In this paper we consider a Markov chain model in an ATM network, which has been studied by Dag and Stavrakakis. On the basis of the iterative formulas obtained by Dag and Stavrakakis, we obtain the explicit analytica...In this paper we consider a Markov chain model in an ATM network, which has been studied by Dag and Stavrakakis. On the basis of the iterative formulas obtained by Dag and Stavrakakis, we obtain the explicit analytical expression of the transition probability matrix. It is very simple to calculate the transition probabilities of the Markov chain by these expressions. In addition, we obtain some results about the structure of the transition probability matrix, which are helpful in numerical calculation and theoretical analysis.展开更多
AIM: To study the natural progression of diabetic retinopathy in patients with type 2 diabetes.METHODS: This was an observational study of 153 cases with type 2 diabetes from 2010 to 2013. The state of patient was not...AIM: To study the natural progression of diabetic retinopathy in patients with type 2 diabetes.METHODS: This was an observational study of 153 cases with type 2 diabetes from 2010 to 2013. The state of patient was noted at end of each year and transition matrices were developed to model movement between years. Patients who progressed to severe non-proliferative diabetic retinopathy(NPDR) were treated.Markov Chains and Chi-square test were used for statistical analysis.RESULTS: We modelled the transition of 153 patients from NPDR to blindness on an annual basis. At the end of year 3, we compared results from the Markov model versus actual data. The results from Chi-square test confirmed that there was statistically no significant difference(P =0.70) which provided assurance that the model was robust to estimate mean sojourn times. The key finding was that a patient entering the system in mild NPDR state is expected to stay in that state for 5y followed by 1.07 y in moderate NPDR, be in the severe NPDR state for 1.33 y before moving into PDR for roughly8 y. It is therefore expected that such a patient entering the model in a state of mild NPDR will enter blindness after 15.29 y.CONCLUSION: Patients stay for long time periods in mild NPDR before transitioning into moderate NPDR.However, they move rapidly from moderate NPDR to proliferative diabetic retinopathy(PDR) and stay in that state for long periods before transitioning into blindness.展开更多
This paper proposes an efficient method for quantifying the stratigraphic uncertainties and modeling the geological formations based on boreholes.Two Markov chains are used to describe the soil transitions along diffe...This paper proposes an efficient method for quantifying the stratigraphic uncertainties and modeling the geological formations based on boreholes.Two Markov chains are used to describe the soil transitions along different directions,and the transition probability matrices(TPMs)of the Markov chains are analytically expressed by copulas.This copula expression is efficient since it can represent a large TPM by a few unknown parameters.Due to the analytical expression of the TPMs,the likelihood function of the Markov chain model is given in an explicit form.The estimation of the TPMs is then re-casted as a multi-objective constrained optimization problem that aims to maximize the likelihoods of two independent Markov chains subject to a set of parameter constraints.Unlike the method which determines the TPMs by counting the number of transitions between soil types,the proposed method is more statistically sound.Moreover,a random path sampling method is presented to avoid the directional effect problem in simulations.The soil type at a location is inferred from its nearest known neighbors along the cardinal directions.A general form of the conditional probability,based on Pickard’s theorem and Bayes rule,is presented for the soil type generation.The proposed stratigraphic characterization and simulation method is applied to real borehole data collected from a construction site in Wuhan,China.It is illustrated that the proposed method is accurate in prediction and does not show an inclination during simulation.展开更多
Background:Markov chains(MC)have been widely used to model molecular sequences.The estimations of MC transition matrix and confidence intervals of the transition probabilities from long sequence data have been intensi...Background:Markov chains(MC)have been widely used to model molecular sequences.The estimations of MC transition matrix and confidence intervals of the transition probabilities from long sequence data have been intensively studied in the past decades.In next generation sequencing(NGS),a large amount of short reads are generated.These short reads can overlap and some regions of the genome may not be sequenced resulting in a new type of data.Based on NGS data,the transition probabilities of MC can be estimated by moment estimators.However,the classical asymptotic distribution theory for MC transition probability estimators based on long sequences is no longer valid.Methods:In this study,we present the asymptotic distributions of several statistics related to MC based on NGS data.We show that,after scaling by the effective coverage d defined in a previous study by the authors,these statistics based on NGS data approximate to the same distributions as the corresponding statistics for long sequences.Results:We apply the asymptotic properties of these statistics for finding the theoretical confidence regions for MC transition probabilities based on NGS short reads data.We validate our theoretical confidence intervals using both simulated data and real data sets,and compare the results with those by the parametric bootstrap method.Conclusions:We find that the asymptotic distributions of these statistics and the theoretical confidence intervals of transition probabilities based on NGS data given in this study are highly accurate,providing a powerful tool for NGS data analysis.展开更多
Node importance or centrality evaluation is an important methodology for network analysis.In this paper,we are interested in the study of objects appearing in several networks.Such common objects are important in netw...Node importance or centrality evaluation is an important methodology for network analysis.In this paper,we are interested in the study of objects appearing in several networks.Such common objects are important in network-network interactions via object-object interactions.The main contribution of this paper is to model multiple networks where there are some common objects in a multivariate Markov chain framework,and to develop a method for solving common and non-common objects’stationary probability distributions in the networks.The stationary probability distributions can be used to evaluate the importance of common and non-common objects via network-network interactions.Our experimental results based on examples of co-authorship of researchers in different conferences and paper citations in different categories have shown that the proposed model can provide useful information for researcher-researcher interactions in networks of different conferences and for paperpaper interactions in networks of different categories.展开更多
This paper presents a simple but informative mathematical model to describe the mixing of three dissimilar components of particulate solids that have the tendency to segregate within one another. A nonlinear Markov ch...This paper presents a simple but informative mathematical model to describe the mixing of three dissimilar components of particulate solids that have the tendency to segregate within one another. A nonlinear Markov chain model is proposed to describe the process. At each time step, the exchange of particulate solids between the cells of the chain is divided into two virtual stages. The first is pure stochastic mixing accompanied by downward segregation. Upon the completion of this stage, some of the cells appear to be overfilled with the mixture, while others appear to have a void space. The second stage is related to upward segregation. Components from the overfilled cells fill the upper cells (those with the void space) according to the proposed algorithm. The degree of non-homogeneity in the mixture (the standard deviation) is calculated at each time step, which allows the mixing kinetics to be described. The optimum mixing time is found to provide the maximum homogeneity in the ternary mixture. However, this “common” time differs from the optimum mixing times for individual components. The model is verified using a lab-scale vibration vessel, and a reasonable correlation between the calculated and experimental data is obtained展开更多
Rainfall forecasting can play a significant role in the planning and management of water resource systems.This study employs a Markov chain model to examine the patterns,distributions and forecast of annual maximum ra...Rainfall forecasting can play a significant role in the planning and management of water resource systems.This study employs a Markov chain model to examine the patterns,distributions and forecast of annual maximum rainfall(AMR)data collected at three selected stations in the Kurdistan Region of Iraq using 32 years of 1990 to 2021 rainfall data.A stochastic process is used to formulate three states(i.e.,decrease-"d";stability-"s";and increase-"i")in a given year for estimating quantitatively the probability of making a transition to any other one of the three states in the following year(s)and in the long run.In addition,the Markov model is also used to forecast the AMR data for the upcoming five years(i.e.,2022-2026).The results indicate that in the upcoming 5 years,the probability of the annual maximum rainfall becoming decreased is 44%,that becoming stable is 16%,and that becoming increased is 40%.Furthermore,it is shown that for the AMR data series,the probabilities will drop slowly from 0.433 to 0.409 in about 11 years,as indi-cated by the average data of the three stations.This study reveals that the Markov model can be used as an appropri-ate tool to forecast future rainfalls in such semi-arid areas as the Kurdistan Region of Iraq.展开更多
1 引言迭代函数系IFS(Iterated Function Systems),是混沌分形理论研究的一个重要部分,其理论与方法是分形自然景观模拟及分形图像压缩的理论基础。1985年,Williams和Hutchinson开创了分形几何中IFS的研究,建立了IFS的一般基础理论;M.F....1 引言迭代函数系IFS(Iterated Function Systems),是混沌分形理论研究的一个重要部分,其理论与方法是分形自然景观模拟及分形图像压缩的理论基础。1985年,Williams和Hutchinson开创了分形几何中IFS的研究,建立了IFS的一般基础理论;M.F.Barnsley和S.Demko的进一步工作使得这一方法成为构造任意维数分形集方便、有效的方法,并将之应用到图像的压缩与处理,使得该方法引起人们的关注。展开更多
基金This work is supported by the National Key Project of China(No 970211017,the National Natural Science Foundation of China(No,10271102)and Hebei Province Doctoral Foundation(No.2002131)
文摘In this paper we consider a Markov chain model in an ATM network, which has been studied by Dag and Stavrakakis. On the basis of the iterative formulas obtained by Dag and Stavrakakis, we obtain the explicit analytical expression of the transition probability matrix. It is very simple to calculate the transition probabilities of the Markov chain by these expressions. In addition, we obtain some results about the structure of the transition probability matrix, which are helpful in numerical calculation and theoretical analysis.
文摘AIM: To study the natural progression of diabetic retinopathy in patients with type 2 diabetes.METHODS: This was an observational study of 153 cases with type 2 diabetes from 2010 to 2013. The state of patient was noted at end of each year and transition matrices were developed to model movement between years. Patients who progressed to severe non-proliferative diabetic retinopathy(NPDR) were treated.Markov Chains and Chi-square test were used for statistical analysis.RESULTS: We modelled the transition of 153 patients from NPDR to blindness on an annual basis. At the end of year 3, we compared results from the Markov model versus actual data. The results from Chi-square test confirmed that there was statistically no significant difference(P =0.70) which provided assurance that the model was robust to estimate mean sojourn times. The key finding was that a patient entering the system in mild NPDR state is expected to stay in that state for 5y followed by 1.07 y in moderate NPDR, be in the severe NPDR state for 1.33 y before moving into PDR for roughly8 y. It is therefore expected that such a patient entering the model in a state of mild NPDR will enter blindness after 15.29 y.CONCLUSION: Patients stay for long time periods in mild NPDR before transitioning into moderate NPDR.However, they move rapidly from moderate NPDR to proliferative diabetic retinopathy(PDR) and stay in that state for long periods before transitioning into blindness.
基金supported by the National Natural Science Foundation of China(Grant Nos.71732001 and 52192661)National Key Research&Development Program,China(Grant No.2021YFF0501001)+1 种基金ShenzhenHong Kong-Macao S&T Program(Category C)(Grant No.SGDX20201103095203031)the Fundamental Research Funds for the Central Universities(Grant No.2021XXJS079)。
文摘This paper proposes an efficient method for quantifying the stratigraphic uncertainties and modeling the geological formations based on boreholes.Two Markov chains are used to describe the soil transitions along different directions,and the transition probability matrices(TPMs)of the Markov chains are analytically expressed by copulas.This copula expression is efficient since it can represent a large TPM by a few unknown parameters.Due to the analytical expression of the TPMs,the likelihood function of the Markov chain model is given in an explicit form.The estimation of the TPMs is then re-casted as a multi-objective constrained optimization problem that aims to maximize the likelihoods of two independent Markov chains subject to a set of parameter constraints.Unlike the method which determines the TPMs by counting the number of transitions between soil types,the proposed method is more statistically sound.Moreover,a random path sampling method is presented to avoid the directional effect problem in simulations.The soil type at a location is inferred from its nearest known neighbors along the cardinal directions.A general form of the conditional probability,based on Pickard’s theorem and Bayes rule,is presented for the soil type generation.The proposed stratigraphic characterization and simulation method is applied to real borehole data collected from a construction site in Wuhan,China.It is illustrated that the proposed method is accurate in prediction and does not show an inclination during simulation.
基金Supported by NSFC grants(Nos.11571349 and 91630314)the National Key R&D Program of China under Grant 2018YFB0704304,NCMIS of CAS,LSC of CAS+1 种基金the Youth Innovation Promotion Association of CAS.JR and FS were supported by US National Science Foundation(NSF)(DMS-1518001)National Institutes of Health(NIH)(R01GM120624,1R01GM131407).
文摘Background:Markov chains(MC)have been widely used to model molecular sequences.The estimations of MC transition matrix and confidence intervals of the transition probabilities from long sequence data have been intensively studied in the past decades.In next generation sequencing(NGS),a large amount of short reads are generated.These short reads can overlap and some regions of the genome may not be sequenced resulting in a new type of data.Based on NGS data,the transition probabilities of MC can be estimated by moment estimators.However,the classical asymptotic distribution theory for MC transition probability estimators based on long sequences is no longer valid.Methods:In this study,we present the asymptotic distributions of several statistics related to MC based on NGS data.We show that,after scaling by the effective coverage d defined in a previous study by the authors,these statistics based on NGS data approximate to the same distributions as the corresponding statistics for long sequences.Results:We apply the asymptotic properties of these statistics for finding the theoretical confidence regions for MC transition probabilities based on NGS short reads data.We validate our theoretical confidence intervals using both simulated data and real data sets,and compare the results with those by the parametric bootstrap method.Conclusions:We find that the asymptotic distributions of these statistics and the theoretical confidence intervals of transition probabilities based on NGS data given in this study are highly accurate,providing a powerful tool for NGS data analysis.
基金supported in part by National Natural Science Foundations of China(Nos.10671077,10971075)Research Fund for the Doctoral Program of Higher Education of China(No.20104407110002)+2 种基金Guangdong Provincial Natural Science Foundations,P.R.China(No.9151063101000021)supported in part by NSFC under Grant no.61073195,Shenzhen Science and Technology Program under Grant no.CXB201005250024A and ZD201006100018ANatural Scientific Research Innovation Foundation in HIT under Grant no.HIT.NSFIR.2010128.
文摘Node importance or centrality evaluation is an important methodology for network analysis.In this paper,we are interested in the study of objects appearing in several networks.Such common objects are important in network-network interactions via object-object interactions.The main contribution of this paper is to model multiple networks where there are some common objects in a multivariate Markov chain framework,and to develop a method for solving common and non-common objects’stationary probability distributions in the networks.The stationary probability distributions can be used to evaluate the importance of common and non-common objects via network-network interactions.Our experimental results based on examples of co-authorship of researchers in different conferences and paper citations in different categories have shown that the proposed model can provide useful information for researcher-researcher interactions in networks of different conferences and for paperpaper interactions in networks of different categories.
文摘This paper presents a simple but informative mathematical model to describe the mixing of three dissimilar components of particulate solids that have the tendency to segregate within one another. A nonlinear Markov chain model is proposed to describe the process. At each time step, the exchange of particulate solids between the cells of the chain is divided into two virtual stages. The first is pure stochastic mixing accompanied by downward segregation. Upon the completion of this stage, some of the cells appear to be overfilled with the mixture, while others appear to have a void space. The second stage is related to upward segregation. Components from the overfilled cells fill the upper cells (those with the void space) according to the proposed algorithm. The degree of non-homogeneity in the mixture (the standard deviation) is calculated at each time step, which allows the mixing kinetics to be described. The optimum mixing time is found to provide the maximum homogeneity in the ternary mixture. However, this “common” time differs from the optimum mixing times for individual components. The model is verified using a lab-scale vibration vessel, and a reasonable correlation between the calculated and experimental data is obtained
文摘Rainfall forecasting can play a significant role in the planning and management of water resource systems.This study employs a Markov chain model to examine the patterns,distributions and forecast of annual maximum rainfall(AMR)data collected at three selected stations in the Kurdistan Region of Iraq using 32 years of 1990 to 2021 rainfall data.A stochastic process is used to formulate three states(i.e.,decrease-"d";stability-"s";and increase-"i")in a given year for estimating quantitatively the probability of making a transition to any other one of the three states in the following year(s)and in the long run.In addition,the Markov model is also used to forecast the AMR data for the upcoming five years(i.e.,2022-2026).The results indicate that in the upcoming 5 years,the probability of the annual maximum rainfall becoming decreased is 44%,that becoming stable is 16%,and that becoming increased is 40%.Furthermore,it is shown that for the AMR data series,the probabilities will drop slowly from 0.433 to 0.409 in about 11 years,as indi-cated by the average data of the three stations.This study reveals that the Markov model can be used as an appropri-ate tool to forecast future rainfalls in such semi-arid areas as the Kurdistan Region of Iraq.
文摘1 引言迭代函数系IFS(Iterated Function Systems),是混沌分形理论研究的一个重要部分,其理论与方法是分形自然景观模拟及分形图像压缩的理论基础。1985年,Williams和Hutchinson开创了分形几何中IFS的研究,建立了IFS的一般基础理论;M.F.Barnsley和S.Demko的进一步工作使得这一方法成为构造任意维数分形集方便、有效的方法,并将之应用到图像的压缩与处理,使得该方法引起人们的关注。