI亦有增加趋势;TPR明显降低(P<0.05),C值增加(P<0.05)。口服安慰剂前后观察指标未见显著性变化(P>0.05)。结果提示TFH能增强正常人心脏的收缩性能及泵功能,并能降低外周阻力,增加血管弹性。