Objective(s):To assess the diagnostic accuracy of spot urine protein-creatinine (P/C) ratio and its compareson with 24-hour urine proteinuria for predicting eclampsia. Method(s): Spot urine P/C ratio was determined in...Objective(s):To assess the diagnostic accuracy of spot urine protein-creatinine (P/C) ratio and its compareson with 24-hour urine proteinuria for predicting eclampsia. Method(s): Spot urine P/C ratio was determined in a mid-stream urine sample, and the 24-hour urine protein was measured. The correlation between the spot P/C ratio and 24-hour urine protein amount was done. Logistic regression analysis and ROC curve analysis have been used to analyse data. Result(s): There was a strong correlation between the spot P/C ratio and 24-hour urine protein excretion (pearson’s correlation coefficient r = 0.71;P < 0.0001). The optimal spot P/C ratio cutoff point was 0.25, for 300 mg/24 h of protein excretion, with sensitivity and specificity of 69% and 75% respectively. Conclusion(s): Spot urine P/C ratio is a quick and reliable tool which can be used as an alternative method for evaluation of proteinuria for diagnosis of pre-eclampsia.展开更多
文摘Objective(s):To assess the diagnostic accuracy of spot urine protein-creatinine (P/C) ratio and its compareson with 24-hour urine proteinuria for predicting eclampsia. Method(s): Spot urine P/C ratio was determined in a mid-stream urine sample, and the 24-hour urine protein was measured. The correlation between the spot P/C ratio and 24-hour urine protein amount was done. Logistic regression analysis and ROC curve analysis have been used to analyse data. Result(s): There was a strong correlation between the spot P/C ratio and 24-hour urine protein excretion (pearson’s correlation coefficient r = 0.71;P < 0.0001). The optimal spot P/C ratio cutoff point was 0.25, for 300 mg/24 h of protein excretion, with sensitivity and specificity of 69% and 75% respectively. Conclusion(s): Spot urine P/C ratio is a quick and reliable tool which can be used as an alternative method for evaluation of proteinuria for diagnosis of pre-eclampsia.
文摘目的 研究妊娠高血压综合征的诊断价值及肾损害的评估指标.方法 采用全自动生化分析仪,测定20例健康孕妇和36例妊娠高血压综合征孕妇在孕早期（11-12周）,孕中期（18-20周）及孕晚期（36-38周）的24 h尿蛋白及血尿酸（UA）、肌酐（Cr）水平.结果 从孕中期开始,妊娠高血压综合征组与健康孕妇组的24 h 蛋白尿比较差异有统计学意义（P〈0.01）,且妊娠高血压综合征组的阳性率为91.7%;UA水平健康孕妇组与中、重度妊娠高血压综合征组比较差异有统计学意义（P〈0.01）,轻度妊娠高血压综合征组与中、重度妊娠高血压综合征组比较差异有统计学意义（P〈0.05）,且其随着病情的严重程度逐渐升高.结论 24 h 蛋白尿对妊娠高血压综合征的早期患病风险提示有一定临床意义,可将它作为妊娠妇女在孕中期的常规检验项目,有助于早期发现妊娠高血压综合征;UA可作为判断轻、中、重度妊娠高血压综合征肾损害程度的重要指标.
